ACTA BIOCHIMICA ET BIOPHYSICA SINICA
·
2024
·Vol. 57
·期 4
·604
·
IF 3.3
Xuewei Li,Jinghui Feng,Haiqin Cheng,Ning Jin,Shanshan Jin,Zhizhen Liu,Jun Xu,Jun Xie
Liver fibrosis is a critical stage in the progression of various chronic liver diseases to cirrhosis and liver cancer. Early inhibition of liver fibrosis is crucial for the treatment of liver disease. Hepatectomy, a common treatment for liver-related diseases, promotes liver regeneration. However, in the context of liver fibrosis, liver regeneration is hindered. Many studies have shown that mesenchymal stem cells (MSCs) can promote liver regeneration after partial hepatectomy (PH). However, there are few reports on the impact of MSC therapy on liver regeneration post-PH in the context of hepatic fibrosis. The objective of this study is to examine the impact of MSCs on liver regeneration following PH in the fibrotic liver and uncover the related molecular mechanisms. This study reveals that MSC therapy significantly enhances liver function and mitigates liver inflammation after PH in the context of hepatic fibrosis. MSCs also significantly promote liver regeneration and alleviate liver fibrosis. In addition, this study identifies the role of MSCs in promoting liver regeneration and alleviating liver fibrosis via the activation of Wnt/β-catenin signaling. The combination of MSCs with hepatectomy may offer a novel approach for the treatment of liver fibrotic diseases.
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高影响因子
CHEMISTRY OF MATERIALS
·
2025
·
IF 7
Kexin Xu,Yifan Lv,Xinrui Cui,Wenyu Lai,Cun-Yue Guo,Baolin Li
As a type of organic small molecule (OSMs), the introduction of sulfur atoms in fused-ring thiophenes can reduce the dihedral angle between fused rings, which helps to form planar structures and makes it easier to form tightly packed crystal structures, creating more continuous paths for charge transfer. Therefore, they have aroused widespread research interest. However, little research has been conducted on benzo[1,2-b:3,4-b′:5,6-b″]trithiophenes (BTTs), and their simple and efficient syntheses still need to be urgently developed. Herein, we have developed a synthetic approach for BTTs via C–H thienannulation. This protocol features streamlined domino synthetic procedures, eliminating the requirement for the introduction of halogen functional groups, catalysts, and additives. BTTs exhibit planar structures, enabling tight crystal packing that creates a continuous pathway for charge transport. These structural attributes endow BTTs with substantial promise for application in organic electronic materials. Therefore, 2,5,8-tris(4-propylphenyl)benzo[1,2-b:3,4-b′:5,6-b″]trithiophene ((C3-Ph)3-BTT) and its brominated derivative ((C3-Ph)3-Br3-BTT) were investigated as organic small molecules (OSMs) for doping with single-walled carbon nanotubes (SWCNTs) to fabricate OSM/SWCNT composite thermoelectric materials. The composite films exhibited excellent thermoelectric performance, achieving a maximum power factor of 515.23 ± 3.54 μW m–1 K–2 at room temperature. This value represents the highest reported power factor for thiophene derivative/SWCNT thermoelectric composites, marking a significant advancement in the development of high-performance composite thermoelectric materials based on thiophene derivatives.
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Advanced Composites and Hybrid Materials
·
2026
·Vol. 9
·期 1
·72
·
IF 21.8
Wang Aoxuan,Fang Yuan,Wang Xianfeng,Zheng Dapeng,Yang Haibin,Cao Xiangpeng,Zhang Zuhua,Xing Feng
With the increasing use of aluminum-rich (Al-rich) supplementary cementitious materials (SCMs), clarifying the roles of aluminum in C-A-S-H gels and in surplus Al-rich phases is critical for assessing chloride resistance. An Al-rich C-A-S-H material was synthesized under precise stoichiometric conditions and exposed to accelerated chloride ingress for up to 120 days. The evolution of phase assemblage, gel chemistry and physicochemical properties was monitored during the exposure. A time-dependent model was developed to describe chloride ingress and binding. Chloride ion binding in the Al-rich C-A-S-H occurred through both chemical solidification in Friedel’s salt and physical adsorption, with physical adsorption on C-A-S-H surfaces being dominant, accounting for approximately 60–70% of total bound chloride. The Al-rich phase primarily acted as a “reservoir,” releasing Ca 2+ and Al 3+ which facilitated the formation of Friedel’s salt and promoted the subsequent formation of C-A-S-H gel. Furthermore, the subsequent re-incorporation of aluminum into the C-A-S-H gel under chloride leading to a partial transformation from cross-linked to non-cross-linked silicate chains. This structural evolution is accompanied by a marked micromechanical degradation, with the Young’s modulus decreasing from 11.1 to 6.9 GPa under highly accelerated, severe exposure conditions. Overall, these results provide a time-resolved mechanistic picture of how C-A-S-H gel and surplus Al phases co-evolve under chloride attack, offering a new basis for the durability design of SCM-rich cementitious composites.
