JOURNAL OF HAZARDOUS MATERIALS
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2026
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IF 10.6
Yaxin Zheng,Zexiu An,Weihua Liu,Minghua Wang,Yichun Ren,Dongchen Yang,Wei Gao,Ningzhao Shang,Jinlin Zhang,Chun Wang,Shutao Gao
Nitrogen vacancy incorporation into Co 4 N-600 upshifts the D-band center and facilitates the generation of Co IV =O. • The Co 4 N-600/PMS system yields a modified kinetic rate constant of 300.6 min⁻ 1 M⁻ 1 . • Rapid degradation of different types of pollutants within Co 4 N-600/PMS system. High‑valent cobalt-oxo species (Co IV =O) have been demonstrated to exhibit efficient degradation capability toward emerging contaminants (ECs). However, the 3d 7 electronic configuration of Co(II) sites in Co‑based catalysts severely restricts their binding affinity to the terminal oxygen of peroxymonosulfate (PMS), which is unfavorable for the generation of Co IV =O. Herein, we report a nitrogen vacancy (Nv)‑rich cobalt nitride nanozyme Co 4 N-600. The introduction of Nv markedly reduces the d‑electron occupancy of Co, upshifts the d‑band center, and promotes the formation efficiency of Co IV =O. Remarkably, employing 150 mg L −1 peroxymonosulfate (PMS) as the oxidant, the Co 4 N-600 nanozyme achieves complete degradation of 10 mg L −1 imidacloprid within 10 min at an ultralow catalyst loading of 1 mg L −1 , yielding an excellent modified kinetic rate constant of 300.6 min −1 M −1 . These findings establish d -band center engineering as an effective strategy for boosting the catalytic performance of nanozymes by promoting the generation of high-valent metal-oxo (HVMO) species. Download: Download high-res image (179KB) Download: Download full-size image
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INTERNATIONAL IMMUNOPHARMACOLOGY
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2018
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IF 3.118
Zheng Li,Haihua Feng,Yue Wang,Bingyu Shen,Ye Tian,Lin Wu,Qiaoling Zhang,Meiyu Jin,Guowen Liu
Rosmarinic acid (RA) has antioxidation, anticancer, antibacterial, anti-inflammatory and various biological functions. In our study, we aim to evaluate effects of RA on acute liver injury caused by LPS and d -galactosamine ( d -GalN) and its underlying molecular mechanism in mice. Our findings showed that RA could protect C57BL/6 mice from LPS/ d -GalN-induced acute liver injury, which not only reflected on declining aspartate aminotransferase (AST) and alanine aminotransferase (ALT) of the serum, but also restrained the phosphorylation of nuclear factor-kappa B (NF-κB), extracellular signal-regulated kinase (ERK1/2) and p38 protein expression and the content of tissue myeloperoxidase (MPO) elevation. Moreover, RA could enhance the level of glutathione-dependent peroxidase (GSH-PX). Furthermore, RA promoted that nuclear factor erythroid-2-related factor 2 (Nrf2) transported into nucleus, and then up-regulated heme oxygenase 1 (HO-1), glutamate-cysteine ligase catalytic (GCLC), glutamate cysteine ligase modifier (GCLM) and quinone oxidoreductase (NQO1). These results indicated that RA could protect the mice from acute liver injury induced by LPS/ d -GalN.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Jinhong Gao,Lingli Zhang,Dongxin Zhao,Xin Lu,Qiang Sun,Heng Du,Hongyan Yang,Kui Lu
Aspergillus oryzae β-D-galactosidase (β-Gal) efficiently hydrolyzes sesaminol triglucoside into sesaminol, which has higher biological activity . However, β-Gal is difficult to be separate from the reaction mixture and limited by stability. To resolve these problems, β-Gal was immobilized on amino-functionalized magnetic nanoparticles mesoporous silica pre-activated with glutaraldehyde (Fe 3 O 4 @mSiO 2 -β-Gal), which was used for the first time to prepare sesaminol. Under the optimal conditions, the immobilization yield and recovered activity of β-Gal were 57.9 ± 0.3 % and 46.5 ± 0.9 %, and the enzymatic loading was 843 ± 21 U enzyme /g support . The construction of Fe 3 O 4 @mSiO 2 -β-Gal was confirmed by various characterization methods, and the results indicated it was suitable for heterogeneous enzyme-catalyzed reactions. Fe 3 O 4 @mSiO 2 -β-Gal was readily separable under magnetic action and displayed improved activity in extreme pH and temperature conditions. After 45 days of storage at 4 °C, the activity of Fe 3 O 4 @mSiO 2 -β-Gal remained at 92.3 ± 2.8 %, which was 1.29 times than that of free enzyme, and its activity remained above 85 % after 10 cycles. Fe 3 O 4 @mSiO 2 -β-Gal displayed higher affinity and catalytic efficiency. The half-life was 1.41 longer than free enzymes at 55.0 °C. Fe 3 O 4 @mSiO 2 -β-Gal was employed as a catalyst to prepare sesaminol, achieving a 96.7 % conversion yield of sesaminol. The excellent stability and catalytic efficiency provide broad benefits and potential for biocatalytic industry applications.
