Crystals
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2017
·Vol. 7
·期 2
·45
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IF 1.566
Yaling Li,Yong Ye,Yunde Fan,Ji Zhou,Li Jia,Bin Tang,Xungai Wang
We reported the fabrication of an in situ surface-enhanced Raman scattering (SERS) monitoring platform, comprised of a porous eggshell membrane (ESM) bioscaffold loaded with Ag nanoprism via an electrostatic self-assembly approach. The localized surface plasmon resonance (LSPR) property of silver nanoprism leads to the blue color of the treated ESMs. UV-vis diffuse reflectance spectroscopy, scanning electron microscope (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) measurements were employed to observe the microstructure and surface property of Ag nanoprisms on the ESMs. The silver nanoprism-loaded eggshell membrane (AgNP@ESM) exhibited strong catalytic activity for the reduction of 4-nitrophenol by sodium borohydride (NaBH4) and it can be easily recovered and reused for more than six cycles. Significantly, the composites also display excellent SERS efficiency, allowing the in situ SERS monitoring of molecular transformation in heterogeneous catalysis. The results indicate that the AgNP@ESM biocomposite can achieve both SERS and catalytic functionalities simultaneously in a single entity with high performance, which promotes the potential applications of ESM modified with functional materials.Keywords:eggshell membrane;silver nanoprism;catalysis;SERS
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Science China-Chemistry
·
2016
·Vol. 59
·期 8
·1045-1050
·
IF 2.429
Zhen Shujun,Wu Tong,Huang Xin,Li Yuanfang,Huang Chengzhi
We report a new strategy to prepare gold nanoflowers (AuNFs) using a two-step seed-mediated method. The as-prepared AuNFs were employed as surface-enhance Raman scattering (SERS) substrates, showing strong signal enhancement. We further found that iodide ions (I – ) could selectively induce the morphological transformation of AuNFs to spheres, resulting in a blue-shift of the localized surface plasmon resonance (LSPR) bands, a color change of the AuNFs solution from blue to red, and decreased SERS activity. This behavior allows the AuNFs to be used in the determination of I – .
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BIOSENSORS & BIOELECTRONICS
·
2016
·
IF 7.476
Long Wu,Xiaoyan Xiao,Kun Chen,Wenmin Yin,Qin Li,Pan Wang,Zhicheng Lu,Jing Ma,Heyou Han
Abstrcact Highly sensitive and selective detection of specific DNA sequences is of great importance in clinical diagnosis, environmental and food monitoring, but it still remains challenges to develop a facile method for real sample detection in aqueous solution. Here, a simple and recyclable surface enhanced Raman scattering (SERS) sensor was constructed for Bacillus thuringiensis (Bt) special gene fragment detection by Fe 3 O 4 magnetic beads (MBs) and Au–Ag core-shell nanorods (Au@Ag NRs). A hairpin DNA with sulfhydryl and biotin was attached to Au@Ag NRs as indicator, and MBs with streptavidin (SA) were acted as the capture probe. On the basis of the biotin–SA specific interaction, target sequences were first hybridized with the hairpin DNA and exposed the biotin. Subsequently, the Au@Ag NRs were captured by the streptavidin modified MBs, which reduced the suspended NRs and led to the change of Raman intensity . Under the optimal conditions, the SERS intensity revealed a good linearity with Bt transgene fragment ranging from 0.1 pM to 1 nM with a detection limit of 0.14 pM (S/N=3). To demonstrate the specificity of the strategy, the single-base mismatch in DNA was discussed in the SERS assay. The results showed that the sensitivity and accuracy of the proposed method was acceptable in DNA detection, revealing a great potential in special gene detection.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Jing-Xiang Wang,Yan-Dan Qin,Ri-Hui Su,Wei-Wei Zhu,Song-Song Zhao,Shu-Fang Zhang,Xue-Cai Tan,Ke-Jing Huang,Jun Yan
A flexible 3D plasmonic starch aerogel substrate was fabricated for susceptible detection of thiabendazole (TBZ) and doxycycline hydrochloride (DH). Based on the unique structure features of starch, an aerogel with high porosity and a large specific surface area was formed without any extra cross-linking agents. Silver nanoparticles (Ag NPs) uniformly distribute throughout starch aerogel and generate dense hot spots while aerogel structure collapses, which leads to significant SERS enhancement. The as-prepared aerogel substrate exhibits good SERS activity with a low detection limit of 1 × 10 −10 M for rhodamine 6G and 1 μg/L for 4-Aminothiophenol (4-ATP). In practical application for real sample, the TBZ residue on the surface of citrus was successfully detected by wipe sampling, with a good recovery rate of 96.2 %–98.8 % and a low limit of detection (LOD) of 0.031 mg/L range from 0.1 to 100 mg/L. The substrate also exhibited excellent performance in detecting DH in chicken, with recovery rates ranging from 96.9 % to 98.1 %. The LOD was 0.066 mg/L, and the detection range spanned from 0.1 to 100 mg/L. Results demonstrate that the prepared aerogel is an ideal material as a SERS substrate due to its unique properties such as strong adsorption capacity, dense hot spot, and ease of use. Therefore, the developed SERS platform-based flexible 3D plasmonic aerogel substrate paves a new avenue for highly sensitive SERS detection in the field of food safety.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2024
