FOOD RESEARCH INTERNATIONAL
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2022
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IF 7.425
Yuanfei Ge,Jinyong Wu,Min Pang,Dan Hu,Zhongkui Li,Xiangqin Wang,Lijie Sun,Xiangsong Chen,Jianming Yao
In this study, carboxymethyl chitosan (CMCS) and N - acetylneuraminic acid (NeuAc) were used to develop C-NeuAc hydrogels to encapsulate Pediococcus pentosaceus QK-1. The mechanical properties, thermal stability, in vitro degradation, and pH sensitivity of the hydrogel were evaluated. The C-NeuAc concentration required for optimal hydrogel performance was 3% (w/v). Hydrogel swelling behaviour was effectively assessed by Fickian diffusion and Schott’s second-order kinetic models. The hydrogel demonstrated excellent biocompatibility and low in vitro cytotoxicity. An in vitro assay revealed that the viability of Pediococcus pentosaceus QK-1 in C-NeuAc had decreased by only 1.41 log (CFU/ mL) after exposure to simulated acidic gastric fluid. Moreover, the survival rate of the encapsulated and free Pediococcus pentosaceus QK-1 cells were 80.1% and virtually zero, respectively, after passage through the gastrointestinal tract. It was empirically determined that low temperature and freeze-drying were the ideal condition and method to ensure storage longevity of the hydrogel-encapsulated probiotic. Hence, C-NeuAc hydrogel is highly desirable as a food-grade probiotic delivery vehicle.
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Materials Today Communications
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2022
·
IF 3.662
Enqi Jin,Minjie Wu,Shuangshuang Wang,Zhiyong Qiao,Manli Li,Wensheng Linghu
Inexpensive, biodegradable and antibacterial nanofibers were developed through graft-quaternization double modification of chitosan (CS) as a potential substitute for those from petroleum products . Chitin is available in large quantities at low price from fishery by-products, such as crab and prawn shells. However, native chitin and its derivative - CS have poor solubility in common spinning solvents, are difficult to be used as regenerated fibers, exhibit mediocre antibacterial property, and have limited medical application as functional fiber. In this research, CS- g -polydimethylaminoethyl methacrylate (PDMAEMA) and its quaternized product were prepared successively. Various nanofiber membranes were produced by electrospinning using the modified CS/PVA acetic acid blend spinning solutions. Effects of grafting ratio ( GR ) of DMAEMA and degree of quaternization ( DQ ) on major application performance of the blend nanofiber membranes, e.g. fiber fineness, tensile property , moisture-penetrability, and inhibition of E.coli and S.aureus , were evaluated systematically. When the GR and the DQ were 21.5% and 12.3% respectively, the quaternized CS- g -PDMAEMA/PVA blend nanofiber membrane possessed satisfied fiber fineness and smoothness, high tensile property and moisture-penetrability. In addition, the nanofiber thus produced had higher inhibition function to S.aureus than many commonly used antibacterial fibrous membranes .
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CARBOHYDRATE POLYMERS
·
2022
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IF 10.723
Guangyao Wang,Junwei Ye,Miao Wang,Ye Qi,Siqi Zhang,Lei Shi,Yueguang Fang,Yiming Tian,Guiling Ning
Chronic wounds resulting from bacterial infection are a global healthcare challenge as they usually impair the healing process and induce various complications. In this work, a chitosan (CS) membrane loaded with copper boron–imidazolate framework (Cu–BIF) was successfully prepared by self-assembly method for bacterial-infected wound-healing dressing. The as-prepared Cu–BIF/CS membrane possessed desirable biocompatibility. The antibacterial activity of Cu–BIF/CS membrane was evaluated by the spread plate and disc diffusion method, which was also verified by the fluorescence-based viability and morphological changes of bacteria. Moreover, Cu–BIF/CS membrane could increase wound closure rate and accelerate skin regeneration via combination therapy with chitosan, Cu 2+ and hydroxyl radicals during infected wound healing process. These results exhibit that Cu–BIF/CS membrane has great potential as wound dressings in the field of clinical treatment of bacterial-infected wounds.
