JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Junxian Wang,Yuxuan Ren,Xiangkai Zhu,Yunfeng Guo,Jiamao Li
In this paper, novel Ca 3 (Co 1/6 Cu 1/6 Mg 1/6 Zn 1/6 Ni 1/6 Mn 1/6 ) 2 SiV 2 O 12 (CRSV) ceramics were designed, aiming to obtain low permittivity (ε r ), high quality factor ( Q × f ) and exceptional temperature stability through high-entropy strategy. The simultaneous occupation of the B-site by six cations in garnet structure resulted in higher conformational entropy, which contributed to reducing the sintering temperature and obtaining exceptional temperature stability for CRSV ceramics. Every ceramic sample exhibited a cubic garnet structure with the Ia - 3d space group, as demonstrated by X-ray diffraction (XRD) analysis along with Rietveld refinement . The relative density and grain size of CRSV ceramic samples first increased and subsequently decreased with rising sintering temperature. The ε r showed a strong correlation with the relative density, while the change trend of the Q × f was opposite to that of the full width at half maximum (FWHM) observed in Raman spectra. However, the τ f did not show a strong temperature dependence. Typically, exceptional microwave dielectric properties of ε r = 11.0, Q × f = 63,300 GHz, τ f = -13.7 ppm/°C were obtained for CRSV ceramics sintered at 1050 °C. Meanwhile, the ceramics exhibited a Vickers hardness of 5.65 GPa and a fracture toughness of 1.10 MPa‧m 1/2 . The current work demonstrates that the high-entropy engineering is a promising pathway to develop high-performance microwave dielectric ceramics for practical applications.
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DRUG DEVELOPMENT RESEARCH
·
2021
·Vol. 82
·期 7
·969-979
·
IF 4.36
Ruixian Xing,Xuewen Liu,Buxian Tian,Yan Cheng,Longguang Li
Parkinson's disease (PD) is a disabling neurodegenerative disease mainly caused by degeneration of mesencephalic dopaminergic neurons in the substantia nigra pars compacta (SNpc). The neuroprotective role of Na + /H + exchangers isoform-1 (NHE1) inactivation in cerebral ischemic damage has been elucidated. The current study aimed to investigate the impacts of NHE1 in PD. In this study, 6-hydroxydopamine (6-OHDA)-induced PD rat models were established to attempt to illuminate the role and underlying mechanisms of NHE1 in SNpc neurons of PD. Meanwhile, nerve growth factor-stimulated PC12 cells followed by 6-OHDA treatment was used to mimic PD in vitro. Results showed that the protein levels of NHE1 were significantly increased in the SNpc neurons of rats and differentiated PC12 cells after 6-OHDA treatment. Inactivation of NHE1 with chemical inhibitor HOE642 suppressed SNpc neuronal loss and NHE1 expression in PD rats. The overlays of tyrosine hydroxylase and NHE1 displayed that NHE1 expression was not colocalized but closely associated with TH. Besides, treatment with HOE642 relieved the dyskinesia, mitochondrial dysfunction, and neuronal apoptosis. Further in vitro evidence confirmed that inhibition of NHE1 by genetic-knockdown prevented mitochondrial dysfunction and apoptosis. Our study represents the first experimental evidence of a potential role for NHE1 in the pathogenesis of PD.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Jiana Lin,Ying Chen,Gongke Li,Yuling Hu
Monitoring seafood freshness is critical for ensuring nutritional value and food quality, but targeted analysis in complex matrices remains challenging. Herein, a thiol-functionalized calix[6]arene covalent organic framework grafted with AuNPs, denoted as CX6-SCOF-AuNPs, was strategically designed for rapid, sensitive and selective detection of tryptamine in seafood by surface-enhanced Raman spectroscopy (SERS). CX6-SCOF-AuNPs featured extensive pocket-like hydrophobic cavities integrated within an ordered porous structure, enabling specific capture of tryptamine with exceptional enrichment capacity (203.4 mg/g) and rapid adsorption kinetics (within 2 min). The selectivity mechanism stemmed from the formation of a ground-state charge-transfer complex driven by specific “pocket effect” between CX6-SCOF and size-matched tryptamine. CX6-SCOF-AuNPs was successfully applied to enrichment and detection of tryptamine in seafood, achieving high sensitivity (LOD of 3.4 μg/L) and satisfactory recoveries (90.6 % – 107.4 %). This work provides a promising strategy for supramolecular recognition and targeted SERS analysis of trace hazards in complex food matrices.
