JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2019
·
IF 2.298
Lemeng Wang,Xiangfeng Tian,Chi Fang,Hao Huang,Dong Fu,Yuheng Quan
In this work, the surface tensions (γ) of the aqueous blends of 1-dimethylamino-2-propanol (DMA2P) + amino acid ionic liquids (AAILs) were studied using the Wilhelmy plate method at temperatures from 303.2 to 323.2 K and atmospheric pressure. The AAILs include tetramethylammoniumglycinate ([N1111][Gly]), 1-butyl-3-methylimidazolium glycinate ([Bmim][Gly]), and 1-butyl-3-methylimidazolium-l-lysinate ([Bmim][Lys]). The concentrations of DMA2P and AAILs were varied between 0.300 and 0.500 wt % and 0.025 and 0.075 wt %, respectively. A thermodynamic correlation approach with respect to the mass fraction and temperature was employed to correlate the surface tension of DMA2P–AAILs aqueous solutions. The surface entropy (SS) and surface enthalpy (HS) were calculated from the analytical formulation, and their variation with mass fraction and temperature was demonstrated. The effects of the types of AAILs on the surface properties were also analyzed and compared.
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ORGANIC & BIOMOLECULAR CHEMISTRY
·
2019
·Vol. 17
·期 21
·5381-5391
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IF 3.49
Chunfeng Jiang,Quan Liu,Jiaming Liu,Kaixuan Liu,Liangliang Tian,Mingfei Duan,Ying Wang,Zhufang Shen,Youjun Xu
A convenient synthesis of novel 3-deoxy-5-hydroxy-1-aminocarbasugars was developed here. The benzyl-protected glucose-derived ketone 12 was selectively converted in high yield to enone 13via retro-Michael elimination of BnOH. The double bond of 13 was regio- and stereo-selectively reduced by the induction of C4-α-OBn to the multi-functionalized 15. 15 contained all the functionalities with similar configurations to carbasugars but with 3-H and 5-OH in the ring, and it would be a very interesting building block for organic synthesis or for bioactive compounds. As one application, 15 was further transformed into 1-amino-carbasugars by the reductive amination and final deprotection of benzyls. The targets were subjected to the in vitro inhibitory activity test against sucrase or maltase. The inhibitory activity of 17b, 17h or 17j against sucrase was nearly similar to that of voglibose. In comparison with voglibose, in vivo results similarly showed that 17b, 17h or 17j could lower the post-prandial blood glucose level after sucrose loading in healthy male ICR mice, while miglitol or acarbose was less effective. The molecular modeling study of some targets or voglibose with human sucrase could explain the inhibiting action.
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DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
·
2019
·
IF 3.119
Liting Wu,Enxu Zhou,Along Gao,Linghe Kong,Siwei Wu,Xia Bian,Yuan Li,Bingxi Li,Shengli Fu,Zheng Guo,Jianmin Ye
B lymphocyte-induced maturation protein 1 (Blimp-1), a transcription factor containing zinc finger , is required and sufficient to trigger terminal differentiation of B cells in mammals. The Blimp-1 ( OnBlimp-1 ) from Nile tilapia ( Oreochromis niloticus ) was identified and characterized its expression pattern during B cell activation and maturation. The cDNA of OnBlimp-1 open reading frame is 2547 bp encoding a protein of 848 amino acids and the predicted molecular weight is 93.36 kDa. OnBlimp-1 contains a SET domain and five ZnF_C2H2 domains, which shares high homology with that of other species. OnBlimp-1 transcription was detected in all examined tissues with high expression in the spleen (SPL). Analysis of sorted lymphocyte populations , including IgM + and IgM − cells from peripheral blood (PBL), SPL and anterior kidney (AK), indicated that the OnBlimp-1 transcription was highly expressed in the IgM + B cells. Upon LPS stimulation, OnBlimp-1 expression was up-regulated in tissues of PBL, SPL and AK significantly. The expression of OnBlimp-1 , as well as the secreted IgM , was significantly up-regulated in the SPL and AK leukocytes stimulated with anti-OnIgM monoclonal antibody and LPS in vitro , respectively. Above results suggest that OnBlimp-1, a cytokine regulating the terminal differentiation of activated B cells to antibody-secreting cells, is likely to play important roles in B cell activation and maturation in Nile tilapia.