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CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Leyi Lin,Zhiping Su,Haishan Zhang,Guowen Zhou,Haonan Zhou,Junli Ren,Xiaoying Wang,Chuanfu Liu,Xiaohui Wang
The increasing environmental burden generated by disposable plastic wastes makes the development of sustainable substitute materials an emergent task. As one of the most abundant bioresources, chitosan (CS) has been considered as a potential candidate for plastic substitution. Conventionally, CS-based materials are fabricated through a solution-processing procedure due to the high crystallinity of CS. Herein, we designed a CS-based material via integrating CS into the network of polyimine (PI), which shows thermomechanical processability similar to plastics. Strong interactions were achieved through dynamic imine bond and hydrogen bond and thus formed a thermo-processable dynamic composite network. These CS-based plastic substitutes exhibit exceptional mechanical performances, excellent thermal/chemical stability, and a series of self-adaptiveness, including re-healing, reprocessing and multi-layer laminating. Notably, CPs can be easily degraded and 100% recycled for the production of next-generation materials. This work provides an alternative route to produce green and sustainable biomass materials as a plastic substitute.
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CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Yuanping Hao,Wenwen Zhao,Hao Zhang,Weiping Zheng,Qihui Zhou
Triggering the repair process of diabetic wounds is a huge clinical challenge due to microbial infection, the reduced migration and proliferation of fibroblasts, decreased angiogenesis and collagen formation caused by the long-term negative stimulation of high blood glucose levels . Herein, bio-multifunctional benzaldehyde-terminated 4-arm PEG (4-arm-PEG-CHO)/carboxymethyl chitosan (CMCS)/basic fibroblast growth factor (bFGF) hydrogels (BP/CS-bFGF) are prepared via the dynamic Schiff base reaction for diabetic wound treatment. BP/CS-bFGF hydrogel dressing shows strong wet-tissue adhesion, self-mending, and antibacterial property . Biological assessments display that the BP/CS-bFGF hydrogel has excellent biocompatibility and fast hemostasis capacity. Importantly, BP/CS-bFGF hydrogel dressing significantly accelerates full-thickness diabetic wound repair by increasing the production of Ki67, promotes the generation of epithelialization and collagen, induces the formation of hair follicles, and enhances neovascularization by upregulating the production of CD31 and CD34 . Thus, our work demonstrates that BP/CS-bFGF hydrogel dressing displays great potential for diabetic chronic wound management.
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ACS Sustainable Chemistry & Engineering
·
2022
·
IF 9.224
Qiong Wu,Lu Wang,Yan Yan,Shuang Li,Shitao Yu,Jingguo Wang,Lang Huang
Carbon dots with fluorescence from blue to green have been prepared by a microwave-assisted hydrothermal reaction of a chitosan and sodium hydroxide solution. The carbon dots are conjugated graphite nuclei with developed groups on the surface. OH– acts as an activation agent to induce changes in carbon nuclei and surface properties, leading to a high percentage of C═O, C–N═C, and C═C groups on carbon dots, which are crucial for n−π* and π–π* transitions that contribute to emission at a long wavelength. Na+ is helpful in conquering quenching and favorable for the enhanced emission. When it is embedded into a matrix of PVA and boric acid, the composite exhibits obvious room-temperature property phenomena (RTP) that can be easily recognized by the naked eye for up to 12 s with a lifetime of up to 623 ms. The N and O atoms favor the facilitation of intersystem crossing (ISC) to effectively populate triplet excitons, which contributes to the RTP with a low energy gap. The carbon dots can also act as electron donors and enable a 184% capacitance increase in graphene oxide. The prepared carbon dots exhibit potential applications in the security, sensing, and energy storage fields.
