SENSORS AND ACTUATORS B-CHEMICAL
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2025
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IF 7.7
Xin Lei Xu,Yi Wei Zhou,Yue Yu,Shi Gang Liu,Lei Han
It is imperative to design a highly selective, sensitive, and portable approach for the reliable determination and monitoring of mercury ion (Hg 2+ ) given its severe toxicity to both ecosystems and public health. Herein, we develop a colorimetric and photothermal-derived multimodal sensor for point-of-care testing of Hg 2+ based on the Hg 2+ -sensitized oxidase-mimetic activity of CoSe 2 nanorods. The synthesized CoSe 2 nanorods show negligible oxidase-mimetic activity. It can bind with CoSe 2 nanorods via an Hg-Se bond when Hg 2+ is present. The generation of HgSe on the surface of CoSe 2 nanorods booms the oxidase-like activity of CoSe 2 nanorods to catalyze the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) into oxidative TMB (oxTMB), generating a hyperchromic effect and light-driven thermal effect. Consequently, the color and absorbance of the solution changed, realizing the colorimetric and visual sensing of Hg 2+ . The limit of detection (LOD) is 7.3 nM for colorimetry. Meanwhile, a photothermal sensor was also developed under the drive of a laser with a LOD of 12.3 nM. The developed sensor also shows high selectivity toward Hg 2+ because of the strong affinity between the CoSe 2 and Hg 2+ . Furthermore, the latent application of this sensor is confirmed by determining Hg 2+ in real water samples. More significantly, multimodal detection not only enhances accurate detection results through mutual authentication of different signals but also satisfies the demands of diversified detection by consolidating the advantages of photothermal and colorimetric approaches.
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ACS Sustainable Chemistry & Engineering
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2025
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IF 7.3
Jie Zhao,Saifang Huang,Yuyan Zhao,Bing Wu,Haiqin Lin,Zixuan Chen,Yudong Zhang,Weiji Dai,Can Cui
Solid-state lithium metal batteries (SSLMBs) face critical challenges, including low ionic conductivity, unstable electrode–electrolyte interfaces, and lithium dendrite growth issues. To address these issues, we designed a PVDF-based composite electrolyte embedded with NiSe nanosheets (PVDF-NS). The two-dimensional NiSe facilitated the in situ formation of Li2Se at the interface, promoting dendrite suppression by enhancing Li+ transport (room-temperature ionic conductivity: 5.53 × 10–4 S·cm–1; transference number: 0.449) and constructing a stable SEI layer. Notably, PVDF-NS supported Li||Li symmetric cells demonstrated excellent stability for over 2000 h at 0.2 mA·cm–2. When paired with NCM811 cathodes, full cells demonstrated 86.3% capacity retention over 300 cycles at 2 C. Additionally, the electrolyte exhibited high oxidative stability (4.83 V vs Li+/Li) and retained a capacity of 65.6 mAh·g–1 at 5 C, underscoring its practical applicability. This interfacial engineering approach presents a scalable and effective route for developing durable, high-performance solid electrolytes for next-generation SSLMBs.
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Cell Chemical Biology
·
2025
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IF 7.2
Yixin Sun,Baoyuan Zhang,Jiayao Wang,Xin Li,Zhonggui He,Chutong Tian,Bingjun Sun,Jin Sun
Designing highly selective nanomedicines with precise recognition of biological interfaces for efficient cancer therapy represents a tremendous challenge. Inspired by the inherent chirality and enantioselectivity of organisms, we constructed dynamic chiral cyclic diselenide-conjugated paclitaxel prodrug nanoassemblies (CSEPNs) to simulate the chiral recognition process. The optimal chiral configuration with potent antitumor effects was screened by deconstructing the lock-and-key biorecognition of CSEPNs. Compared with R-(−)-CSEP, S-(+)-CSEP displayed steady chirality-dependent self-assembly due to the balance of intermolecular interaction and steric hindrance. With ring-tensioned backbone and superior chiral topology, S-(+)-CSEPNs exhibited ultra-high redox sensitivity and enhanced clathrin-mediated endocytosis. More importantly, S-(+)-CSEPNs presented the in vivo transport advantages of high tumor accumulation and low excretion rate. Finally, CSEPNs exerted robust synergistic tumor suppression through chemotherapy, tumor redox axis modulation, and tumor angiogenesis inhibition. These findings confirmed the dominant role of chiral lock-and-key biorecognition in determining the biological fate of the nanomedicines.
