JOURNAL OF CHROMATOGRAPHY A
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2024
·
IF 3.8
Xiaobin Zhang,Suling Zhang,Ting Lü,Wenfei Huang,Hongting Zhao,Hui Wang,Dong Zhang,Weixuan Yao
Anabolic steroids and β-agonists are commonly prohibited substances found in doping control studies; therefore, the determination of anabolic substances in biological samples is crucial. To analyze the anabolic compounds in urine, an adsorbent, polyethylene glycol (PEG)-grafted magnetic nanoparticle material (Fe 3 O 4 @SiO 2 -PEG), with low toxicity and strong biocompatibility was prepared in this investigation. Compared to those of Fe 3 O 4 and Fe 3 O 4 @SiO 2 , the grafted PEG chains (approximately 5.4 wt.%) on the magnetic nanoparticles improved the extraction efficiencies by factors of 3.9–17.0 and 2.5–2.9, respectively, likely due to the electrostatic attraction and hydrogen bonding. To achieve maximum extraction efficiency, several extraction parameters were optimized, including the kind and volume of desorption solvent, pH, and the extraction and desorption time. The standard curves were linear within the range of 0.5–20 μg/L for methyltestosterone and trenbolone, and 0.02–5 μg/L for clenbuterol. The limits of detection for the three drugs were 0.01–0.12 μg/L. The limits of quantification were 0.02–0.40 μg/L. The levels of precision of the optimized method were assessed based on the respective intra- and inter-day and batch-to-batch relative standard deviations in the ranges of 3.2–5.2 % ( n = 5), 5.9–11.3 % ( n = 4), and 6.7–9.2 % ( n = 3). The Fe 3 O 4 @SiO 2 -PEG nanoparticles could exclude urine matrix interferences (matrix effect of 91.8–98.1 %) and achieve satisfactory recoveries (75.5–116.1 %), affording sensitive and accurate determination of trace anabolic substances in urine.
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高影响因子
Reaction Chemistry & Engineering
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2024
·
IF 3.4
Yongming Xu,Wenzhao Liu,Bo Xu,Ke Wang,Jinchu Yang,Yueqi Si,Xuebin Zhao,Tingting Zhang,Zhan Zhang,Xueyi Qiao,Tianliang Lu
Glycolic acid finds extensive applications in the production of biodegradable polymers, pharmaceuticals, and fine chemicals. In this study, a Pt catalyst supported on the Sn-Beta zeolite (Pt/Sn-Beta) was developed to achieve the efficient and highly selective catalytic oxidation of ethylene glycol with molecular oxygen to prepare glycolic acid at near-room temperature (30 °C). Characterization results, including XRD, TEM, XPS, FT-IR, and O2-TPD, revealed that the relatively uniform dispersion of Pt particles, the optimal density of Lewis and Brønsted acid sites in the catalyst, and the synergistic interaction between Sn and Pt sites might be key factors contributing to the excellent catalytic performance of the Pt/Sn-Beta catalyst. By optimizing the reaction conditions, a 90% conversion of ethylene glycol and an 81% selectivity of glycolic acid were obtained. Furthermore, Pt/Sn-Beta exhibited excellent stability, with no significant decrease in catalytic performance after six repeated uses.
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高影响因子
Journal of Energy Storage
·
2025
·
IF 9.8
Peiyuan Li,Xinquan Zou,Yuwei Feng,Jiangfeng Luo,Shuolei Ma,Jianxiong Wang,Weihong Guo,Jikui Wang
Phase change materials (PCMs) are widely used in thermal energy storage and temperature regulation due to their ability to absorb and release latent heat during phase transitions. However, conventional PCMs often suffer from leakage and low thermal conductivity, which significantly limits their practical applications. Although polymer networks have been employed to encapsulate PCMs, challenges such as lack of functional modification, complex processing steps and high production costs still need to be resolved. We presented a strategy for synthesizing a double-network composite phase change material through the in situ self-assembly of graphene oxide (GO) within a sodium alginate (SA) matrix, combined with ionic crosslinking between SA and Ca 2+ , resulting in a reduced graphene oxide/calcium alginate/polyethylene glycol (RGO/CA/PEG) composite phase change material. CA imparted good dispersibility to RGO under the premise of effective encapsulation of PEG, and reduced the pressure of RGO encapsulation, resulting in a significant reduction in the preparation cost of the material. The results show that the RGO/CA/PEG has a high energy storage density (145.54 J/g) and can be maintained at 70 °C for 6 h without any leakage. Meanwhile, the construction of the RGO/CA double network enabled the PEG to have good thermal conductivity (127.78 % improvement over pure PEG) and photothermal conversion (85.54 %). The above studies show that the material has good application prospects for solar energy harvesting, battery thermal management, and thermal energy storage.