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npj Science of Food
·
2025
·
IF 7.8
Cao Liguang,Li Guojin,Liu Kai,Gao Wenrui,Dong Yifei,Yang Zifeng,Luo Jianchun,Lei Lin,Du Xiliang,Song Yuxiang,Li Xinwei,Gao Wenwen,Liu Guowen
Deoxynivalenol (DON) and fumonisin B1 (FB1) are prevalent mycotoxins commonly found together in dairy cow feed, posing significant risks to cow health and food safety. This study investigates combined toxic effects of DON and FB1 on bovine mammary epithelial cells (BMECs), and role of AMPK-Caspase 6 axis in mycotoxin-induced apoptosis in BMECs and mouse model. We showed that even subcytotoxic doses of DON, combined with FB1, induced synergistic or additive toxic effects, reducing cell viability, increasing LDH release, and promoting apoptosis. This combination also impaired milk triglyceride synthesis and downregulated genes involved in milk fat and protein production. Silencing Caspase 6 via siRNA, inhibiting with Z-VEID-FMK, or activating AMPK with AICAR alleviated apoptosis. Conversely, overexpressing Caspase 6 diminished AMPK’s protective effects. In vivo, inhibiting Caspase 6 alleviated apoptosis in mammary tissues. These findings highlight therapeutic potential of targeting the AMPK-Caspase 6 pathway to mitigate combined toxicity of DON and FB1.
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MOLECULAR HUMAN REPRODUCTION
·
2021
·Vol. 27
·期 11
·
IF 4.025
Guo Fang,He Yongpei,Fan Yixian,Du Zhenzhen,Sun Huanhuan,Feng Zuohua,Zhang Guimei,Xiong Ting
Evidence accumulated in recent years has revealed that neutrophils are involved in the initial establishment of endometriosis, which is well-known as a chronic inflammatory disease. So far, why and how neutrophils promote the formation of early endometriosis are still unclear. In this study, using a mouse model of endometriosis, we demonstrated that endometriosis mice (EMs mice) had a significantly increased number of neutrophils in peritoneal fluids and lesions, and increased levels of granulocyte colony-stimulating factor (G-CSF) and IL-6 in serum and peritoneal fluids compared to the control group. In the neutrophils and uterine fragments co-injection experiment, neutrophils regulated by G-CSF and IL-6 had a similar effect to neutrophils from EMs mice, increasing the number, area, weight and microvessel density (MVD) of endometriotic lesions. Blocking the effect of G-CSF and IL-6 in EMs mice resulted in a decrease in the number, area and weight of endometriotic lesions. Following the depletion of neutrophils in vivo using a anti-Ly6G antibody, the MVD in the lesions of mice treated with neutrophils from EMs mice and neutrophils from pG/pI6 mice were significantly reduced. Neutrophils from EMs mice and neutrophils from pG/pI6 mice altered the expression levels of Mmp9, Bv8 and Trail genes compared to the neutrophils from PBS-treated mice. IL-6 together with G-CSF induced a higher expression of phospho-STAT3 and STAT3 in neutrophils. These findings suggest that neutrophils modulated by G-CSF and IL-6 through the STAT3 pathway alter the expression levels of the angiogenesis-related genes Mmp9, Bv8 and Trail, and may promote the establishment of early endometriosis.
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LUMINESCENCE
·
2013
·Vol. 29
·期 6
·614-620
·
IF 1.273
Feng Feng,Haoling Zhang,Zhaoqin Zhu,Cong Li,Yuxin Shi,Zhiyong Zhang
Here, we aimed to assess the feasibility of anti-ESAT-6 monoclonal antibody (mAb) coupling with IR783 and rhodamine fluorescent probe in the detection of ESAT-6 expression in tuberculosis tissue of mice using near-infrared fluorescence imaging. IR783 and rhodamine were conjugated to the anti-ESAT-6 mAb or IgG. Mice in the experimental group were injected with fluorescence-labeled mAb probe, and mice in the control group were injected with fluorescence-labeled non-specific IgG antibody. Twenty-four hours later, the lung tissue of mice was examined using ex vivo near-infrared fluorescence imaging. In addition, the contrast-to-noise ratio (CNR) was calculated by measuring the signal intensities of the pulmonary lesions, normal lung tissue and background noise. The frozen lung tissue section was examined under fluorescence microscopy and compared with hemoxylin and eosin (HE) staining. The ex vivo near-infrared fluorescence imaging showed that the fluorescence signal in the lung tuberculosis lesions in the experimental group was significantly enhanced, whereas there was only a weak fluorescence signal or even no fluorescence signal in the control group. CNR values were 64.40 ± 7.02 ( n = 6) and 8.75 ± 3.87 ( n = 6), respectively ( t = 17.01, p < 0.001). The fluorescence accumulation distribution detected under fluorescence microscopy was consistent with HE staining of the tuberculosis region. In conclusion, anti-ESAT-6 mAb fluorescent probe could target and be applied in specific ex vivo imaging of mice tuberculosis, and may be of further use in tuberculosis in living mice. Copyright © 2013 John Wiley & Sons, Ltd.
