JOURNAL OF MOLECULAR STRUCTURE
·
2026
·
IF 4.9
Yufan Liu,Linhan Jian,Xinxin Zhang,Md Ibrahim Khalil,Guowen Wang,Hongchao Ma,Yinghuan Fu
A 3D Bi 2 MoO 6 @Black-TiO 2 heterojunction photoelectrode was successfully fabricated. • Interfacial regulation induces Type-II band alignment and a built-in electric field. • Enhanced charge separation promotes generation of •OH and 1 O 2 reactive species. • The optimized electrode achieves 92.3% PEC degradation of KN-R dye. A Bi 2 MoO 6 @B-TiO 2 composite photoelectrode was successfully fabricated via a sequential hydrothermal-hydrogenation-solvothermal process. The three-dimensional network architecture constructed from ultrathin Bi 2 MoO 6 nanosheets and black-TiO 2 (B-TiO 2 ) nanowire arrays achieves uniform interfacial chemical distribution, integrating the merits of each component and endowing the electrode with low charge‑transfer resistance, favorable charge‑transport kinetics, and more accessible electroactive sites for PEC reactions. Band structure analysis suggests the possible formation of a Type-II heterojunction between B-TiO 2 and Bi 2 MoO 6 . Upon photoexcitation, this heterojunction can drive the migration of photogenerated electrons from Bi 2 MoO 6 to B-TiO 2 and holes in the opposite direction, effectively suppressing charge carrier recombination while promoting the generation of dominant reactive species such as •OH and ¹O₂. In photoelectrocatalytic degradation experiments of reactive brilliant blue KN-R, the optimized electrode achieves a removal rate of 92.3%, significantly higher than the sum of its photocatalytic and electrocatalytic performances, and maintains 78.9% activity after five cycles. This work provides a feasible interfacial regulation strategy for constructing high-performance photoelectrodes. Download: Download high-res image (324KB) Download: Download full-size image
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高影响因子
APPLIED SURFACE SCIENCE
·
2026
·
IF 6.6
Ming Ya,Teng Guo,Chenxi Xiong,Jie Zhu,Zhenyu Zhang,Huiping Ji,Jianghao Wang,Bolong Li,Jie Fu
Boron doping activates MoS 2 basal planes and constructs B-Mo dual Lewis acid sites for NRR. • B-MoS 2 -5 delivers superior NRR performance of NH 3 yield of 22.1 μg mg -1 cat. h −1 , and a FE of 27.1%. • In-situ ATR-FTIR confirms B-Mo sites enhance N 2 activation and suppress HER. Ambient electrochemical nitrogen reduction reaction (NRR) powered by renewable electricity offers a sustainable alternative to the energy-intensive Haber-Bosch process. However, achieving efficient N≡N bond activation while suppressing the competing hydrogen evolution reaction (HER) in aqueous electrolytes remains a major challenge. Herein, we fabricated Boron-doped MoS 2 (B-MoS 2 ) nanoflowers with abundant asymmetric B-Mo Lewis acid sites as electrocatalysts for NRR. In 0.1 M Na 2 SO 4 , the optimized B-MoS 2 achieves an ammonia yield rate of 22.1 μg mg -1 cat. h −1 at −0.35 V vs. reversible hydrogen electrode (RHE) and faradaic efficiency (FE) of 27.1% at −0.3 V vs. RHE, outperforming most previous reports. The superior performance is attributed to the synergistic effect of the B-Mo dual Lewis acid sites: the electron-deficient B site enhances N 2 adsorption by capturing its lone-pair electrons, while Mo promotes π-backdonation to polarize and activate the N≡N bond. Simultaneously, the strong Lewis acidity of B suppresses H⁺ adsorption, inhibiting HER. In-situ electrochemical attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy further confirms B-Mo sites boost N 2 adsorption and activation, favoring NRR over HER. This work provides insights for the rational design of sustainable electrocatalysts for ambient nitrogen fixation. A phase-engineered boron-doped MoS 2 nanoflowers were synthesized for enhancing B-Mo dual-site accessibility and efficient electrochemical nitrogen fixation. Download: Download high-res image (144KB) Download: Download full-size image
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高影响因子
RSC Advances
·
2026
·Vol. 16
·期 22
·20381-20390
·
IF 6.1
Fan Mo,Chen Tian,Rongrong Ji,Shixing Dong,Linwei Liang,Ling Zhou,Hao Wu,Xipo Zhao