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CHEMICAL PHYSICS LETTERS
·
2018
·
IF 1.686
Juhyok So,Cholho Pang,Hongxing Dong,Paeksan Jang,Juhyok U,Kumchol Ri,Cholyong Yun
Surface molecularly imprinting polymer (SMIP) was utilized in the removal of a residual pesticide (carbaryl (CBL)) in water and simulated fruit juice. Being the crosslinking agent, ethylene glycol dimethacrylate (EGDMA) was copolymerized with the monomer , methacrylic acid (MAA) and CBL as the template molecules on the surface of the silica gel particles to produce the SMIP adsorbents. The SMIP adsorbents showed good selectivity and good adsorption capacity for CBL in the competitive adsorptions with two structurally related carbamate pesticides . The effect of the pretreatment solvents on the adsorption capacity of the SMIP adsorbent was investigated with the results of the numerical simulations. The adsorption isotherms and the adsorption kinetics were well described by the Freundlich equilibrium model and the pseudo-second-order kinetic model, respectively. Scatchard plot analysis revealed that there were two classes of binding sites populated in the SMIP adsorbents. In addition, the good selective adsorption of CBL by the SMIP adsorbent in a simulated fruit juice containing vitamin C and fructose indicated the great potential of the SMIP adsorbents to remove residual pesticide in food industry and processing industry for agricultural products.
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JOURNAL OF PHYSICAL ORGANIC CHEMISTRY
·
2014
·Vol. 27
·期 6
·498-503
·
IF 1.245
Yimei Tang,Xiaoling Hu,Ping Guan,Xiangping Lin,Xiaoqian Li
Using microwave-assisted synthesis method, a series of paramagnetic ionic liquids comprising 1-vinyl-3-alkylimidazolium VRIM + cation and tetrahalogenidoferrate (III) FeCl m Br 4 − m − anion were designed and synthesized. The structure was analyzed using 1 H NMR and Raman spectroscopy. Ultraviolet–visible absorption spectra, thermal stability, magnetic susceptibility, viscosity, ionic conductivity, and solubility were characterized. Results show that elongation of the alkyl chain leads to replacement of bromides with a small amount of chlorides in the anion, shifting of UV maximum absorption peaks to shorter wavelengths, reduction of ionic conductivity, and solubility in polar solvents, as well as increase in fluidity, magnetic susceptibility, and solubility in nonpolar solvents. Copyright © 2014 John Wiley & Sons, Ltd.
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FUEL
·
2015
·
IF 3.52
Fuping Tian,Zhikai Fu,Huan Zhang,Jianjun Zhang,Yongying Chen,Cuiying Jia
Adsorption desulfurization is one of the most promising ways to reduce the sulfur content of gasoline at deeper level. In this work, thiophene (TP) adsorption capacity in cyclohexane onto [Cu 3 (BTC) 2 (H 2 O) 3 ] (HKUST-1) was measured by batch method, and the effect of cyclohexene and toluene on sulfur capacity was investigated. Adsorption isotherms of TP, cyclohexene, and toluene in cyclohexane onto HKUST-1 were conducted at 298.15–313.15 K to explicate the different extent of influence by cyclohexene or toluene addition. The results showed that, compared with cyclohexene, the addition of toluene in model gasoline led to a moderate decline in sulfur capacity of HKUST-1. The isotherm data of TP adsorption were well-correlated using Langmuir equation, while those of cyclohexene or toluene adsorption fitted Freundlich model, indicating different adsorption mechanisms between TP and competitors. The adsorption capacities followed the order of toluene < cyclohexene ≪TP at the same equilibrium concentrations, implying the order of the adsorption affinities, which is in good agreement with the different extent of influence by cyclohexene and toluene. The excellent regeneration performance of HKUST-1 in TP adsorption benefits from the physical adsorption mechanism, which was hinted by the enthalpy of TP adsorption (−37.31 ± 2.04 kJ mol −1 ) and no detection of new sulfur species.