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ANALYTICAL SCIENCES
·
2017
·Vol. 33
·期 5
·585-590
·
IF 1.228
Zhu Xiaoqian,Huang Min,Li Jiao,He Hanping,Zhang Xiuhua,Wang Shengfu
In this paper, a novel electrochemical sensor was developed for the rapid detection of G-G mismatched DNA based on hexaammineruthenium(III) chloride ([Ru(NH 3 ) 6 ]C l3 ) as a redox indicator. The sensor platform was constructed by immobilizing small molecules (NC-linker) on the gold electrode via amide bonds. The as-prepared NC-linker as the nucleic acids recognition molecule can interact with the G base of DNA. After the sensor was incubated with G-G mismatched DNA, the double-stranded DNA (dsDNA) acted as carriers of the signal tags-[Ru(NH3)6]Cl3, which resulted in a remarkable electrochemical signal. More binding of [Ru(NH 3 ) 6 ]C l3 led to increases of the electrochemical signal. Other mismatched DNA produced only a low response, as well as complementary DNA. Thus G-G mismatched DNA can be easily discriminated from other mismatched and complementary DNA based on the sensor. Furthermore, the method was simple, rapid and repeatable for the detection of G-G mismatched DNA. The selective detection of target dsDNA was achieved by a relative current ratio of the target and control DNA. These results demonstrated that this strategy could provide great promise for the rapid and specific detection of other sequence-specific DNA.
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SCIENCE OF THE TOTAL ENVIRONMENT
·
2020
·
IF 6.551
Qi Tang,Kang Wang,Xiaoming Ren,Qunchao Zhang,Weiwei Lei,Tao Jiang,Dean Shi
Antibacterial polymer membranes have been widely used in many fields of our daily life. In this study, porous PA6 membrane with ZnO nanoparticles attaching on to the surface of inner pore walls is prepared. Firstly, SMA (styrene maleic anhydride copolymer) is used to graft onto the surface of ZnO nanoparticle in DMF (dimethylformamide). Then the pre-treated ZnO nanoparticles (ZnO-SMA) are added into SEBS (Styrene-ethylene-butylene-styrene copolymer)/PA6 (60/40 wt/wt) blends with co-continuous morphology. The effects of SMA molecular structure (molecular weight and maleic anhydride content) used for ZnO-SMA nanoparticles on their dispersion states in SEBS/PA6/ZnO-SMA nanocomposites are investigated. When SMA3 (MAH = 8 wt%, Mn = 250,000 g mol −1 ), which has relatively higher molecular weight and lower MAH content, is used as the pre-treating agent, ZnO-SMA3 nanoparticles tend to be dispersed at the phase interface in SEBS/PA6/ZnO-SMA nanocomposites. However, when SMA2 (MAH = 23 wt%, Mn = 110,000 g mol −1 ) with relatively lower molecular weight and higher MAH content is used, no ZnO-SMA2 nanoparticles locate at the interface but stay within PA6 phase. Porous PA6 membranes are obtained by selectively etching SEBS phase out with xylene. It can be found that porous PA6 membrane containing ZnO-SMA3 nanoparticles still exhibits much better antibacterial property (R = 3.76) toward S. aureus even at a very low ZnO content (0.5 wt%). This result should be ascribed to almost all the ZnO-SMA3 nanoparticles being exposed to the surface of inner pore walls of PA6 membrane. This work proposes an effective method to prepare porous polymer membrane with functional nanoparticles selectively located at the inner pore walls.