·
IF 4.3
Haoyu Cai,Guojun Weng,Jianjun Li,Gaofeng Wu,Jian Zhu,Junwu Zhao
Gold deposition on Au nanoparticles is a common method to control the shape and further modify the properties of nanoparticles as their properties have a strong correlation with their nanostructures. For Au nanobipyramid (Au NBP), it has advantages such as the enhancement of electric field and a higher tunability in plasmon wavelength than the Au nanorod and thus owns a greater potential in shape control. In this paper, we demonstrate a scheme of depositing Au on the surface of Au NBP with the presence of a type of ligand 2-mercaptobenzoimidazole-5-carboxylic acid (MBIA) to synthesize Au NBP@Au dimers. The growth mode of Au depositing on Au NBP can be controlled by the coverage of MBIA. As the coverage is low, with a concentration of MBIA below 0.4 mM, the rough core–shell nanostructure is synthesized; However, as the coverage is high, with a concentration of MBIA over 0.8 mM, gold deposition may form islands on the surface of Au NBP. The SERS performance of Au depositing on Au NBP can also be enhanced by growth mode. For the rough-surface core–shell growth mode, the enhancement is more significant as the EF is improved from 3.5 × 10 5 to 1.06 × 10 6 than the islands-growing growth mode due to the coupling between core and shell. And our results show that with multiple types of nanosturctures easy to obtained by changing modified ligand coverage, the controlled growth has a great potential in the dimer design and SERS enhancement using Au NBP.
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TALANTA
·
2024
·
IF 5.6
Tao Gai,Jiaolai Jiang,Shaofei Wang,Ling Zhang,Yiming Ren,Zhen Qin,Qian Wu,Jun Zhang,Junsheng Liao
Uranium is an essential nuclear material in civilian and military areas; however, its extensive application raises concerns about the potential safety issues in the fields of environmental protection and nuclear industry. In this study, we developed an Ag/Ag 2 O–COF (covalent-organic framework) composite SERS substrate to detect uranyl ions (UO 2 2+ ) in environmental aqueous solutions. Herein, the strong SERS effect of uranyl adsorbed in Ag/Ag 2 O composite and the high adsorption efficiency of COF TpPa-1 were combined to realize the trace detection of uranyl ions. This method displayed a linear range of 10 −8 mol L −1 to 10 −6 mol L −1 with the detection limit of 8.9 × 10 −10 mol L −1 for uranyl ions. Furthermore, common metal cations and oxo-ions hardly affected the SERS detection of uranyl, which is helpful for the trace analysis of uranyl in natural water samples. Although the proposed strategy is deployed for uranyl detection, the reusable and high-efficiency system may be expanded to trace detection of other substance with Raman activity.
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APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Shenghui Yi,Mingde Yang,Yixin Yu,Zebiao Li,Deng Zhang,Fengwan Han,Aleksei Grishko,Ye Li,Qinghua Qin,Binbin Zhou
Compared to rigid surface-enhanced Raman scatting (SERS) substrates, flexible SERS substrates offer significant advantages for the detection of pesticide residues on vegetable and fruit surfaces, primarily due to their convenient sampling process and shorter detection times. However, for paper-based SERS substrates, gold nanoparticles (AuNPs) are easy to form ineffective dispersion in the three-dimensional network structure of paper, resulting in unsatisfactory SERS enhancement. To address this challenge and achieve high-performance flexible SERS substrates, a novel sandwich structure is proposed. Specifically, AuNPs are aggregated on expanded graphite (EG) through a chemical enhancement process facilitated by LiCl. EG is found to improve the adsorption capacity of targeted molecules while preventing signal attenuation caused by filter papers. By employing an aggregating agent at specific concentrations, it is possible to significantly increase the amounts of hot spots to provide a more pronounced enhancement effect. Furthermore, the developed flexible SERS substrates are applied to qualitatively and quantitatively detect pesticide residues, including Thiram, Nitrofural and Dinotefuran. The flexible SERS substrates demonstrate high accuracy and robustness, making them easily storable and suitable for practical applications.
