LIFE SCIENCES
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2022
·
IF 6.78
Tianfeng Yang,Cheng Cheng,Rui Xu,Jian Huo,Xiujuan Peng,Yanbin Chen,Yonghong Liang,Zhiheng Su,Yanmin Zhang
Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third most common cause of cancer-related deaths. The WW-domain containing oxidoreductase (WWOX) protein suppresses carcinogenesis and its absence is closely related to aggressive HCC phenotypes. In this study, by using SPR analysis, cell viability assay and xenograft mice models, we found that albendazole (ABZ), a safe and effective anthelmintic drug, exhibited the binding affinity with WWOX protein and potential inhibition effect on HCC cells in vitro and in vivo . Overexpression and knockdown of WWOX confirmed that the suppression of HCC by ABZ. Flow cytometric analysis, western blotting analysis and Co-IP were conducted to study the mechanism of ABZ. Our data showed that ABZ regulated the interaction between WWOX and its binding proteins including p53 and C-MYC. Furthermore, ABZ triggered p53-induced intrinsic apoptosis and suppressed EMT-mediated migration by C-MYC/Fibronectin axis. In addition, ∆NP73 expression was significantly inhibited by ABZ, which further sensitized p53-induced intrinsic apoptosis and cell cycle arrest. In summary, ABZ could suppress the proliferation and migration of HCC cells by regulating WWOX-dependent signaling pathway.
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PubMed
高影响因子
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
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2022
·
IF 6.76
Jianing Yin,Han Yan,Meng Cai,Shijie Song,Xiaoqiang Fan,Minhao Zhu
The multiple advantages of flake MoS 2 are of great significance for improving the fretting wear resistance of bonded solid lubricant coating. Herein, the coating was constructed with liquid-phase exfoliated flake MoS 2 as lubricating filler and epoxy resin as binder. The tangential fretting characteristics for the contact of AISI 52,100 steel ball against the as-prepared coating on the AISI 1045 steel were investigated under three displacement amplitude. Results show that the average friction coefficient and wear rate of the coating with flake MoS 2 maximumly reduce by 45.5% and 89.8% than those with bulk MoS 2 . Moreover, the fretting regime is regulated by the coatings with different composition and performance. Such excellent anti-fretting features depend on: (a) the intrinsic shearing properties of flake MoS 2 ; (b) the repairing effect on the worn area; (c) the formation of uniform transfer film.
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高影响因子
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
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2022
·
IF 6.117
Hui-jian Chen,Xi-yue Yan,Ao Sun,Li Zhang,Jing Zhang,You-e Yan
Obesity and metabolic disorders are threats to human health . Extracellular matrix (ECM) is an important member of adipose microenvironment . ECM remodeling contributes to obesity and insulin resistance, but the roles of every single ECM component is still not fully understood. We observed glucose and lipids metabolic disorders in high-fat diet (HFD)-fed mice and humans with obesity. Higher levels of inflammatory factors and hormones existed in serum of HFD-fed mice. Multiple collagens , laminins , fibronectin , nidogen , and Hspg2 were upregulated in obese white adipose tissue (WAT) from mice and humans. These effects were stronger in subcutaneous WAT than visceral WAT in mice, but the fat depot difference was reversed in humans. The ECM structure and the morphology of adipocytes seeded on ECM were changed in the HFD group. In human visceral WAT, ECM genes showed positive correlations with blood lipids and glucose. In vitro , collagen I/IV and LAMA4 proteins showed similar changes with C/EBPα during the differentiation of adipocytes. Macromolecular crowders (MMC) promoted partial collagen and non-collagen gene expression. Oleic acid (OA) and MMC upregulated collagen I/IV and LAMA4 proteins, and the effects of MMC were stronger than that of OA. Moreover, MMC promoted the differentiation of adipocytes, but OA increased the size of lipid droplets . Positive correlations were observed between ECM genes and adipogenesis-related genes in adipocytes. In conclusion, some obesogens (such as HFD) induce ECM remodeling, and the upregulation of ECM components is closely related to adipogenesis , suggesting that adipose ECM deposition is an indicator of obesity and metabolic disorders.
