BMC MICROBIOLOGY
·
2015
·Vol. 15
·期 1
·171
·
IF 2.729
Wan Lei,Luo Gang,Lu Haibin,Xuan Dongying,Cao Hong,Zhang Jincai
Background Hemolysins are crucial virulence factors which help pathogens to survive and persist in the host. This study investigated whether common electrolytes will affect the hemolysins of Candida species. The hemolysins from 25 Candida isolates were investigated using a plate specially designed for Candida species in the presence of three electrolytes, CaCl 2 , NaCl and KCl, at different concentrations. The hemolytic activity was determined after 48 h and the hemolytic index was calculated. Results All three electrolytes caused a decrease in the hemolytic activity. Significant differences existed between varying concentrations of NaCl, while no significant differences existed for the CaCl 2 and KCl groups. Additionally, the peripheral hemolytic index was highly correlated with the hemolytic index ( r = 0.656, p < 0.001). Conclusions Our findings indicate that electrolytes reduce hemolysis by Candida species and a correlation exists between the peripheral hemolytic index and the translucent hemolytic index.
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高影响因子
Alzheimers Research & Therapy
·
2024
·Vol. 16
·期 1
·167
·
IF 7.9
Knapskog Anne-Brita,Edwin Trine Holt,Ueland Per Magne,Ulvik Arve,Fang Evandro Fei,Eldholm Rannveig Sakshaug,Halaas Nathalie Bodd,Giil Lasse M.,Saltvedt Ingvild,Watne Leiv Otto,Aksnes Mari
Background Sex differences in neuroinflammation could contribute to women’s increased risk of Alzheimer’s disease (AD), providing rationale for exploring sex-specific AD biomarkers. In AD, dysregulation of the kynurenine pathway (KP) contributes to neuroinflammation and there is some evidence of sex differences in KP metabolism. However, the sex-specific associations between KP metabolism and biomarkers of AD and neuroinflammation need to be explored further. Methods Here we investigate sex differences in cerebrospinal fluid concentrations of seven KP metabolites and sex-specific associations with established AD biomarkers and neopterin, an indicator of neuroinflammation. This study included 311 patients with symptomatic AD and 105 age-matched cognitively unimpaired (CU) controls, followed for up to 5 years. Results We found sex differences in KP metabolites in the AD group, with higher levels of most metabolites in men, while there were no sex differences in the CU group. In line with this, more KP metabolites were significantly altered in AD men compared to CU men, and there was a trend in the same direction in AD women. Furthermore, we found sex-specific associations between kynurenic acid and the kynurenic acid/quinolinic acid ratio with neopterin, but no sex differences in the associations between KP metabolites and clinical progression. Discussion In our cohort, sex differences in KP metabolites were restricted to AD patients. Our results suggest that dysregulation of the KP due to increased inflammation could contribute to higher AD risk in women.
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高影响因子
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
·
2015
·Vol. 122
·期 1
·329-338
·
IF 2.042
Bu Jiang,Liang Hongbo,Zhang Dandan,Xiong Lei,Huang Shengmei
N , N′ -bis(2,4-di(acryloyloxyethyl)-[1,3,5]-triazin-2-yl)-hexane-1,6-diamine(BDAETH) and 2,2-dimethyl-1,3-propanediol glycerol-methacrylate phosphate (PGMH) were synthesized from cyanuric chloride and phosphorus oxychloride. BDAETH and PGMH were further blended in different ratios to prepare UV-curable intumescent flame-retardant coatings. The thermal behaviors of their cured films were studied by thermal gravimetric analysis, and the results showed that degradation process of cured blend films could be divided into three degradation regions. The degradation mechanism was further investigated by in situ Fourier transform infrared spectra. The flame-retardant properties and the expansion process of the intumescent flame-retardant coatings were further monitored by limiting oxygen index and a self-made equipment, which indicated the synthetic effect between BDAETH and PGMH.
