BIOSENSORS & BIOELECTRONICS
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2024
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IF 10.7
Yanpei Xu,Haoyu Wu,Meng Sun,Hongyu Song,Chuxiao Sun,Fudong Jia,Qi Wang
In the detection of biomolecules, surface plasmon resonance (SPR) sensors require high sensitivity. In this study, we propose a sensitivity-enhanced functionalized plasmonic interface based on Ag–TiO 2 –Co(OH) 2 nanosheets structure. Compared to unmodified SPR sensors, the sensitivity of the sensor decorated with TiO 2 and Co(OH) 2 nanosheets is increased by 130.84%, reaching 5764.27 nm/RIU. This enhancement is attributed to the high refractive index of the coating, as well as the high specific surface area and abundant active sites provided by the synthesized Co(OH) 2 nanosheets with a multi-grooved structure. Additionally, employing a double-antibody sandwich method, the antibody-functionalized plasmonic interface enables specific detection of human serum albumin (HSA). The linear response of this sensor was in the wide range of 0.4–150 μM, and the LOD reached 154.89 nM(K D is approximately 1.73 × 10 −6 M). This novel SPR sensor offers a new strategy for biochemical sensing and provides a highly sensitive platform for immunoassays.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2025
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IF 8.3
Haiyan Ji,Zhaowen Wu,Tong Li,Guidong Ju,Huaming Li,Yong Wang,Hui Xu,Junfeng Liu
The high energy requirements of water electrolysis, driven largely by the sluggish kinetics of the oxygen evolution reaction (OER), hinder its widespread application for hydrogen production. This study presents an innovative alternative by replacing OER with the thermodynamically favorable furfural oxidation reaction (FOR), utilizing a CuPt nanowire (NW)/Cu electrocatalyst. The incorporation of Pt into Cu NWs significantly enhances FOR activity, enabling the production of value-added furoic acid alongside hydrogen gas at reduced voltages. The CuPt NWs/Cu catalyst also exhibits excellent hydrogen evolution reaction (HER) performance in alkaline media. By employing CuPt NWs/Cu as both the anodic and cathodic catalyst, we develop a two-electrode electrolyzer that integrates FOR and HER, allowing simultaneous hydrogen production at both electrodes. Operating at a current density of 10 mA cm −2 , the system requires an exceptionally low cell voltage of 0.39 V and an electricity consumption of 0.47 kWh per m 3 H 2 , demonstrating its efficiency for energy-saving bipolar hydrogen generation.
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2024
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IF 4.5
MengYing Lei,Qing Chen,Yang Wang,Gang Wang
Oral absorption of carrier-free self-assembly nanoplatform was limited by mucus barrier, p-gp efflux and liver metabolism. In this study, Pip-Cur-TA nanoparticle were constructed by co-assembly of tannic acid, curcumin and piperine via inter-molecular hydrogen-bonded and π-π interaction to improve the oral chemotherapy. The optimized Pip-Cur-TA nanoparticle showed an average diameter of 60 nm with a drug encapsulation efficiency of 67.02 % and loading capacity of 61.37 %. Pip-Cur-TA nanoparticles showed pH-dependent drug release, mucosal adhesion, inhibition of p-gp and liver metabolism and improved membrane permeability. Oral Pip-Cur-TA nanoparticle produced high oral delivery efficiency and relative oral bioavailability of 12.84 % in rats, and further showed significant tumor inhibition on PC-3 tumor cells. These findings confirmed that Pip-Cur-TA nanoparticle might be a promising oral drug formulation for chemotherapy.
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Materials
·
2024
·Vol. 17
·期 6
·1417
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IF 3.1
Chen Zheng,Xu Han,Fangfang Sun,Yue Zhang,Zihang Huang,Tianyi Ma
Aqueous supercapacitors have occupied a significant position among various types of stationary energy storage equipment, while their widespread application is hindered by the relatively low energy density. Herein, N/F co-doped carbon materials activated by manganese clusters (NCM) are constructed by the straightforward experimental routine. Benefiting from the elevated conductivity structure at the microscopic level, the optimized NCM-0.5 electrodes exhibited a remarkable specific capacitance of 653 F g−1at 0.4 A g−1and exceptional cycling stability (97.39% capacity retention even after 40,000 cycles at the scanning rate of 100 mV s−1) in a neutral 5 M LiCl electrolyte. Moreover, we assembled an asymmetric device pairing with a VOxanode (NCM-0.5//VOx), which delivered a durable life span of 95% capacity retention over 30,000 cycles and an impressive energy density of 77.9 Wh kg−1. This study provides inspiration for transition metal element doping engineering in high-energy storage equipment.