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2025
·
IF 7.7
Yuqing Zhu,Qihua Sun,Miaomiao Liu,Weiyu Zhang,Bo Ran,Ping Hu,Ning Tian,Jun Sun,Zhaofeng Wu
Ethylene glycol (C 2 H 6 O 2 ) is an organic compound widely used in industry and daily life. However, it is toxic to animals and humans and can cause serious health problems when ingested. It is important to explore new sensing materials to achieve effective detection of C 2 H 6 O 2 . In this work, pumpkin shaped aspergillus niger with submicron scale has been cultured, aspergillus niger-derived carbon (ANDC) was prepared by simple carbonization, and then novel ANDC/ZIF-8 composite was prepared using a solvothermal method. ANDC/ZIF-8 exhibits considerable selectivity for C 2 H 6 O 2 at room temperature, and the detection limit was 0.84 ppm and the response/recovery time was 13.9/10.6 s, respectively. Compared to ANDC, the gas sensitive performance of ANDC/ZIF-8 composite is greatly improved. This enhancement should be mainly attributed to the formation of heterogeneous junctions and hydrogen bonding interaction between ZIF-8 and C 2 H 6 O 2 . In this way, the mould with regular shapes produced by biomanufacturing was prepared into biochar, which in turn created a new type of gas sensing material and pioneered the introduction of biomanufacturing into the preparation process of gas sensing materials.
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Surfaces and Interfaces
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2024
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IF 5.7
Chong Ouyang,Xinyao Quan,Zhanglian Hong,Kehan Wang,Zi Ang Chen,Mingjia Zhi
In this work, polyethylene glycol is adopted as the solvent for the synthesis of ZnIn 2 S4 photocatalyst by the solvothermal method . Compared with the pristine ZnIn 2 S 4 synthesized in H 2 O solvent, those ones prepared in the polyethylene glycol solvent possess several unique features that are beneficial for photocatalytic CO 2 reduction, such as the increased Zinc vacancy level, the enlarged band gap, and the enhanced built-in internal electric field . These features allow for better charge separation efficiency, thereby improving the photocatalytic activity . The optimized ZnIn 2 S 4 can achieve a CO yield rate of 20.14 µmol/g/h at the gas-solid interface, which is 8.36 times that of the pristine ZnIn 2 S 4 .
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
·
IF 9.4
Chun-Miao Zhang,Yun-Ze Qiu,Hao Wu,Jing Guan,Shu-Guang Wang,Xue-Fei Sun
Capacitive deionization (CDI) is flourishing as an energy-efficient and cost-effective water desalination method. However, challenges such as electrode degradation and fouling have hindered the practical deployment of CDI technology. To address these challenges, the key point of our strategy is applying a hydrophilic coating composed of polyethylene glycol (PEG)-functionalized nano-TiO 2 /polyvinylidene fluoride (PVDF) to the electrode interface (labeled as APPT electrode). The PEG/PVDF/TiO 2 layer not only mitigates the co-ion depletion, but also imparts the activated carbon (AC) electrode hydrophilicity. As anticipated, the APPT electrode possessed an enhanced desalination capacity of 83.54 μmol g −1 and a low energy consumption of 17.99 Wh m −3 in 10 mM sodium chloride solution compared with the bare AC electrode. Notably, the APPT maintained about 93.19 % of its desalination capacity after 50 consecutive adsorption–desorption cycles in the presence of bovine serum albumin (BSA). During the trial, moreover, no obvious overall performance decline was noted in concentration reduction (Δc), water recovery (WR) and productivity (P) over 50 cycles. This strategy realizes energy-efficient, antifouling and stable brackish water desalination and has great promise for practical applications.
