CARBOHYDRATE POLYMERS
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2021
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IF 9.381
Rining Jin,Jiajun Xu,Lijie Duan,Guanghui Gao
Recently, flexible and wearable sensors assembled from conductive hydrogels have attracted widespread attention. However, it is still a great challenge to make hydrogels with sufficient mechanical properties, self-adhesiveness and strain sensitivity. Here, a strong, tough, and self-adhesive hydrogel is successfully fabricated by a one-pot method, which introducing chitosan and 2-acrylamido-2-methylpropane sulfonic acid into the polyacrylamide network. The hydrogels exhibited adhesion (the peel strength reaches 798 N/m), mechanical property (The breaking strength and strain can reach 111 kPa and 2839%) and electrical conductivity (conductivity up to 0.0848 S/cm), which are suitable for wearable epidermal sensors. Besides, the hydrogels also possessed transparency. Therefore, this work would provide a novel insight on the fabrication of multi-functional self-adhesive hydrogel sensors.
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CARBOHYDRATE POLYMERS
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2021
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IF 9.381
Zhengwei Liu,Xiaoqiong Mo,Fenbo Ma,Sijing Li,Guofeng Wu,Bin Tang,Lijun Lin
Osteoarthritis (OA) is an age-related joint disorder and one of the leading causes of physical disability. In this study, we designed and synthesized a new polysaccharide complex, carboxymethyl chitosan strontium (CMCS-Sr), which is believed to have positive effects on relieving OA. The synthesized CMCS-Sr was structurally verified by SEM, EDS, FTIR, etc. The therapeutic effects of CMCS-Sr were evaluated using various biological experiments. The cell viability and apoptosis results reveal that CMCS-Sr can significantly promote the proliferation and suppress OA chondrocytes apoptosis in vitro . The immunofluorescence staining results suggest that CMCS-Sr facilitates the promotion of the secretion of Type II collagen (Col-II). The transcriptomic results support the observed positive effects of CMCS-Sr on inhibiting chondrocytes apoptosis and alleviating inflammatory reactions. Moreover, animal study demonstrates that CMCS-Sr effectively reduced articular cartilage damage and subchondral bone degradation. Therefore, we propose the use of CMCS-Sr as a promising candidate for relieving OA.
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RSC Advances
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2020
·Vol. 10
·期 73
·45130-45138
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IF 3.119
Li Li,Shasha Han,Sengqun Zhao,Xurui Li,Bingmi Liu,Yu Liu
Metal–organic frameworks (MOFs) are composed of both organic linkers and metallic ions, which have emerged as excellent drug delivery agents for the treatment of cancer and other diseases. Currently, MOF studies are mainly focused on intravenous administration, while studies dedicated to oral administration are relatively scarce. In this study, five MOFs, namely UiO-66, UiO-66-NH2, UiO-66-COOH, UiO-67 and Zr-NDC, were synthesized, of which Zr-NDC had the largest drug loading capacity for 5-FU. Next, a chitosan (CS) modified Zr-NDC was developed to provide a strong impetus for the oral administration of 5-FU. In vitro release experiments of fluorescein isothiocyanate (FITC)-labeled chitosan demonstrated that the cumulative release rates of FITC-labeled chitosan in artificial gastric juice and artificial intestinal fluid were about 20% and 90%, respectively. The in vitro drug release profiles showed that under the protection of CS-MOF, the release of 5-FU into an acidic environment was only 20%, but the release in artificial intestinal fluid reached 70%. Pharmacokinetic analysis revealed that the coating of chitosan on the surface of MOFs exerted a controlled drug release effect, and further improved the oral bioavailability of 5-FU. These findings suggest that CS coating can break through the limitation of MOF intolerance to acid. It is expected that CS-MOF@5-FU can serve as a potential drug delivery system for the oral administration of 5-FU.
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IONICS
·
2020
·Vol. 26
·期 12
·6371-6378
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IF 2.394
Xu Haoyan,Han Chuanlong,Liu Sicheng,Hao Xin,Rao Yu,Gong Zexin,Sun Zhuangzhi
Due to the efficiency of ion movement is greatly affected by moisture environment, this article explores the effects of the changing the moisture content of the self-degraded ionic hydrogel-based electrolyte layer made of sodium alginate and chitosan on the improvement of the electromechanical properties of the soft ionic actuator. Specifically, sodium alginate-chitosan ionic hydrogel-based soft ionic actuator is fabricated and analyzed by voltammetry analysis, AC impedance, charge and discharge, electrical conductivity, displacement, and output force. Furthermore, the further application of this soft ionic actuator on bionic flytrap is developed and discussed. The results show that soft ionic actuator with the moisture content of 78.64% has the best electromechanical properties. Furthermore, soft ionic actuators with different moisture contents show different degrees of deflection due to the shift of the anions to the cathode under charged conditions. Therefore, it can be found that moisture content is beneficial to improve the electromechanical properties of ionic hydrogel-based soft artificial muscle.