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INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
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2022
·Vol. 57
·期 5
·2872-2878
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IF 3.612
Lingyu Zhao,Imran Mahmood Khan,Bin Wang,Lin Yue,Yin Zhang,Zhouping Wang,Wenshui Xia
Summary Inventions into chitosan oligosaccharide (COS) derivatives over recent decades have hugely broadened their application in food safety. Herein, monomethyl fumaric acid (MFA) was grafted on the OH position of COS to synthesise new COS-O-MFA derivatives and evaluated their in vitro antibacterial properties. The degrees of substitution (DS) of the derivatives yielded almost 15% with the range of 0.093 to 0.260. The in vitro antibacterial properties of the new COS-O-MFA1-3 derivatives against Staphylococcus aureus ( S. aureus ) and Escherichia coli ( E. coli ) were significantly enhanced concerning COS. Based on the finding, the introduction of MFA and increasing DS have a great impact on the enhancement of antibacterial properties of the COS-O-MFA1-3 derivatives. This work proves that COS-O-MFA1-3 derivatives can be potential novel antibacterial agents and also open up a new avenue to improve their antibacterial attributes.
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ANALYTICA CHIMICA ACTA
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2022
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IF 6.911
Sheng Peng,Yuyan Huang,Sai Ouyang,Junlong Huang,Yueru Shi,Yuan-Jun Tong,Xueli Zhao,Nan Li,Jiating Zheng,Juan Zheng,Xinying Gong,Jianqiao Xu,Fang Zhu,Gangfeng Ouyang
The design and synthesis of novel high-performance solid phase microextraction (SPME) coatings towards organic pollutants with diverse chemical properties is still a challenge in sample preparation. Herein, a stable chitosan cross-linked graphene oxide (GOCS) aerogel was reported as a novel coating for solid phase microextraction. The interpenetrated meso- and macropores ensured the large surface area and high accessibility of the functional groups across the aerogel, resulting in high extraction performance towards target hydrophobic pollutants. The extraction capacities of the GOCS-coated SPME fiber towards analytes (e.g. polycyclic aromatic hydrocarbons , organophosphorus pesticides , organochlorine pesticides , pyrethroids , and polychlorinated biphenyls) were about 0.5–13 times as high as those obtained by the commercial fibers (30 μm polydimethylsiloxane (PDMS), 65 μm polydimethylsiloxane/divinylbenzene (PDMS/DVB)), which was attributed to the hydrophobic, π-π, halogen bond and hydrogen bond interactions between the coating and the analytes. Under the optimized extraction conditions, superior analytical performances for PAHs were achieved with a wide linearity (0.5–1000 ng L −1 ), high enhancement factors (311–3740), and the low limits of detection (0.03–1.28 ng L −1 ). Finally, the GOCS-coated SPME fiber was successfully applied to the determination of PAHs in real water samples with good recoveries (91.6%–110%).
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FOOD HYDROCOLLOIDS
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2022
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IF 11.504
Shenwan Wang,Lili Zheng,Xiaoyan Zheng,Yang Yang,Dao Xiao,Haide Zhang,Binling Ai,Zhanwu Sheng
The inhibitory effects of eight common hydrocolloids on the formation of advanced glycation end products (AGEs) were evaluated using chemical models. Among the hydrocolloids, chitosan (CTS) showed the best inhibition of AGEs formation. CTS greatly decreased the concentrations of fluorescent and non-fluorescent AGEs in the models when added at 0.5% (w/w). The effect of CTS was also evaluated in sponge cakes . Addition of 0.5% (w/w) CTS to the cake batter, decreased AGEs by 30.31%–61.22% and improved the hardness and moisture content of the cake without changing the color. The contents of N ε -carboxymethyllysine and the N ε -carboxyethyllysine in the free state were reduced by 51.68% and 42.43%, respectively. The inhibition mechanism of CTS was studied and we found that CTS decreased the availability of substrate of glycation by reacting with protein and competing reducing sugars with lysine and arginine in the chemical models. This resulted in inhibition of proteins oxidation and retarded the reaction between dicarbonyl compounds and proteins. The results of this study indicate that CTS is a potential inhibitor of AGEs formation for use in baked products.