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高影响因子
Materials
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2018
·Vol. 11
·期 12
·2454
·
IF 2.467
Alfredo Ronca,Ugo D’Amora,Maria Grazia Raucci,Hai Lin,Yujiang Fan,Xingdong Zhang,Luigi Ambrosio
In this study, an innovative polymer blend, based on double network (DN) approach, has been developed by integrating a poly(ethylene glycol) diacrylate (PEGDA) network into a chemically modified hyaluronic acid sodium salt (HAs) hydrogel matrix. Here, the HAs was chemically functionalized with photocrosslinkable moieties by reacting with maleic anhydride (MAA) to obtain a maleated hyaluronic acid (MaHA). Furthermore, nanocomposite DN hydrogels were suitably prepared by physical blending of hydroxyapatite nanoparticles (HAp), obtained by sol-gel synthesis, within the hydrogel. Physico-chemical, thermal, morphological and mechanical analyses were performed. Results showed enhanced mechanical properties and a homogenous microstructure as highlighted by mechanical and morphological investigations. This suggests that nanocomposite DN hydrogels are promising candidates for biomedical applications.Keywords:double network;hyaluronic acid derivative;nanocomposite;sol-gel method;PEGDA
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高影响因子
MOLECULES
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2019
·Vol. 24
·期 10
·2024
·
IF 3.06
Yi He,Hongli Li,Xiangyu Zheng,Mingwei Yuan,Renyu Yang,Minglong Yuan,Cui Yang
In order to enrich the types ofPanax notoginsengsaponins (PNS) sustained-release preparations and provide a new research idea for the research and development of traditional Chinese medicine sustained-release formulations, a series ofPanax notoginseng saponinsmicrospheres was prepared by a double emulsion method using a series of degradable amphiphilic macromolecule materials polyethylene glycol monomethyl ether-polymandelic acid (mPEG-PMA) as carrier. The structure and molecular weight of the series of mPEG-PMA were determined by nuclear magnetic resonance spectroscopy (1HNMR) and gel chromatography (GPC). The results of the appearance, particle size, drug loading and encapsulation efficiency of the drug-loaded microspheres show that the mPEG10000-PMA (1:9) material is more suitable as a carrier for loading the total saponins ofPanax notoginseng. The particle size was 2.51 ± 0.21 μm, the drug loading and encapsulation efficiency were 8.54 ± 0.16% and 47.25 ± 1.64%, respectively. The drug-loaded microspheres were used for in vitro release and degradation experiments to investigate the degradation and sustained release behaviour of the drug-loaded microspheres. The biocompatibility of the microspheres was studied by haemolytic, anticoagulant and cytotoxicity experiments. The pharmacological activity of the microspheres was studied by anti-inflammatory and anti-tumour experiments. The results showed that the drug-loaded microspheres could be released stably for about 12 days and degraded within 60 days. At the same time, the microspheres had good biocompatibility, anti-inflammatory and anti-tumour activities.Keywords:Panax notoginseng saponins;microspheres;sustained-release;biocompatibility;anti-inflammatory;anti-cancer
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高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
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2012
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IF 3.456
Qian Guo,Ping Luo,Yu Luo,Fang Du,Wei Lu,Shiyuan Liu,Jin Huang,Jiahui Yu
Biodegradable micelles with sheddable poly(ethylene glycol) shells were fabricated based on poly(ethylene glycol)- block -poly(γ-benzyl l -glutamate) (mPEG-SS-PBLG) diblock copolymer and applied as the carrier of 7-ethyl-10-hydroxy-camptothecin (SN-38) in order to enhance its solubility and stability in aqueous media. The diblock polymer was designed to have the hydrophilic PEG moiety and hydrophobic PBLG moiety linked by biodegradable disulfide bond, so in reducing environment the PEG shells can be detached. The polymer was able to form the micelles of nano-scale in aqueous media, suggesting their passive targeting potential to tumor tissue. Water-insoluble antitumor drug, SN-38, was easily encapsulated into mPEG-SS-PBLG nanomicelles by lyophilization method. When setting theoretical drug loading content at 10 wt%, the drug encapsulation efficiency (EE) was assayed as 73.5%. Owing to the disulfide bond in mPEG-SS-PBLG, intense release of SN-38 occurred in the presence of dithiothreitol (DTT) at the concentration of simulating the intracellular condition, however, micelles showed gradual release of SN-38 in the absence of DTT. Also, the mPEG-SS-PBLG micelles effectively protected the active lactone ring of SN-38 from hydrolysis under physiological condition. Compared with free SN-38, SN-38-loaded nanomicelles showed essentially decreased cytotoxicity against L929 cell line in 24 h, bare mPEG-SS-PBLG nanomicelles showed almost non-toxicity.