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EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
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2024
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IF 4.4
Shixin Li,Bing Yang,Liang Ye,Shuqi Hu,Benhong Li,Yanjun Yang,Yichuan Hu,Xiaobin Jia,Liang Feng,Zhiwei Xiong
The integration of multiple therapeutic agents within a single nano-drug carrier holds promise for advancing anti-tumor therapies, despite challenges posed by their diverse physicochemical properties. This study introduces a novel multi-stage microfluidic co-encapsulation platform designed to address these challenges. By carefully orchestrating the nano-precipitation process sequence, this platform achieves sequential encapsulation of two drugs with markedly different physicochemical characteristics. Using the multi-stage microfluidic TrH chip, hybrid nanoparticles (HNPs) loaded with paclitaxel (PTX)-simvastatin (SV), PTX-lenvatinib (LV), and SV-LV were synthesized. Unlike conventional Bulk methods and existing commercial microfluidic Tesla and Baffle chips, the HNPs produced here exhibit a core–shell structure and uniform particle size distribution, crucial for enhancing drug delivery efficacy. Notably, this method achieves nearly 100 % encapsulation efficiency for both drugs across a dual-drug feed ratio range from 1:4 to 4:1. Drug loading efficiencies were quantified for PTX-SV/HNPs (14.97 ± 1.19 %), PTX-LV/HNPs (16.58 ± 0.69 %), and SV-LV/HNPs (19.21 ± 2.38 %). PTX-SV/HNPs demonstrated sequential release characteristics of SV and PTX, as confirmed by in vitro drug release experiments. Significantly, PTX-SV/HNPs exhibited superior cytotoxicity against HepG2 cells compared to individual PTX and SV treatments, underscoring their potential in cancer therapy. In conclusion, the developed multi-stage microfluidic platform represents a robust strategy for co-encapsulating drugs with substantial physicochemical disparities, thereby offering a promising avenue for advancing multi-drug delivery in nanomedicine applications.
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Inorganics
·
2024
·Vol. 12
·期 6
·154
·
IF 3.1
Yujia Cheng,Yan Huang,Guang Yu
Carbon dots (CDs) have emerged as significant fluorescent nanomaterials due to their bright, stable fluorescence, good biocompatibility, facile synthesis, etc. They are widely used in various scientific and practical applications, particularly in combination with mesoporous, florescent, or magnetic nanomaterials to enhance their properties. Recent research has focused on employing CDs and their composites in drug analysis, drug loading, biological imaging, disease diagnosis, and temperature sensing, with a growing interest in their biological and medical applications. In this study, we synthesized blue-fluorescent S, N-co-doped CDs (cys-CDs) using hydrothermal synthesis with L-cysteine and sodium citrate. These resulting cys-CD particles were approximately 3.8 nm in size and exhibited stable fluorescence with a quantum yield of 0.66. By leveraging the fluorescence quenching of the cys-CDs, we developed a rapid and sensitive method for baicalein detection, achieving high sensitivity in the low micromolar range with a detection limit for baicalein of 33 nM. Our investigation revealed that the fluorescence-quenching mechanism involved static quenching and inner-filter effect components. Overall, cys-CDs proved to be effective for accurate quantitative baicalein detection in real-world samples.