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2024
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IF 20.2
Shanpeng Li,Yuling Zhuo,Dong Liu,Hui Pan,Zhenbo Wang
Improving the Pt atoms utilization efficiency on self-supported electrodes is crucial for industrial seawater hydrogen production , but effective strategies are still lacking. Herein, we reported a novel strategy to anchor highly surface-exposed Pt single atoms on Ni 3 S 2 /Co 9 S 8 with abundant S vacancies (Pt–Ni 3 S 2 /Co 9 S 8 –Sv) as a self-supported electrode. Physical characterizations and theoretical calculations confirm that the strong Pt–S electron bridges with the coordinating role of surface S vacancies triggers the d -orbital electron rearrangements and regulates the local electron structures between the Co/Ni and Pt sites. Notably, the Pt–Ni 3 S 2 /Co 9 S 8 –Sv electrode displays an ultralow overpotential of 18 mV at 10 mA cm −2 in alkaline seawater . More importantly, our Pt–Ni 3 S 2 /Co 9 S 8 –Sv electrode assembled into an alkaline electrolysis cell can work continuously for 50 h under alkaline seawater @ 60 °C. This work provides a promising strategy for designing highly surface-exposed single-atomic catalyst for large-scale hydrogen evolution through seawater electrolysis.
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International Journal of Polymeric Materials and Polymeric Biomaterials
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2016
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IF 1.667
Zhaosheng Hou,Hao Zhang,Wenqiang Qu,Zhen Xu,Zheng Han
In the study, a new approach for synthesizing biomedical segmented polyurethanes (SPUs) based on polyethylene glycol (PEG, Mn = 800), poly(ε-caprolactone-co-D,L-lactide) (PCLA) and aliphatic diurethane diisocyanates with a long uniform hard segment was developed. By the chain extension of a mixture of PEG diol and PCLA diol with diurethane diisocyanates based on inexpensive 1,6-hexanediisocyanate, three SPUs (SPU-I, SPU-II, and SPU-III) with different contents of hydrophilic segments (PEG) and hard segments were obtained. The chemical structures of diurethane diisocyanates, PCLA and SPUs were confirmed by 1H NMR, 13C NMR, FT-IR, HR-TOF-MS, and GPC. The SPU films exhibited similar thermostability, indicating that the hard segment content marginally affects on the thermostability. From the results of differential scanning calorimetry, two glass transition temperatures were observed, suggesting the microphase separation of soft and hard segments. The SPU films exhibited satisfactory mechanical properties with ultimate stress of 17.4–22.3 MPa and strain at break of 890–1060%, and the initial modulus increased with the increasing content of hard segments. In vitro degradation studies indicated that the time of SPU films to become fragments was 22–33 days, and the degradation rate increased with the increasing content of hydrophilic segments in SPU. Hence, the degradation time of SPU films could be controlled by adjusting the PEG content in SPU, which made them good candidates for further biomedical applications. Studies of in vitro drug release were conducted using vitamin B1 as model drugs. Drug-loaded films exhibited a high initial release rate and matrix-controlled release for more than two weeks, thereby demonstrating a promising material for a long-acting controlled release system. Cytotoxicity test of film extracts and cell attachment on the film surface were conducted using L929 mouse fibroblasts, and the results indicated that the SPU films possess excellent cytocompatibility and cell adhesive ability.