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Gels
·
2022
·Vol. 8
·期 2
·131
·
IF 4.432
Sizhao Zhang,Qi Xiao,Yunyun Xiao,Zhengquan Li,Shixian Xiong,Feng Ding,Junpeng He
Chitosan (CTS) aerogel is a new type of functional material that could be possibly applied in the thermal insulation field, especially in energy-saving buildings. However, the inhibition method for the very big shrinkage of CTS aerogels from the final gel to the aerogel is challenging, causing great difficulty in achieving a near-net shape of CTS aerogels. Here, this study explored a facile strategy for restraining CTS-based aerogels’ inherent shrinkage depending on the chemical crosslinking and the interpenetrated supramolecular interaction by introducing nanofibrillar cellulose (NFC) and polyvinyl alcohol (PVA) chains. The effects of different aspect ratios of NFC on the CTS-based aerogels were systematically analyzed. The results showed that the optimal aspect ratio for NFC introduction was 37.5 from the comprehensive property perspective. CTS/PVA/NFC hybrid aerogels with the aspect ratio of 37.5 for NFC gained a superior thermal conductivity of 0.0224 W/m·K at ambient atmosphere (the cold surface temperature was only 33.46 °C, despite contacting the hot surface of 80.46 °C), a low density of 0.09 g/cm3, and a relatively high compressive stress of 0.51 MPa at 10% strain.Keywords:chitosan aerogels;shrinkage;nanofibrillar cellulose;mechanical property;thermal insulation
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2022
·
IF 9.965
Hecheng Han,Xiaoying Xu,Haopeng Kan,Yunxiang Tang,Chang Liu,Hongling Wen,Lili Wu,Yanyan Jiang,Zhou Wang,Jiurong Liu,Fenglong Wang
Globally, drug-resistant bacteria are a potential threat to human society owing to the overuse of antibiotics and thus, non-antibiotic bactericides are urgently needed. Herein, an innovative antibacterial nanoplatform based on quaternized chitosan (QCS)/ silver (Ag)/ cobalt phosphide (CoP) nanocomposites is envisaged for achieving near-infrared (NIR) laser-inducible rapid sterilisation. In the core-shell hybrids, Ag nanoparticles (NPs) with a size of ∼ 25 nm were uniformly deposited on CoP nanoneedles , upon which a layer of QCS (approximately 10 wt%), is coated. Numerical calculations revealed that under NIR irradiation, high-energy hot electrons arising from the surface plasmon resonance effect of Ag migrate into the interface between Ag and CoP, and amplify the photothermal effect of CoP. Meanwhile, photo-excited electrons from CoP are transported onto Ag NPs because the Schottky heterostructure facilitates the production of reactive oxygen species . Ag loading simultaneously enhances the photocatalytic and photothermal effects of CoP, achieving rapid antibacterial activity synergistically. The QCS coating improves the dispersibility of power in an aqueous system and provides contact between the antiseptics and bacteria. The ternary QCS/Ag/CoP nanocomposites achieved greater than 99.6% inactivation against S. aureus and E. coli within 10 min. In addition, the nanocomposites were confirmed to be noncytotoxic to mammals. Consequently, the QCS/Ag/CoP nanoplatforms possess great potential for rapid and effective antibacterial applications.
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MOLECULES
·
2022
·Vol. 27
·期 4
·1355
·
IF 4.927
Jiliu Pei,Shengyu Zhu,Yu Liu,Yukang Song,Feng Xue,Xiaohui Xiong,Chen Li
Riboflavin (RF) was considered to be possessed of photoactivity to generate reactive oxygen species (ROS) under ultraviolet (UV) light, which is thought to be a favorable antibacterial candidate. Herein, RF was incorporated into chitosan (CS) coatings and treated under UV with different exposure times (2, 4, and 6 h) to improve the physicochemical and antibacterial properties. The results showed that the light transmittance and antibacterial performance of chitosan coatings gradually increased with the extension of the UV irradiation time. The antibacterial ability of chitosan coatings correlated with the generation of ROS: ∙OH and H2O2, which achieved 1549.08 and 95.48 μg/g, respectively, after 6 h irradiation. Furthermore, the chitosan coatings with UV irradiation also reduced the pH value, total volatile basic nitrogen (TVB-N), ΔE, and total viable counts (TVC) and improved sensory attributes of pork. In conclusion, the UV irradiated chitosan coatings could be used as an environmentally friendly antimicrobial packaging material to effectively delay the spoilage of pork, maintain its sensory quality and prolong its shelf life.Keywords:chitosan;riboflavin;UV irradiation;pork preservation;antibacterial activity
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