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PubMed
高影响因子
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
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2022
·Vol. 26
·期 11
·2435-2443
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IF 2.747
Jiang Demin,Zhu Chenyi,He Yuan,Xing ChengCheng,Xie Kun,Xu Yan,Wang Yuqiao
Anodes play an important role in the extracellular electron transfer (EET) process in microbial fuel cells (MFCs). Herein, polyaniline modified multilayer MXene (PANI-MXene) on carbon cloth was used as an anode to improve the EET efficiency. The PANI-MXene was formed by the electrostatic interaction between the negatively charged groups of MXene and the positively charged protonated amino groups of PANI to enhance the bacterial adhesion and biofilm formation. The MFCs obtained a high maximum power density (737.3 mW·m -2 ) with the efficient EET process. This work provides a meaningful way to decorate anodes using binder-free modifiers for MFCs.
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2022
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IF 9.221
Haiyan Zhang,Fei Feng,Yangyang Zhao,Bin Zhao,Lei Li,Dan Zheng,Xinxin Li
Increasing the aspect ratio of the microchannels of microfabricated gas chromatographic columns (μGCCs) can allow analytes to quickly reach equilibrium between the stationary phase and mobile phase , which helps improve their separation performance. In this paper, an all-silicon microfabricated gas chromatographic column (AS-μGCC) with a high aspect ratio was proposed and fabricated using deep reactive-ion etching (DRIE) and silicon direct bonding. Two AS-μGCCs with the lengths of 2 m and the aspect ratios of 6.6 (100 µm-width × 660 µm-depth) and 25 (30 µm-width × 750 µm-depth) were successfully fabricated. The effects of different aspect ratios on the column efficiency of AS-μGCCs were studied. A separation experiment showed that the column efficiency of the AS-μGCC with an aspect ratio of 25 (AS-μGCC-25) was 12 times higher than that of the AS-μGCC with an aspect ratio of 6.6 (AS-μGCC-6.6). The column efficiency of the AS-μGCC-25 was 1961 plates/m, and a heavy hydrocarbon mixture (C8–C20) could be separated using AS-μGCC-25 within 4.5 min
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CHEMICAL ENGINEERING & TECHNOLOGY
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2022
·Vol. 45
·期 10
·1842-1849
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IF 2.215
Junteng Ma,Weihua Shen,Wenxuan Wei,Yunjin Fang
The catalytic activity of an ionic liquid catalyst decreased during the transesterification of propylene carbonate (PC) with methanol to dimethyl carbonate (DMC). The interaction between the strong basic sites of ionic liquid catalyst and carbonyl compounds of PC and/or DMC was considered to attribute to this deactivation. The presence of H 2 O accelerated this process by the formation of OH – . The strong basic ionic liquid reacted with the trace amount of H 2 O in the reaction system to generate OH – , which then reacted with the carbonyl structure in PC and/or DMC to form the inactive compound HCO 3 – , resulting in the deactivation of the ionic liquid catalyst. A plausible mechanism was proposed for the deactivation of the ionic liquid catalyst in this reaction.