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高影响因子
ADVANCED POWDER TECHNOLOGY
·
2022
·
IF 4.969
Zhiwei Wang,Mingqiang Cheng,Jiaojiao Bu,Lei Cheng,Juanjian Ru,Yixin Hua,Ding Wang
Tin is one of the vital substances in the material and chemical industry. Deep eutectic solvent (DES) possesses excellent physicochemical properties for metal preparation. In this study, the electrochemical behavior of Sn(II) and metallic tin preparation in choline chloride-ethylene glycol (ChCl-EG) DES were investigated. Linear sweep voltammetry is carried out to study the effects of substrate material (Ni, Cu, Pt, C, Fe, Al, W, glassy carbon (GC) and Ti), temperature (313–353 K) and SnCl 2 concentration (10–100 mM) on the electrochemical behavior of Sn(II)/Sn. Results demonstrate that metallic tin is easier to be prepared on the Ni electrode, and increasing temperature and SnCl 2 concentration both facilitate the reduction of Sn(II). Electrospray ionization mass spectrometry (ESI-MS) shows that the main form of Sn(II) is [SnCl 3 ] - . Chronoamperometric tests indicate that with the increase of applied potential, the nucleation of Sn(II) on the nickel electrode becomes close to the instantaneous nucleation. Simultaneously, the nucleation rate and the number of active sites on the electrode surface increase significantly. Pure tin with a dendritic structure could be prepared with higher current efficiency of 96.4% and lower energy consumption of 320.5 kW·h·t −1 without any additives. All these studies provide a fundamental basis for the preparation of tin powders in ChCl-EG DES.
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高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
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2018
·Vol. 20
·期 10
·1-14
·
IF 2.127
Hua Jisong,Teng Peng,Zou Yingying,Zhang Chao,Shen Xujie,Cai Jianfeng,Hu Yong
The bacterial infections, especially wound infection, have become a growing problem threatening the human health. Small molecular antimicrobial agents were synthesized to fight against the bacteria but the clinical application in wound inflection treatment was restricted because of their hydrophobicity and poor skin permeation. Here, we synthesized a novel quinoline compound to be used as an antimicrobial agent. Due to its hydrophobic property, this quinoline compound could be successfully encapsulated into poly(epsilon-caprolactone)-poly(ethylene glycol) (PCL-PEG) nanoparticles (NPs) with a mean size of about 100 nm and showed a sustained drug release manner in vitro. Compared to the free drug of this quinoline compound, these drug-loaded PCL-PEG NPs had better water solubility and lower cytotoxicity in vitro. Results of in vivo wound healing experiments demonstrated that these drug-loaded NPs could not only greatly suppress the bacterial infection around the wound, but also significantly accelerate the curing rate of wound. Thus, these quinoline compound-loaded PCL-PEG NPs could act as a promising drug delivery system for wound healing applications.
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高影响因子
Science of Advanced Materials
·
2016
·Vol. 8
·期 8
·1617-1627
·
IF 1.812
Wen Zhen,Su Jun-Qing,Chen Qing,Chen Li-Di
To improve the physicochemical and pharmacokinetic properties, solid lipid nanoparticles (SLNs) modified with (Polyethylene glycol-2000)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine (PEG2000-DSPE) were prepared using glyceryl monostearate as a lipid carrier and resveratrol as a model
drug. Compared to ordinary SLNs, SLNs doped with low amount of PEG2000-DSPE [m(PEG2000-DSPE):m(lipids) = 1:5, w/w] exhibited improved physicochemical and pharmacokinetic properties, including higher entrapment efficiency (above 80%), smaller particle size (approximately 100 nm), more
distinguished drug release at low pH values (pH < 6.0), and longer drug circulation in vivo. According to the characterizations performed, the DSPE moiety was doped into lipid matrix to form a PEG2000-DSPE/lipid eutectic dopant, inhibiting lipid polymorphism transformation
from α-form to β-form, thereby preventing drug expulsion from the lipid. The dopant contained lattice defects, allowing for the incorporation of more resveratrol. Resveratrol was released in a sustained and pH-sensitive pattern due to nanoparticles destabilization
induced by partial protonation of PEG2000-DSPE. PEG chains distributed on the nanoparticle surface caused steric hindrance and “stealth” properties, thus maintaining dispersion stability and extending circulation time of nanoparticles. These results confirm that PEG2000-DSPE modification
effects are attributable to the matrix and surface structures of nanoparticles, which consist of a core containing DSPEinduced lattice defects and a shell coated with PEG chains.
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