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ACS Applied Materials & Interfaces
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2014
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IF 5.9
Xiaoyu Mu,Juan Qiao,Li Qi,Ying Liu,Huimin Ma
Developing facile and high-throughput methods for exploring pharmacological inhibitors of d-amino acid oxidase (DAAO) has triggered increasing interest. In this work, DAAO was immobilized on the magnetic nanoparticles, which were modified by a biocompatible reactive polymer, poly(glycidyl methacrylate) (PGMA) via an atom transfer radical polymerization technique. Interestingly, the enzyme immobilization process was greatly promoted with the assistance of a lithium perchlorate catalyst. Meanwhile, a new amino acid ionic liquid (AAIL) was successfully synthesized and employed as the efficient chiral ligand in a chiral ligand exchange capillary electrophoresis (CLE-CE) system for chiral separation of amino acids (AAs) and quantitation of methionine, which was selected as the substrate of DAAO. Then, the apparent Michaelis–Menten constants in the enzyme system were determined with the proposed CLE-CE method. The prepared DAAO-PGMA-Fe3O4 nanoparticles exhibited excellent reusability and good stability. Moreover, the enzyme reactor was successfully applied in screening DAAO inhibitors. These results demonstrated that the enzyme could be efficiently immobilized on the polymer-grafted magnetic nanoparticles and that the obtained enzyme reactor has great potential in screening enzyme inhibitors, further offering new insight into monitoring the relevant diseases.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2024
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IF 8.1
Yuanchuan Ren,Yan Hu,Nanqi Ren,Xiaojuan Su,Fenghui Wu,Dandan Chen,Xuejun Zhu,Qiang Niu,Yan Guo
Persulfate (PMS) is an excellent free radical initiator with selective degradation of organic pollutants. This article presents the preparation of a high-performance Cu-SA@NCA(Single atom copper modified nitrogen doped aerogel carbon) electrocatalyst with adjustable interfacial separation enhancement effect for the first time. Under the optimal process parameters, the removal rates of ENO, COD, and TOC obtained after 5 min of reaction were 100 %, 73.41 % and 55.15 %, respectively. The average energy consumption was saved by 59.63∼123.25 kWh/kg ENO. After 6 cycles of degrading ENO wastewater, the removal rate of ENO only decreased by 8.55 %. It was demonstrated through characterization such as high-angle annular dark field-scanning transmission electron microscopy (HAADF-STEM), X-ray absorption near edge structure (XANES), and Fourier Transform Extended X-ray Absorption Fine Spectroscopy (FT-EXAFS) that the single atom copper loaded on the Cu-SA@NCA surface is tightly bound to N in NCA through Cu-N 4 bond bridges, promoting the formation of double electron centers on the catalyst surface. The particle electrode catalyst significantly enhances the PMS activation process over a wide pH range and can accelerate the degradation of enoxacin (ENO). As the reaction center for PMS adsorption and activation, Cu-N 4 has a lower charge transfer resistance and can attract PMS to the catalyst surface, resulting in a higher current response in the PMS system. Organic pollutants release electrons through the carbon matrix of carbon based catalysts and transfer them to Cu-SA@NCA-PMS, promoting PMS activation and the formation of high valence copper ions, enhancing the degradation of pollutants. Density functional theory (DFT) further indicate that the regulatory effect of N on the electron distribution of Cu d orbitals is beneficial for the stretching and cleavage of Cu active centers by PMS, accelerating the process of SO 4 − · and ·OH generation rate, which is consistent with the results of XANES. In addition, during the degradation process of salt containing organic pollutants in PMS, Cu-SA@NCA exhibits strong resistance to inorganic ions, natural organic matter, and pH value. This work developed a new catalyst that selectively produces SO 4 − · and ·OH with 97.46 % selectivity, achieving high selectivity and efficiency in degrading pollutants.
