DYES AND PIGMENTS
·
2025
·
IF 4.2
Xiang-Yi He,Gui-Xin Guo,Qing Li
This study introduces a dual-mode sensing platform based on a cerium-based metal-organic framework (UIO-66-NH 2 (Ce)) that exhibits dual-enzyme-like activity for the sensitive and selective detection of tetracycline (TC) in water and milk. It employs feedback-regulated dual-enzyme cascades along with Ce 3+ /Ce 4+ redox-mediated ligand-to-metal charge transfer (LMCT) to achieve signal inversion in both colorimetric and fluorescence outputs. The phosphatase-like activity of UIO-66-NH 2 (Ce) hydrolyzes L-ascorbyl-2-phosphate (AAP), resulting in the generation of ascorbic acid (AA), which subsequently reduces Ce 4+ to Ce 3+ within UIO-66-NH 2 (Ce). This reduction suppresses its oxidase-like activity while enhancing fluorescence through LMCT inhibition. In the presence of TC, the phosphatase-like activity is selectively inhibited, thereby restoring Ce 4+ -driven oxidase activity and quenching fluorescence. The platform offers broad detection ranges, low limits (5.95 nM fluorescence, 17.54 nM colorimetry), high selectivity, and real sample applicability, with smartphone-based analysis via RGB signals for rapid, on-site testing, aiding environmental and food safety monitoring.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2021
·Vol. 19
·期 1
·1-21
·
IF 10.435
Wang Tian-Long,Zhou Zi-Fei,Liu Jun-Feng,Hou Xiao-Dong,Zhou Zhi,Dai Yun-Lu,Hou Zhi-Yong,Chen Feng,Zheng Long-Po
Background Skin injury and the resultant defects are common clinical problems, and usually lead to chronic skin ulcers and even life-threatening diseases. Copper, an essential trace element of human body, has been reported to promote the regeneration of skin by stimulating proliferation of endothelial cell and enhance angiogenesis. Results Herein, we have prepared a new donut-like metal–organic frameworks (MOF) of copper-nicotinic acid (CuNA) by a simple solvothermal reaction. The rough surface of CuNA is beneficial for loading/release basic fibroblast growth factor (bFGF). The CuNAs with/without bFGF are easily processed into a light-responsive composite hydrogel with GelMA, which not only show excellent mechanical properties, but also display superior biocompatibility, antibacterial ability and bioactivity. Moreover, in the in vivo full-thickness defect model of skin wound, the resultant CuNA-bFGF@GelMA hydrogels significantly accelerate the wound healing, by simultaneously inhibiting the inflammatory response, promoting the new blood vessels formation and the deposition of collagen and elastic fibers. Conclusions Considering the superior biocompatibility, antibacterial ability and bioactivity, the CuNA and its composite light-responsive hydrogel system will be promising in the applications of skin and even other tissue regeneration. Graphic abstract
研究领域:
材料科学
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生物材料
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组织工程
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生物医学工程
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药剂学
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FOOD RESEARCH INTERNATIONAL
·
2026
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IF 8.8
Chan Li,Xue Yang,Yunfei Zou,Li Zhang,Chuhuan Wei,Yan Ran,E. Zhao,Jibiao Yuan,Keshan Wang,Yongguo Jin,Ying Zhou,Qiujin Zhu,Yuxin Cheng,Yuanyuan Liu
Egg white gel (EWG) is a highly important raw and auxiliary material in food industry. With the increasing demand of consumers for nutrition, developing a modification method for regulating the texture of traditional egg white gel while enhancing its nutritional efficacy has become a challenge. Herein, a hierarchical W/O/W double emulsion filled gel was fabricated via a two-level emulsification process. The primary W/O emulsion, stabilized by synthesized γ-cyclodextrin metal-organic frameworks (CD-MOFs) Pickering emulsifiers, was incorporated into an egg white solution, where the endogenous emulsifying properties of the proteins facilitated the formation of the secondary O/W interface. The stability and morphology of the CD-MOFs-stabilized W/O emulsion (CDME) were analyzed, and the gel properties, molecular interactions, and microstructure of the W/O/W emulsion filled EWG gel (CDME-EWG) was then evaluated. The results indicated that CD-MOFs at 6 mg/mL (CDME-6) significantly enhanced the stability of the Pickering emulsion. This effect was achieved through the formation of a dense interfacial film at the oil/water boundary, which effectively promoted droplet dispersion and suppresses coalescence. Furthermore, the emulsion filled gel with 6 mg/mL CD-MOFs (CDME-EWG6) promoted the cross-linking within the gel network, leading to a more compact structure, enhanced water retention (52.84%) and hardness (887.00 g), as well as the enhancement in encapsulation capability (81.77%) and bioavailability (41.18%) of lutein. This study proposed a novel strategy for improving the performance of protein gels, which also provided the potential for co-encapsulation of multi-component bio-actives via the porous CD-MOFs and compartmentalized chamber within the W/O/W emulsion