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2015
·
IF 7.435
Haiping Li,Tingxia Hu,Jianqiang Liu,Shue Song,Na Du,Renjie Zhang,Wanguo Hou
A series of BiOBr nanosheets was hydrothermally synthesized through pH adjustment of precursor suspensions. X-ray diffraction, X-ray photoelectron spectroscopy, electronic microscopy and UV–vis diffuse reflectance spectroscopy analyses indicate that these nanosheets possess similar crystallinity, surficial composition, structures, band gaps and highly exposed (0 1 0) facets, but different lateral sizes and thicknesses. The visible-light photoactivity of these nanosheets in photodegradation of salicylic acid increases with reduced nanosheet thickness. An inversely linear relationship was obtained between the pseudo-first-order rate constant ( k ) and the nanosheet thickness. The photoactivity enhancement of the samples with reduced nanosheet thickness is ascribed to the decreasing recombination efficiency of photogenerated charge carriers. This study indicates that the photoactivity of the BiOBr nanosheets with dominant exposed (0 1 0) facets decisively depend on the nanosheet thickness, rather than the percentage of exposed active facets ((0 0 1) facets), which may be universal for other two-dimensional photocatalysts.
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BIOCONJUGATE CHEMISTRY
·
2015
·
IF 4.513
De-Hong Yu,Ya-Rong Liu,Xin Luan,Hai-Jun Liu,Yun-Ge Gao,Hao Wu,Chao Fang,Hong-Zhuan Chen
Multidrug resistance is the main cause of clinical chemotherapeutic failure. Antiangiogenic cancer therapy with nanomedicine that allows the targeted delivery of antiangiogenic agents to tumor endothelial cells may contribute to innovative strategies for treating multidrug-resistant cancers. In this study, we developed a new nanodrug delivery system (nano-DDS), with improved antiangiogenic efficacy against multidrug resistant human breast cancer MCF-7/ADR cells. Here, the IF7 ligand was a peptide designed to bind the annexin 1 (Anxa 1), a highly specific marker of the tumor vasculature surface, with high affinity and specificity. IF7-conjugated Anxa 1-targeting nanoparticles containing paclitaxel (IF7-PTX-NP) allowed controlled drug release and displayed favorable prolonged circulation in vivo. IF7-PTX-NP was significantly internalized by human umbilical vein endothelial cells (HUVEC) through the IF7-Anxa 1 interaction, and this facilitated uptake enhanced the expected antiangiogenic activity of inhibiting HUVEC proliferation, migration, and tube formation in a Matrigel plug relative to those of Taxol and PTX-NP. As IF7-PTX-NP targeted the tumor vessels, more nanoparticles accumulated in MCF-7/ADR tumors, and more importantly, induced significant apoptosis of the tumor vascular endothelial cells and necrosis of the tumor tissues. Low dose paclitaxel (1 mg/kg) formulated in IF7-PTX-NP showed significant anticancer efficacy, delaying the growth of MCF-7/ADR tumors. The same efficacy was only obtained with an 8-fold dose of paclitaxel (8 mg/kg) as Taxol plus XR9576, a potent P-gp inhibitor. The anticancer efficacy of IF7-PTX-NP was strongly associated with the improved antiangiogenic effect, evident as a dramatic reduction in the tumor microvessel density and pronounced increase in apoptotic tumor cells, with no obvious toxicity to the mice. This nano-DDS, which targets the tumor neovasculature, offers a promising strategy for the treatment of multidrug-resistant cancer.
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FUEL PROCESSING TECHNOLOGY
·
2015
·
IF 3.352
Mei-Xia Zhao,Xian-Yong Wei,Meng Qu,Zhan-Ku Li,Jing Liu,Jiao Kong,Dong-Dong Zhang,Hong-Lei Yan,Zhi-Min Zong
A highly active solid acid was prepared by impregnating trifluoromethanesulfonic acid (TFMSA) onto mesostructured zirconium oxide (MSZO). Di(1-naphthyl)methane (DNM) was used as a coal-related model compound to evaluate the catalytic activity of TFMSA/MSZO for cleaving strong C–C bridged bonds in coals. As a result, TFMSA/MSZO was found to be effective for hydrocracking DNM to naphthalene and 1-methylnaphthalene in cyclohexane without adding gaseous hydrogen and MSZO is a much better support than activated carbon, γ-Al 2 O 3 , and ZSM-5 zeolite . Based on the kinetic investigation, the apparent activation energy of DNM hydrocracking over TFMSA/MSZO is only 32.0 kJ·mol −1 , which is much lower than the dissociation energy (355.6 kJ·mol −1 ) of the bridged bond in DNM. The proton transfer directly from TFMSA/MSZO and/or via cyclohexane dehydrogenation over TFMSA/MSZO to the ipso -position of DNM could be the crucial step for DNM hydrocracking.