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Nanoscale Horizons
·
2025
·
IF 6.6
Jingwen Yang,Zaihua Duan,Wenxin Zeng,Yichen Bu,Xing Tang,Guosheng Wang,Xin Zhou,Qian Dai,Zhen Yuan,Yadong Jiang,Huiling Tai
Quantum dots (QDs) have emerged as promising materials for next-generation infrared semiconductors due to their facile solution processing, low-cost, tunable bandgap and superior optoelectronic properties. However, organic long-chain ligands that modify the surface of QDs hinder charge transfer, thus impairing the performance of QD infrared photodetectors. Here, we report a two-step ligand exchange strategy that decouples the native long-chain ligands from the QDs using specific molecules and then attaches the short-chain ligands, resulting in high response for lead-rich lead selenide (PbSe) QD photodetectors. During the layer-by-layer film deposition process, 1-octanethiol is first used for primary ligand exchange to remove stable ligands, followed by 3-mercaptopropionic acid for secondary exchange to ensure thorough passivation of surface defects. The two-step processing PbSe QD photodetector has a responsivity of up to 1.28 A W−1, a detectivity of 9.65 × 1012 Jones and a record high external quantum efficiency of 144.4% at a bias voltage of 0.5 V at 1100 nm. Benefitting from the high performance, the PbSe QD photodetector can be integrated into a pulse monitoring platform, achieving a physiological sign monitoring by capturing real-time pulse signals of human superficial arteries.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2025
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IF 6.3
Lingxin Kong,Hui Luo,Sihai Lv,Yongzhi Cheng,Qifan Li,Fu Chen,Xiangcheng Li
With the increase in electromagnetic wave pollution, the development of high-performance microwave absorbers has become a critical research focus. Multi-interface dielectric loss microwave absorbers have emerged as a promising strategy to address electromagnetic pollution. In this study, multi-interface carbon-based selenide composites were synthesized via solvothermal treatment and pyrolytic selenization. The thermal treatment temperature significantly influences the crystal phase, defects, and the electromagnetic properties. The results demonstrate that the carbon-based selenide composite exhibits excellent microwave absorption. The maximum reflection loss reaches −52.37 dB at a thickness of 2.9 mm, while the effective absorption bandwidth is 4.43 GHz at a thickness of 1.75 mm. The designed periodic unit cell metamaterial structure, based on MMSC composites, achieves an effective absorption bandwidth of 11 GHz at a thickness of 6.0 mm. This study proposes a novel strategy for synthesizing multi-interface carbon-based bimetallic selenide composites as high-performance microwave absorbers.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2025
·
IF 9.7
Tingting Liu,Zhian Dou,Zhen Li,Yiran Sun,Chunyi Wang,Longchen Li,Hao Yin,Jiwen Li,Xiaozhong Wu,Jinglin Mu,Pengfei Zhou,Jin Zhou
Li/CF x primary batteries are renowned for their exceptional energy density, yet their practical deployment is hindered by the inherently sluggish kinetics of the CF x cathode. This study addresses this limitation by incorporating selenium (Se) into CF x (denoted as CF x /Se) via a facile low-temperature thermal treatment, significantly enhancing its electrochemical performance. Comprehensive spectroscopic and electrochemical analyses reveal that Se doping induces the formation of C Se bonds, which promote semi-ionic C F bonding, thereby accelerating Li + diffusion and reducing charge transfer resistance. Density functional theory calculations further demonstrate that Se doping modulates the electronic structure of CF x , narrowing its bandgap to establish an efficient conductive network and markedly improving electronic conductivity. The optimized CF x /Se-1 composite (Se:CF x = 1:9) delivers outstanding performance, achieving a discharge capacity of 383.9 mAh g −1 at a high current density of 20 A g −1 with an energy density of 765.7 Wh kg −1 and a power density of 3.99 × 10 4 W kg −1 . Moreover, CF x /Se-1 exhibits remarkable wide-temperature operability (−35 to 60 °C), retaining a capacity of 485.3 mAh g −1 at 0.5 A g −1 with a stable 2.0 V plateau even at −35 °C. This work underscores the pivotal role of Se doping in tailoring the band structure of CF x , unlocking its potential for high-power and extreme-temperature Li/CF x batteries.