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POLYMER
·
2020
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IF 4.231
Xiangli Li,Dongsheng Yang,Youbo Zhao,Xingyuan Diao,Hongwei Bai,Qin Zhang,Qiang Fu
Stereoblock copolymerization is regarded an appealing strategy to substantially enhance the melt stability (i.e., the survival ability of the intermolecular collaboration between poly( l -lactide) (PLLA) and poly( d -lactide) (PDLA) upon melting) of high-molecular-weight (high-MW) stereocomplex-type polylactide (SC-PLA), however it usually suffers from complicated synthetic procedures and even impaired sustainability. Herein, solid-state transesterification (SST) has been devised as a facile and robust route to prepare unique multi-stereoblock PLA copolymers with outstanding melt stability and unexpectedly strong crystallizability from commercial available linear high-MW PLLA/PDLA (50/50) blends. The SST was performed through low-temperature (i.e., 180 °C) melt-blending of PLLA and PDLA in the presence of trace amounts (0.03–0.035 wt%) of catalysts, where the enantiomeric PLA chains could rapidly co-crystallize into solid-state SC crystallites upon melting and subsequently the hetero-chain transesterification reaction occurs exclusively in the mobile amorphous phase of the pre-formed SC crystallites. As a result, multiblock-like PLLA- b -PDLLA- b -PDLA copolymers with long crystallizable PLLA and PDLA blocks are in-situ generated. The results show that high-content SC crystallites can be exclusively formed in the melt-crystallization of the copolymers even at high cooling rates (e.g., 40 °C/min) and low temperatures (e.g., 140 °C). More interestingly, the presence of the non-crystallizable PDLLA blocks not only does not disturb the SC crystallizability of the enantiomeric PLA blocks, as evidenced by the same high crystallinity and melting temperature as those of starting PLLA/PDLA blends, but also increase the crystallization rate by stabilizing the clusters of ordered PLLA/PDLA segments in the copolymer melt. Overall, these findings could open a new pathway to develop melt-processible all SC-PLA for engineering applications.
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LWT-FOOD SCIENCE AND TECHNOLOGY
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2022
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IF 6.056
Renjie Zhou,Cheng Yang,Ting Xie,Jian Zhang,Chenqiang Wang,Ziqiang Ma,Lianfu Zhang
Amadori compounds (ACs) are the first stable product formed in the initial stage of the Maillard reaction and are widely present in processed foods. In addition to being widely known as the flavor precursors, ACs have attracted attention in recent years because many functions have been revealed, including ACE inhibition. In this work, we synthesized four ACs ( N -(1-Deoxy-D-fructos-1-yl)-glycine (Fru-Gly), N -(1-Deoxy-D-fructos-1-yl)-proline (Fru-Pro), N -(1-Deoxy-D-fructos-1-yl)-serine (Fru-Ser) and N -(1-Deoxy-D-fructos-1-yl)-threonine (Fru-Thr)) and characterized them using UPLC-Q-TOF-MS spectra. The four ACs’ angiotensin-converting enzyme (ACE) inhibitory activities were verified for the first time, the IC 50 value range was 1.447–4.204 mmol/L, the Fru-Gly has the best effect. And all the four ACs showed good digestion stability, the content remained above 70% after 5 h of continuous digestion simulation. In order to reveal the mechanism of ACs inhibiting ACE, we selected Fru-Gly, beacuse of the best inhibitory effect, to carried out enzyme kinetics, circular dichroism spectroscopy, fluorescence spectroscopy, thermodynamics and molecular docking analysis. The results showed that Fru-Gly was a noncompetitive inhibitor, it spontaneously binds to the inactive site of ACE by hydrogen bond and causes the conformation change of ACE to inactivate it. The reaction is easier to proceed at low temperatures.
