Asian Journal of Pharmaceutical Sciences
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2024
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IF 10.7
Xiaomei Wu,Renxiang Yuan,Yichong Xu,Kai Wang,Hong Yuan,Tingting Meng,Fuqiang Hu
The challenge in the clinical treatment of Parkinson's disease lies in the lack of disease-modifying therapies that can halt or slow down the progression. Peptide drugs, such as exenatide (Exe), with potential disease-modifying efficacy, have difficulty in crossing the blood-brain barrier (BBB) due to their large molecular weight. Herein, we fabricate multi-functionalized lipid nanoparticles (LNP) Lpc-BoSA/CSO with BBB targeting, permeability-increasing and responsive release functions. Borneol is chemically bonded with stearic acid and, as one of the components of Lpc-BoSA/CSO, is used to increase BBB permeability. Immunofluorescence results of brain tissue of 15-month-old C57BL/6 mice show that Lpc-BoSA/CSO disperses across the BBB into brain parenchyma, and the amount is 4.21 times greater than that of conventional LNP. Motor symptoms of mice in Lpc-BoSA/CSO-Exe group are significantly improved, and the content of dopamine is 1.85 times (substantia nigra compacta) and 1.49 times (striatum) that of PD mice. α-Synuclein expression and Lewy bodies deposition are reduced to 51.85% and 44.72% of PD mice, respectively. Immunohistochemical mechanism studies show AKT expression in Lpc-BoSA/CSO-Exe is 4.23 times that of PD mice and GSK-3β expression is reduced to 18.41%. Lpc-BoSA/CSO-Exe could reduce the production of α-synuclein and Lewy bodies through AKT/GSK-3β pathway, and effectively prevent the progressive deterioration of Parkinson's disease. In summary, Lpc-BoSA/CSO-Exe increases the entry of exenatide into brain and promotes its clinical application for Parkinson's disease therapy.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2024
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IF 2.7
Yuanwen Hou,Jia Tang,Li Jiang,Ning Xie,Hongquan Fu,Juan Zhang,Hejun Gao,Bin Xu,Yunwen Liao
Piezocatalytic technology represents an innovative form of advanced oxidation technology for degradation of organic pollutants. Piezoelectric catalysis technology combines electrochemistry and piezoelectric properties, and promotes charge transfer through a piezoelectric field, thus promoting catalytic reactions. This study employed a one-step microwave method to fabricate an α-Bi2O3/BiO2 heterojunction with a narrow bandgap. This catalyst exhibited a high efficiency in the degradation of methyl orange dye, achieving a removal rate of 93% in 60 minutes, with a reaction rate constant of 0.0324 min−1. The investigation of the catalytic mechanism demonstrates that the construction of the α-Bi2O3/BiO2 heterojunction facilitates the separation of charge carriers, increases the degree of polarization, and consequently enhances the efficiency of piezoelectric catalytic degradation. This work opens the way for the design and development of high-performance piezoelectric catalysts.
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高影响因子
FUEL
·
2025
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IF 7.5
Geng Chen,Zexiang Bi,Xu Li,Jinxiang Dong
The industrial utilisation of Fischer–Tropsch synthesis (FTS) products, particularly the valuable C5–C9 linear α-olefins, has been hindered by the high energy-intensive separation of olefins and alkanes with identical carbon numbers. This study presents a comprehensive process integrating the selective dimerisation of linear α-olefins to α-olefin dimers, enabling their separation from paraffins in FTS products. These dimers are subsequently converted into branched-chain aldehyde intermediates through heterogeneous hydroformylation using Rh/C as the catalyst. Notably, optimising the reaction conditions achieved the main product aldehyde of α-olefin dimers with excellent selectivity (up to 86.66 %) at 65 °C, compared to linear α-olefins, which exhibited only 49.31 % selectivity. In-situ IR spectroscopy was used to monitor the entire reaction process. The resulting branched aldehyde intermediates were further transformed into branched acids or branched alcohols through oxidation or reduction reactions, respectively. These products have diverse applications as surfactants, coal flotation agents, and cutting fluid additives. The synthesised compounds were characterised using FT-IR, GC, GC–MS, and NMR. In addition, a comprehensive evaluation of their physicochemical properties was conducted. This study provides a versatile design strategy for developing high-value intermediates from α-olefins in the FTS.