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VIBRATIONAL SPECTROSCOPY
·
2022
·
IF 2.382
Zhiqiang Wang,Siqi Duan,Bin Fang,Zhenxiang Liu,Ruiting Zhang,Lin Ma,Ke Lin
Identifying the molecular structures of drugs are important for understanding the molecular interactions between drugs and proteins. Especially in situ measurement of drug structures that interact with proteins in aqueous solutions or cells is a challenge. In this work, mandelic acid (MA) was used as a model molecule to prove that the Raman spectra in the C-H or C-D stretching region can be employed to identify the molecular structure through theoretical and experimental Raman spectra and molecular dynamics simulations methods. Using the experimental and theoretical Raman spectra of MA rotamers, C α -H was determined to be trans (higher than 2950 cm −1 ) and nontrans (below 2950 cm −1 ) from the α-OH group for solid DL-MA (~2961 cm −1 ) and D -MA (~2898 cm −1 ), respectively, which agreed well with the results from X-ray diffraction. Molecular dynamic (MD) simulations and Raman band of the MA aqueous solution revealed that the C α -H group was determined to be nontrans from the α-OH group, the structure of the carboxyl group was cis (~2910 cm −1 ), the carboxyl group was roughly vertical to the C α -benzene bond, and the benzene ring was approximately coplanar with the C α -H bond. Our work also paves that the Raman spectra in the C-D or C-H stretching region could be used as fingerprint regions to study the structure of drugs.
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ADVANCED MATERIALS
·
2021
·Vol. 34
·期 5
·2105410
·
IF 30.849
Leping Yang,Xu Zhang,Lingxiao Yu,Jianhua Hou,Zhen Zhou,Ruitao Lv
Noble-metal-free, durable, and high-efficiency electrocatalysts for oxygen reduction and evolution reaction (ORR/OER) are vital for rechargeable Zn–air batteries (ZABs). Herein, a flexible and free-standing carbon fiber membrane immobilized with atomically dispersed Fe–N 4 /C catalysts (Fe/SNCFs-NH 3 ) is synthesized and used as air cathode for ZABs. The intertwined fibers with hierarchical nanopores facilitate the gas transportation, electrolyte infiltration and electron transfer. The large specific surface area exposes a high concentration of Fe–N 4 /C sites embedded in the carbon matrix. Modulation of local atomic configurations by sulfur doping in Fe/SNCFs-NH 3 catalyst leads to excellent ORR and enhanced OER activities. The as-synthesized Fe/SNCFs-NH 3 catalyst demonstrates a positive half-wave potential of 0.89 V and a small Tafel slope of 70.82 mV dec –1 , outperforming the commercial Pt/C (0.86 V/94.74 mV dec –1 ) and most reported M–N x /C (M = Fe, Co, Ni) catalysts. Experimental characterizations and theoretical calculations uncover the crucial role of S doping in regulating ORR and OER activities. The liquid-state ZABs with Fe/SNCFs-NH 3 catalyst as air cathode deliver a large peak power density of 255.84 mW cm –2 and long-term cycle durability over 1000 h. Solid-state ZAB shows stable cycling at various flat/bent/flat states, demonstrating great prospects in flexible electronic device applications.
