Journal of Materials Chemistry B
·
2015
·Vol. 3
·期 32
·6618-6625
·
IF 4.726
Changjiang Fan,Chao Zhang,Liqiong Liao,Sheng Li,Weiping Gan,Jinping Zhou,Dong-An Wang,Lijian Liu
Abundant research efforts have been devoted to meet the demands for high-strength hydrogels in biomedical applications. Double-network (DN) hydrogels and homogeneous hydrogels are two typical samples. In this study, a novel ultra-strong and resilient double macromolecular network (DMMN) hydrogel system has been developed via a two-step sequential cross-linking process using hyaluronan (HA) and high molecular weight poly(ethylene glycol) (PEG) for the first and second network, respectively. A lower concentration of the HA precursor solution and a higher concentration of the PEG precursor solution as well as a higher molecular weight of the PEG precursor are beneficial to produce high-strength DMMN gels. Dynamic light scattering measurements demonstrate that DMMN gels possess the more evenly distributed polymer networks; the distinctive double and relatively evenly distributed networks of the DMMN gel make it combine the current DN and homogeneous network strategies for preparing robust hydrogels. The optimized DMMN gel is capable of sustaining up to 50 MPa of compressive stress. Besides, DMMN gels exhibit excellent cytocompatibility. This study expands the DN principle in designing and fabricating high-strength hydrogels with biocompatible macromolecules that show a promising prospect for biomedical applications.
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高影响因子
COLLOID AND POLYMER SCIENCE
·
2014
·Vol. 293
·期 2
·441-451
·
IF 2.41
Cao Hongyan,Wang Qian,Li Min,Chen Zhiyong
A series of poly(ethylene glycol) diacrylate/methacrylic acid (PEGDA/MAA)-based nanogels showing multiresponsiveness toward temperature, salt concentration, and pH value were synthesized by aqueous precipitation polymerization. The effect of monomer loading amount, cross-linking degree, and cross-linker type on synthesis of hydrogels was investigated, and so were the influences of MAA content in the feed of synthesis of hydrogel, pH value, and NaCl concentration on the thermosensitivity of hydrogels. The lower critical solution temperature (LCST) of poly(PEGDA/MAA) hydrogels decreased with an increase of MAA content or NaCl concentration and a decrease of pH value. One of the resultant hydrogels (PEGDA575/MAA, 40/60 mol/mol) displayed a distinct LCST of 35 °C under a gastric liquid-like condition (pH 1.0, 150 mM NaCl). Such hydrogel showed a good potential in controlling the release of 5-fluorouracil (5-FU), an anticancer agents, under the above gastric liquid-like condition and also an intestinal liquid-like one.
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eScience
·
2023
·
IF 0
Minghong Huang,Changsheng Cao,Li Liu,Wenbo Wei,Qi-Long Zhu,Zhenguo Huang
Delicately designed metal–organic framework (MOF)-derived nanostructured electrocatalysts are essential for improving the reaction kinetics of the oxygen evolution reaction and tuning the selectivity of small organic molecule oxidation reactions. Herein, novel oxalate-modified hollow CoFe-based layered double hydroxide nanocages (h-CoFe-LDH NCs) and yolk–shell ZIF@CoFe-LDH nanocages (ys-ZIF@CoFe-LDH NCs) are developed through an etching–doping reconstruction strategy from a Co-based MOF precursor (ZIF-67). The distinctive nanostructures, along with the incorporation of the secondary metal element and intercalated oxalate groups, enable h-CoFe-LDH NCs and ys-ZIF@CoFe-LDH NCs to expose more active sites with high intrinsic activity. The resultant h-CoFe-LDH NCs exhibit outstanding OER activity with an overpotential of only 278 mV to deliver a current density of 50 mA cm −2 . Additionally, controlling the reconstruction degree enables the formation of ys-ZIF@CoFe-LDH NCs with a yolk–shell nanocage nanostructure, which show outstanding electrocatalytic performance for the selective ethylene glycol oxidation reaction (EGOR) toward formate, with a Faradaic efficiency of up to 91%. Consequently, a hybrid water electrolysis system integrating the EGOR and the hydrogen evolution reaction using Pt/C||ys-ZIF@CoFe-LDH NCs is explored for energy-saving hydrogen production, requiring a cell voltage 127 mV lower than water electrolysis to achieve a current density of 50 mA cm −2 . This work demonstrates a feasible way to design advanced MOF-derived electrocatalysts toward enhanced electrocatalytic reactions.