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Jun Luo,Chengcheng Ding,Yonghai Gan,Yang Guo,Yibin Cui,Cheng Sun
A dual-MOFs (Fe and Co)/g-C 3 N 4 heterojunction composite was successful constructed and used to activate peroxymonosulfate (PMS) for degrading sertraline (SER). The composite showed outstanding catalytic activity with 100% of SER removal efficiency in 60 min and the degradation rate 0.057 min −1 . At the same time, the amount of catalyst, concentration of PMS and environmental pH on the degradation for SER were investigated in detail. The main degradation products and pathways of SER were analyzed by Gaussian theory calculation and high-performance liquid chromatography-mass spectrometry (HPLC-MS). Based on the free radical quenching experiments and electron paramagnetic resonance (EPR) characterization analysis, it was confirmed that •OH and SO 4 •- were produced in the catalytic reaction process, and explained catalytic mechanism elaborately. This work demonstrates the connection of MOF-Fe nanoparticles , micropores and heterojunction with the catalytic activity, providing an efficient catalytic system that can promote electron transfer and circulation of high activity center.
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ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Rui Jiao,Yanming Wang,Yuxia Pang,Dongjie Yang,Zhixian Li,Hongming Lou,Xueqing Qiu
Metal–organic frameworks (MOFs) have become promising accommodation for enzyme immobilization in recent years. However, the microporous nature of MOFs affects the accessibility of large molecules, resulting in a significant decline in biocatalysis efficiency. Herein, a novel strategy is reported to construct macroporous MOFs by metal competitive coordination and oxidation with induced defect structure using a transition metal (Fe2+) as a functional site. The feasibility of in situ encapsulating β-glucosidase (β-G) within the developed macroporous MOFs endows an enzyme complex (β-G@MOF-Fe) with remarkably enhanced synergistic catalysis ability. The 24 h hydrolysis rate of β-G@MOF-Fe (with respect to cellobiose) is as high as approximately 99.8%, almost 32.2 times that of free β-G (3.1%). Especially, the macromolecular cellulose conversion rate of β-G@MOF-Fe reached 90% at 64 h, while that of β-G@MOFs (most micropores) was only 50%. This improvement resulting from the expansion of pores (significantly increased at 50–100 nm) can provide enough space for the hosted biomacromolecules and accelerate the diffusion rate of reactants. Furthermore, unexpectedly, the constructed β-G@MOF-Fe showed a superior heat resistance of up to 120 °C, attributing to the new strong coordination bond (Fe2+–N) formation through the metal competitive coordination. Therefore, this study offers new insights to solve the problem of the high-temperature macromolecular substrate encountered in the actual reaction.
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Journal of Materials Chemistry C
·
2022
·Vol. 10
·期 9
·3576-3584
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IF 8.067
Yu Zhang,Xin Xu,Bing Yan
Lanthanide metal organic frameworks (Ln-MOFs) as excellent fluorescent materials have shown enormous potential applications, especially in fluorescence sensing and anticounterfeiting. However, very few examples of Ln-MOFs can realize both fluorescence sensing and anticounterfeiting simultaneously based on the same fluorescence response mechanism. Herein, a multifunctional platform constructed by a multicolour-switchable fluorescent Ln-MOFs (isostructural Eu-MOFs and Tb-MOFs) triggered by anti-cancer drugs (6-MP and 6-TG) were prepared by a simple hydrothermal method. The multifunctional platform is composed of a sensing platform for detecting anti-cancer drugs and an anticounterfeiting platform for information on encryption and decryption. The sensing platform based on Eu-MOFs exhibits great selectivity, high sensitivity, and low detection limit toward anti-cancer drugs (6-MP and 6-TG) with the assistance of sensing intermedium (Cu2+). On the other hand, multiple and switchable fluorescent colours (purple–red–blue/cyan–green–blue) triggered by Cu2+ and 6-MP/6-TG make the prepared Ln-MOFs inks good luminescent materials to build an anticounterfeiting platform with high-level security. This work illustrates the inspiring and promising applications of luminescent Ln-MOFs in anti-drug sensing and information of anticounterfeiting for the first time and will open the possibility of the design of Ln-MOFs with tuneable and multiple luminescence as a multifunctional optical platform.