Poly(ester amide) (PEA) contains both ester bonds (–COO–) and amide bonds (–NHCO–) within its molecular backbone. Through strategic monomer selection and molecular structure design, PEAs have the potential to simultaneously exhibit excellent biodegradability and mechanical properties, making them a promising class of materials with significant research interest and application potential. In this study, poly(lactic acid) (PLA) was synthesized from L-lactic acid via melt polycondensation, followed by terminal thiolation modification. Subsequently, a biodegradable PLA-b-PA4 block poly(ester amide) was prepared through a thiol–ene click reaction with the synthesized polyamide 4 (PA4). The molar ratios of polyester to polyamide repeating units in the copolymers were 11 : 26 and 23 : 26. Comprehensive structural characterization of thiol-terminated PLA and the synthesized block poly(ester amide) was conducted using MALDI-TOF MS, FTIR, Raman, XPS, and 1H-NMR spectroscopy. Systematic study revealed that variations in PLA chain length significantly influenced the properties of the PEA, with the PLA and PA4 segments undergoing phase separation in the melt and exhibiting mutually suppressed crystallization behavior. Electrospinning was employed to process the PEA. The electrospinning process reduces the crystallinity of both PLA and PA4. The morphology and properties of the electrospun fibers were influenced by the PLA block ratio. Poly(ester amide)s containing short-chain PLA segments produced electrospun fibers with larger diameters, exhibiting better mechanical strength and ductility. As the PLA chain length increased in the copolymer, bead formation appeared in the electrospun fibers, accompanied by a decrease in fiber diameter and a deterioration in mechanical performance. This study provides experimental evidence and theoretical insights into the structure–property relationships of fully biodegradable block poly(ester amide)s and their application in electrospinning.
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高影响因子
CERAMICS INTERNATIONAL
·
2026
·
IF 6
Fang Yu,Chaohai Li,Dong Yang,Jiayu Li,Xiaodan Cao,Biaolin Peng,Kailiang Ren
The electrocaloric (EC) effect in ferroelectric materials has attracted extensive attention because of its high efficiency and potential applications in chip cooling. In this work, we successfully prepared a Pb(Sc 0.25 Ta 0.25 In 0.25 Nb 0.25 )O 3 (PSINT) ceramic via a solid-state reaction method with high-polar entropy. Next, the prepared ceramics were quenched at 1050 °C for various durations. The grain size of the quenched PSINT samples initially decreased to 0.39 μm and then gradually increased to 0.61 μm with a quenching time of 50 h. X-ray diffraction (XRD) patterns of the PSINT ceramics indicate that the PSINT sample transforms from the tetragonal (pseudo-cubic) to an R-3C rhombohedral phase. The measurements of the electrocaloric effect revealed a significant adiabatic temperature change (Δ T ) of approximately 1.98 K at 60 kV cm −1 and room temperature with a quenching time of 40 h. This value is 0.5 K higher than that of untreated PSINT ceramics. Moreover, the B-site atoms of the PSINT high-polar-entropy ceramics changed from a long-range ordered phase to a disordered phase after quenching. This study provides a new technical approach for room-temperature cooling devices by designing B-site disorder in relaxor ferroelectric ceramics.
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高影响因子
AQUACULTURE
·
2026
·
IF 4.4
Yuhua Lin,Yiwen Chai,Jugan Han,Weiheng Shi,Along Gao,Jianmin Ye,Liting Wu
The CC motif chemokine ligand 25 (CCL25), which specifically binds to the CC chemokine receptor 9 (CCR9), plays a critical role in immune responses during bacterial infections. Although its importance is well-established in mammals, comprehensive studies on the CCL25/CCR9 axis in fish remain limited. In this study, we identified and characterized two alternatively spliced isoforms of CCL25 ( On CCL25a and On CCL25b) and two isoforms of CCR9 ( On CCR9a and On CCR9b) in Nile tilapia ( Oreochromis niloticus ). These genes were expressed in various tissues, with OnCCR9 showing significantly higher expression in IgM + B cells compared to IgM − leukocytes. Following infection with Streptococcus agalactiae or Aeromonas hydrophila , the expression levels of the CCL25/CCR9 axis components were significantly up-regulated in leukocytes from peripheral blood (PBL), spleen (SPL), and head kidney (HK). To investigate functional roles, recombinant On CCL25a and On CCL25b proteins were utilized. Our finding revealed that the CCL25/CCR9 axis promotes B cells differentiation without inducing their differentiation into plasma cells. Additionally, the axis did not influence the migration of PBL, SPL, HK leukocytes, or IgM + B cells, nor did it affect the behavior of HK monocytes/macrophages. Most importantly, the CCL25/CCR9 axis exhibited strong antibacterial activity, including both direct antibacterial effects of On CCL25 and indirect in vivo effects mediated through immune regulation. Specifically, the axis reduced bacterial load and improved survival in Streptococcus agalactiae -infected Nile tilapia. This study provides the first comprehensive characterization of the CCL25/CCR9 axis in Nile tilapia, elucidating its regulatory mechanism on immune cells and highlight s its critical role in host defense against bacterial pathogens.
