ANALYST
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2021
·Vol. 146
·期 22
·6815-6821
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IF 4.616
Yuan-Ju Tang,Shu-jie Zhang,Zi-Tao Zhong,Wen-Ming Su,Yuan-Di Zhao
Solid-state nanochannels have attracted considerable attention for their similar ion transport properties to biological ion channels. The construction of porous ion channels with good stability at the submicro/micrometer scale is very beneficial to develop large-area ion channel devices. In this manuscript, based on in-situ thermal crosslinking of a small organic molecule containing triphenylamine and styrene groups, we construct a heterogeneous membrane with asymmetrical charge and wettability on cylindrical anodic aluminum oxide (AAO) channels (D ≈ 319 nm). This heterogeneous membrane has typical ion current rectification characteristics with a high rectification ratio of 36.9 and good stability. This work provides an effective strategy for the construction of submicrochannel heterogeneous membranes and also broadens the application range of bionic ion channels.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2022
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IF 4.831
Yue Zhang,Ji Zhou,Ying He,Yong Ye,Jing An
Functional composite fibers were prepared by a wet-spinning method and used for pH sensing based on surface enhanced Raman scattering (SERS). Alginate solution with gold nanoparticles (AuNPs) was spun to fibers that acting as active substrate showed distinct SERS enhancement for low concentrations of dyes (1.0 × 10 -9 M for rhodamine 6G and 1.0 × 10 -8 M for crystal violet). After AuNPs were modified with 4-mercaptopyridine (4-MPY), the as-synthesized composite fibers (AuNPs@4-MPY/Ca-ALG fibers) displayed pH dependent SERS spectra due to the changes of chemical structures of 4-MPY under different pH conditions. The AuNPs@4-MPY/Ca-ALG fibers achieved fast response to the pH changes between 1.00 and 13.00. The flexible composite fibers were woven to a wearable “wrist band”, which has potential applications in health monitoring involving pH variation.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2021
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IF 5.279
Duo Liang,Wentao Su,Xue Zhao,Jiaxuan Li,Zheng Hua,Song Miao,Mingqian Tan
Improving the stability of fucoxanthin in the gastrointestinal tract is an important approach to enhance its oral bioavailability. The study proposed a new microfluidic device allowing for the synthesis of a structurally well-defined nanoscale delivery system with a uniform size for encapsulation and colon-target release of fucoxanthin. The rapid mixing in the microfluidic channel ensured that the mixing time was shorter than the aggregation time, thus realizing the controllable control of the coprecipitation of fucoxanthin and shellac polymer. In vitro digestion tests showed that a pH stimulus-responsive release of fucoxanthin from FX/SH NPs was observed under alkaline pH conditions. The fluorescence colocalization imaging indicated that FX/SH NPs did not affect the intestine function and had a protective effect on Caco-2 cells damaged by H2O2 by enhancing their antioxidant capacity. Overall, this work illustrated the promise of using a microfluidic approach to fabricate the biomimetic nanodelivery system for better biocompatibility and targeting efficacy.
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JOURNAL OF CONTROLLED RELEASE
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2021
·
IF 9.776
Ye Wu,Yu Wang,Linyu Long,Cheng Hu,Qingquan Kong,Yunbing Wang
Fabricating injectable hydrogel with multifunctions that matchs the highly ordered healing process of skin regeneration has greatly desired in treatment of chronic diabetic wounds. Herein, a pH/reactive oxygen species (ROS) dual responsive injectable glycopeptide hydrogel based on phenylboronic acid-grafted oxidized dextran and caffeic acid-grafted ε-polylysine was constructed, which exhibited inherent antibacterial and antioxidant capacities . The mangiferin (MF) with the ability to promote angiogenesis was encapsulated into pH-responsive micelles (MIC). Subsequently, diclofenac sodium (DS) with anti-inflammatory activities and MIC@MF were embedded into the hydrogel. The hydrogel possessed good biodegradability, stable rheological property and self-healing ability, and could realize the spatiotemporal delivery of DS and MF. The in vitro and in vivo data showed that the hydrogel was biocompatible with effective anti-infection, anti-oxidation and anti-inflammation at early stages, then further promoted angiogenesis and accelerated wound repairing. Collectively, this novel glycopeptide hydrogel provides a facile and effective strategy for chronic diabetic wound repairing.
