Advanced Science
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2025
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IF 14.1
Yueyang He,Jinyan Lin,Jingwen Bai,Xiao Shen,Kangliang Lou,Yuanyuan Zhu,Zishan Qiao,Weiling Chen,Yang Li,Xiaolong Liu,Guojun Zhang
Breast-conserving surgery (BCS) has become the standard care for early-stage breast cancer. The accurate assessment of tumor margins is urgently required for BCS because positive resection margins often lead to local recurrence. To address this clinical dilemma, a Hf(IV)-coordinated NIR-II fluorescence “turn-on” nanoprobe based on the clinically approved NIR-II fluorescent dye indocyanine green (ICG) for intraoperative tumor visualization is developed. Notably, the fluorescence of ICG can be efficiently quenched by Hf(IV) and subsequently recovered in vivo, showing a remarkable fluorescence “quenching-recovery-amplification” capacity. This nanoprobe can effectively accumulate in tumor sites, accurately identifying submillimeter-sized primary and residual tumors with high sensitivity. In addition, subcutaneous, muscle-infiltrating, and orthotopic breast cancer models are built to repeatedly prove that this ultrasensitive nanoprobe is feasible for precise imaging-guided surgery in breast cancer. Overall, this study constructs an activatable fluorescent nanoprobe for real-time intraoperative tumor margin visualization, holding promise for complete surgical resection and reduction of local recurrence.
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PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2024
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IF 5.1
Kai Lv,Xu Liang,Qinglin Yao,Liangmiao Zhang,Zongtao Zhang,Yanfeng Gao
This work reports a series of yellow-green near-infrared (NIR) reflective pigments, Ba(Mg 6-x-y Zn y Ti 6-x Cr 2x )O 19 (x = 0–1.0, y = 0–2.5), with strong NIR reflectivity for solar thermal energy regulation. Comprehensive analyses were carried out to characterize the obtained pigments including X-ray diffraction, scanning electron microscopy, X-ray photoelectron spectroscopy, UV–Vis–NIR spectrophotometry, and CIE L*a*b* color measurement. Absorption spectra of Ba(Mg 6-x Ti 6-x Cr 2x )O 19 showed that the yellow-green absorption is attributed to the octahedrally coordinated Cr 3+ with d-d electron transitions of 4 A 2 (F)→ 4 T 1 (F) and 4 A 2 (F)→ 4 T 2 (F). However, their broad absorption peak centered at 1200 nm severely deteriorated the insulating properties of the pigments. Through substituting Mg with Zn, the obtained pigment Ba(Mg 2.5 Zn 2.5 Ti 5 Cr 2 )O 19 showed an excellent NIR solar reflectance (R* = 67 %) with color performances (L* = 61.98, a* = −18.72, b* = 22.23). EnergyPlus simulation results show that for a warm city (Haikou), the Ba(Mg 2.5 Zn 2.5 Ti 5 Cr 2 )O 19 coating for the external surface of a model house (TSR = 35 %, R* = 55 %) can reduce annual cooling energy consumption by 8 % of the house.