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CELLULOSE
·
2022
·Vol. 29
·期 12
·6783-6796
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IF 6.123
Yu Shimo,Zhao Xinfu,Zhang Jing,Liu Sijia,Yuan Zhipeng,Liu Xiaochan,Liu Benxue,Yi Xibin
High CO 2 concentration in atmosphere causes serious environmental issues, and carbon capture and storage technologies have attracted attention as a means to reduce the atmospheric CO 2 concentration. Metal-organic frameworks (MOFs) can potentially be used for CO 2 adsorption, but their poor stability and microporosity limit their applications. Herein, a novel strategy was proposed to combine a cellulose aerogel and hierarchically-porous MOFs (HP-MOFs) with larger pores. According to this strategy, a series of microcrystalline cellulose/HP-UIO-66-NH 2 hybrid aerogels (MC-HUN-X) was constructed by adding a modulator (monocarboxylic acid, MA), followed by the in-situ growth of HP-UIO-66-NH 2 on a cellulose aerogel. By adjusting the chain length of MA, the structure–function relationship between pore size and the CO 2 adsorption capacity of MC-HUN-X was explored. The results showed that the CO 2 adsorption capacity increased first and then decreased upon increasing the MOFs pore size, while the adsorption selectivity of CO 2 continuously increased. Among all samples, MC-HUN-4 with a moderate pore size had the highest CO 2 adsorption capacity (1.90 mmol/g at 298 K and 1 bar) and adsorption selectivity (13.02 and 2.40 for CO 2 /N 2 and CO 2 /CH 4 ). The combination with a cellulose aerogel endowed MC-HUN-X with excellent mechanical stability and reusability. Graphical abstract Cellulose/HP-UIO-66-NH 2 hybrid aerogel with larger aperture sizes of MOF showed excellent adsorption capacity and selectivity for CO 2 , and the combination with aerogel could effectively improve the mechanical stability and reusability.
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CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Zhiqun Xie,Zhiping Lyu,Jinnan Wang,Aimin Li,Philippe François-Xavier Corvini
Ultrafine-Mn 2 O 3 @N-doped porous carbon hybrids [Mn 2 O 3 @NC] derived from Mn-MOFs was constructed with 1 O 2 and O 2 −• as main Reactive oxygen species (ROS). Cation-π bonds and N-Mn complexation induced the formation of electron-rich Mn centre which provided electron for peroxymonosulfate activation to produce radicals, accompanying with generation of 1 O 2 via chain reaction. Notably, the porous structure of N-doped carbon shell could not only facilitate free radical recombination for generation of 1 O 2 but also provide adsorption sites for organics. On the other hand, as electron-poor centre, N-doped carbon shell could improve the electrons transfer from organic intermediate radicals to electron-rich Mn centre via π -π reaction, C-O-Mn and C-N-Mn bonds, which promote the redox of Mn to avoid peroxymonosulfate invalid decomposition. Being attributed to synergistic effects of dual-reaction centres and strong oxidation ability of 1 O 2 , Mn 2 O 3 @NC achieved high mineralization of BPA at low-dose peroxymonosulfate (0.033 g/L).