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2020
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IF 4.389
Chenmeizi Wang,Ling Wang,Qingle Zhang,Lu Cheng,Haitao Yue,Xin Xia,Huimin Zhou
Addition of nanomaterials into polymer matrix is a promising avenue to reinforce the mechanical properties of composites. In this work, chitosan-based hydrogels reinforced by cellulose nanofibers (CNFs) have been prepared by chitosan as matrix. The effect of CNFs (1vt%, 1.5vt% and 2vt%) on the structure-property relationship in mechanical, swelling capability, pH sensitivity and antibacterial have been investigated, respectively. Different from normal reinforced particle, CNFs with special fiber shape and abundant hydrogen bonding can form interconnected porous structure with chitosan hydrogel, which can spread stress and defer permanent damage under compressing. And the compressive strength increases nearly 20 % and swelling capacity achieve 140 %, when 1.5vt% CNFs added. Thanks to CNFs which obtained from apocynum venetum generated positive effect on the antibacterial rate against E. coli and S. aureus of composite hydrogel. It proves that CNFs display an excellent mechanical and antibacterial enhancement in composite, and it provided a new prospect for the rational selection of the different shapes and aspect ratio of reinforced materials. The obtained CNFs reinforced composite hydrogels could be potentially applied in antibacterial biological and food packaging area.
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CARBOHYDRATE POLYMERS
·
2020
·
IF 7.182
Jun Wang,Leyna G. Liu,Wen-Qiao Jiao,Hua Yang,Jing Liu,Dahai Liu
In order to achieve high loading and efficient delivery of curcumin, phenylboronic acid-conjugated chitosan nanoparticles were prepared by a simple desolvation method. These nanoparticles exhibited a regular spherical shape with the average size about 200−230 nm and narrow size distribution, which were kinetically stable under physiological condition. Due to boronate ester formation between curcumin and phenylboronic acid groups in the nanoparticles, and the hydrogen bonding interactions between curcumin and nanocarriers, curcumin was successfully loaded into the nanoparticles with high drug loading content. These curcumin-loaded nanoparticles showed pH and reactive oxygen species (ROS)-triggered drug release behavior. In vitro cell experiments revealed that the blank nanoparticles were completely nontoxic to cultured cells, and the curcumin-loaded nanoparticles exhibited efficient antitumor efficiency against cancer cells. Moreover, the drug-loaded nanoparticles performed an enhanced growth inhibition in three-dimensional multicellular tumor spheroids. Thus, these nanocarriers would be a promising candidate for curcumin delivery in tumor treatment.
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CARBOHYDRATE POLYMERS
·
2020
·
IF 7.182
Xiaoyu Zhang,Huabing Yang,Junping Zheng,Nan Jiang,Guangjun Sun,Xinkun Bao,Aizhen Lin,Hongtao Liu
This study was designed to explore the improvement of chitosan oligosaccharides (COS) on constipation through regulation of gut microbiota. Here, we proved that COS treatment profoundly boosted intestinal motility, restrained inflammatory responses, improved water-electrolyte metabolism and prevented gut barrier damage in constipated mice induced by loperamide . By 16S rDNA gene sequencing, the disbalanced gut microbiota was observed in constipated mice, while COS treatment statistically reversed the abundance changes of several intestinal bacteria at either phylum, family and genus levels, which partly led to the balance in production of intestinal metabolites including bile acids, short-chain fatty acids and tryptophan catabolites. In addition, COS failed to relieve the constipation in mice with intestinal flora depletion, confirming the essentiality of gut microbiota in COS-initiated prevention against constipation. In summary, COS can ameliorate the development of loperamide-induced constipation in mice by remodeling the structure of gut microbial community.
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MATERIALS LETTERS
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2021
·
IF 3.423
Siyin Qin,Huabing Li,Chengzhi Hu
Microencapsulated phase-change materials (MEPCMs) possess promising application in storing energy and protecting environment of biomaterials. However, the MEPCMs have the difficulty of low encapsulation efficiency and irregular shape. In this study, biodegradable chitosan/gelatin co-emulsifier as composite shell was used to encapsulate n -tetradecanol through oil-in-water-in-oil (O/W/O) method, and then crosslinked with glutaraldehyde (GTA). The results reveal that the latent heat and encapsulation efficiency of the microcapsules reach 146.88 J g −1 and 70.94%, respectively. Besides, the prepared microcapsules exhibit great thermal stability and thermal cycling reliability during the phase change process.