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BIODEGRADATION
·
2016
·Vol. 27
·期 1
·37-46
·
IF 2.208
Zhou YuYang,Huang Huanlin,Shen Dongsheng
This study evaluated substrate interactions during the aerobic biodegradation of 1, 4-dioxane and BTEX mixtures by a pure culture, Acinetobacter baumannii DD1, which is capable of utilizing 1, 4-dioxane for growth. A. baumannii DD1 could utilize BTEX as a sole carbon source, but could not utilize m -xylene and p -xylene. In binary mixtures, there was a lag of about 14 h before the degradation of BTE, and 1, 4-dioxane only started to be utilized when BTE was completely degraded by 1, 4-dioxane-grown DD1. Furthermore, the biodegradation rate of 1, 4-dioxane decreased from 73.33 to 40.74 mg/(h g dry weight) after the biodegradation of benzene. 1, 4-dioxane could not be degraded after the biodegradation of o -xylene in 80 h. DD1 could also not degrade m -xylene and p -xylene coexisting with 1, 4-dioxane. The ability of DD1 to degrade BTEX occurred in the following order: benzene > ethylbenzene > toluene > o -xylene > m -xylene = p -xylene. The biodegradation of 1, 4-dioxane was not activated in the mixture with o -xylene, primarily because of the accumulation of the specific toxic intermediate, 2, 3-dimethylphenol. The lag in BTE degradation was presumably because of the induction of enzymes necessary for BTE degradation. Additionally, SDS-PAGE analysis demonstrated that there were different proteins during the degradation of benzene and 1, 4-dioxane.
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ANALYST
·
2014
·Vol. 139
·期 19
·4917-4923
·
IF 3.906
Hongmei Cao,Daixin Ye,Qianqian Zhao,Juan Luo,Song Zhang,Jilie Kong
A novel strategy for the quantitative determination of human colon cancer DLD-1 cells utilizing an electrochemical aptasensor was developed by effective surface recognition between Mucin 1 glycoprotein over-expressed on the cell membrane and MUC-1 aptamer (MUC-1) bound on carbon nanospheres (CNSs). An MTT assay revealed that the as-prepared CNSs by green route exhibited satisfactory biocompatibility for cell viability, providing a suitable platform for the cell adhesion study. Furthermore, using CNSs as a sensing layer accelerated electron transfer and provided a highly stable matrix for the convenient conjugation of target MUC-1 aptamer, considerably amplifying the electrochemical signals. Electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV) were applied to assess the optimal conditions and detection performance of the as-fabricated aptasensor. The attachment of colon cancer DLD-1 cells onto the MUC-1 aptamer immobilized CNSs led to increased EIS responses, which changed linearly in cell concentration ranging from 1.25 × 102 to 1.25 × 106 cells per mL with a lower detection limit of 40 cells per mL. With this method, colon cancer DLD-1 cells can be easily distinguished from normal cells, Human astrocytes 1800. The novel aptasensor revealed high specificity to DLD-1 cells. Furthermore, the aptasensor described here showed good reproducibility and high stability because of the CNSs of high stability and biocompatibility. The proposed protocols are a promising technique for the early monitoring of human colon cancer, and might have potential clinical applications such as cancer diagnosis, drug screening.
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CHEMICAL ENGINEERING JOURNAL
·
2016
·
IF 5.31
Yang Li,Chunyan Ma,Hongling Yang,Zhongshen Zhang,Xin Zhang,Nanli Qiao,Junhui Wang,Zhengping Hao
The traditional reaction temperatures of 1-butene isomerization to 2-butene tend to above 100 °C, while here we report the unique catalytic performance of a Pd loaded silica nanospheres catalyst for 1-butene double-bond-shift isomerization at room temperature and showed 2-butene yield of 37.0%. Furthermore, the introduction of O 2 into the reaction mixture dramatically improved the yield efficiency to 57.2% without the formation of by-product CO 2 . The reaction process is proved that the ratio of trans -2-butene to cis -2-butene in the final product was determined by the trans : cis ratio of the butenylcarbenium ion intermediate, and the ratio of trans -2-butene to cis -2-butene decreased with the increasing reaction temperature. Unlike other palladium catalyst systems, Pd 0 nanoparticles were proved to act as catalytic active sites, and their oxidation and aggregation resulted in a decrease in activity. Most importantly, the catalyst acidity affected the catalytic performance, which provides theoretical basis for the choice of catalysts.
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