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高影响因子
Advanced Optical Materials
·
2024
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IF 8
Min Zhang,Peipei Dang,Yujia Wan,Yingsheng Wang,Zixun Zeng,Dongjie Liu,Qianqian Zhang,Guogang Li,Jun Lin
Visible-to-near-infrared (VIS-NIR) luminescent materials are in great demand in the field of non-destructive testing such as component determination and hyperspectral imaging. Although Cr 3+ -activated phosphors are widely reported, controllable tailoring ultra-wide VIS-NIR luminescence excited by blue light is still a challenge. The strategies of cationic substitution and energy transfers are effective for adjusting the luminescence of Cr 3+ -activated phosphors. In this work, a series of Cr 3+ -doped Sc-based solid solution phosphors (Ba 3-m Sr m Sc 4 O 9 :Cr 3+ ) are reported. Under the excitation of blue light, these phosphors exhibit broadband emission due to the different luminescence centers induced by Cr 3+ occupying different cationic sites. Because of the weaker crystal field strength, Cr 3+ realizes a broadband emission with a longer peak position (λ em = 820 nm) and broader full width at half maximum (FWHM≈182 nm) in Ba 2 SrSc 4 O 9 . Furthermore, Ce 3+ /Yb 3+ ions are introduced into Ba 2 SrSc 4 O 9 :Cr 3+ , achieving an ultra-wide VIS-NIR luminescence (460–1200 nm) by the Ce 3+ →Cr 3+ →Yb 3+ multiple energy transfers. Designing energy transfers is beneficial to improve the quantum efficiency and weaken the thermal quenching. Finally, the NIR phosphor-converted light-emitting diode (pc-LED) fabricated by Ba 2 SrSc 4 O 9 :Cr 3+ demonstrates great potential in night-vision and water component detection. This work provides an effective design idea for controllable tailoring ultra-wide VIS-NIR luminescence by chemical substitution and energy transfer.
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高影响因子
OPTICAL MATERIALS
·
2025
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IF 4.2
Sihan Yang,Xinyu Li,Qian Zhang,Meiting Li,Xuejiao Wang,Nan Wu
Studies have shown that emissions in the NIR-II and NIR-III regions exhibit high tissue penetration, along with superior performance in biological and medical imaging applications. Therefore, developing NIR phosphors capable of simultaneously show emissions in both the NIR-II and NIR-III regions holds significant value. Herein, we developed a novel Cr 3+ /Er 3+ co-doped NaBaScSi 2 O 7 phosphor that demonstrates efficient dual-band emission in both NIR-II and NIR-III regions under visible light excitation, enabled by highly effective Cr 3+ →Er 3+ energy transfer. The energy transfer efficiencies calculated by the emission intensity and fluorescence lifetime are 65.3% and 47.4%, respectively, with the energy transfer mechanism dominated by dipole-dipole interaction. The prepared phosphor can be effectively excited by multiple excitation sources (378 nm, 492 nm, 808 nm, and 980 nm), generating distinct emission responses, highlighting its potential for anti-counterfeiting applications. Additionally, the distinct temperature-dependent optical properties of Cr 3+ and Er 3+ offer a viable approach for non-contact temperature detection, achieving a relative sensitivity of 0.8% K -1 and a temperature resolution of 0.126 K at 498 K. The NIR-II/III pc-LED fabricated by NaBaScSi 2 O 7 : 1%Cr 3+ , 0.2%Er 3+ demonstrates outstanding non-invasive imaging capability and accurate predictions for organic solvents. This study presents a strategy for developing phosphors capable of simultaneous NIR-II/III emission, and significantly advances their multifunctional applications in NIR optical thermometry and NIR pc-LED technologies.
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高影响因子
DYES AND PIGMENTS
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2025
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IF 4.2
Mingdi Yang,Kaiwen Li,Yingcui Bu,Lixin Ma,Yingyong Ni,Jing Huang,Jingyan Zhang,Hongping Zhou
The development of organic molecules activated by near-infrared II (NIR-II) light holds considerable potential for deep image-guided disease diagnosis and therapeutic applications. However, the design and synthesis of such materials remain a significant challenge due to limitations in controllable molecular architecture. In this study, two small molecules, TPEPyC2 and DTPEPyC5 , were firstly synthesized. Subsequently, their respective assemblies, namely TPEPyC2@HSA and DTPEPyC5@HSA , were obtained through co-assembled with the hydrophobic human serum albumin (HSA). Comprehensive analyses demonstrated that only DTPEPyC5@HSA exhibited superior photostability, biosafety, and a large three-photon absorption cross-section (3.85 × 10 −80 cm 6 s 2 ). Notably, this probe enabled precise mitochondrial targeting in live HepG2 cells, as indicated by a co-localization coefficient of Pr = 0.88, and achieved tumor tissue penetration of 143 μm using three-photon fluorescence imaging. This bio-protein encapsulation strategy provides a novel molecular design framework for developing NIR–II–excitable fluorescent probes, thereby significantly enhancing their imaging performance.