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Materials Science & Engineering C-Materials for Biological Applications
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2021
·
IF 7.328
Yang Yang,Alastair Campbell Ritchie,Nicola M. Everitt
Animal-derived collagen may contain viruses, and its impurity can cause immunological reactions. Chitosan, always required a neutralization step in fabricating it into the biocompatible tissue engineering scaffolds. To avoid these risks and simplify the production process, a series of recombinant human collagen/carboxylated chitosan (RHC-CHI) based soft hydrogel scaffolds were prepared by crosslinking-induced gelation and then investigated their feasibilities for use as soft tissue engineering scaffolds. The gelation time was optimized by modulating the biopolymer concentration or reaction temperature. The hydrogel swelling, degradation rate, and mechanical properties were also investigated. The results showed that these parameters could be tuned by adjusting either the RHC-to-chitosan ratio or the total polymer concentration. The mechanical properties of the hydrogels were improved by adding chitosan, but excess chitosan reduced the hydrogel mechanical strength and accelerated the degradation speed. Cytotoxicity tests showed that all fabricated soft hydrogels were biocompatible and displayed no cytotoxicity. Cytocompatibility tests and qRT-PCR studies indicated that the hydrogel system promoted the adhesion and proliferation of NIH-3T3 cells, and cellular activities were directly up-regulated by RHC. Finally, our in vivo study proved these hydrogels were able to accelerate the cell infiltration and wound closure. These results show that the soft RHC-CHI hydrogels show promise in soft-tissue engineering.
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Carbohydrate Polymer Technologies and Applications
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2020
·
IF 0
Wentao Huang,Liping Zhu,Dezhong Liu,Jiefu Li,Shuguang Yang
Alginate (ALG) and chitosan (CHI) are naturally occurring polymers, and present broad applications in various fields. Owing to the electrostatic interactions between the two polymers, ALG and CHI are combined to prepare fibers via diffusion controlled in-situ polyelectrolyte complexation. A map of the concentration combination of spinning and coagulation solution is presented for the fabrication of the complex fibers. When concentration combination meets the requirements for fiber formation, increasing the concentration of the spinning or coagulation solution will slow down the diffusion, which will affect the composition and mechanical properties of the prepared fibers. Prolonging complexation time or increasing temperature will enhance the diffusion, and more polyelectrolytes with opposite charged-groups will be taken from the coagulation solution, hence the fibers modulus will increase. In addition, the fiber composition and initial modulus are found to be correlated, and the inner structure of the fiber is revealed using the fluorescence imaging technique.
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REACTIVE & FUNCTIONAL POLYMERS
·
2021
·
IF 3.975
Xianlin Xu,Jiajing Yu,Chang Liu,Guang Yang,Lei Shi,Xupin Zhuang
Biomass can adsorb dyes and then degrade. Although this material has remarkable prospects, its application is limited by its adsorption capacity and the simultaneous adsorption of cations/anions. Herein, a pore-forming agent in a solvent exchange phase transformation was used to fabricate chitosan xanthate and cellulose xanthate (xanthated chitosan/cellulose) sponges. Owing to the hierarchical pores and the presence of xanthic acid and amino groups, the sponges show efficient removal ability for anionic (congo red) and cationic (methylene blue) dyes. The adsorption mechanism, isotherm, kinetics, and thermodynamics were comprehensively studied. The xanthated chitosan/cellulose sponges exhibited the maximum adsorption capacities of 213.220 and 289.855 mg g −1 toward methylene blue and Congo red, respectively. The mechanism is a spontaneous physic-sorption process that fitted well with the pseudo-second-order and Langmuir isotherm models. These results revealed that xanthated chitosan/cellulose sponges are effective adsorbents for the removal of methylene blue and Congo red dyes and provide a new platform for dye decontamination .
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CARBOHYDRATE POLYMERS
·
2020
·
IF 7.182
Xiao Ma,Guomin Wu,Fangfang Dai,Dan Li,Hao Li,Li Zhang,Hongbing Deng
Silk fibroin (SF) is increasingly needed in tissue engineering for its superior biocompatibility. However, the practical applications of pure SF biomaterials confront bacterial infection problems. In this study, chitosan (CS) and polydopamine (PDA) were introduced into electrospun nanofibrous SF mats through layer-by-layer self-assembly (LBL) to obtain enhanced antibacterial ability and cytocompatibility. The surface morphology and composition analysis confirmed the successful deposition. After depositing 15 bilayers , the tensile modulus of the mats in wet condition increased from 2.16 MPa (pristine SF mats) to 4.89 MPa. A trend towards better hydrophilicity performance was also recorded with more bilayers coating on the mats. Besides, LBL structured mats showed improved antibacterial ability of more than 98 % against E. coli and S. aureus . In addition, advancement in biocompatibility was observed during the proliferation experiment of L929 cells. Overall, the deposition of CS and PDA may further expand the use of SF in biomedical field.
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