POLYMERS FOR ADVANCED TECHNOLOGIES
·
2019
·Vol. 31
·期 2
·338-349
·
IF 2.162
Lei Yang,He-qing Fu
Based on the strong adsorption of the diphosphate group to Fe and Al ions, first, the Fe 3 O 4 and Al (OH) 3 nanoparticles were modified by alendronate sodium (ALN), and organic phosphorus coated nanoparticles (Fe 3 O 4 -ALN and Al (OH) 3 -ALN) with the active group ─NH 2 were prepared. Novel [ x Fe 3 O 4 –2 x Al(OH) 3 ]/waterborne polyurethane nanocomposite with superparamagnetism and excellent flame retardancy were prepared by in situ polymerization. The experimental results showed that when the content of Fe 3 O 4 -ALN increased, the M s increased. And the saturation magnetization reached 14.35 emu/g when the Fe 3 O 4 -ALN content was 10 wt%. The nanoparticle network formed by Fe 3 O 4 and Al (OH) 3 can prevent the melting deformation of waterborne polyurethane (WPU) composite film and reduce the burning area. And the dual physical protective layer formed by nanoparticle network and char layer can prevent the combustible gas contacting with oxygen and giving off combustion heat, which effectively reduced the heat and smoke gas release. When the content of x Fe 3 O 4 –2 x Al(OH) 3 was 20 wt%, the oxygen index of the composite was 28.4%, and the flame retardancy of nanocomposite was classified as V-0 rating in the UL-94 test.
✓ 已验证
产品关联
DOI
高影响因子
International Journal of Nanomedicine
·
2019
·
IF 4.471
Weiguang Li,Jianpeng Xue,Hanmei Xu
Background S-HM-3 is a tumor angiogenesis inhibitor with short half-life (25 min). In this present, TPGS/Solutol polymeric micelles was prepared to load together insoluble paclitaxel (PTX) and soluble S-HM-3, expecting to together deliver them to the tumor site with long-circulating, targeting function and combating multi-drug resistance (MDR). Materials and methods PTX and S-HM-3 loaded TPGS/Solutol micelles (PHTSm) were prepared by the method of thin-film evaporation, and characterized by dynamic light scattering, transmission electron microscope (TEM), atomic force microscopy (AFM) and releasing properties. The anticancer effect of the polymeric micelles system was evaluated and confirmed by experiments of in vitro cell uptake study, in vivo pharmacokinetics, and pharmacodynamics studies. Results Micelles exhibited smooth spherical morphology with 20~30 nm and low critical micelle concentration (CMC) value of 0.000124 mg/mL. Only about 30% of PTX were slowly released from micelles at 48h, which can beneficial to the long circulation in blood. The results of in vitro cell assay proved that S-HM-3 could be easier to get into MDA-MB-231 cell, and its angiogenesis inhibition ability was also enhanced after integrating into micelles. In particular, the results of in vivo studies showed that the half-life of S-HM-3 and PTX was significantly prolonged 25.27 and 5.54 folds, and their AUC 0–∞ was enhanced 129.78 and 15.65 times, respectively. Meanwhile 83.05% tumor inhibition rate of PHTSm was achieved compared with 59.99% of PTX. Conclusions TPGS and Solutol micelles hold promising potential to resolve the conundrum of combined therapy of cytotoxic drug and angiogenesis inhibitor with different physicochemical property and anticancer mechanism in clinical use.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2019
·
IF 2.298
Rongrong Li,Shiyun Zhan,Gang Chen,Yanxian Jin,Binbin Yu,Jia Zhao,Deman Han,Huajun Fan
The solid–liquid solubility of indole-3-acetic acid in pure methanol, ethanol, n-propanol, isopropanol, acetone, n-butanol, acetonitrile, chloroform, ethyl acetate, 1,4-dioxane, N,N-dimethylformamide (DMF), and dimethyl sulfoxide (DMSO) was measured by using a isothermal saturation method. The determination temperature range is from 278.15 to 323.15 K. The order of solubility data from high to low was ethyl acetate > DMSO > DMF > n-butanol > acetone > isopropanol > 1,4-dioxane > n-propanol > ethanol > methanol > acetonitrile > chloroform. Two thermodynamic models (modified Apelblat equation and λh equation) were used to correlate the solubility values of indole-3-acetic acid in different monosolvents, and the two equations can correlate the experimental values very well. The values of root-mean-square deviations (RMSDs) and relative average deviations (RADs) between the experimental and calculated solubility values were not exceeding 0.27 × 10–6 and 0.75 × 10–2, respectively. In order to study the effect of solvation interaction on solubility, the solute–solvent and solvent–solvent interactions were discussed.