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高影响因子
ACS Applied Materials & Interfaces
·
2024
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IF 8.3
Hanyu Hu,Zeyu Lyu,Dashuai Sun,Shuai Wei,Jia Liu,Xin Wang,Luhui Zhou,Hongpeng You
Although there have been numerous reports on broadband near-infrared (NIR) emitting phosphors, their emissions are mainly concentrated in the range of 700–1000 nm (NIR-I). Herein, we successfully synthesized a broadband near-infrared phosphor CaMgGeO4:Cr4+(CMG:Cr4+) with an emission in the range of 1000–1600 nm (NIR-II). The introduction of Er3+ ions into CMG:Cr4+ resulted in a wider near-infrared emission phosphor CaMgGeO4:Cr4+,Er3+ (fwhm = 361 nm), compensating for the luminescence of 1500–1600 nm. More importantly, an energy transfer from Cr4+ to Er3+ ions has been discovered. Furthermore, a NIR pc-LED was fabricated by combining the CMG:Cr4+,Er3+ phosphor with a 590 nm chip. The changes in intensity and profile of the transmission spectra of light passing through different liquids reveal its potential application in organic compound recognition. This work opens a direction for the development of NIR-II phosphors.
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高影响因子
Advanced Science
·
2025
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IF 14.1
Jiang Shi,Erkui Yue,Xuejin Zhu,Lin Zhao,Weifeng Chen,Xiangqun Yu,Hongliang Huang,Ying Qian,Zhengfang Zhang,Jianguo Wu
In fresh maize breeding, developing robust and accurate near-infrared (NIR) calibration models traditionally requires significant time, cost, and labor. To address these challenges, a novel machine learning approach is proposed using a Prediction-Correction Neural Network (PCNN) that enables effective modeling from small sample sets augmented with synthetic data based on NIR spectroscopy. For key quality traits such as amylopectin, protein, crude fiber, and total sugar, the PCNN achieved residual predictive deviation (RPD) values between 2.821 and 4.862, and coefficients of determination ( R V 2 $R_V^2$ ) ranging from 0.869 to 0.951, using an average of only 32 calibration samples. For sugars including fructose, glucose, and sucrose, the model yielded RPD >2 and R V 2 ≥ 0.747 $R_V^2 \ge 0.747$ with just 62 samples. The PCNN method has also been successfully applied to NIR model development for small sample sets in intact kernel of fresh maize and other crops, including forage maize, rice, wheat, and barley. Compared to Partial Least Squares (PLS) and traditional Artificial Neural Networks (ANN), PCNN delivered RPD improvements of 38.99%−63.20% over PLS and 7.07%−25.82% over ANN. These results highlight the PCNN's high efficiency and accuracy, offering a scalable and cost-effective solution for rapid quality evaluation in fresh maize and other cereals.