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ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Jia Yao,Pengtao Chen,Dingqi Xie,Jianqingchen Chen,Xiao Lin,Yujin Xu
Radiotherapy (RT) is a widely used clinical treatment for cancer, leveraging ionizing radiation; however, some patients exhibit resistance to radiation due to insufficient reactive oxygen species (ROS) production. Copper-based nanomaterials represent a promising class of antitumor agents capable of generating abundant ROS. In this study, R837 and Cu2–xSe were incorporated into PLGA (50:50)20k-PEG2k-iRGD to develop a targeted nanomaterial for tumor therapy. These nanoparticles effectively induced cuproptosis, inhibited tumor cell proliferation, remodeled the tumor immune microenvironment (TME), and promoted immunogenic cell death (ICD), thereby enhancing the efficacy of PD-1 checkpoint blockade therapy (αPD-1). Furthermore, our results demonstrated that the Cu2–xSe(R837)-iRGD nanoformulations, in combination with radiotherapy, promoted the infiltration of CD8+ T cells and activated antitumor immune responses in vivo. In conclusion, our study confirmed that Cu2–xSe(R837)-iRGD nanoformulations combined with radiotherapy yielded promising therapeutic outcomes and held potential for clinical application in osteosarcoma (OS) treatment.
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Nature Nanotechnology
·
2025
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IF 34.9
Wang Dong,Ji Lei,Li You,Xu Meng,Wang Hao,Brovelli Sergio,Qiao Zeng-Ying,Zhang Jiatao,Li Yadong
Chemodynamic therapy and sonodynamic therapy are two promising tumour therapeutic strategies. However, lack of highly effective sonosensitizers and control over chemodynamic therapy limit their application. Here we synthesize silver-doped zinc selenide quantum dots with atomically dispersed superficial Fe and show that they act as efficient sonosensitizers, catalysers and immunoreagents. Surface modification with an in situ self-assembly peptide drives accumulation in tumours. Superficial Fe III remains stable and converts to Fe II only under ultrasonic processing, reverting to Fe III upon ultrasound cessation. Under ultrasound stimulation, superficial Fe undergoes valence change with concomitant amelioration of the hypoxic tumour microenvironment and production of sonodynamic therapy-beneficial hydroxyl radicals. Furthermore, silver doping suppressed nonradiative recombination of excitons, leading to improved production of singlet oxygen. Meanwhile, selenium promotes robust systemic immune responses for the inhibition of tumour metastases. This nano-platform allows control of valence switching of atomically dispersed catalysts, representing an effective tool for chemodynamic/sonodynamic/immunotherapy.
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ADVANCED MATERIALS
·
2025
·
IF 26.8
Dong Li,Bing-Xuan Zhu,Wen He,Pei-Yu Huang,Qian Zhang,Wen-Bo Duan,Liang Zhen,Yang Li,Jing-Kai Qin,Cheng-Yan Xu
Lamed by the Shockley–Queisser limit, complex device architectures and material selection, traditional photovoltaic (PV) technologies based on heterojunctions are difficult to implement reconfigurable PV generation with high power efficiency. Here, the universal bulk ionicphotovoltaic (BIPV) effect in 2D quaternary metal thio(seleno)phosphates (QMTPs) crystals is reported, and demonstrates the giant photocurrent generation with excellent reconfigurability. The programmable ion migration driven by an electric field not only leads to the in-plane electric potential gradient, but also contributes to the reversible modulation of crystal inversion asymmetry. The formation of reconfigurable in-plane homojunction in 2D CuBiP 2 Se 6 channel results into the pronounced conductance rectification with a high ratio exceeding 10 3 , contributing to an extremely large short-circuit PV current density of 1.6 A cm −2 under 532 nm illumination, among the highest values of state-of-the-art 2D PV devices. More importantly, the electric potential gradient and degree of centrosymmetric of 2D QMTPs channel can be precisely controlled by the direction and magnitude of programming voltage pulses, which enables the linearly programmed BIPV current generation with an ideal nonlinearity factor of 0.09. The photoelectric conversion relying on the BIPV effect breaks the integration bottleneck of reconfigurability and power efficiency, providing a transformative strategy for developing next-generation PV devices.