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Applied Materials Today
·
2021
·
IF 10.041
Siyu Chen,Xiaoying Wang,Minghui Lin,Yingke Hou,Mengbin Ding,Deping Kong,Haitao Sun,Qin Zhang,Jingchao Li,Quan Zhou
Natural killer (NK) cell-mediated immunotherapy has shown a great promise for treatments of tumors, while some strategies that can improve its therapeutic efficacy and reduce potential adverse events are highly desired. We herein report a pH-sensitive second near-infrared (NIR-II) photothermal liposomal nanocomplex for enhanced NK cell-based immunotherapy of breast cancer. Such nanocomplex (LNC DS ) consists of charge-transfer nanoparticles (CTN) with pH-sensitive NIR-II photothermal effect, deoxyribonuclease I (DNase I), NK cell stimulant (SIS3) and a surface coated thermal-responsive liposome shell. Upon 1064 nm laser irradiation, LNC DS generates mild heat in a controlled manner, which results in destruction of thermal-responsive liposome shell to allow on-demand release of stimulants and DNase I in tumor sites. The released DNase I not only kills cancer cells, but also induces immunogenic cell death (ICD), which synergizes with the action of the released SIS3 to promote activation of NK cells and cytotoxic T lymphocytes, contributing to enhanced therapeutic efficacy of immunotherapy. As a result, a single treatment of LNC DS upon NIR-II photoactivation greatly inhibits the growths of subcutaneously implanted primary and distant tumors in a breast cancer murine model, and even completely prevents lung metastasis. This study thus offers a photo-controlled drug delivery nanosystem for efficacy and precise NK cell-mediated immunotherapy of cancer.
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EUROPEAN POLYMER JOURNAL
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2021
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IF 4.598
Liyuan Qiao,Chengde Liu,Cheng Liu,Lishuai Zong,Hongjian Gu,Chenghao Wang,Xigao Jian
Smart hydrogels have wide potential in biological field owing to their self-healing property, pH or temperature sensitivity. However, the preparation of smart hydrogels often requires complicated synthesis process, and the single functionality of hydrogels might limit their application. To solve these problems, we developed a self-healing, pH-sensitive and shape memory hydrogel of poly (diacetone acrylamide- co -acrylamide -co -acrylic acid)/alginate (PDAAc-A), taking advantage of the Schiff-base reaction and the hydrogen bonding interaction in a one-step method. The tensile modulus, fracture stress, fracture strain and toughness of the developed PDAAc-A3 hydrogel are 0.021 MPa, 0.013 MPa, 7.5 mm/mm and 0.07 MJ/m 2 , respectively. The dynamic and reversible acylhydrazone and hydrogen bonds endow hydrogels with self-healing property and pH-sensitive gel-sol transformation ability. The tensile tests demonstrate that the self-healing efficiency of hydrogel could reach up to 85% after about 30 min. Furthermore, PDAAc-A hydrogel exhibits pH-sensitivity during drug release. In PBS solution with pH value of 5, the hydrogel shows the fastest drug release rate and the highest drug release ratio, which is near 100% after about 4 h. Moreover, in 1 M ferric chloride solution, the shape memory time, shape memory ratio and shape recovery ratio of the resultant hydrogel are 2 min, 100% and 100%, respectively.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2021
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IF 4.539
Weiwei Sui,Huawen Hu,Yinlei Lin,Peng Yi,Lei Miao,Haichen Zhang,Haiying He,Guangji Li
Stimuli-responsive materials with switchable wettability for bidirectional oil-water separation show great potential in practical applications. Inspired by mussels, we use dopamine as an anchor molecule to construct a polydopamine (PDA) coating on the surface of copper foam (CF). Silver particles are deposited on the PDA coated surface to construct a multiscale composite structure, and the long-chain alkylthiol with carboxyl and methyl groups at the end is subsequently self-assembled to the modified copper foam surface. The as-modified copper foam has unique pH responsiveness, that is, the water contact angle (WCA) is measured to be about 140° under acidic and neutral conditions, while alkaline conditions radically change the surface property from superhydrophobic to superhydrophilic due to the measured WCA turning to 0°. It can be used efficiently for the bidirectional separation of an oil-water mixture, e.g., the separation efficiency of a 1,2-dichloroethane/water mixture can reach as high as 98.2%. Besides, it maintains 98% separation efficiency and stable wettability for an octane/water mixture, together with excellent mechanical durability; the WCA of the surface maintains at about 130° after ten wear cycles.
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CHEMOSPHERE
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2021
·
IF 7.086
Yaohong Ma,Leilei Xiao,Yunwei Wei,P. Senthil Kumar,Yang Tan,Yiwei Li,Hengchang Zang
Microbial fuel cells (MFCs) are sensitive to acidity variations in both bioelectricity generation and biochemical digestion aspects, therefore online pH monitoring is of necessity to guarantee optimal function of MFCs. Present pH meters hardly fulfill this special need. In this work, we designed a novel voltammetric pH sensor based on electrochemically reduced graphene oxide (rGO) modified screen printed electrode. By surface doping of alizarin, good linearity of pH sensing over the range of 4.0–9.0 can be realized. Fast readout can be acquired within 15 s for each test. pH monitoring for artificial wastewater with inoculum of granular activated sludge in a MFC was successfully illustrated. Specially, it was verified that the performance was improved with alizarin doping due to the enhanced rGO surface proton diffusion. This approach provides an online, calibration-free and long stable pH monitoring method for the future MFC development.