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高影响因子
APPLIED SURFACE SCIENCE
·
2025
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IF 6.9
Chen Zhang,Chuan Ding,Mingyue Li,Jinyang Zhou,Tao Yuan,Zhemin Shen
The infrared energy of the sun’s rays accounts for more than 40 %. Heterostructures were constructed to enable broad-spectrum response of photocatalysts, and enhance the utilization of sunlight, especially that of infrared lights. A robust heterostructured upconversion composite material decorated with Ag nanoparticles (AgNPs), β-NaLuF 4 @ NaLuF 4 :Yb 3+ ,Tm 3+ @ AgNPs@BiOBr (NLF@NLFT@Ag@Bi), was built through a multi-step hydrothermal method. NLF@NLFT@Ag@Bi demonstrates enhanced photocatalytic activity under UV–Vis-NIR, Vis-NIR, and NIR irradiation compared to pure BiOBr and NLF@NLFT@Ag/BiOBr mixture, achieving 99 % Rhodamine B (RhB) degradation in 0.5 h (UV–Vis-NIR) and 96 % in 3 h (NIR), with degradation over 80 % for Bisphenol A (BPA), Norfloxacin (Nor), and Methyl Orange (MO) in 3 h (UV–Vis-NIR). The upconversion luminescence (UCL) of NLF@NLFT@Ag is tuned by its core–shell structure and AgNPs’ plasmonic effect, while NLF@NLFT@Ag@Bi’s enhanced photocatalysis arises from boosted UCL and AgNPs-facilitated Förster resonance energy transfer (FRET) between NLFT and BiOBr. The material’s efficacy in infrared-driven photocatalysis offers a prospective approach for extending catalyst response ranges. It greatly enhances degradation effects of organic pollutants under sun’s rays.
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高影响因子
Materials Today Bio
·
2025
·
IF 10.2
Wenkang Liu,Tao Wu,Wenxuan Ye,Mingyang He,Jianfu Zhao,Wei Xue,Siming Yu
Currently, Pseudomonas aeruginosa ( P. aeruginosa ) infections pose a significant threat to public health, owing to the high morbidity, mortality and antibiotic resistance. Alkyl radical (AR)-based photodynamic therapy exhibits great potential in antibacterial applications due to its oxygen-independent advantage. Nevertheless, targeted delivery systems capable of precisely controlling AR release at bacterial infectious foci are still lacking. In the present work, a mesoporous gold nanorod (mGNR)-based multifunctional nanogenerator with P. aeruginosa -targeting and near infrared (NIR) laser-controlled AR release properties was fabricated for enhanced bacterial wound treatment. Herein, mGNR with mild-photothermal therapeutic (MPTT) effect was firstly synthesized and used as a carrier for effective loading of an AR initiator 2, 2′-azobis[2-(2-imidazolin-2-yl)propane]-dihydrochloride (AIPH). Then, cysteamine and polymer of HOOC-PEG 5000 -Mal were added in sequence to functionalize the nanosystem, obtaining nanogenerator of mGNR@AIPH@PEG-Mal. Due to the specific maleimide (Mal) and Type IV Pilus (T4P) reaction, mGNR@AIPH@PEG-Mal displayed high binding efficiency on P. aeruginosa . Upon NIR laser irradiation, mGNR@AIPH@PEG-Mal triggered AIPH cleavage to generate substantial amount of AR, which enabled high-efficient inhibition on P. aeruginosa and biofilms via the synergistic MPTT/AR antibacterial effect. Moreover, mGNR@AIPH@PEG-Mal exhibited excellent antibacterial and wound healing effect on P. aeruginosa infectious rats’ wounds. In-depth mechanism study revealed that the synergistic MPTT/AR therapeutic effect of mGNR@AIPH@PEG-Mal induced P. aeruginosa death by breaking bacterial membrane, triggering ROS boost, GSH depletion and DNA damage, as well as promoted wound healing by repolarizing M2-type macrophages and upregulating CD 31 and α-SMA expressions.