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2023
·
IF 22.1
Chang Wang,Shihao Zhou,Qingqiang Cui,Mengya Zhang,Linqi Zheng,Shuang Li,Xiangdong Liu,Ming Chen
Photo-thermal catalytic (PTC) degradation as an ideal candidate for wastewater treatment is yet suffering from the unsatisfied recyclability due to the thermal effect-exacerbated serious photocorrosion of semiconductor-based catalysts. Based on polymeric graphite carbon nitride (g-C 3 N 4 ) hybridized with antioxidative hexagonal boron nitride (h-BN) and grafted with stable Au nanoparticles (NPs), we provide thermostable g-C 3 N 4 /h-BN/Au nano-catalysts for high-efficient degradation of organic dyes at solar-activated heating condition. The fantastic PTC activity with optimal degradation rate up to ∼ 0.30 min −1 is far better than most mainstream hybrid catalysts. The unprecedented thermal recyclability is convincingly verified by consecutive 10 repeated tests within 500 min measurements under solar-driven heating condition (∼60 °C), wherein the negligible drop of degradation efficiency is only ∼ 0.2% lower than pristine one. The ingenious self-floating PTC membranes can be conveniently established by immobilizing the resultant nano-catalysts into bio-carbon porous frames and viscous bacterial nano-celluloses, facilitating practical wastewater decontamination in real-world scenarios.
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INDUSTRIAL CROPS AND PRODUCTS
·
2019
·
IF 4.191
Xiaoyun Li,Jiaxin Yang,Rui Xu,Lefu Lu,Fangong Kong,Min Liang,Lijie Jiang,Shuangxi Nie,Chuanling Si
The production of platform chemicals from lignocellulosic biomass is scientifically valuable but technologically challenging. With the aim to establish a green reaction system for the production of furfural from lignocellulosic biomass, in the current work, H-SAPO-34 was investigated for catalysis of the conversion of Eucalyptus sawdust to furfural in γ-valerolactone (GVL). H-SAPO-34 was prepared and characterized by XRD, SEM, FTIR, BET, TGA and ammonia adsorbed FTIR. H-SAPO-34 possesses Brønsted and Lewis acid sites and a large specific surface area. The average pore diameter of H-SAPO-34 was 0.86 nm, which is beneficial for the spread of xylose and furfural and the inhibition of humin production. In this work, a peak furfural yield of 99.28% from Eucalyptus was achieved at 210 °C in 120 min with 30 g/L H-SAPO-34. The Brønsted/Lewis acid bifunctionality and the solvent effect of γ-valerolactone possibly contributed to the high furfural yield from real biomass. The kinetics of the conversion of Eucalyptus sawdust to furfural was also studied, and the activation energy for furfural production was calculated. Additionally, the catalytic activity and stability of the regenerated catalyst were estimated.
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Regenerative Biomaterials
·
2014
·Vol. 1
·期 1
·27-35
·
IF 0
Cai Teng-Teng,Lei Qi,Yang Bin,Jia Hui-Zhen,Cheng Hong,Liu Li-Han,Zeng Xuan,Feng Jun,Zhuo Ren-Xi,Zhang Xian-Zheng
A novel Uralic (U)-rich linear-hyperbranched mono-methoxy poly (ethylene glycol)-hyperbranched polyglycerol-graft-Uralic (mPEG-HPG-g-U) nanoparticle (NP) was prepared as drug carrier for antitumor methotrexate (MTX). Due to the H-bond interaction of U with MTX and hydrophobic interaction, this NP exhibited high drug loading efficiency of up to 40%, which was significantly higher than that of traditional NPs based on U-absent copolymers (<15%). In addition, MTX-loaded mPEG-HPG-g-U NPs also demonstrated an acidity-accelerated drug release behavior.
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ADVANCED FUNCTIONAL MATERIALS
·
2024
·Vol. 34
·期 52
·2411183
·
IF 18.5
Song Yin,Xuewei Jiao,Xudong Liu,Mingxuan Liu,Bingshun Xu,Na Li,Yonghao Lu,Shaopeng Yang,Weiguang Kong
The role of MA in FAMA mixed perovskite remains far from being fully understood, due to the intricate chemical evolutions in the precursor solutions. Adjusting the content of MA in FAMA mixed perovskite arbitrarily remains a great challenge. This study elucidates a synergistic effect between H + and I − oxidation which helps to reduce the content of MA in FA-dominated perovskite. Briefly, excessive H + boosts the balanced and rapid assembly of MA and FA components in FA-dominated perovskite and hampers unfavorable chemical evolution induced by nucleophilic reaction between MA and FA in the precursor solution, while I − oxidation accelerates the in situ crystallization of perovskite. Leveraging this synergistic effect, centimeter-scaled FA x MA (1-x) PbI 3 single crystals with arbitrarily adjustable values of x are successfully fabricated. In addition, peroxyacetic acid is introduced as the additive, enabling the blade-coated FA 0.9 MA 0.1 PbI 3 perovskite solar cells (PSCs) to achieve an impressive efficiency of 23.7%. The efficiency achieved here is among the highest values for blade-coated PSCs with FA content exceeding 90% so far. The optimized solution developed in this study achieved exceptional stability, allowing it to be stored under air conditions for over 2 months without significant degradation in cell efficiency. This outcome satisfies the requirements for commercialization.