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高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2021
·Vol. 32
·期 11
·14274-14285
·
IF 2.478
Gao Qianqian,Dai Yuqiang,Wei Xile,Zhou Changping,Gong Wenfeng,Song Haixiang,Guo Zhanhu,Li Chengbo
The Aurivillius compound Pb x Bi 6− x Fe 0.5 Co 0.5 Ti 4 O 18 thin films were prepared via chemical solution deposition method and the influence of Pb 2+ ions doping on the structure, ferroelectric and leakage properties were studied. With the increasing concentration of Pb 2+ ions, the lattice distortion is increased and the growth of the films along ab plane is promoted. The calculation results show that the internal stress of the films increases with the increase of Pb 2+ concentration. For the samples with low Pb 2+ doping concentration ( x < 0.6), the leakage current densities are also decreased, which can be attributed to the decrease in oxygen vacancy concentration. Due to the enhanced lattice distortion and decreased leakage current densities, the ferroelectric properties are improved. The film with x = 0.2 has a high saturation polarization of 42.3 µC/cm 2 . According to the fitting results, the leakage conduction mechanism is attributed to the combined effect of space-charge-limited conduction mechanism and ionic conduction mechanisms.
研究领域:
材料科学
·
凝聚态物理
·
功能材料
·
铁电学
·
薄膜制备
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高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2023
·Vol. 34
·期 13
·1096
·
IF 2.8
Gu Wen,Liu Bingguo,Li Shunzi,Hu Baofu,Xu Jian,Wang Jian,Du Baoli
Cu 2 SnS 3 (CTS), as a potential thermoelectric (TE) material, the electrical and thermal transport properties are heavily determined by its original phase structure and the following phase evolution upon heating. Unlike previous studies that induced CTS phase transition by doping, this study used mechanical alloying powder as the precursor and successfully prepared phase-pure cubic (c-) and monoclinic (m-) CTS samples, as well as two-phase mixed samples with different percentage composition of c-CTS and m-CTS, by simply adjusting the hot pressing temperature. Firstly, phase structures of hot-pressed specimens were determined and confirmed by XRD refinement, SEM, TEM, and Raman spectroscopy. Secondly, thermodynamic property was analysis by DSC analysis, and phase evolution was detailed by analyzing specimens quenched at various temperatures. Then, the electrical and thermal transport properties were measured up to 500 °C, and were correlated with phase evolution analyzed above. Benefiting from cationic disorder, a maximum zT of 0.42 at 500 °C was achieved in c-CTS samples hot-pressed at 575 °C. The phase evolution of CTS was comprehensively investigated by using high-quality samples. The results indicate that phase transition is the potential mechanism for the doping effect in most studies, providing some guidance for improving the performance of environmentally friendly TE sulfides.
研究领域:
材料科学
·
凝聚态物理
·
无机化学
·
能源材料
·
热电转换
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高影响因子
IONICS
·
2016
·Vol. 22
·期 11
·2225-2233
·
IF 2.119
Lu Juanjuan,Liu Yuelin,Liu Xinhe,Lu Xiaoquan,Liu Xiuhui
In this article, we constructed an electrochemical sensor for highly sensitive determination of β-nicotinamide adenine dinucleotide (NADH) using the poly(diallyldimethylammonium chloride)-functionalized reduced graphene oxide nanocomposite modified electrode (PDDA-rGO/GCE). The nanocomposite was characterized by transmission electron microscopy, Fourier transform-infrared spectrometry, ultraviolet-visible absorption spectrometry, cyclic voltammetry, and electrochemical impedance spectroscopy. The experimental results demonstrated that the fabricated sensor exhibited excellent electrocatalytic activity on the oxidation of NADH with a decreased about 200 mV in overpotential and 5.0-fold increment in the oxidation peak current compared to a bare GCE. Applying cyclic voltammetry, a wide linear range from 1.0 × 10 −7 to 2.9 × 10 −3 M with low limit of detection (LOD) of 3.4 × 10 −8 M and high sensitivity of 463.3 μA mM −1 cm −2 were obtained, which was superior to other NADH electrochemical sensors reported previously. Furthermore, the fabricated NADH sensor possessed excellent selectivity, reproducibility, and stability. The oxidation mechanism of NADH at the PDDA-rGO/GCE was also discussed in detail.
A simple NADH sensing platform based on PDDA-rGO composite is constructed, which exhibits an ultra-low detection limit ( 3.4×10-8 M) towards the oxidation of NADH, and the electrochemical reaction mechanism of NADH is discussed in detail.