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高影响因子
Journal of Building Engineering
·
2026
·
IF 8.1
Xi Deng,Kaiyuan Li,Yongqiang Ye,Xinke Huo,Wei He,Fei Xiao
The inherent combustibility of wood represents a critical vulnerability, compromising the structural integrity and fire safety of wooden buildings. This work reports on a highly fire-safe P/N/B wood composite. This material was fabricated based on the freeze-thaw strategy, involving the co-impregnation of amino trimethylene phosphonic acid (ATMP) and boric acid (BA) into the wood substrate. Benefiting from the pore size changes caused by freeze-thaw cycles, the total loading of ATMP and ATMP/BA in wood increased by 37.5% and 21.9%, respectively, as compared the untreated sample. The freeze-thawed wood composite exhibited an ultra-high limiting oxygen index (LOI) of 87.9 % and a V-0 rating was reached in the UL-94 vertical burning test (5 mm). The peak heat release rate (pHRR) and total heat release rate (THR) decreased by 57% and 91%, respectively, as compared to untreated wood. The results showed that the improved fire retardancy performances were attributed to the char layer formed during the combustion, which acts as a thermal barrier, preventing the transfer of heat and mass. SEM, Raman, XPS, FTIR, and XRD results confirmed that phosphates and borophosphates species were formed during burning and acted as reinforcing substances to enhance the strength and stability of the char layer. In summary, this study provides a simple and effective approach for modifying the fire safety of wood, with great potential for construction applications.
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高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2026
·
IF 5.1
Huihui Dong,Guorui Ma,Jingtian Ni,Shuting Xi,Jing Li,Feng Li
The practical deployment of Zinc oxide (ZnO) photoanodes for photoelectrochemical (PEC) water splitting is severely impeded by rapid photogenerated carrier recombination and sluggish oxygen evolution reaction (OER) kinetics. Herein, we elucidate a synergistic structural engineering strategy integrating interstitial boron (B) doping, Type-II heterojunction construction, and coherent grain boundary regulation to tailor high-performance B-ZnO@ZnS nanorod arrays. Comprehensive characterizations corroborate that B-doping introduces abundant oxygen vacancies to modulate the electronic band structure, while the coherent B-ZnO/ZnS interface establishes a robust built-in electric field, thereby facilitating bulk charge separation and accelerating interfacial hole transfer. Consequently, the optimized photoanode exhibits a remarkable photocurrent density of 1.054 mA cm −2 at 1.23 V vs. RHE (representing a 1.67-fold enhancement over pristine ZnO) and a substantial cathodic shift in onset potential to 0.24 V. Notably, in situ ATR-IR spectroscopy captures the dynamic evolution of key *OOH intermediates, corroborating an adsorption evolution mechanism (AEM) where the multidimensional engineering significantly ameliorates the energy barrier for intermediate formation. This work offers a pivotal paradigm for designing durable and high-efficiency photoelectrodes via precise defect and interface manipulation.