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JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
·
2024
·
IF 2.8
Xijin Yang,Ying Li,Qiju Shao,Zhirong Li,Zeli Chun,Yan Wang,Yaping Zhou,Rongxiang Chen
Persicaria chinensis (L.) H. Gross ( P. chinensis ), also known as “Huotanmu” in Chinese, is a traditional ethnic herbal medicine and a functional food ingredient. In this study, liquid chromatography − electrochemical detection (LC-ECD) screening, liquid chromatography − tandem mass spectrometry (LC-MS/MS) identification, and multivariate statistical analysis were combined to clarify the antioxidant components in P. chinensis . The samples were extracted using 80 % aqueous methanol under ultrasound-assisted extraction and their in vitro antioxidant activities were evaluated. The fingerprint of P. chinensis was established using LC-ECD, while the identification of major chemical components was performed using LC-MS/MS through comparison of ion fragments. Subsequently, grey correlation analysis and partial least squares regression analysis were used to investigate the association of different compounds with antioxidant activity. P. chinensis from different sources showed excellent DPPH radical scavenging capacity, ABTS radical scavenging capacity, and ferric reducing antioxidant power. A total of 25 common peaks were obtained and identified in the LC-ECD fingerprint of P. chinensis , which were primarily comprised of tannins and flavonoids. The similarity between samples of different batches was ≥ 0.767, indicating relatively consistent quality. The comprehensive analysis results of grey relational analysis and partial least squares regression analysis indicated that tannins such as di-galloyl-HHDP-hexoside and davidiin were the major contributors to the antioxidant activity of P. chinensis . Therefore, LC-ECD can rapidly screen the potential phenolic antioxidants of P. chinensis , providing a basis for its product development, resource utilization, and quality control.
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GREEN CHEMISTRY
·
2021
·Vol. 24
·期 1
·384-393
·
IF 10.182
Qi Zhang,Shouxin Liu,Xia Tian,Yidong Liu,Shiming Fan,Baibiao Huang,Andrew Whiting
A highly selective, green and sustainable chlorination of aliphatic C–H bonds is reported using MCln under the co-catalysis of visible light and nano-Cu@CuCl, which was synthesised via a one-step, hydrothermal strategy using copper(II) sulfate and D-glucose as the reducing agent in a KCl solution. A novel cascade method of producing Cl2 occurs in situ chlorinating C(sp3)–Hs, achieved through nano-Cu@CuCl catalysis using inorganic chloride MCln as a chlorine source under visible light and without the need for a strong oxidant. The reaction was applied to the chlorination of different alkylarene α-Hs and cyclic hydrocarbons C–HS and was developed for use in a photocatalytic serial reactor system which accomplished the chlorination of toluene α-Hs to give 92% conversion, 90% yield and 98% selectivity. Electron spin resonance (ESR) studies of DMPO-Cl. revealed that the reaction mechanism belonged to a free radical process.
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APPLIED CATALYSIS A-GENERAL
·
2022
·
IF 5.723
Shipei He,Sheng Fan,Kai Yuan,Shujia Guo,Sen Wang,Zhangfeng Qin,Mei Dong,Weibin Fan,Jianguo Wang
Herein, K + was added in the synthesis gel to regulate the distribution of acid sites in the ITQ-13 zeolite and enhance its catalytic performance in the conversion of methanol to olefins (MTO). The results indicate that a proper content of K + ions in the synthesis gel can not only expedite the crystallization of ITQ-13 zeolite, but also significantly decrease the proportion of paired Al and distribute more Al atoms in the 10-ring sinusoidal channel out from the intersection cavity. Accordingly, over the H-ITQ-13(0.3 K) zeolite prepared using the synthesis gel with a KCl/Al 2 O 3 molar ratio of 0.3, the alkene cycle of MTO keeping to the dual cycle hydrocarbon pool (HCP) mechanism is preferably enhanced, whereas the hydride transfer and aromatization reactions are substantially suppressed. As a result, H-ITQ-13(0.3 K) exhibits much longer catalytic lifetime and higher selectivity to propene and butene , in comparison with the H-ITQ-13 counterpart obtained without adding K + .
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