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高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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2022
·Vol. 23
·期 15
·8380
·
IF 6.208
Zhipeng Dong,Yunxue Yin,Jun Luo,Bingxia Li,Fangning Lou,Qiyan Wang,Qingfa Zhou,Baofen Ye,Yue Wang
Liposome modification by targeting ligands has been used to mediate specific interactions and drug delivery to target cells. In this study, a new peptide ligand, CP7, was found to be able to effectively bind to FGFR1 through reverse molecular docking and could cooperate with VEGFR3 to achieve targeting of A549 cells. CP7 was modified on the surface of the liposome to construct a targeted and safe nanovehicle for the delivery of a therapeutic gene, Mcl-1 siRNA. Due to the specific binding between CP7 and A549 cells, siRNA-loaded liposome-PEG-CP7 showed increased cellular uptake in vitro, resulting in significant apoptosis of tumor cells through silencing of the Mcl-1 gene, which is associated with apoptosis and angiogenesis. This gene delivery system also showed significantly better antitumor activity in tumor-bearing mice in vivo. All of these suggested that siRNA-loaded liposome-PEG-CP7 could be a promising gene drug delivery system with good bioavailability and minimal side effects for treatment.Keywords:CP7;liposome;target delivery;FGFR1;gene drug
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PubMed
高影响因子
FOOD CHEMISTRY
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2022
·
IF 9.231
Ying Wan,Jian Li,Jitong Ma,Yanan Li,Ren Wang,Zhengxing Chen,Tao Wang
In this study, co-assembled protein-polysaccharide complexes (ZCs) were prepared by fixing zein nanoparticles at the fibrillar carboxymethyl cellulose (CMC) by pH-driven anti-solvent precipitation. The complexation boosted the dispersity of zein from 17.3% to 88.6%. Scanning electron microscopy and atomic force microscopy confirmed the formation of network structures where the fibrous polysaccharides inserted into the interval of granular proteins. Circular dichroism spectrum, fluorescence spectrum, and X-ray diffraction verified the electrostatic interaction pattern between zein and CMC. Besides, the ZCs presented favorable amphiphilic properties, and the electrostatic interaction between zein and CMC can be fine-tuned by the substitution degree (DS) of carboxymethyl in CMC. Therefore, the Pickering emulsions stabilized by ZCs had controllable size and long-term stability using DS as a stimulus. Our study offers a novel strategy developing bio-based materials as novel stabilizers of Pickering emulsions.
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PubMed
高影响因子
Inorganic Chemistry Frontiers
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2022
·Vol. 9
·期 18
·4642-4650
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IF 7.779
Pingping Chen,Xiaohui Wang,Rui Yu,Yu Gu,Yuchao Lyu,Yupeng Tian,Jianye Fu,Xinmei Liu
Mo dispersion is the key factor promoting the performance of an Mo/ZSM-5 catalyst for the methane dehydroaromatization (MDA) reaction. Citric acid (CA) was introduced during the conventional wetness impregnation step to ameliorate the Mo dispersion over the Mo/ZSM-5 catalyst. After introducing CA, all catalysts bear high crystallinity relative to that of ZSM-5 zeolite, which proves that CA treatment does not damage the physical structure of catalysts. CA introduction also enhances the Mo dispersion significantly. The metal particle size of 3Mo/ZSM-5-CA1.5 (sample with an Mo loading of 3 wt% and nCA : nMo ratio of 1.5) is within 5–15 nm and is lower than that of pristine 3Mo/ZSM-5 (within 10–20 nm). The role of CA in improving Mo dispersion can be further certified by the higher band gap energy of molybdenum atoms, the higher proportion of surface oxygen in molybdenum oxide and the fewer Brønsted acid sites for the catalysts prepared with the aid of CA. High Mo dispersion contributes to the high activity and selectivity of the catalysts. The aromatic yield of 3Mo/ZSM-5-CA1.5 is almost twice that of pristine 3Mo/ZSM-5. The improvement of Mo dispersion is attributed to the chelation between CA and Mo species, leading to the subsequent isolation of the active components during calcination. Moreover, this effect is more distinct for the catalysts with higher Mo loading. When Mo loading increases to 9 wt%, the aromatic selectivity of 9Mo/ZSM-5-CA1.5 is more than 93% and the coke resistance is obviously elevated compared to that of a catalyst prepared without CA. Based on the above findings, it is clear that adding CA during the Mo/ZSM-5 preparation is an effective way to improve Mo dispersion.