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高影响因子
JOURNAL OF FOOD SCIENCE
·
2024
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IF 3.2
Huixian Wang,Xiaolu Zhou,Yixuan Liu,Wenxuan Xie,Derui Yang,Dongxue Huo,Quan Guo,Ruimin Wang
Opuntia ficus-indica fruit (OFI) is rich in bioactive compounds, which can promote human health. In this work, the purified OFI extract was prepared from OFI and its bioactivities were investigated. Xanthine oxidase (XOD) and α-glucosidase (α-Glu) inhibitors of the purified OFI extract were screened and identified by bio-affinity ultrafiltration combined with UPLC-QTRAP-MS/MS technology. The inhibitory effect of these inhibitors on enzymes were verified, and the potential mechanism of action and binding sites of inhibitors with enzymes were revealed based on molecular docking. The results showed that the total phenolic content of the purified OFI extract was 355.03 mg GAE/g DW, which had excellent antioxidant activity. Additionally, the extract had a certain inhibitory effect on XOD (IC 50 = 199.00 ± 0.14 µg/mL) and α-Glu (IC 50 = 159.67 ± 0.01 µg/mL). Seven XOD inhibitors and eight α-Glu inhibitors were identified. Furthermore, XOD and α-Glu inhibition experiments in vitro confirmed that inhibitors such as chlorogenic acid, taxifolin, and naringenin had significant inhibitory effects on XOD and α-Glu. The molecular docking results indicated that inhibitors could bind to the corresponding enzymes and had strong binding force. These findings demonstrate that OFI contains potential substances for the treatment of hyperuricemia and hyperglycemia.
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高影响因子
FOOD RESEARCH INTERNATIONAL
·
2025
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IF 8
Simiao Liu,Meixi Liu,Yuzhuo Wang,Xin Liu,Fazheng Ren,Hao Zhang
This study investigated the product characteristics and prebiotic properties of lactose-N-neotetraose (LNnT) after the Maillard reaction with α-lactalbumin (α-LA). LNnT and α-LA were reacted in a simulated system at 60 °C and 79 % relative humidity for 96 h to create Maillard reaction products (MRPs). During the reaction, the absorbances at 294 nm and 420 nm and the fluorescence intensity of α-LA-LNnT increased, whereas the free amino groups and free sugar content decreased. Matrix-assisted laser desorption/ionization time-of-flight/time-of-flight (MALDI-TOF/TOF) analysis revealed that each α-LA was attached with eight LNnT molecules. After the reaction, the far-ultraviolet circular dichroism (CD) and fluorescence spectra showed that the random coil content of α-LA-LNnT significantly increased ( p < 0.05), with the side chains of α-LA's tertiary structure affected. In terms of prebiotic properties, the bacterial density of Bifidobacterium decreased from 0.63 to 0.36, and the short-chain fatty acids production decreased from 12.60 mM to 5.38 mM using the in vitro fermentation medium. In summary, various MRPs were formed by the reaction between LNnT and α-LA at different heating stages, and the Maillard reaction reduced the prebiotic properties of LNnT. The findings provide insights into the impact of the Maillard reaction on the prebiotic properties of human milk oligosaccharides and direct our attention to the interactions of nutrients in infant formula.
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高影响因子
ACS Applied Materials & Interfaces
·
2025
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IF 8.2
Ning Wang,Weifeng Yang,Shuhan Wang,Kerui Li,Yaogang Li,Qinghong Zhang,Chengyi Hou,Hongzhi Wang
Triboelectric textiles have been extensively studied for wearable energy applications, including single-fiber power generation, humidity-resistant power generation, air-breakdown-based power generation, etc. However, intrinsic tribo-charge transfer in fiber- or textile-based triboelectric materials remains at a low level. Here, we propose a polarization strategy to enhance triboelectric performance using α-phase polyamide 11 nanoribbons. By employing a high-voltage electrostatic field during electrospinning, we achieve in situ polarization of polyamide 11, resulting in an 116% improvement in the performance of polyamide 11-based energy nonwovens. Additionally, we apply cold pressing to optimize the specific surface area and air permeability of the all-fiber-energy nonwoven, achieving a balance of high electrical performance and wearability. We further demonstrate applications of this nanofiber-based energy textile in wireless sensing and breathable energy insoles. This all-fiber performance enhancement strategy provides valuable insights for the development of high-performance triboelectric textiles in the future.