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INORGANIC CHEMISTRY
·
2024
·
IF 4.3
Nannan Zhang,Jie Li,Wanyu Liang,Yangping Zhang,Zhengying Wu,Yukou Du
2D nanodendrites (NDs) and nanosheets (NSs) have been regarded as efficient nanocatalysts for enhancing the electrocatalytic performance due to their low coordinated sites and abundant electrocatalytic centers. Nevertheless, it remains challenging to construct advanced NDs and NSs in a single reaction system. Herein, by tuning the volume ratios of mixed solvents, the reduction and diffusion rate of Sn2+ on Pd NSs template was rationally controlled to prepare PdSn NDs and PdSn NSs. Ascribed to the open 2D nanostructure, high specific surface area, and robust synergistic effect, the as-prepared PdSn NDs and PdSn NSs exhibited distinguished electrocatalytic activities for ethylene glycol oxidation reaction (EGOR) and ethanol oxidation reaction (EOR), as well as commendable electrocatalytic durability, which were far superior to the Pd NSs and commercial Pd/C. In addition, the PdSn NDs exhibited enhanced reaction kinetics because the characteristic branch structure exposed a high density of active sites. This work may provide significant guidance for preparing excellent nanocatalysts with various morphological features by simply optimizing the content of the coexisting solvents.
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PubMed
高影响因子
SOLAR ENERGY MATERIALS AND SOLAR CELLS
·
2024
·
IF 6.3
Yichi Liu,Minming Zou,Shikun Xiao,Wenjing Chen,Yuqiong Xie,Wenxing Luo,Lixiang Luo,Xiaowu Hu,Xiongxin Jiang,Yinshui He,Qinglin Li
Ag nanoparticles are commonly used for phase change material (PCM) modification to improve the photo-thermal convertibility in composite phase change materials (CPCM) owing to enhance carrier's ability to absorb photons by virtue of its unique localized Surface Plasmon Resonance effect (LSPR). Currently, redox method is considered to be the most effective method for the preparation of Ag nano-coating. However, it is still challenging to obtain a dense and uniform Ag nano-coating on the carrier surface due to the difference in the binding force between Ag nanoparticles and different carriers. Herein, a new preparation strategy is demonstrated, in which the carrier is pre-modified by adding a polydopamine (PDA) coating to enhance the bonding between the carrier and the silver nanoparticles, and then a stable three-dimensional silver nano-conducting network is obtained by redox. Consequential stable architecture contributes to polyethylene glycol (PEG) loadings reach 98%, simultaneously with an ultra-high photo-thermal conversion efficiency of 97.9%. Furthermore, this paper demonstrates the effect of carbonization temperature on the flexibility of melamine carbon foam (CMF), and different nano-Ag concentrations on the thermal conductivity of CPCM. This finding provides valuable guidance for the engineering of high photo-thermal conversion performance CPCM and strengthens their practical implementation in solar energy storage and thermal management.
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高影响因子
Materials
·
2018
·Vol. 11
·期 12
·2454
·
IF 2.467
Alfredo Ronca,Ugo D’Amora,Maria Grazia Raucci,Hai Lin,Yujiang Fan,Xingdong Zhang,Luigi Ambrosio
In this study, an innovative polymer blend, based on double network (DN) approach, has been developed by integrating a poly(ethylene glycol) diacrylate (PEGDA) network into a chemically modified hyaluronic acid sodium salt (HAs) hydrogel matrix. Here, the HAs was chemically functionalized with photocrosslinkable moieties by reacting with maleic anhydride (MAA) to obtain a maleated hyaluronic acid (MaHA). Furthermore, nanocomposite DN hydrogels were suitably prepared by physical blending of hydroxyapatite nanoparticles (HAp), obtained by sol-gel synthesis, within the hydrogel. Physico-chemical, thermal, morphological and mechanical analyses were performed. Results showed enhanced mechanical properties and a homogenous microstructure as highlighted by mechanical and morphological investigations. This suggests that nanocomposite DN hydrogels are promising candidates for biomedical applications.Keywords:double network;hyaluronic acid derivative;nanocomposite;sol-gel method;PEGDA
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PubMed
高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
·
2018
·Vol. 20
·期 10
·1-14
·
IF 2.127
Hua Jisong,Teng Peng,Zou Yingying,Zhang Chao,Shen Xujie,Cai Jianfeng,Hu Yong
The bacterial infections, especially wound infection, have become a growing problem threatening the human health. Small molecular antimicrobial agents were synthesized to fight against the bacteria but the clinical application in wound inflection treatment was restricted because of their hydrophobicity and poor skin permeation. Here, we synthesized a novel quinoline compound to be used as an antimicrobial agent. Due to its hydrophobic property, this quinoline compound could be successfully encapsulated into poly(epsilon-caprolactone)-poly(ethylene glycol) (PCL-PEG) nanoparticles (NPs) with a mean size of about 100 nm and showed a sustained drug release manner in vitro. Compared to the free drug of this quinoline compound, these drug-loaded PCL-PEG NPs had better water solubility and lower cytotoxicity in vitro. Results of in vivo wound healing experiments demonstrated that these drug-loaded NPs could not only greatly suppress the bacterial infection around the wound, but also significantly accelerate the curing rate of wound. Thus, these quinoline compound-loaded PCL-PEG NPs could act as a promising drug delivery system for wound healing applications.