✓ 已验证
产品关联
DOI
高影响因子
AMB Express
·
2019
·Vol. 9
·期 1
·1-9
·
IF 2.226
Zhao Shuxue,Hu Chunhui,Guo Lizhong,Li Kuiran,Yu Hao
A 3-hydroxypyridine degrading bacterium, designated strain DW-1, was isolated from petroleum contaminated soil in Liao River China. 16S rRNA-based phylogenetic analysis indicates that strain DW-1 belongs to genus Agrobacterium. The optimal cultivation temperature and pH for strain DW-1 with 3-hydroxypyridine were 30 °C and 8.0, respectively. Under optimal conditions, strain DW-1 could completely degrade up to 1500 mg/L of 3-hydroxypyridine in 66 h. The 3-hydroxypyridine degradation pathway of strain DW-1 was suggested by HPLC and LC–MS analysis. The first reaction of 3-hydroxypyridine degradation in strain DW-1 was α-hydroxylation so that the major metabolite 2,5-dihydroxypyridine was produced, and then 2,5-dihydroxypyridine was transformed by a Fe2+-dependent dioxygenase to form N-formylmaleamic acid. N-Formylmaleamic acid will be transformed to maleic acid and fumaric acid through maleamic acid. This is the first report of the 3-hydroxypyridine degradation pathway and the utilization of 3-hydroxypyridine by a Agrobacterium sp. It may be potentially used for the bioremediation of environments polluted with 3-hydroxypyridine.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2019
·
IF 9.518
Chi Zhang,Dongsheng Zhang,Zhanfang Ma,Hongliang Han
Efficient signal amplification strategies are crucial for ultrasensitive detection of tumor markers. Herein, a new signal amplification strategy by coupling cascade catalysis-initiated radical polymerization with impedimetric immunoassay was proposed for ultrasensitive detection of carbohydrate antigen 15–3 (CA15-3). Copper-based metal-organic framework nanoparticles (Cu-MOF), as peroxidase mimics, combined with CA15-3 antibody (Ab 2 ) and glucose oxidase (GOx) were employed as immunoprobes to initiate radical polymerization by cascade catalysis. In this work, the oxidation of glucose was catalyzed by GOx to generate hydrogen peroxide (H 2 O 2 ), which reacted with acetylacetone (ACAC) via Cu-MOF catalysis to yield ACAC radicals for the polymerization of N-isopropylacrylamide (NIPAM). The polymer, poly (N-isopropylacrylamide) (PNIPAM), was generated in situ from the radical polymerization. As resistance enhancer, PNIPAM was covered on electrode surface to amplify resistance value by its poor conductivity. With the help of polymerization-based amplification, the resistance differences caused by target were improved significantly. Under optimum conditions, the designed biosensor showed wide detection ranges from 10 μU/mL to 10 mU/mL and 10 mU/mL to 100 U/mL, with ultralow detection limit of 5.06 μU/mL for CA15-3. Such an approach opened a new avenue for signal amplification, thus offering an ultrasensitive detection platform for a broad range of tumor markers.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2018
·Vol. 22
·期 8
·2405-2412
·
IF 2.509
Mo Zunli,Niu Xiaohui,Gao Huhu,Li Zhenliang,Meng Shujuan,Guo Ruibin
A novel and simple chiral sensing platform had been successfully fabricated by means of amidation reaction between 3, 4, 9, 10-perylenetetracarboxylic acid (PTCA) and chitosan (CS) to form 3, 4, 9, 10-perylenetetracarboxylic acid–chitosan (PTCA–CS) composite film. Since CS has chiral center and PTCA has excellent electrical conductivity, the PTCA–CS composite modified glassy carbon electrode (PTCA–CS/GCE) could be treated as an effective electrochemical chiral sensor and applied for chiral discrimination of tryptophan (Trp) enantiomers theoretically. PTCA–CS composite was characterized by Fourier transform infrared (FTIR) spectroscopy and cyclic voltammetry (CV). When the prepared chiral sensing interface interacted with tryptophan isomers, a higher selectivity was received from D-Trp by differential pulse voltammetry (DPV). It indicated that the PTCA–CS/GCE can be treated as an electrochemical chiral sensor for the discrimination of Trp enantiomers. Further study demonstrated that the peak currents were linearly increased with the increasing percentage of L-Trp of Trp racemic mixture. Furthermore, the enantioselective interaction of the PTCA–CS/GCE was systematically studied by other experimental factors, such as the incubation time and acidity.