研究领域:
生物电化学
·
生物传感器
·
纳米生物技术
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分子诊断
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转化医学
·
电分析化学
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高影响因子
IONICS
·
2018
·Vol. 25
·期 1
·241-251
·
IF 2.347
Wen Xinge,Dong Tao,Liu Ao,Zheng Shuohang,Chen Shimou,Han Yifan,Zhang Suojiang
As a polymer host, one polymeric ionic liquid poly(methyl methacrylate-1-vinyl-3-ethyl-imidazolium bis(trifluoromethylsulfonyl) imide) (abbr. P(MMA-co-VEImTFSI)) was successfully synthesized and characterized. Four poly(vinylidene fluoride-co-hexafluoropropylene) (abbr. PVDF-HFP)-based polymer electrolytes were prepared by blending 0, 5,15, and 25 wt% P(MMA-co-VEImTFSI). The electrochemical performances of the prepared electrolytes were studied carefully. The results revealed that increasing the polymeric ionic liquid content, the ionic conductivity of the polymer electrolytes could be enhanced and it obeyed the Arrhenius rule. The highest ionic conductivity of the polymer electrolytes was up to 2.09 × 10 −3 S cm −1 at room temperature. The polymer with 25 wt% polymeric ionic liquid showed an excellent electrochemical performance for supercapacitor electrolyte. After 2000 cycles, the retention of capacitance in P(MMA-co-VEImTFSI)-based polymer electrolyte was above 80%. It implied that the present P(MMA-co-VEImTFSI) polymeric ionic liquid was a decent component candidate in the high-performance polymer electrolytes.
研究领域:
材料科学
·
电化学
·
高分子化学
·
能源存储
·
功能材料
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高影响因子
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2018
·Vol. 34
·期 2
·279-284
·
IF 1.248
Xu Chao,Yin Xuhan,Zhang Chuan,Chen Hongyue,Huang He,Hu Yi
Various imidazolium and choline-based functional ionic liquids(ILs) comprising different cations and anions were grafted onto Burkholderiacepacia lipase(BCL) through surface amino acids coupling. The catalytic ac-tivity, thermostability, organic solvent tolerance and adaptability to temperature and pH changes of the modified BCL were then evaluated in olive oil hydrolysis reaction. The results showed that different combinations of cations and anions in ILs had important influence on the catalytic performance of the modified lipases. BCL modified with IL [Choline][H 2 PO 4 ] was the most improved lipase, in which increases by 1.2 folds in relative activity, 2.5 folds in typi-cal proton solvent(10% methanol, volume fraction), and 1.4 folds in thermostability(after incubation at 70 °C for 2 h) were achieved in relative toits native form. BCL modified with [HOOCEPEG 350 IM][BF 4 ] had higher optimal tempe- rature and pH, and better thermosability compared with the native and other modified BCLs. The conformational changes of BCLs were also confirmed by fluorescence spectroscopy and circular dichroism spectroscopy.
研究领域:
酶工程
·
生物催化
·
离子液体
·
蛋白质修饰
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高影响因子
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES INDIA SECTION A-PHYSICAL SCIENCES
·
2017
·Vol. 87
·期 2
·181-188
·
IF 0.425
Wei Jinrui,Liu Kun,Du Chuanrong,Zhou Yong,Lin Cuiwu
A novel Mannich derivative of protocatechuic acid, 3-diethylaminomethyl-4,5-dihydroxy-benzoic acid ( PADE ), was synthesized for the first time. The structure of PADE was confirmed by infrared spectrum, mass spectrum, and X-ray crystallography. The derivative PADE crystallizes in the monoclinic space group P 2(1)/ c with cell parameters of a = 8.820(2) Ǻ, b = 11.469(3) Ǻ, c = 14.227(4) Ǻ, β = 107.128(3)°, V = 1375.3(6) Ǻ 3 and Z = 4. The average H···A distance is 1.980 Ǻ, which indicates the existence of strong hydrogen bond. The intermolecular and intramolecular hydrogen bonds generate the Mannich derivative PADE into a three-dimensional architecture. The antioxidant activity of PADE was evaluated by scavenging 1,1-diphenyl-2-picrylhydrazyl (DPPH) and reducing power determination. The results showed that PADE displayed dose-dependency in DPPH radical scavenging and reducing power assays. DPPH radical scavenging activity of PADE (IC 50 , 1.2 × 10 −5 mol/l) was higher than that of protocatechuic acid (5.2 × 10 −5 mol/l) and ascorbic acid (2.5 × 10 −5 mol/l). The reducing power of PADE was higher than that of ascorbic acid but weaker than that of the raw material protocatechuic acid. The 3D structure of PADE is stabilized by intermolecular and intramolecular hydrogen bonds, which may raise its antioxidant activity.