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高影响因子
JOURNAL OF ANALYTICAL CHEMISTRY
·
2020
·Vol. 75
·期 2
·219-224
·
IF 0.84
Liang Demin,Gao Yihan,Zheng Saijing,Li Gang,Wu Da,Shen Yi
Abstract A simple and rapid gas chromatographic–mass spectrometric (GC–MS) method using selected ion monitoring mode was developed for simultaneous determination of propylene glycol, glycerol and lactic acid in rat plasma and serum. The method employed a single-step derivatization using bis(N,O-trimethylsilyl) trifluoroacetamide with trimethylchlorosilane and required only a small amount of plasma or serum (100 μL). The calibration curves showed linearity with the correlation coefficients of 0.996–0.999. To validate the method, the intra- and inter-day repeatability of the proposed method in rat plasma was evaluated. Recovery was assessed by the standard addition method. To test the applicability of the method, twenty plasma samples in two different time points were analyzed and levels of both propylene glycol and lactic acid in plasma were found to increase after exposure to the propylene glycol aerosol (500 mg/kg). With satisfactory repeatability and recovery the proposed GC–MS method can be successfully applied for analysis of plasma and serum samples.
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高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2012
·
IF 3.456
Qian Guo,Ping Luo,Yu Luo,Fang Du,Wei Lu,Shiyuan Liu,Jin Huang,Jiahui Yu
Biodegradable micelles with sheddable poly(ethylene glycol) shells were fabricated based on poly(ethylene glycol)- block -poly(γ-benzyl l -glutamate) (mPEG-SS-PBLG) diblock copolymer and applied as the carrier of 7-ethyl-10-hydroxy-camptothecin (SN-38) in order to enhance its solubility and stability in aqueous media. The diblock polymer was designed to have the hydrophilic PEG moiety and hydrophobic PBLG moiety linked by biodegradable disulfide bond, so in reducing environment the PEG shells can be detached. The polymer was able to form the micelles of nano-scale in aqueous media, suggesting their passive targeting potential to tumor tissue. Water-insoluble antitumor drug, SN-38, was easily encapsulated into mPEG-SS-PBLG nanomicelles by lyophilization method. When setting theoretical drug loading content at 10 wt%, the drug encapsulation efficiency (EE) was assayed as 73.5%. Owing to the disulfide bond in mPEG-SS-PBLG, intense release of SN-38 occurred in the presence of dithiothreitol (DTT) at the concentration of simulating the intracellular condition, however, micelles showed gradual release of SN-38 in the absence of DTT. Also, the mPEG-SS-PBLG micelles effectively protected the active lactone ring of SN-38 from hydrolysis under physiological condition. Compared with free SN-38, SN-38-loaded nanomicelles showed essentially decreased cytotoxicity against L929 cell line in 24 h, bare mPEG-SS-PBLG nanomicelles showed almost non-toxicity.