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CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Wenzhe Zhang,Ying Wan,Chaoyi Xue,Zhengxing Chen,Ren Wang,Wei Feng,Yanan Li,Tao Wang
Multicompartmented nanostructures, which mirror the complexity of living cells, are promising for bio-related applications. However, controlling the spatial arrangement within natural biopolymer assemblies, like protein nanoparticles, is challenging. In our study, we reveal a facile method for compartmentalizing the interiors of protein nanoparticles by co-assembling rice proteins (RPs) and soy protein isolates (SPIs) through simultaneous folding. The assembly of these two protein types results in nanoparticles with a hydrophobic core to accommodate hydrophobic substances, such as eugenol, leading to its internalization. The protein–ligand (SPI-eugenol) interaction then triggers SPI gelation within the nanoparticle cores, forming distinct physical barriers hindering the complete merging of eugenol droplets. Subsequent dialysis of the nanoparticles containing eugenol against water facilitated the removal of eugenol. This step was crucial for forming multicompartmented nanoparticles (MCNPs) with adjustable interior complexities, including varying numbers of compartments and different hollowing rates related to various SPI:RP mass ratios. This allows us to endow MCNPs with adjustable barrier effects tailoring controllable responses of the encapsulated payload, vitamin D 3 (VD 3 ), under different physicochemical conditions. Our study demonstrates a straightforward method for constructing biomacromolecular architectures with precise control over their compartmentalization.
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CHEMICAL ENGINEERING JOURNAL
·
2024
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IF 13.3
Chenglong Qin,Tingting Ren,Chengxiang Gui,Peng Liu,Qingjiao Wei,Wenjing Liu,Zuwei Zhou,Yaning Huang,Kun Fan,Lu Huang
Solar-driven photocatalytic hydrogen production is considered to be a reliable, simple and effective technology for producing green hydrogen. However, a large amount of solar energy absorbed by the photocatalyst material is not utilized but directly dissipated into the atmosphere in the form of waste heat. Meanwhile, the dependence of photocatalytic hydrogen production system on the water supply chain also limits its promotion in water-scarce and arid areas. Herein, a solar-driven hydrogen and water co-generation (SHWC) device based on atmospheric water harvesting (AWH) technology is proposed. The integrated device consists of a water self-supply layer (WSL) and a photocatalytic layer (PL) for simultaneous hydrogen production and freshwater harvesting from the atmosphere. Under one sun illumination (1000 W m −2 ), the AWH-SHWC device obtains an average hydrogen production rate of 25.98 mmol m -2 h −1 with 81.78 g m -2 h −1 of condensate water. In the natural sunlight, 118.21 mmol m −2 day −1 of hydrogen production and 230 g m −2 day −1 of condensate water are obtained. At night, the WSL can achieve regeneration by adsorbing atmosphere water. This integrated device may offer a creative approach to addressing freshwater resource scarcity and the fossil energy crisis.
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WATER SCIENCE AND TECHNOLOGY
·
2024
·Vol. 90
·期 4
·1132-1148
·
IF 2.5
Wang Rui,Dai Zhineng,Zhang Wenqi,Ma Chao
View large Download slide View large Download slide Close modal Efficient degradation of industrial organic wastewater has become a significant environmental concern. Electrochemical oxidation technology is promising due to its high catalytic degradation ability. In this study, Co–Bi/GAC particle electrodes were prepared and characterized for degradation of 1,4-dioxane. The electrochemical process parameters were optimized by response surface methodology (RSM), and the influence of water quality factors on the removal rate of 1,4-dioxane was investigated. The results showed that the main influencing factors were the Co/Bi mass ratio and calcination temperature. The carrier metals, Co and Bi, existed mainly on the GAC surface as Co 3 O 4 and Bi 2 O 3 . The removal of 1,4-dioxane was predominantly achieved through the synergistic reaction of electrode adsorption, anodic oxidation, and particle electrode oxidation, with ·OH playing a significant role as the main active free radical. Furthermore, the particle electrode was demonstrated in different acid–base conditions (pH = 3, 5, 7, 9, and 11). However, high concentrations of Cl − and NO 3 - hindered the degradation process, potentially participating in competitive reactions. Despite this, the particle electrode exhibited good stability after five cycles. The results provide a new perspective for constructing efficient and stable three-dimensional (3D) electrocatalytic particle electrodes to remove complex industrial wastewater. A Co–Bi/GAC particle electrode for the 3D/E system was prepared by the one-step method. The production of ·OH was increased significantly by adding a 3D particle electrode. Fast and effective removal was achieved in the high range of initial 1,4-dioxane concentration. The Co–Bi/GAC particle electrode has a high catalytic activity. The 1,4-dioxane was removed via electrode adsorption and oxidation synergy.