研究领域:
有机化学
·
药物化学
·
晶体学
·
抗氧化研究
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DOI
高影响因子
IONICS
·
2022
·Vol. 28
·期 6
·2693-2700
·
IF 2.961
Ma Dongjuan,Chen Long,Li Yuan,Liu Yan,Zhang Hao,Wang Biyan
Solid polymer electrolyte (SPE) is an ideal substitute for routine liquid electrolyte for next-generation safety lithium (Li) batteries. Nevertheless, SPE cannot effectively impede Li dendrite growth due to the poor mechanical strength, which prevents its practical applications. Herein, an asymmetric sandwich solid electrolyte constructed by dopamine-modified Li 1.4 Al 0.4 Ti 1.6 (PO 4 ) 3 (PDA@LATP) on one side was prepared by solution casting method. The asymmetric electrolyte exhibits admirable ionic conductivity (1.2 × 10 –4 S cm −1 at 25 °C), high ionic transference number (0.47), wide voltage window (4.6 V vs . Li/Li + ) and good thermal stabilities. The PDA@LATP can not only impede Li dendrite growth, but also avoid the LATP reaction with Li anode. The assembled solid-state LiFePO 4 |Li battery assembled with asymmetric solid electrolyte delivers a satisfactory capacity retention up to 88.2% after 300 cycles at 0.5 C and under 25 °C (88.1% after 100 cycles at 0.5 C and under 70 °C). The asymmetric design of solid electrolyte provides a promising options for realizing safe energy storage systems. Graphical abstract We propose an asymmetric sandwich solid electrolyte, which can enable LiFePO 4 |Li battery stably and safely cycled at 25 °C and 70 °C, respectively, with excellent ionic conductivity, electrochemical and thermal stability. This asymmetric electrolyte ensures the inhibition of Li dendrites and stable electrolyte/anode interface.
研究领域:
材料科学
·
储能
·
电化学
·
电池技术
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高影响因子
CATALYSIS LETTERS
·
2015
·Vol. 145
·期 4
·1014-1021
·
IF 2.307
Li Yan,Li Bing,Geng Longfei,Wang Jun,Wang Yong,Huang Jun
Vanadium catalysts supported on N-doped carbon materials (CN) were prepared and the catalyst VOSiW showed high activity for the hydroxylation of various aromatics with O 2 . Aromatics with electron-withdrawing groups such as CN, NO 2 , COOH, CF 3 , COCH 3 and aromatic halides (F, Cl and Br) were oxygenated to the corresponding phenols in considerable yields. The CN materials were not only indispensable for the reusability of the vanadium catalyst VOSiW, but also favorable to the high catalytic activity. The VOSiW catalyst is ready for the hydroxylation of aromatics with O 2 as both V 4+ and V 5+ species are coexisted in the VOSiW catalyst. Graphical
研究领域:
催化化学
·
有机化学
·
材料科学
·
绿色化学
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高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2016
·Vol. 27
·期 6
·6382-6388
·
IF 1.798
Wang Yuxuan,Liang Weizheng,Huang Wen,Gao Min,Zhang Yin,Lin Yuan
Fe-doped BaTiO 3 thin films were grown on (001) oriented LaAlO 3 substrates using a polymer-assisted deposition technique. The microstructural and chemical state characters of the films with the Fe doping range from 1 to 10 at% were systematically investigated by X-ray diffraction and X-ray photoelectron spectroscopy. Evolution of the preferred orientation and strain status of BaTiO 3 films could be observed with increasing doping amount of Fe. Meanwhile, UV–Vis spectra of doped BaTiO 3 thin films showed that the band gap could be strongly affected by the doping amount of Fe with the smallest value at the Fe doping rate of 3 at%, which is proposed to be associated with the inevitable oxygen vacancies and the substitution of Ti ions by the Fe dopants.
研究领域:
材料科学
·
薄膜技术
·
凝聚态物理
·
光学材料
·
铁电材料
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DOI
高影响因子
危险品化学品经营许可证（带存储）