✓ 已验证
产品关联
DOI
高影响因子
Food Science & Nutrition
·
2018
·Vol. 6
·期 8
·2020-2027
·
IF 1.521
Hong Fu,Mengqi Li,Ruimin Ni,Yangming Martin Lo
Two different fish oil preparations, namely triglycerides and ethyl esters containing, respectively, 30.02% and 74.38% of omega-3 fatty acids, were employed as the substrates for transesterification. Catalyzed by immobilized lipase using imidazolium-based ionic liquid systems, the total content of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in the resulting triglyceride reached 63.60% when 4% hydrophobic ionic liquid was used, which was 11.74% higher than that of the triglyceride produced in a solvent-free reaction system. The activation energy of the product (triglyceride-type fish oil) was 173.64 KJ mol −1 , which was not significantly different from that of the commercial ethyl ester-type fish oil, so were the other thermal oxidative kinetic parameters. The kinetic parameters depicting the thermal and oxidative stability of the fish oil product provide the basis for industrial processing, storage, and applications.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
THIN SOLID FILMS
·
2018
·
IF 1.939
Sanyin Qu,Yanling Chen,Wei Shi,Mengdi Wang,Qin Yao,Lidong Chen
Herein, we demonstrate a concept of making flexible thermoelectric (TE) generators by applying cotton thread as the platforms for poly(3-hexylthiophene) (P3HT) and Argentum (Ag) paste through selectable coating method. The coated thermoelectric cotton thread can be sewed on the flexible fabrics with different knitting pictures and form thermoelectric devices. The most important is that the temperature gradient of the device was in the direction of cross-plane of the flexible fabrics, that is, between the inner and outer surfaces of clothing, therefore the flexible device can be easily wore on the body since the temperature gradient between the human body and surrounding environment is in the cross-plane direction. The maximum output power of the device with thirteen P N type legs reached 1.15 μW at a temperature gradient of 50 K when the load resistance matched the resistance of the module. Cotton-based TE device coated with P3HT may be useful for the development of self-powered wearable electronics.
✓ 已验证
产品关联
DOI
高影响因子
BIODEGRADATION
·
2018
·Vol. 29
·期 6
·593-603
·
IF 2.41
Shi Zhoukun,Dong Weiliang,Xin Fengxue,Liu Jiawei,Zhou Xinhai,Xu Fanli,Lv Ziyao,Ma Jiangfeng,Zhang Wenming,Fang Yan,Jiang Min
Abstract An acetamiprid-degrading fungus was isolated from contaminated soil and identified as Fusarium sp. strain CS-3 based on physiological, biochemical, and molecular analyses. Strain CS-3 exploited 50 mg/L as the sole carbon source in liquid culture, removing 98% in 96 h. Strain CS-3 retained its acetamiprid degradation abilities over a wide range of pH (5.0–8.0) and temperature (20–42 °C). HPLC–MS analysis showed that N ′-[(6-chloropyridin-3-yl)methyl]- N -methylacetamide, 2-chloro-5-hydroxymethylpyridine, and 6-chloronicotinic acid were identified as the most predominant metabolites, forming the basis for a newly described acetamiprid degradation pathway. Strain CS-3 efficiently degraded 99.6% of 50 mg/kg acetamiprid in soil, indicating potential for soil remediation. Graphical abstract
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Polymers
·
2018
·Vol. 10
·期 8
·815
·
IF 2.935
Sanyin Qu,Chen Ming,Qin Yao,Wanheng Lu,Kaiyang Zeng,Wei Shi,Xun Shi,Ctirad Uher,Lidong Chen