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Small Structures
·
2024
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IF 13.9
Zhenliang Li,Yujian Rao,Zhehan Wang,Tuo Zhang,Guodong Wu,Litao Sun,Yuan Ren,Li Tao
Two-dimensional (2D) transition metal dichalcogenides (TMDs) are widely used in interfacial reactions and electronic devices due to their tunable bandgap and high efficiency of carrier transport. However, the lack of fully exposed active sites in bulk samples or stacked nanosheets leads to limited performances. In this work, a general method is developed to construct ordered mesoporous TMDs/metal oxides (OM-TMDs/MOs) heterostructures, including WS 2 /WO 3 , WSe 2 /WO 3 , WTe 2 /WO 3 , MoS 2 /MoO 3 , and V 3 S 4 /V 2 O 3 , through one-step thermal sulfurization (selenidation/tellurization) of self-assembled amphiphilic block copolymer/polyoxometalates clusters nanocomposites with ordered mesostructures. The OM-TMDs/MOs possess highly OM structures with high specific surface area, large pore size, and rich active edge sites in the frameworks of heterostructures. The chemiresistive gas sensor based on OM-WS 2 /WO 3 shows excellent NO 2 -sensing performances at room temperature, with high sensitivity, ultrahigh selectivity ( S NO 2 $S_{\left(\text{NO}\right)_{2}}$ / S gas > 20), and fast response speed (6 s). Theoretical study reveals that the strong adsorption capacity of WS 2 /WO 3 heterostructure and edge sites of WS 2 for NO 2 molecules and the high charge transfer between them contribute to high selectivity and sensitivity of the sensor. This universal method provides novel strategy for synthesis of OM TMDs-based nanomaterials, showing great potential in various applications such as electronic devices, catalysis, energy storage, and conversions.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-11
·
IF 14.7
Liu Jiale,Zhang Shuoning,Wang Zichen,Xia Xinzhao,Zhang Jianying,Yu Yinuo,Xiao Yixian,Ren Yunxiao,Chen Jiajun,Yang Bo,Xie Wenting,Hu Wei,Yang Huai
Optical properties of cholesteric liquid crystal elastomers (CLCEs) can be tuned by an external field, however, it will spontaneously restore to the original state after the field is removed. Here, we introduce diselenide dynamic covalent bonds (DCBs) into CLCEs, whose optical properties can be reversibly and precisely tuned under the combined action of force and light. The tuned optical properties will be written into and remembered by the CLCEs, thus a programming effect is achieved. The prepared dynamical diselenide bonded CLCE films have the typical reversibly mechanochromism property, and high-resolution colourful patterning can be programmed by adjusting exposure time and intensity of masked visible-light under different tensile or compressive strain states. The DCB-CLCEs combine the novel anisotropy of CLCEs and the dynamic chain exchangeable ability of DCBs, which endows the materials with reprogrammable optical properties. We demonstrate a simple strategy of writing naked-eye high-resolution colourful patterning into a film with mechanochromism property by thermal or visible-light, it shows great potential in display devices, anticounterfeiting labels, sensors, optical films and smart materials.
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MOLECULES
·
2024
·Vol. 29
·期 16
·3970
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IF 4.2
Xinfeng Cheng,Huixian Li,Xiaomeng Sun,Tianxu Xu,Zhenzhen Guo,Xianchao Du,Shuai Li,Xuyang Li,Xiaojing Xing,Dongfang Qiu
To synthesize an effective and versatile nano-platform serving as a promising carrier for controlled drug delivery, visible-light-induced diselenide-crosslinked polyurethane micelles were designed and prepared for ROS-triggered on-demand doxorubicin (DOX) release. A rationally designed amphiphilic block copolymer, poly(ethylene glycol)-b-poly(diselenolane diol-co-isophorone diisocyanate)-b-poly(ethylene glycol) (PEG-b-PUSe-b-PEG), which incorporates dangling diselenolane groups within the hydrophobic PU segments, was initially synthesized through the polycondensation reaction. In aqueous media, this type of amphiphilic block copolymer can self-assemble into micellar aggregates and encapsulate DOX within the micellar core, forming DOX-loaded micelles that are subsequently in situ core-crosslinked by diselenides via a visible-light-triggered metathesis reaction of Se-Se bonds. Compared with the non-crosslinked micelles (NCLMs), the as-prepared diselenide-crosslinked micelles (CLMs) exhibited a smaller particle size and improved colloidal stability. In vitro release studies have demonstrated suppressed drug release behavior for CLMs in physiological conditions, as compared to the NCLMs, whereas a burst release of DOX occurred upon exposure to an oxidation environment. Moreover, MTT assay results have revealed that the crosslinked polyurethane micelles displayed no significant cytotoxicity towards HeLa cells. Cellular uptake analyses have suggested the effective internalization of DOX-loaded crosslinked micelles and DOX release within cancer cells. These findings suggest that this kind of ROS-triggered reversibly crosslinked polyurethane micelles hold significant potential as a ROS-responsive drug delivery system.
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