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高影响因子
CERAMICS INTERNATIONAL
·
2026
·
IF 6
Ning Zhang,Ning Guan,Jian Li,Qingfeng Li,Huaicheng Xiang,Weishuang Fang,Yang Yang,Peilin Qing,Ying Tang,Liang Fang
A series of tetragonal scheelite-type Ca 1- x La x W 1- x Ta x O 4 (CLWT x , x = 0.1–0.4) ceramics were successfully fabricated using the traditional solid-state sintering method. The effects of A- and B-site dual substitution on phase formation, microstructural morphology, and microwave dielectric performance were comprehensively characterized using X-ray diffraction, Rietveld refinement, Raman spectroscopy, and scanning electron microscopy. The results revealed that single-phase scheelite ceramics were obtained over the compositional range x = 0.1–0.3, whereas a secondary Ca 0.5 TaO 3 phase emerged at x = 0.4. Within the single-phase scheelite solid-solution region (0.1 ≤ x ≤ 0.3), the unit cell volume expanded linearly from 315.07 Å 3 to 321.15 Å 3 with increasing substitution level, accompanied by elongation of A–O bonds and contraction of B–O bonds. The bond valence analysis indicated that the co-substitution strategy effectively mitigated the rattling effect of the overall crystal structure. Consequently, the τ f increased monotonically from −41.10 ppm/°C to +8.12 ppm/°C, with a near-zero τ f of −7.22 ppm/°C achieved at x = 0.3. The Q × f decreased gradually from 69,172 GHz to 61,630 GHz for x = 0.1–0.3, primarily attributed to reduced packing fraction, decreased lattice energy, and enhanced Raman FWHM. The optimal microwave dielectric properties (εr = 16.4, Q × f = 61,630 GHz, τ f = - 7.22 ppm/°C) were obtained for CLWT 0.3 ceramic sintered at 1400 °C. Furthermore, a cylindrical dielectric resonator antenna was designed and simulated, which exhibited a reflection coefficient S 11 of −47.90 dB, an impedance bandwidth of 200 MHz, and a radiation efficiency exceeding 93% at 3.99 GHz, demonstrating the potential of this material for S-band wireless communication applications.
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高影响因子
AQUACULTURE
·
2025
·
IF 3.9
Tianyang Sun,Xinzhan Meng,Yaru Li,Hongquan Zhang,Ruitao He,Ruicong He,Tiegang Liu,Wenyao Lv,Xiaoyan Xu,Yubang Shen,Jianfeng Ren,Jiale Li
Aquaculture is critical for global food security, yet genetic improvement in farmed fish has progressed more slowly than in terrestrial livestock. Myostatin (MSTN), a conserved negative regulator of skeletal muscle growth in vertebrates, presents a prime target for enhancing aquaculture productivity. In this study, we employed CRISPR/Cas9 ribonucleoprotein (RNP) complexes to disrupt mstnb , the orthologous gene of livestock mstn , in grass carp ( Ctenopharyngodon idella ), the most economically important freshwater aquaculture species in China. Co-injection of five single-guide RNAs (sgRNAs) targeting mstnb exon 1 with Cas9 protein into single-cell embryos achieved 62.0–97.8 % editing efficiency in F 0 mosaic individuals, with an overall population efficiency of 67.1 %. At 7 months post-hatching, mstnb -knockout (KO) fish displayed 17.5 % greater body weight, 8.8 % increased body width, and 7.6 % higher body height compared to control siblings. Histological analysis revealed marked muscle fiber hypertrophy, with cross-sectional area increases of 9.0–26.3 % in cephalosome, trunk, and rump muscles. KO fish also displayed reduced hepatic lipid and glycogen accumulation, indicative of improved metabolic efficiency. While muscle amino acid composition remained largely unchanged, we observed a modest decrease in ω-3 polyunsaturated fatty acids (e.g., EPA and DHA). This study marks the first successful application of CRISPR/Cas9 in grass carp, demonstrating that mstnb disruption enhances growth and muscle development without substantially compromising meat quality. Our results underscore the potential of genome editing for sustainable aquaculture breeding, offering a promising strategy to address rising global protein demands.
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高影响因子
BMC Pharmacology & Toxicology
·
2025
·Vol. 26
·期 1
·1-13
·
IF 2.7
Fu Wenying,Lu Hui,Yan Ying,Shu Chongchong,Xu Chenxin,Chen Yinghua,Xia Yiqun,Chen Jundixia,Chen Yunzhi,Zou Peng,Cui Ri,Ni Daoyong
Section
Background
Lung cancer continues to rank as a leading cause of cancer-related mortality worldwide. Despite notable advances in medical research, therapeutic options for advanced-stage lung cancer remain inadequate. Heat shock protein 90 (HSP90) has been identified as a potential therapeutic target in multiple malignancies, such as lung and colon cancers, owing to its pivotal role in stabilizing numerous oncoproteins. Nonetheless, the clinical application of HSP90 inhibitors has faced challenges, including suboptimal efficacy and the development of resistance mechanisms. B-AP15 is a promising small molecule in cancer therapy that functions by inhibiting deubiquitinating enzymes, which regulate protein degradation through the proteasome pathway. In this study, we aim to investigate its combinatorial activity with the HSP90 inhibitor tanespimycin (TAU) in lung cancer cells.