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CURRENT CANCER DRUG TARGETS
·
2022
·Vol. 22
·期 1
·86-95
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IF 2.907
Yiyan SongYang,Yang Songyisha,Li Dejia,Li Wen
Background: Non-Small-Cell Lung Cancer (NSCLC) is the most prevalent form of lung cancer, accounting for approximately 85% of all lung cancer cases and resulting in high morbidity and mortality. Previous studies have demonstrated that 1,25-dihydroxy-vitamin-D3 (vitamin D) exhibited
anti-cancer activity against breast and prostate cancer. Objectives: The aim of the current study is to investigate the effect of vitamin D on NSCLC and its underlying mechanism. Methods: The effects of vitamin D on stemness maintenance and the Warburg effect in NSCLC cells were
investigated both in vitro and in vivo. Results and Discussion: In vitro experiments revealed that vitamin D inhibited glycolysis and stemness maintenance in A549 and NCI-H1975 cells. Both in vitro and in vivo experiments indicated that vitamin D attenuated the expression of metabolism-related
enzymes associated with the Warburg effect (GLUT1, LDHA, HK2, and PKM2). In addition, vitamin D down-regulated the expression of stemness-related genes (Oct-4, SOX-2, and Nanog) and the expression of PI3K, AKT, and mTOR. Conclusion: Overall, these findings suggest that vitamin D suppresses
the Warburg effect and stemness maintenance in NSCLC cells via the inactivation of PI3K/AKT/mTOR signaling, thereby inhibiting the progression of NSCLC. The current study indicates that vitamin D is a potential candidate in therapeutic strategies against NSCLC.
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JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
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2013
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IF 2.207
Feng Xu,Ting-Ting Yan,Yan-Ling Luo
Novel amphiphilic block copolymers consisting of hydrophobic poly(D,L-lactide) segments and hydrophilic poly(N-isopropylacrylamide-co-N, N-dimethylacrylamide) blocks were designed and synthesized through a simple free radical copolymerization route based on a bifunctional initiator, followed by the ring-opening polymerization of D,L-lactide. The copolymers self-assembled into thermosensitive spherical-nanosized core–shell micelles in aqueous solution in the presence or the absence of the model drug prednisone. The chemical and physical characterizations of drug-loaded and unloaded micelles revealed a lower critical solution temperature of 40°C–47°C, and a critical micelle concentration less than 7.20 mg L−1, a transmission electron microscope mean particle size from 50 to 75 nm, and a narrow dynamic light scattering diameter below 180 nm. The prepared blank and drug-loaded micellar nanoparticles were thermodynamically stabile and employed in targeted drug delivery by responding to the higher temperature of the local microenvironment. Based on prednisone release kinetic studies, structural changes of the self-assembled micelles as well as temperature- or environment-induced diffusion controlled drug release and improved bioavailability. The copolymer micelles exhibited good biocompatibility as established by the MTT cytotoxicity assay. Therefore, an effective target therapy against lesion tissues is feasible using these polymeric micelles.
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JOURNAL OF MEDICINAL CHEMISTRY
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2024
·
IF 6.8
Ruoqing Zeng,Meimiao Fang,Ancheng Shen,Xiaolei Chai,Yumiao Zhao,Mingyao Liu,Lingfeng Zhu,Weiwei Rui,Bo Feng,Liang Hong,Chunyong Ding,Zilan Song,Weiqiang Lu,Ao Zhang
Accumulating evidence has demonstrated a critical pathological role of oxysterol receptor GPR183 in various inflammatory and autoimmune diseases, including inflammatory bowel disease (IBD). However, the currently reported GPR183 antagonists are very limited and not qualified for in vivo studies due to their inferior druglike properties. Herein, we conducted a structural elaboration focusing on improving its PK and safety profile based on a reference antagonist NIBR189. Of note, compound 33, bearing an aminobenzothiazole motif, exhibited reduced hERG inhibition, improved PK properties, and robust antagonistic activity (IC50 = 0.82 nM) with high selectivity against GPR183. Moreover, compound 33 displayed strong in vitro antimigration and anti-inflammatory activity in monocytes. Oral administration of compound 33 effectively improved the pathological symptoms of DSS-induced experimental colitis. All of these findings demonstrate that compound 33 is a novel and promising GPR183 antagonist suitable for further investigation to treat IBD.
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