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ELECTROCHIMICA ACTA
·
2021
·
IF 6.901
Cuizhu Ye,Xingguang Chen,Dong Zhang,Junjun Xu,Huiting Xi,Tiantian Wu,Danwen Deng,Chunhong Xiong,Jinsheng Zhang,Ganhui Huang
Coated with polypyrrole (Ppy)-based molecularly imprinted polymer (MIP), 3D CoFe-metal organic frameworks (CoFe-MOFs) with gold nanoparticles (AuNPs) was developed for electrochemical trace detection of norfloxacin (NOR). On one hand, the trace detection of NOR was realized with MIP/CoFe-MOFs/AuNPs/Glassy carbon electrode (GCE). The effective surface area of the imprinted cavities capable of identifying NOR on MIP/CoFe-MOFs/AuNPs/GCE increased to 0.1058 cm 2 after 3D CoFe-MOFs/AuNPs was modified, which indicates that CoFe-MOFs/AuNPs could generate more imprinted cavities, thus contributing to a lower limit of detection (LOD) of 0.131 pmol L −1 (S/N = 3) with a wider linear range (5–100, 100–1000 and 1000–6000 pmol L −1 ). On the other hand, the recognition reaction to NOR by MIP/CoFe-MOFs/AuNPs/GCE is an irreversible electrochemical oxidation reaction involving an electron and a proton, controlled by a mixed adsorption-diffusion mechanism. Rapid and precise detection of NOR in prescription (norfloxacin capsules with the specification of 0.1 g) and pure milk with the recovery rates between 97.04 and 110.2% and the relative standard deviations (RSD) were less than 5.7%. The measured results by MIP/CoFe-MOFs/AuNPs/GCE were close to the commercial norfloxacin enzyme-linked immunosorbent assay (ELISA) kit, demonstrates its high potential to NOR trace detection in environmental and animal foods.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2021
·
IF 5.316
Wei Liu,Liang-Min Ning,Shao-Qing Li,Wei-Xing Liu,Qiang Zhang,Jia Shao,Jin-Lei Tian
A rational and convenient strategy was designed to synthesize high level N-doped Co@NCNTs composites derived from adenine-based AD-MOF-1 and Bio-MOF-11 via one-step pyrolysis method. Adenine can be used as an endogenous nitrogen source to apparently increase the N content of the materials. N-rich CNTs form a protecting layer for Co nanoparticles to avoid the aggregation of metal nanoparticles . The abundant nitrogen content can enhance electronic conductivity and bring additional active sites. The prepared Co@NCNTs display high catalytic efficiency for various nitro aromatics reduction in aqueous solution. The Co@NCNT-1-800 implies outstanding catalytic efficiency of 96% for the reduction of 4-NP. A mechanistic analysis revealed the abundant Co catalytic sites on the surface of catalysts to promote electron transfer efficiency and improve catalytic performance significantly. Moreover, the magnetic Co-based catalysts remained excellent catalytic activity and reusability even after five cycles.
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TALANTA
·
2020
·
IF 5.339
Chao Xia,Yan Xu,Meng-Meng Cao,Yun-Peng Liu,Jin-Feng Xia,Dan-Yu Jiang,Guo-Hong Zhou,Rong-Jun Xie,Da-Feng Zhang,Hui-Li Li
In the present study, a kind of Eu(III) post-functionalized Zr(IV)-based metal-organic framework (UiO-66(COOH) 2 , Zr-MOF: Eu 3+ ) was synthesized and utilized as an independently luminescent probe for sensing bilirubin (BR) in human serum, a biomarker of jaundice hepatitis. It can be served as a turn-off fluorescent switch for BR because its red emission from Eu 3+ can be easily quenched by BR through a fluorescent resonant energy transfer (FRET) process between BR and its ligands, and as a result, BR is recognized successfully. Particularly, Zr-MOF: Eu 3+ has shown many appealing properties, such as high sensitivity, quick response (less than 1 min), broad response window (0–15 μM), and excellent selectivity. Most importantly, a kind of portable test paper based on Zr-MOF: Eu 3+ probe has been developed for directly assessing the level of BR in real human serum and further diagnosing bilirubin-related diseases via visually observing the luminescent color variation.
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RSC Advances
·
2020
·Vol. 10
·期 6
·3084-3091
·
IF 3.119
Caixue Lin,Hailu He,Yongqi Zhang,Mingyue Xu,Feng Tian,Ling Li,Yingxi Wang
In recent years, the construction of drug carriers that integrate diagnosis and treatment has become a new trend. In this article, a metal–organic framework (Zr-MOF) was synthesized and functionalized using acetaldehyde-modified-cystine (AMC) to form the functional drug carrier Zr-MOF/AMC which could be used to determine the concentration of glutathione (GSH) for cancer diagnosis, and to achieve pH/GSH dual-responsive release of methotrexate (MTX) for cancer therapy. The cleavage of the AMC disulfide bond by GSH generates two fluorescent molecules that produce strongly enhanced fluorescence, and the intensity is proportional to the GSH concentration. The green fluorescence of Zr-MOF/AMC in cancer cells proves that it can be applied in cell imaging to detect abnormal GSH concentrations for early diagnosis. In addition, MTX loaded on the Zr-MOF/AMC is released by the cleavage of the –S–S– and –CN– bonds at the high GSH concentration and low pH in cancer cells. This dual-responsive drug release helps to deliver drugs to cancer cells more precisely. All the experiments suggest that this novel type of pH/GSH dual-responsive Zr-MOF/AMC nanoparticle may serve as a new drug delivery system for cancer diagnosis and treatment.
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