查找使用阿拉丁产品的科研文献

Big World in the Small Space: Constructing Hollow Zeolite Microspheres Using a Sustainable Template

Meng Pan,Jiajun Zheng,Yujian Liu,Qinglan Kong,Huiping Tian,Ruifeng Li

Hollow zeolite microspheres have attracted considerable interest due to their unique properties and great potential applications. In this work, we report a simple and cost-effective approach for constructing hollow zeolite microspheres based on a biomass-derived template, i.e., carboxymethylcellulose sodium (CMC). As an example, a hollow ZSM-5 microsphere with a hollow core smaller than 1 μm in diameter and a complete crystal shell is synthesized. This approach overcomes most of the limitations associated with the existing methods, such as complex operations and costly spherical templates. By studying the growth process in detail, a possible formation mechanism is proposed. The crystallization of the hollow zeolite microsphere is through a “surface to core” process, in which the interaction between the CMC and the zeolite gel and the decomposition of the polymer network play the critical roles.

Amphiphilic dendritic nanomicelle-mediated co-delivery of 5-fluorouracil and doxorubicin for enhanced therapeutic efficacy

Rui Han,Yuan Sun,Chen Kang,Huijing Sun,Wenguang Wei

Synthesis and biological evaluation of novel 2-(substituted isoxazol-4-yl)-5-arylamino-1,3,4-oxadiazoles

Liu Feng,Wang Meiyan,Teng Xinhuan,Zhang Peizhi,Jiang Lin

A series of 2-(5-methyl-3-(4-chloro/trifluoromethylphenyl)isoxazol-4-yl)-5-arylamino-1,3,4-oxadiazoles were synthesized from 4-chloro/trifluoromethyl benzaldehyde, ethyl acetoacetate, hydroxylamine hydrochloride, hydrazine hydrate, and aryl isocyanate by multi-step reactions. The structures of the target compounds were elucidated by IR, 1 H NMR, MS, and elemental analysis. All these compounds were tested for in vitro antifungal activities against Botrytis cinerea and Rhizoctonia cerealis by the mycelium growth rate method, and the results indicated that some compounds displayed high antifungal activity against Botrytis cinerea.

The neuronal ALAS2/5-ala axis mitigates chemotherapy-induced neurotoxicity via the BACH1/NRF2 pathway

Wen-yuan Zhang,Qian-qian Wei,Tao Zhang,Chunmei Geng,Hai-yan Wu,Chang-shui Wang,Jing Chen,Lei Feng,Pei Jiang

Background and Purpose Despite breakthroughs in immunotherapy and targeted therapies, chemotherapy remains indispensable in oncology. Experimental Approach This study seeks to pinpoint key pathways in doxorubicin (DOX)-treated mouse hippocampus, utilising comprehensive transcriptomic and metabolomic analyses, and validating the mechanisms in vitro and in vivo. Key Results Our multi-omics investigation revealed that sustained DOX exposure induced significant down-regulation of 5-aminolevulinate synthase 2 (ALAS2) and its catalytic product 5-aminolevulinic acid (5-ALA) in the hippocampal region. ALAS2 deficiency was specific to hippocampal neurons, which were more sensitive to oxidative damage than astrocytes or microglia. In vivo and in vitro studies demonstrated that 5-ALA administration or ALAS2 overexpression protected the brain from DOX-induced neurotoxicity. ALAS2 catalyses the condensation of glycine and succinyl-CoA to form 5-ALA, the key precursor of haem. Beyond its role in erythropoiesis, haem is a metabolite that modulates cellular redox homeostasis through interactions with the BACH1 (BTB and CNC homology 1)/NRF2 (nuclear factor erythroid 2 like 2) pathway. We found that DOX suppressed the ALAS2/5-ALA axis, thereby enhancing BACH1 stability. This stabilised BACH1 competes with NRF2 for binding to antioxidant response elements (AREs) in target gene promoters. Conversely, reinforcing the ALAS2/5-ALA axis elevated intracellular haem levels, promoting BACH1 degradation and enhancing NRF2 activity. Using a zebrafish model, we further highlighted the antioxidant and neuroprotective role of 5-ALA against DOX-induced neurotoxicity. Conclusions and Implications In conclusion, this study elucidates a novel endogenous neuroprotective mechanism wherein the ALAS2/5-ALA axis modulates the BACH1/NRF2 pathway. 5-ALA shows promise for repurposing to mitigate chemotherapy-associated neurotoxicity. Graphical

5 nm NiCoP nanoparticles coupled with g-C3N4 as high-performance photocatalyst for hydrogen evolution

Ma Bo,Zhao Jinping,Ge Zhenhua,Chen Yantao,Yuan Zhihao

Graphitic carbon nitride (g-C 3 N 4 ) coupled with NiCoP nanoparticles with sizes around 5 nm have been fabricated via a controllable alcohothermal process. NiCoP is an excellent electron conductor and cocatalyst in photocatalytic reactions. The coupling between tiny NiCoP nanoparticles and g-C 3 N 4 through in-situ fabrication strategy could be a promising way to eliminate the light screening effect, hinder the recombination of photo-induced charge carriers, and improve the charge transfer. The NiCoP/g-C 3 N 4 nanohybrids exhibit an excellent photocatalytic activity in the hydrogen generation, with a significantly improved performance compared with original g-C 3 N 4 , CoP/g-C 3 N 4 and Ni 2 P/g-C 3 N 4 , respectively. This study paves a new way to design transition metal phosphides-based photocatalysts for hydrogen production.