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NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 46
·期 19
·9229-9237
·
IF 3.925
Jiabin Liu,Yuxiang Xin,Yiyang Bai,Wei She,Jing Wang,Gaungming Li
The selective oxidation of alkylbenzenes contributes greatly to the production of high-value chemicals. However, developing novel and efficient catalysts remains a great challenge. To explore new and efficient catalysts, a series of POMs of H(4+n)SiMo(12−n)VnO40 (SiMoVn, n = 1, 2 and 3) were reacted with rht-MOF-1 ([Cu6O(TZI)3(H2O)6]4·nH2O) by a one-pot self-assembly solvothermal method. As a result, three SiMoVn@rht-MOF-1 (1, n = 1; 2, n = 2 and 3, n = 3) were isolated. Single crystal analysis revealed that SiMoVn were successfully introduced in the cages of rht-MOF-1. When complex 3 was employed as a catalyst, it effectively catalyzed the selective oxidation of alkylbenzene with a conversion of 99% and selectivity of 99% under optimized reaction conditions. Recycling experiments proved that complex 3 is stable and recyclable after six cycles. In comparison with analogous catalysts, complex 3 exhibits outstanding catalytic performance. Furthermore, the kinetics and reaction mechanism were investigated and verified by EPR and XPS analysis. This approach paves a facile route to prepare POMs@MOFs for the selective oxidation of various alkylbenzenes.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2023
·
IF 2.6
Lingli Zhang,Chunjuan Huang
The equilibrium solubility of 6-bromo-2-methylquinoline in various binary blends [ethanol/isopropanol/N,N-dimethylformamide (DMF)/methanol + water] and ten monosolvents (methanol, ethanol, n-propanol, isopropanol, ethyl acetate, toluene, acetone, acetonitrile, DMF, and water) was studied by the isothermal method at 278.15–323.15 K under 101.2 kPa. Among the ten pure solvents, the maximum solubility in mole fraction was obtained in toluene (3.318 × 10–2), followed by ethyl acetate (2.991 × 10–2), acetone (2.764 × 10–2), acetonitrile (2.528 × 10–2), DMF (2.220 × 10–2), n-propanol (9.141 × 10–3), isopropanol (8.123 × 10–3), ethanol (3.896 × 10–3), methanol (9.981 × 10–4), and water (2.888 × 10–5) at 323.15 K. In four solvent mixtures, the maximum and minimum solubilities were obtained in the (DMF + water) and (methanol + water) blends. The solubility of 6-bromo-2-methylquinoline in pure solvents was only affected by temperature and calculated by the Apelblat, van’t Hoff, and NRTL models. The Jouyban–Acree (J–A), van’t Hoff–Jouyban–Acree (V–J–A), and modified Apelblat–Jouyban–Acree (A–J–A) models were used to evaluate the solubility data in mixed systems. The calculation of solvent effect deeply explored the dissolution behavior of 6-bromo-2-methylquinoline from the molecular point of view, and the results showed that the interaction between the solute and solvent was dominant. The apparent thermodynamic properties of 6-bromo-2-methylquinoline in pure solvents were obtained by van’t Hoff plots.
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JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
·
2014
·
IF 2.291
Wen-Sheng Zou,Fei-Hua Zou,Qun Shao,Jun Zhang,Ya-Qin Wang,Fa-Zhi Xie,Yi Ding
Fluorescein isothiocyanate (FITC) conjugated to polyethylenimine (PEI) (FITC&PEI) was synthesized and characterized. The nitrogen-containing organic groups played a key role in sensing nitroaromatic compounds that can bind 2,4,6-trinitrotoluene (TNT) to form TNT anions through an acid–base pairing interaction and FITC dye conjugation. The formation of TNT anions efficiently quenched the emission of FITC dye at 516 nm by fluorescent resonance energy transfer and induced the enhancement of a resonance light scattering (RLS) signal. A novel, dual-channel chemosensory FITC&PEI probe was thus constructed. Meanwhile, the FITC&PEI probe also exhibited highly selective fluorescence and RLS responses for TNT over other nitroaromatic compounds. Very good linearity was observed within the ranges of 3.0–150 nM TNT (detection limit down to 0.5 nM and RSD of 5.8%, n = 7) for fluorescence and 1.0–150 nM TNT (detection limit down to 0.2 nM and RSD of 8.4%, n = 7) for RLS. The proposed methods were well-suited for detecting and distinguishing trace amounts of TNT in aqueous solution.
研究领域:
分析化学
·
环境科学
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SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Xueqing Wang,Wensheng Tan,Hong Ji,Feng Liu,Datong Wu,Jianfeng Ma,Yong Kong
In this study, a simple and sensitive method for the determination of nitrite (NO 2 − ) in environmental and food samples by amperometry with nickel hexacyanoferrate/poly(2,6-diaminopyridine) (NiHCF/PDAP) hybrids modified electrode was developed. The NiHCF/PDAP hybrids prepared via a facile one-step electrosynthesis method exhibited significantly high sensitivity and wide linear range for the determination of nitrite due to the high electrocatalytic activity of NiHCF and the preconcentration ability of PDAP in acidic conditions. In addition, the as-prepared NiHCF/PDAP also showed high selectivity with no interferences from other anions, high stability and reproducibility in the determination of nitrite. Finally, the developed hybrids were applied in the determination of nitrite in tap water, lake water and ham sausage samples, and the results demonstrated its potential as a sensitive and selective electrochemical sensor for nitrite.
研究领域:
分析化学
·
环境科学
·
食品科学
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