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高影响因子
Heliyon
·
2024
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IF 3.4
Fanzhuo Zeng,Anqi Chen,Wei Chen,Shuai Cheng,Sen Lin,Rongcheng Mei,Xifan Mei
Background Spinal cord injury (SCI) is a serious and difficult to treat traumatic disease of the central nervous system. Spinal cord injury causes a variety of detrimental effects, including neuroinflammation and ferroptosis, leading to chronic functional impairment and death. Recent studies have shown that microglia/macrophages (M/Ms) at the injury site remain primarily in the pro-inflammatory state, which is detrimental to recovery. However, information on the factors behind pro-inflammatory polarization skew in the injured spinal cord remains unclear. In this study, we found that Tumor Necrosis Factor-α(TNF-α) ablation protected after SCI by suppressing neuroinflammation and ferroptosis. Though using TNF-α knock out mice (TNF−/−), we induced downregulation of TNF-α in M/Ms and further investigated its effect on SCI outcome. In TNF−/− mice, significant behavioral improvements were observed as early as 7 days after injury. We showed that TNF-α inhibition promote injury-mediated M/Ms polarization from pro-inflammatory to anti-inflammatory phenotype in vivo. Furthermore, accumulated iron in M/Ms after SCI increased the expression of TNF-α and the population of M/Ms to pro-inflammatory phenotype. Moreover, zinc supplement reduced the secondary damage caused by iron overload. In conclusion, we found that knock out of TNF-α promotes recovery of motor function after spinal cord injury in mice by inhibiting ferroptosis and promoting the shift of macrophages to an anti-inflammatory phenotype, indicating that there is great potential for this therapy to SCI.
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高影响因子
MOLECULAR PHARMACEUTICS
·
2024
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IF 4.5
Meiqi Xu,Junwei Liu,Jianming Yu,Jingwen Wang,Hui Li,Ting Zhong,Yanli Hao,Zhuoyue Li,Jingru Wang,Xu Huang,Hui Wang,Yubo Tian,Heng Zhao,Qingchao Wei,Xuan Zhang
Improving nanomedicine uptake by tumor cells is key to achieving intracellular drug delivery. In this study, we found that methyl-β-cyclodextrin (MβCD) can significantly promote the intracellular accumulation of nanoparticulated α-linolenic acid-paclitaxel conjugates (ALA-PTX NPs) via enhanced clathrin-mediated endocytosis and limited degradation in lysosomes. Our in vitro results indicated that MβCD not only reduced the plasma membrane cholesterol content and increased plasma membrane fluidity, leading to ALA-PTX NPs being more easily incorporated into the plasma membrane, further enhancing membrane fluidity and making the plasma membrane more susceptible to tensile deformation, forming intracellular vesicles to enhance ALA-PTX NP cellular uptake, but also destroyed lysosomes and then limited ALA-PTX NPs’ degradation in lysosomes. In HepG2 tumor-bearing mice, MβCD was also able to enhance the antitumor activity of ALA-PTX NPs in vivo. Moreover, we found that MβCD specifically promoted PUFA-paclitaxel conjugate NP cellular uptake. The cellular uptake of PTX liposome which shares an endocytosis pathway with ALA-PTX NPs could be enhanced by MβCD combined with ALA or ALA-PTX NPs. Therefore, we suggested that MβCD combined with polyunsaturated fatty acid-conjugation would be an effective strategy for improving intracellular delivery of nanoparticulated chemotherapeutic drugs used for combination administration to enhance antitumor efficiency.
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高影响因子
CERAMICS INTERNATIONAL
·
2024
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IF 5.1
Quan Diao,Zhikuan Liu,Longlong Li,Ziyang Zheng,Ning Li,Genxing Zhu,Zhe Fang,Meng Li,Guangyuan Shi,Mingli Jiao
Metal-organic frameworks (MOF), as a new type of crystalline material with advantages such as high specific surface area, controllable pore size and pore structure, show great potential for application in the field of sensors. In this study, a Fe-centered Materials of institute Lavoisier frameworks (MIL) was synthesized by a simple hydrothermal method using fumaric acid, which was modified to Fe 2 O 3 by a simple heat treatment, and the sensor sensitivity was enhanced by adding oxygen vacancy defects. The composition and characterization of the materials were investigated by XRD, SEM/EDS and XPS, and the performance and stability of the gas sensors were studied using gas sensitivity tests. It is comprehensively found that oxygen vacancies (O V ) have been successfully introduced through defect engineering, and the performance of the sensor is greatly enhanced by the introduction of Ov. The Fe 2 O 3 sintered at 500 °C performs an average increase in response of about 2.45 times compared to the sample without oxygen vacancies, an ultra-low detection limit (27.74 ppt), an extremely high response (20 ppm response value of 349.39), and an excellent selectivity. The outstanding performance is due to the nature of the Fe 2 O 3 -MOF material and the introduction of oxygen vacancy defects. Therefore, oxygen defect engineering of metal-organic framework materials has the potential to be an important candidate for high-performance ethanol sensors, which provides new ideas and avenues for the development of new intelligent and high-efficiency gas sensors.