Bi2(IO3)(IO6): First combination of [IO3]− and [IO6]5− anions in three-dimensional framework

Chuanling Sun,Yuandong Wu,Dajiang Mei,Thomas Doert

A new bismuth (III) iodate periodate , Bi 2 (IO 3 )(IO 6 ) was obtained from hydrothermal reactions using Bi(NO 3 ) 3 ·5H 2 O, and H 5 IO 6 as starting materials. Bi 2 (IO 3 )(IO 6 ) crystallizes in the monoclinic space group P 2 1 / c (No. 14) with lattice parameters ɑ  = 8.1119(6), b  = 5.4746(4), c  = 16.357(1) Å, β  = 99.187(2)°, V  = 717.07(9) Å 3 , Z  = 4. The structure of Bi 2 (IO 3 )(IO 6 ) features a three-dimensional framework which is a combination of [Bi(1)O 5 ] tetragonal pyramids, [Bi(2)O 8 ] bicapped trigonal prisms and [IO 3 ] − and [IO 6 ] 5− anions. Thermal analysis shows that the compound is thermally stable up to about 350 °C. The solid state UV-vis-NIR diffuse reflectance spectrum indicates that Bi 2 (IO 3 )(IO 6 ) is a semiconductor with a band gap of 2.76 eV.

Non-isothermal melt-crystallization kinetics of poly (ethylene terephthalate-co-sodium-5-sulfo-iso-phthalate)

Lipeng Wang,Fucheng Zhang,Yongping Bai,Liping Ding

The kinetic of non-isothermal crystallization of Poly (ethylene terephthalate-co-sodium-5-sulfo- iso -phthalate) (PETI) was investigated using differential scanning calorimetry (DSC). Various macrokinetic models namely the Avrami, Tobin, Ozawa, and Ziabicki were used to describe the non-isothermal crystallization process of PETI. Both of the Avrami crystallization rate constant and the Tobin crystallization rate constant were observed to increase with increasing cooling rate. The Avrami model is better than the Tobin model to describe the non-isothermal crystallization process of PETI. The Ozawa crystallization rate K O was found to decrease with increasing cooling rate, while Ziabicki’s kinetic crystallizability parameter G Z was found to increase with increasing cooling rate. The effective energy barrier △E for non-isothermal crystallization process of PETI, analyzed based on the differential iso-conversional method of Friedman, was found to be an increasing function of the relative crystallinity.

Microstructure, electrical and mechanical properties of MgO nanoparticles-reinforced porous PZT 95/5 ferroelectric ceramics

Junxia Wang,Hengchang Nie,Chunfeng Lan,Genshui Wang,Xianlin Dong,Xuefeng Chen,Fei Cao,Hongliang He

Porous Pb (Zr 0.95 Ti 0.05 ) O 3 / x MgO (PZT/MgO, x =0, 0.1, 0.2, 0.5 and 1.0   wt%) ferroelectric ceramics were prepared with MgO nanoparticles as reinforcing phase. The effects of MgO nanoparticles on the phase, microstructure, electrical and mechanical properties of as-prepared ceramics were investigated. The results show that the grain size is reduced obviously when increasing the amount of MgO. Compared with pure porous PZT, T C of MgO-added PZT ceramics shifts to higher temperature. Moreover, dielectric, ferroelectric and piezoelectric properties show no much degradation. Further, PZT/MgO ceramics possess enhanced mechanical properties compared to pure porous PZT ceramics, the largest increment of the fracture toughness and hardness being 31.3% and 19.8%, respectively. The optimal electrical and mechanical properties are obtained with the addition of less than 0.5   wt% MgO nanoparticles.

Enhanced thermoelectric properties of In2O3(ZnO)5 intrinsic superlattice ceramics by optimizing the sintering process

Li-Jun Cui,Zhen-Hua Ge,Peng Qin,Jing Feng

Thermoelectric (TE) materials have a promising application as they can interconvert thermal energy to electrical energy directly. Oxide TE materials have attracted more attention for this application due to their high temperature stability. In this work, In2O3(ZnO)5 intrinsic superlattice ceramics with a layered structure were synthesized by reaction sintering a mixed powder of In2O3 and ZnO at 1200 °C for different holding times (t = 6, 8, 10, 12 and 15 h) in air. Their thermoelectric properties including the electrical conductivity, Seebeck coefficient and thermal conductivity, were measured from 323 to 973 K. The thermoelectric properties depended on the holding time. The highest ZT value of 0.19 at 973 K was obtained for the sample with a 12 h holding time.