Section
Methods
The levels of the specified molecules were measured by Western blot analysis. Reactive oxygen species (ROS) levels were determined using the 2′,7′-dichlorodihydrofluorescein diacetate (DCFH-DA) probe. 53BP1 foci formation and C/EBP homologous protein (CHOP) expression were assessed by immunofluorescence. Autophagic flux was monitored using mRFP-GFP-tagged microtubule-associated protein 1 light chain 3 (LC3) lentivirus.
Section
Results
Our findings reveal that the combination of TAU and B-AP15 induces significant synergistic antitumor effects, characterized by substantial accumulation of ROS. This ROS accumulation serves as a crucial mediator of the enhanced therapeutic response elicited by the combination treatment. Mechanistic analyses further demonstrated that the combined treatment induces cell death via activation of endoplasmic reticulum (ER) stress and the c-Jun N-terminal kinase (JNK) pathway.
Section
Conclusion
In summary, our study provides robust evidence supporting the potential of combining TAU with B-AP15 as a viable therapeutic option for lung cancer treatment.
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PubMed
高影响因子
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
·
2025
·
IF 3.2
Li Die,Wang Ting,Zhao Ruike,Wang Weiqun,Zhang Yu,Long Ai,Bi Haojie,Wang Hanying,Wang Daoshuang,Shi Jingpei,Li Yupeng,Lyu Lechun
Post-inflammatory hyperpigmentation (PIH) is a reaction process caused by an increase in melanin or abnormal melanin distribution due to inflammatory skin diseases, skin disease treatments, and external stimuli. Ultraviolet radiation can exacerbate PIH. It stimulates melanocytes, increases melanin production and deposition, and deepens the color and prolongs the duration of PIH. This study aims to investigate the inhibitory effects of Coelonin, an extract from Dendrobium officinale, on melanin production and its underlying mechanisms. Through molecular docking analysis, we found that Coelonin has significantly stronger binding capabilities to tyrosinase (TYR) and melanocortin 1 receptor (MC1R) than kojic acid, a well-known whitening agent. This stronger binding ability suggests that Coelonin may inhibit melanin production by regulating the activity of melanin metabolism-related proteins, thereby exerting its whitening effect. Compared with kojic acid, Coelonin demonstrates superior binding characteristics at the molecular level, providing stronger evidence for its potential as a whitening active ingredient. In cell experiments, Coelonin had no significant effect on the proliferation of B16-F10 melanoma cells within the concentration range of 20–40 µM, but it could significantly reduce the intracellular reactive oxygen species (ROS) levels and inhibit TYR activity and melanin production. Western blot results showed that Coelonin could downregulate the expression of TYR, MITF, TRP-1, and TRP-2 proteins. In in vivo experiments, a guinea pig model of PIH was established by Ablative Fractional Resurfacing CO₂ Laser (AFR CO 2 ) combined with UV-B irradiation. It was found that Coelonin treatment could significantly improve skin pigmentation, reduce melanin granule deposition, and did not cause skin inflammation or hyperplasia and other side effects. This study indicates that Coelonin is an efficient and safe melanin synthesis inhibitor and has the potential to be developed as a plant-derived skin whitening agent.
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PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Yayun Jiang,Youwei Li,E. Jianfei,Qi Xin,Yongyi Chen,Qiang Wen,Yang He,Gang Mai
Group B Streptococcus (GBS) poses a significant health risk to mothers and newborns, requiring rapid and accurate detection for effective treatment. Traditional methods, such as bacterial culture and PCR, are time-consuming and procedurally complex. Herein, we developed a visual nucleic acid assay platform by combining loop-mediated isothermal amplification (LAMP) with LAMP-responsive carbon dots—polyethyleneimine carbon dots (PEI-CDs)—for GBS detection. In a positive LAMP reaction (with target DNA), the negatively charged amplification products (DNA and magnesium pyrophosphate) interact with positively charged fluorescence PEI-CDs via electrostatic adsorption to form a large fluorescent precipitate, while in a negative reaction, PEI-CDs remain dispersed. This visual distinction allows for the straightforward identification of GBS presence. To prevent contamination, PEI-CDs are integrated into the reaction tube lid. This visual detection platform achieves a detection limit of 10 2 copies/μL for GBS within 31 min, demonstrating high sensitivity and rapid visual readout. The platform shows significant potential for clinical practice in nucleic acid diagnostics, with versatility to detect other pathogens through primer substitution.
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高影响因子
危险品化学品经营许可证（带存储）