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高影响因子
ACS Applied Materials & Interfaces
·
2025
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IF 8.2
Fengtian Zhang,Weihong Luo,Zhongjie Min,Darong Lu,Weiliang Chen,Lijuan Wen
Targeted mitochondrial-based therapeutic strategies for tumors have emerged as a significant research focus in the field of cancer treatment in recent years. Mitochondria, often referred to as the “energy factory” of cells, play a crucial role in the metabolic reprogramming of tumor cells, as well as in oxidative stress and immune evasion. In this study, we utilized a mitochondria-targeted photosensitizer, IR780, to engineer Celastrol (Cela)-loaded lipid nanoparticles, designed as Cela@Lip-IRH, for the synergistic therapy of chemotherapy and photodynamic therapy (PDT) against glioma. Cela@Lip-IRH could respond to the weakly alkaline environment of tumor cell mitochondria for rapid Cela release. Leveraging the mitochondrial targeting capacity and PDT property of IR780, Cela@Lip-IRH nanoparticles showed enhanced cellular uptake and mitochondria targeting distribution in vitro, as well as obvious tumor accumulation in vivo. Cela@Lip-IRH nanoparticles exhibited prominent intracellular reactive oxygen species (ROS) generation upon NIR laser irradiation, which was accompanied by pronounced photocytotoxicity and cell apoptosis, finally producing remarkable tumor growth suppression efficacy in vivo. We further verified that the potential antitumor molecular mechanism was triggered by the release of Cytochrome C, leading to an activated mitochondrial apoptosis pathway, alongside an immune response characterized by enhanced recruitment of CD4+ T cells and CD8+ T cells in tumor tissues. Currently, this mitochondria-targeted nanoplatform presents an ideal method to enhance the synergistic performance of chemotherapy and PDT in glioma, and it is anticipated that such a strategy will provide a promising alternative to optimize the tumor-targeted therapies.
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高影响因子
Talanta Open
·
2025
·
IF 3.7
Sha Li,Qin Li,Zhihui Yang,Wei Wen,Miao Yan,Haixian Ren
Hydrogen sulfide (H 2 S), a critical gasotransmitter governing physiological functions, presents significant environmental and food safety hazards at aberrant concentrations. Concurrently, mitochondrial viscosity serves as a vital biomarker for cellular pathologies. To address the unmet need for precise dual-parameter monitoring, we engineered a mitochondria-targeted near-infrared (NIR) ratiometric fluorescent probe, T-N , enabling simultaneous and discriminative detection of H 2 S and viscosity through discrete emission channels. The probe exhibits ultrarapid response (<30 s), exceptional sensitivity, and superb selectivity against competing analytes. Leveraging H 2 S-triggered chromogenic shifts, T-N -immobilized test strips facilitate instrument-free, semi-quantitative assessment of food spoilage, validated across environmental waters and industrially relevant beer samples. Moreover, T-N achieves synchronous dual-channel imaging of endogenous/exogenous H 2 S and viscosity dynamics in live cells, with verified mitochondrial localization. This work establishes a versatile sensing platform for tracking H 2 S and viscosity in interconnected environmental, food safety, and biomedical contexts.
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高影响因子
Advanced Healthcare Materials
·
2024
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IF 10
Jing Wang,Yi Zhang,Huadong Chen,Yihan Wu,Jinliang Liu,Hailong Che,Yong Zhang,Xiaohui Zhu
Tumor microenvironment, characterized by dense extracellular matrix and severe hypoxia, has caused pronounced resistance to photodynamic therapy (PDT). Herein, it has designed an artificial nitric oxide (NO) nanotractor with a unique “motor-cargo” structure, where a photoswitching upconversion nanoparticle (UCNP) core serves as the optical engine to harvest NIR light and asymmetrically coated mesoporous silica (SiO 2 ) shell acts as a cargo unit to load nitric oxide (NO) fuel molecule (RBS, Roussin's black salt) and PDT photosensitizer (ZnPc, zinc phthalocyanine). Upon illumination by 980 nm light, the UCNP emits blue light to excite RBS salt and release NO gas. On one hand, NO is used as the driving force to propel the particle with a high speed of ≈194 µm s −1 that generates significant rupture stress (over 0.95 kPa) on cell membrane to promote cellular endocytosis and intratumoral penetration. On the other hand, NO enables to alleviate tumor hypoxia by inhibiting cellular respiration as an oxygen conserver. When the excitation is subsequently switched to 808 nm light, the UCNP emits red light, triggering ZnPc to produce large amount of reactive oxygen species for PDT treatment. This study explores Janus-typed nanostructures for cell-particle interaction and gas-assisted phototherapy, opening avenues for versatile bioapplications.
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高影响因子
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