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PubMed
高影响因子
Italian Journal of Animal Science
·
2025
·
IF 2.3
Yao Huang,Mingmei Shen,Weiyun Zhu,Long Pan
This experiment was conducted to determine the effects of polyethylene glycol (PEG) supplementation on the digestion and fermentation characteristics of sorghum nutrients in the in-vitro simulated porcine gastrointestinal tract. In Exp. 1, high-tannin sorghum grain without or with 50 mg/g PEG was digested by porcine pepsin and pancreatin to measure in-vitro digestibility of nutrients. In Exp. 2, the lyophilised porcine ileal digesta from barrows fed the high-tannin sorghum grain without or with 50 mg/g PEG and the undigested residues from Exp. 1 were, individually, incubated with fresh pig caecal digesta as inoculums for 48 h to simulate the porcine hindgut fermentation. PEG reduced the detectable condensed tannin content by 32% (p < .05) and increased in-vitro digestibility of nutrients especially for crude protein(p < .05). The in-vitro fermentability of nutrients and microbial metabolites including the accumulative gas production excluding the first 12 h, total short-chain fatty acid and microbial protein content in the fermented solutions were improved (p < .05). The relative abundance of Lachnospiraceae NK4A136 was both increased by PEG supplementation regardless of unhydrolyzed residues (p < .05) or ileal digesta (p = .06) as fermentation substrates. In conclusion, PEG supplementation not only directly increased the chemical enzymatic digestion of nutrients in the simulated anterior intestine, but also directly promoted the microbial fermentation including microbial diversities and metabolites in the simulated posterior intestine of porcine. It implies that the increased abundances of Lachnospiraceae by PEG in the hindgut may improve the fermentation capacity of microbiota and thus increase the nutrient digestion in the hindgut.
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产品关联
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高影响因子
Journal of Energy Storage
·
2024
·
IF 8.9
Zhong-Mei Xian,Guo-Long Song,Zeng-Ni Xiang,Jun-Jie Zhou,Fu-Hui Gao,Jia-Xi Mei,Xue-Zhen Zhang,Fan Su,Yu-Long Xiao,Guang-Ming Liang,Mei-Yu Xu,Yao Xiao
Shape-stabilized phase change materials (PCMs) are widely used in thermal energy storage because of their shape stability, excellent PCM load capacity and energy storage performance. Herein, a straightforward strategy was adopted to design and synthesize zirconium based three-dimensional porous metal supramolecular gel (MSG) as support material in PCM. The porous support material exhibits strong hydrogen-bond interactions with polyethylene glycol (PEG) molecules, maintaining the shape stability of the PEG matrix even at 120 °C. Meantime, the load capacity and energy storage capacity of the prepared composite PCM reached an astonishing 99.2 wt% and 95.5 %, respectively. In addition, after 30 heating/cooling cycles, the phase-change composite showed high durability. Latent heat and phase transition temperature did not change significantly.
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高影响因子
Science of Advanced Materials
·
2016
·Vol. 8
·期 8
·1617-1627
·
IF 1.812
Wen Zhen,Su Jun-Qing,Chen Qing,Chen Li-Di
To improve the physicochemical and pharmacokinetic properties, solid lipid nanoparticles (SLNs) modified with (Polyethylene glycol-2000)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine (PEG2000-DSPE) were prepared using glyceryl monostearate as a lipid carrier and resveratrol as a model
drug. Compared to ordinary SLNs, SLNs doped with low amount of PEG2000-DSPE [m(PEG2000-DSPE):m(lipids) = 1:5, w/w] exhibited improved physicochemical and pharmacokinetic properties, including higher entrapment efficiency (above 80%), smaller particle size (approximately 100 nm), more
distinguished drug release at low pH values (pH < 6.0), and longer drug circulation in vivo. According to the characterizations performed, the DSPE moiety was doped into lipid matrix to form a PEG2000-DSPE/lipid eutectic dopant, inhibiting lipid polymorphism transformation
from α-form to β-form, thereby preventing drug expulsion from the lipid. The dopant contained lattice defects, allowing for the incorporation of more resveratrol. Resveratrol was released in a sustained and pH-sensitive pattern due to nanoparticles destabilization
induced by partial protonation of PEG2000-DSPE. PEG chains distributed on the nanoparticle surface caused steric hindrance and “stealth” properties, thus maintaining dispersion stability and extending circulation time of nanoparticles. These results confirm that PEG2000-DSPE modification
effects are attributable to the matrix and surface structures of nanoparticles, which consist of a core containing DSPEinduced lattice defects and a shell coated with PEG chains.
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高影响因子
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