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MOLECULES
·
2025
·Vol. 30
·期 4
·878
·
IF 4.6
Ruijia Hu,Weihao Li,Xi Zhou,Shunmin Yi,Xingfu Zheng,Qiufeng Mo,Wanyu Liu
A novel lignocellulose-based poly(butylene 3-propyladipate-co-furanoate) (PBApF) was synthesized from lignocellulose-derived 3-propyladipic acid (3PAA), 1,4-butanediol (BDO), and 2,5-furandicarboxylic acid (FDCA). The copolyesters were characterized by1H NMR, GPC, DSC, TGA, XRD, DMA, rotational rheology, tensile tests, and enzymatic degradation tests. They were random copolymers whose composition was well controlled, and the number-average sequence lengths of the copolyesters were around 1.35–4.33. By combining the results of tensile tests and DMA, the elongation at break of PBApF45(1865%) had a much greater value than that of PBAF45(1250%), i.e., the branching incorporated into the linear polymer increased the melt strength and conferred tension-hardening properties, which helped to enhance the elongation of the polymer. In addition, the influences of 3PAA content on enzymatic degradation were studied in terms of weight loss; when the content of 3PAA was 55 mol%, the copolyesters exhibited good biodegradability. Thus, depending on their composition, PBApFSmight find end applications as biodegradable elastomers or impact modifiers for other polymers.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Fengcai Lei,Ying Wang,Yuhan Hou,Ruixue Huai,Menghan Zhang,Junfeng Xie,Pin Hao,Yuzhi Song,Jing Yu
The development of efficient catalysts for nitrate reduction to ammonia is crucial for sustainable nitrogen cycle management. In this study, we introduce an amorphous multimetal borides (CoFeNiB) catalyst that demonstrates exceptional performance in the electrochemical reduction of nitrate to ammonia. X-ray photoelectron spectroscopy (XPS) and in-situ Raman spectroscopy reveal that the catalyst exhibits a unique surface reconstruction during the reaction, leading to the formation of CoOOH, where Co 3+ ions can serve as active sites, significantly enhancing the adsorption of nitrate ions and atomic hydrogen, thereby promoting the reduction reaction. Specially, besides the activity enhancement of CoFeNiB compared with CoFeB and CoB, the stability of it can be markedly improved by the synergistic effect of Ni and Fe in the catalyst. Consequently, the CoFeNiB catalyst achieves a stable Faradaic efficiency above 90 % across a broad voltage range of 0 ~ −0.6 V vs reversible hydrogen electrode (RHE) and an ammonia yield peaked of 3961.4 mmol g cat −1 h −1 at −0.6 V vs RHE. The CoFeNiB catalyst offers a promising avenue for the efficient and stable synthesis of ammonia from nitrate, addressing key challenges in environmental sustainability and nitrogen management.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Huan Liu,Shijian Huang,Zhenping Liu,Lang Chen,Jiamei Chen,Xinyi Li,Mengjun Liu,Haoqiang Feng,Weilong Xu,Ruizhi Yang,Minmin Zhang,Lingling Shui
Physically confined assembly of binary colloidal mixtures in emulsion droplets provides a versatile platform for engineering supraparticles with tunable morphologies and functionalities. While single-component and hard-sphere colloidal assemblies have been extensively studied, the co-assembly of binary soft colloids presents unresolved challenges in architecture control and functional integration. In this work, we investigate the co -assembly performance of emulsion droplet confined binary soft colloids of spherical polystyrene nanoparticles (PS) and wire-like carbon nanotubes (CNTs). The supraparticles of CNT/PS with various architectures have been obtained by varying the solvent removal dynamics and the binary colloidal composition. We find out that the binary colloidal size and mass ratio govern the CNT/PS supraparticle structural diversity, ranging from core-shell, core-semishell, garnet-like to densely packed architectures. Spontaneous emulsification and microphase segregation drive the transformation from core-shell to core-semishell architectures, revealing the critical role of fluid dynamics and confinement effects. This understanding of mechanism enables the rational design of hybrid magnetic supraparticles, demonstrating the broad applicability of such an approach. By establishing clear composition-structure correlations, this work advances the controlled co-assembly of binary colloids into hierarchical supraparticles, offering a pathway for constructing functional materials with tailored complexity.
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