The fundamental understanding of the influence of molecular structure on the carrier transport properties in the field of organic thermoelectrics (OTEs) is a big challenge since the carrier transport behavior in conducting polymers reveals average properties contributed from all carrier transport channels, including those through intra-chain, inter-chain, inter-grain, and hopping between disordered localized sites. Here, combining molecular dynamics simulations and experiments, we investigated the carrier transport properties of doped highly oriented poly(3-hexylthiophene) (P3HT) films with different side-chain regioregularity. It is demonstrated that the substitution of side chains can not only take effect on the carrier transport edge, but also on the dimensionality of the transport paths and as a result, on the carrier mobility. Conductive atomic force microscopy (C-AFM) study as well as temperature-dependent measurements of the electrical conductivity clearly showed ordered local current paths in the regular side chain P3HT films, while random paths prevailed in the irregular sample. Regular side chain substitution can be activated more easily and favors one-dimensional transport along the backbone chain direction, while the irregular sample presents the three-dimensional electron hopping behavior. As a consequence, the regular side chain P3HT samples demonstrated high carrier mobility of 2.9 ± 0.3 cm2/V·s, which is more than one order of magnitude higher than that in irregular side chain P3HT films, resulting in a maximum thermoelectric (TE) power factor of 39.1 ± 2.5 μW/mK2at room temperature. These findings would formulate design rules for organic semiconductors based on these complex systems, and especially assist in the design of high performance OTE polymers.Keywords:organic thermoelectric;poly(3-hexylthiophene);regioregularity;carrier transport
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Analytical Methods
·
2018
·Vol. 10
·期 17
·1993-1998
·
IF 2.073
Wei Du,Chunman Jia,Yinfeng Zhang,Qing Chen,Yile Wang,Yan Huang,Qi Zhang
A method that uses a Sc–3-HF complex as a fluorescent chemosensor for the detection of dihydrogen phosphate ions has been developed. The Sc–3-HF complex exhibits excellent selectivity and sensitivity towards dihydrogen phosphate ions. The binding properties of the Sc–3-HF complex towards various anions are evaluated by fluorescence spectroscopic method. The results demonstrate that the Sc–3-HF complex can effectively distinguish H2PO4− from HSO4−, HPO42− and PO43−. These results of fluorescence reversibility experiments show that the Sc–3-HF complex can serve as a relay probe to detect dihydrogen phosphate ions with high selectivity and sensitivity in CH3CN–H2O (1 : 4, v/v) solution.
✓ 已验证
产品关联
DOI
高影响因子
WORLD JOURNAL OF GASTROENTEROLOGY
·
2014
·
IF 2.433
Jia-Yi Ma,Run-Hua Li,Kun Huang,Gao Tan,Chen Li,Fa-Chao Zhi
AIM: To investigate the possible role of chitinase 3-like-1 (CHI3L1) in the progression of colitis-associated carcinoma (CAC). METHODS: Thirty-four Balb/c mice were randomly assigned to five groups, including the control, CAC control, CAC + caffeine, colitis control and colitis + caffeine. Three animals were sacrificed every two weeks for blinded macroscopic inspection, histological analysis, and total RNA extraction. An immunofluorescent assay was performed using specimens from the colitis control and colitis + caffeine groups to investigate whether the protective effect of caffeine was associated with less oxidative DNA damage. In vitro , HT29 cells pre-stimulated with different concentrations of recombinant CHI3L1 protein and H 2 O 2 were loaded with the DCFH-DA fluorescent probe to determine the effect of CHI3L1 on intracellular reactive oxygen species production. RESULTS: CHI3L1 mRNA was increased during the progression of colon carcinogenesis. Tumors were mostly located in the distal end of the colon where the expression of CHI3L1 was higher than in the proximal colon. Caffeine-treated mice developed fewer tumors and milder inflammation than untreated mice. CHI3L1 protein increased reactive oxygen species in HT29 cells when exposed to H 2 O 2 . CONCLUSION: Caffeine reduces tumor incidence by decreasing oxidative DNA damage. CHI3L1 may contribute to CAC by increasing reactive oxygen species production.
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）