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高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Yi Wang,Ruge Lin,Laiming Zhang,Suqing Lan,Xingqian Ye,Haibo Pan,Shiguo Chen
Phenolic compounds are popular in screening novel hypoglycemic agents, but the impact of oxidative degradation on the determination of α-glucosidase inhibitory activity and bioavailability is unclear. Here we showed 12 phenolic compounds structure-dependently degraded during standard simulated digestion, while in physiological hypoxia their retention rates were all over 87.89 %. This enhancement of digestive stability resulted in the biggest drop of 31.72 % in IC 50 against α-glucosidase and a significant increase in bioavailability. Enzyme kinetic and multi-spectroscopic analysis confirmed oxygen weakened the affinity of compounds to α-glucosidase, but the mechanisms were not changed. Moreover, a two-chamber culture system was designed to meet conflicting demands for oxygen between epithelium and cavity, and better α-glucosidase inhibitory activities (51.61 % maximum reduction in glucose production) and absorption rates (up to 1.10 % from undetectable) were obtained than those of uncontrolled oxygen. Hence, the oxygen level should be monitored to assess the activities of phenolic compounds in vitro .
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高影响因子
FUEL
·
2017
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IF 4.601
Ye Zhang,Dawei Liu,Ligong Zhou,Mingxing Tang,Xuekuan Li,Yongxing Yang
Alpha-alumina (α-Al 2 O 3 ) materials has a wide range of applications because of its excellent properties at high temperature. Tabular α-Al 2 O 3 was unexpectedly synthesized by etching mullite from Si x Al y O z composites since our original intention was highly porous α-Al 2 O 3 . Silica-alumina xerogels with different Al/Si molar ratio as 3, 6, 9 and ∞ (pure alumina) were prepared via sol-gel route, followed by calcination at 1400 °C to obtain Si x Al y O z composites. XRD results showed that the composite existed as mullite when the Al/Si ratio equaled to 3 and as the combination of mullite and corundum (α-alumina) when the Al/Si ratio equaled to 6 and 9, while pure α-Al 2 O 3 was obtained when Al/Si ratio equaled to ∞ signed as sol-gel α-Al 2 O 3 . The mullite phase in Si x Al y O z composites could be etched completely by hydrofluoric acid under room temperature in terms of the treating time was long enough and left tabular α-Al 2 O 3 for the samples with Al/Si molar ratio as 6 and 9. The interaction between mullite and α-Al 2 O 3 during the thermo process may direct the formation of tabular morphology. Structural and property characterizations show the tabular morphology, low surface area, perfect crystallinity and weak acidity of α-Al 2 O 3 . Furthermore, the adsorption of dibenzothiophene, a molecular with planar morphology, on tabular α-Al 2 O 3 , sol-gel α-Al 2 O 3 as well as γ-Al 2 O 3 was investigated at room temperature in comparison. Tabular α-Al 2 O 3 exhibited the highest adsorption capacity and best regeneration ability than other two.
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高影响因子
TALANTA
·
2024
·
IF 5.6
Yi Xiao,Pengcheng Huang,Fang-Ying Wu
α-Glucosidase, which directly involves in the metabolism of starch and glycogen and causes an increase in blood sugar level, is the major target enzyme for the precaution and therapy of type II diabetes. Based on the previous work, we adopted a post-synthetic modification method to encapsulate Tb 3+ into Ce-MOF nanozyme which owned mixed valence states. Tb@Ce-MOF displayed induced luminescence characteristic and exceptional oxidase-like activity that could oxidize colorless 3,3′,5,5′-tetramethylbenzidine (TMB) to blue ox-TMB. α-Glucosidase can hydrolyze the substrate l -ascorbic acid-2- O -α- d -glucopyranosyl (AAG) to generate ascorbic acid (AA), which could increase the Ce 3+ /Ce 4+ redox valence mode in Tb@Ce-MOF, leading to the inhibition of the allochroic reaction of TMB and the decreased absorption of ox-TMB at 652 nm. The energy transfer (EnT) process from Ce 3+ to Tb 3+ will enhance due to the increased Ce 3+ /Ce 4+ mode in Tb@Ce-MOF, which will result in an enhanced fluorescence signal of Tb@Ce-MOF at 550 nm. But the addition of inhibitor acarbose will inhibit the above process. We have constructed a dual-mode detection platform of α-glucosidase and its inhibitor via colorimetric and fluorometric method. The linear range of α-glucosidase were 0.01–0.5 U/mL (colorimetric mode) and 0.8–1.5 U/mL (fluorometric mode), respectively, with a detection limit as low as 0.0018 U/mL. Furthermore, our approach was also successfully employed to the analysis of α-glucosidase in serum samples.
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高影响因子
危险品化学品经营许可证（带存储）