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高影响因子
Journal of Materials Chemistry C
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2022
·Vol. 10
·期 23
·8972-8978
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IF 8.067
Qi Wei,Xiaonan Huo,Qiang Fu,Ting Wang,Heming Zhao,Yixuan Wang,Jiansong Yang,Siqi Zhan,Liang Zhou,Shiwei Wang,Penggang Yin
The photoelectric conversion efficiency of lead-based halide perovskite photovoltaic cells (PSC) has reached 25% in recent years, which is the commercial level. A safe and environment-friendly encapsulation material and process for PSC determines its application in building-integrated photovoltaics. In this work, an acrylate hot melt adhesive (AHMA) with good transparency and extensive cohesiveness was obtained by free-radical copolymerization, based on which, the safety sandwich perovskite photovoltaic cell was prepared together with PVB film at 80 °C. It avoids the structural damage of perovskite devices under high-temperature or UV curing. Before and after packaging, 21.58% and 20.88% of the PCE were achieved, respectively, for the perovskite photovoltaic device, which shows good stability. It has been confirmed that more than 96% of lead leakage can still be blocked from the seriously damaged device after heavy rainfall for 6 hours. The encapsulation scheme introduced here is especially suitable for perovskite photovoltaic building integration.
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高影响因子
ADVANCED MATERIALS
·
2022
·Vol. 34
·期 29
·2203073
·
IF 32.086
Xuelian Wei,Baocheng Wang,Zhiyi Wu,Zhong Lin Wang
Robotic perception can have simple and effective sensing functions that are unreachable for humans using only the isolated tactile perception method, with the assistance of a triboelectric nanogenerator (TENG). However, the reliability of triboelectric sensors remains a major challenge due to the inherent environmental limitations. Here, an intelligent tactile sensing system that combines a TENG and deep-learning technology is proposed. Using a triboelectric triple tactile sensor array, typical characteristics of each testing material can be maintained stably even under different contact conditions (touch conditions and external environmental conditions) by extracting features from three independent electrical signals as well as the normalized output signals. Furthermore, a convolutional neural network model is integrated, and a high accuracy of 96.62% is achieved in a material identification task. The tactile sensing system is exhibited to an open environment for material identification and the real-time demonstration. Compared to the complex process that humans must integrate multiple sensing (touching and viewing) to accomplish tactile perception, the proposed sensing system shows a huge advantage in cognitive learning for the visually impaired, biomimetic prosthetics, and virtual spaces construction.
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PubMed
高影响因子
JOURNAL OF POWER SOURCES
·
2022
·
IF 9.794
Hongliang Xie,Zhiyuan Chen,Peng Chu,Jie Wang,Zehao Li,Hailei Zhao
Liquid metal battery (LMB) with low cost, excellent cycle performance and flexible scalability is developed as a promising solution for large-scale energy storage. However, the high melting point of the electrolyte necessitates an elevated operating temperature, which provokes aggravated hermetic seal and corrosion issues, seriously inhibiting the advancement of LMBs. Herein, we elaborately design a novel LiCl–LiBr–KBr electrolyte system based on the mass triangle model to overcome this obstacle. The LiCl and LiBr components can provide required lithium ionic conduction, while the KBr plays a dual role of decreasing the melting point and suppressing metal lithium dissolution. The designed LiCl–LiBr–KBr (33:29:38 mol%) electrolyte possesses low melting point (T m = 327 °C), and high ionic conductivity (1.573 S cm −1 at 420 °C), which enables the Li||Bi battery to work efficiently at 420 °C with high energy efficiency (83%), excellent rate capability, superior cycling stability and freeze/thaw performance. This represents an 80–130 °C decrease in operating temperature compared to most reported LMBs. The unique performance combination together with its low cost makes the designed electrolyte extremely attractive for low-temperature LMB.
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高影响因子
危险品化学品经营许可证（带存储）