Improved Electrochemical Performance of Nd3+- Doped LiNi0.5Mn1.5O4 Cathode Material for 5 V Lithium-Ion Batteries

Ai Jia Wei,Wen Li,Li Hui Zhang,Zhen Fa Liu

Spinel powders of Nd-doped LiNi0.5NdxMn1.5−xO4 with different Nd3+ contents (x = 0, 0.01, and 0.02) have been synthesized by a solid-state ball milling method. The samples was characterized by XRD, SEM and EDS. XRD shows the doping of Nd3+ did not destroy the formation of spinel LNMO.The results show that LiNi0.5Nd0.01Mn1.49O4 sample exhibits a higher rate performance with specific discharge capacities of 134.8, 137.2, 136.5, 130.4, 123.8, 106.4, and 83.1 mAh g−1 at 0.2, 0.5, 1, 2, 3, 5, and 7 C (1 C = 140 mAh g−1), respectively. The results indicate that the Nd3+ doping could reduce the electrode polarization and enhance the rate capacities.

Cr-doped NiFe layered double hydroxide nanosheets for electrocatalytic upgrading of biomass-derived 5-hydroxymethylfurfural

Yongning Chen,Yin Wang,Xiaoxuan Guo,Jianan Li,Yijie Jiang,Wenbo Sun,Wenlong Sun,Chong Peng

The electrocatalytic oxidation of 5-hydroxymethylfurfural (HMF) is an effective method to produce high-value-added chemicals with low energy consumption. In this work, we prepared a highly efficient electrocatalyst by incorporating Cr-doped NiFe layered double hydroxide nanosheets supported on nickel foam (NiFeCr-LDH/NF). For the HMF oxidation reaction (HMFOR) in 1   M KOH electrolyte, the NiFeCr-LDH/NF catalyst achieves an exceptional current density of 100   mA   cm -2 at a low potential of 1.47   V vs . reversible hydrogen electrode (RHE). Critically, it exhibits a high 2,5-furandicarboxylic acid (FDCA) yield of 93.8% and a Faradaic efficiency of 91.5%. Furthermore, in situ Fourier transform infrared spectroscopy (FTIR) studies and transient electrochemical measurements were carried out to investigate the mechanism in the HMFOR. Precisely controlled Cr doping can effectively modulate the synergistic adsorption equilibrium between HMF and hydroxyl intermediates, thereby enhancing electrocatalytic reaction efficiency via optimized interfacial charge transfer dynamics. This work illustrates heteroatom engineering as a powerful strategy for designing efficient electrocatalysts, enabling efficient biomass valorization.

Design, Synthesis, and Antimicrobial Activity Evaluation of 5-(3/4-Hydroxybenzylidene)thiazolidine-2,4-dione Derivatives

Lv Yingmei,Shi Lele,Luo Xi,Huang Yuhang,Du Zhenting

Thiazolidine-2,4-dione (TZD), a privileged scaffold, is a versatile pharmacophore and outstanding sulphur-containing heterocyclic compound found in various drugs. In this work, forty-two substituted 5-arylidene-1,3-thiazolidine-2,4-diones derivatives have been designed and synthesized by introducing sulfonyl groups, benzoyl groups, and amide groups into 5-(3/4-hydroxybenzylidene)thiazolidine-2,4-dione through Knoevenagel condensation, and their antibacterial activities were evaluated in vitro. As a result, thirty-five compounds were new compounds, and seven compounds were known compounds. The in vitro assay results disclosed that compared with B/C-series, A-series compounds presented remarkable antimicrobial activity against S. aureus, E. faecalis , and E. faecium . All twenty-one synthesized A-series compounds exhibited excellent antibacterial activity against S. aureus (MIC 80 ≤ 128 µg/mL). Among these, three compounds demonstrated the highest anti- E. faecalis activities (MIC 80 = 8 µg/mL), while E. faecium showed antibacterial susceptibility to A-series compounds except two of the investigated compounds p -cyanophenyl and p -trifluoromethoxyphenyl substituted sulfonate esters. In contrast, the B-series displayed limited activity, with only three compounds showing measurable anti- S. aureus effects, among which substituted phenyl benzoates exhibited the best antibacterial action against E. faecium (MIC 80 = 64 µg/mL). The C-series compounds demonstrated the weakest activity profile, with two N -substituted acetamides ( N -phenyl and N -methylphenyl) displaying moderate anti- S. aureus activity (MIC 80 = 128 µg/mL), which merely compound N - o -nitrophenyl was sensitive to E. faecalis (MIC 80 = 256 µg/mL). SAR analysis revealed that synthetic TZD-derivatives with substituted sulfonyl groups significantly enhanced antibacterial activity against all tested Gram-positive bacterial strains. These molecules may serve as lead compounds for developing more effective and less toxic antibacterial agents.