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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2021
·Vol. 38
·期 4
·999-1004
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IF 1.307
Yuan Mingwei,Shi Shunli,Luo Yanping,Yu Ying,Wang Shuhua,Chen Chao
Hollow mesoporous silica(HM-SiO 2 ) was prepared by the improved stober method. On this basis, HM-SiO 2 was dispersed in an alkaline solution for surface etching. Meanwhile, calcium source was introduced to combine with SiO
2− 3
on the surface to form a CaSiO 3 shell layer and an unprecedent SiO 2 @CaSiO 3 sphere with a hollow double-shell structure was obtained. The as-synthesized SiO 2 @CaSiO 3 was characterized by X-ray diffraction(XRD), scanning electron microscopy(SEM), transmission electron microscopy(TEM), N 2 -BET, IR and UV-Vis techniques, and its sustained release capacity of doxorubicin(DOX) loading was investigated. The drug loading capacity can be achieved to 0.692 mg DOX/mg SiO 2 @CaSiO 3 , exhibiting pH-responsivity under low pH conditions.
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LANGMUIR
·
2021
·
IF 3.882
Liwei Zhao,Ming Gong,Jian Yang,Jinlou Gu
The construction of a biomimetic ionic channel is of great significance for the fabrication of smart biodevices or logic circuit. Inspired by the selective permeability of the cell membrane toward bioions, a light-induced and pH-modulated artificial nanochannel is herein prepared by integrating the multistimuli-response molecule of carboxylated spiropyran (SP-COOH) into the frameworks of NU-1000 (Zr-based MOFs defined by Northwestern University). The loading density of the SP-COOH could reach as high as 7 wt % while keeping unchanged crystallinity and high porosity. Thanks to the precise matching of pore size of NU-1000 and molecular dimensions of SP-COOH, the loaded molecules could proceed free and reversible for isomerization between the hydrophilic and hydrophobic states. The ion-switchable characteristics of the channel are implemented by the amphiphilic change of the light-controlled gate molecule. Additionally, in the hydrophilic state, the channel presents reversible affinity toward cations or anions due to the reverse charge state induced by pH, thus constructing a pH-controlled subgate. Taking [Ru(NH3)6]3+ and [Fe(NH3)]3– as the model cation and anion, their redox peak currents occur as reversible change under different signal combinations of light and pH. Moreover, in accordance with the ionic selective permeability, several logic circuits/devices are designed to display the relationships between exogenous stimuli and ionic transportations in a computer language, prefiguring their wide application prospects in electronic devices and life sciences.
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CARBOHYDRATE POLYMERS
·
2021
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IF 9.381
Zhilang Xu,Die Yang,Tao Long,Lun Yuan,Shi Qiu,Defu Li,Changdao Mu,Liming Ge
pH-Responsive nanoparticles (NPs) have emerged as an effective antitumor drug delivery system, promoting the drugs accumulation in the tumor and selectively releasing drugs in tumoral acidic microenvironment. Herein, we developed a new amphiphilic modified hydroxyethyl starch (HES) based pH-sensitive nanocarrier of antitumor drug delivery. HES was first modified by hydrophilic imidazole and hydrophobic cholesterol to obtain an amphiphilic polymer (IHC). Then IHC can self-assemble to encapsulate doxorubicin (DOX) and form doxorubicin-loaded nanoparticles (DOX/IHC NPs), which displayed good stability for one week storage and acidic sensitive long-term sustained release of DOX. As a result, cancer cell endocytosed DOX/IHC NPs could continuously release doxorubicin into cytoplasm and nucleus to effectively kill cancer cells. Additionally, DOX/IHC NPs could be effectively enriched in the tumor tissue, showing enhanced tumor growth inhibition effect compared to free doxorubicin. Overall, our amphiphilic modified HES-based NPs possess a great potential as drug delivery system for cancer chemotherapy.
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Materials Today Communications
·
2021
·
IF 3.383
Xiangping Hao,Jingzhi Yang,Lei Zhang,Chenhao Ren,Wen Li,Yuntian Lou,Hongchang Qian,Shougang Chen,Dawei Zhang
Bacterial infections, as one of the main reasons for failure of metallic implants, can increase morbidity and mortality. In this study, polydopamine/graphene oxide- d -leucine (PDA/GO-Leu) films that possess pH-responsive antibacterial and anti-adhesion properties were synthesized by the soaking method. Due to the unique features of ampholyte, d -leucine has the same type of charge as the immobilized GO surface when the pH value of the environment is identical to that of the humoral environment. It contributes to the d -leucine release from the GO surface and exerts antibacterial and anti-adhesion effects of such films. The synergistic actions between d -leucine and GO of such films were analyzed by the table colony counting method and dead/live fluorescence. The results indicated that the released d -leucine is the key point within this multilayer system. The PDA/GO-Leu films exhibited both outstanding antibacterial and anti-adhesion properties for E. coli and S. aureus, respectively when pH of the culture medium was 7.4. Meanwhile, the cytotoxicity of the PDA/GO-Leu films was evaluated by CCK-8 and dead/live fluorescence, and the results demonstrated that such films have good biocompatibility.
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