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SENSORS AND ACTUATORS B-CHEMICAL
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2024
·
IF 8
Linge Nian,Wenhua Li,Minhui Dai,Chunxia Zhang,Lu Li,Guangrui Zhang,Jianxi Xiao
The precise detection of pathological type I collagen is critical for diagnosing and prognosticating various diseases such as fibrosis and tumors. Surface-enhanced Raman scattering (SERS) is emerging as a promising high-resolution imaging technique, yet the intricate process of covalently modifying antibodies often results in SERS probes with diminished selectivity. We herein for the first time report the development of dual SERS peptide probes, Ag@R1@PCTP (S-P) and Ag@R2@ICTP (S-I), which integrate collagen targeting peptides (CTPs), Raman reporters, and silver nanoparticles (Ag NPs) for specific imaging of pathological type I collagen in connective tissues. The S-P/S-I dual SERS peptide probes displayed distinct peaks at 2154 cm −1 and 2227 cm −1 in the Raman silent region with no overlap, showcasing their capability for multiplex imaging free from cross-interference. The SERS peptide probe S-P is specifically tuned to target pathological collagen, excluding intact collagen, while S-I effectively recognizes type I collagen in both its pathological and healthy states. The S-P/S-I probes have exhibited outstanding effectiveness in identifying pathological type I collagen across various connective tissues and have been successfully applied for imaging this collagen in a variety of cancer tissues. The innovative dual SERS peptide probes offer a highly specific and robust tool for imaging pathological type I collagen in tissues, presenting significant potential for the accurate diagnosis and treatment of a range of collagen-related diseases.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2024
·
IF 8
Haoyu Dong,Shuang Lin,Guoqiang Fang,Yiran Liu,Huachuang Li,Li Wang
Metal film over nanosphere (MFON) as a classical SERS-active substrate has attracted numerous attention and applications due to its excellent sensitivity and signal uniformity. However, such MFON substrates prepared by metal deposition require strictly controlled experimental conditions with high cost to obtain high batch reproducibility. In addition, the precise adjustment of the metal particle fineness and crystal facet is hard to conduct, limiting the SERS signal for further improvement. In this work, we propose multifaceted Au nanocrystal over nanosphere (AuNCFON) structures based on a facile and robust interfacial assembly technique. Notably, the preparation method could reduce significant loss of metallic materials without the requirement of large-scale instrumentation, and allows precise control of the metal film thickness and the nanocrystal facet. Specifically, the size and facet of nanocrystals on PS spheres are systematically regulated and the Au dodecahedral films with {110} facet on PS arrays exhibit optimal SERS activity. The SERS intensity is amplified by an enhancement factor of 0.13 × 10 7 with excellent signal homogeneity and batch reproducibility. Finally, the sensitive and accurate distinction of similarly structured molecules including crystal violet and malachite green (fungicides) is demonstrated assisted by principal component analysis-partial least squares (PCA-PLS) algorithm. The AuNCFON SERS substrate combined with deep learning analysis has a broad application prospect in reliable identification of chemical pollutants.
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Tao Wang,Shuang Zhang,Dongling Wu,Maohua Li,Yalan He,Yunpeng Shen
The polyol reduction method has performed well in Ag nanocube (AgNC) synthesis but is hindered by high-temperature requirements, impacting environmental sustainability and economy. Using polyethylene glycol (PEG)/deionized water as a solvent mitigates these issues, by leveraging PEG’s high solubility, bio-compatibility, low cost, and redox properties. The synthesis conditions were optimized, resulting in relatively uniform AgNC. The synthetic AgNC were loaded on porous, cheap, flexible and biocompatible filter paper (FP) by a simple self-assembly, and the formed flexible substrate (AgNC@FP) was used for surface-enhanced Raman scattering (SERS) detection. The AgNC@FP substrate had a high enhancement factor (EF) of 9.8 × 10 7 , with a detection limit of Rhodamine 6G (R6G) of 5.2 × 10 -12 M. Meanwhile, the substrate showed good reproducibility and stability, with a relative standard deviation (RSD) of 5.9 % and a decrease in Raman signal strength of only 25 % after 30 days. Furthermore, the direct sampling of apples and pears from their surface thereby enables the rapid identification of ultra-low thiram residue concentrations, with a sensitivity of 8.3 × 10 -7 M. The high SERS enhancement factor and sensitivity were attributed to the result of the high hot spot density generated by the FP surface, excellent uniformity and superior sample collection efficiency. It can therefore be concluded that this flexible AgNC@FP substrate, which is manufactured at a low cost and allows for label-free SERS detection, represents a promising SERS platform for analytical and biosensing applications.
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MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Zelong Li,Xue Han,Lan Fu,Guochao Shi,Shiqi Xu,Mingli Wang,Wenzhi Yuan,Wenying Zhou,Jiahao Cui
The combination of surface-enhanced Raman scattering (SERS) and machine learning algorithm provides an effective means for the identification of pharmacodynamic substances. This paper reported a biomimetic synthesis route of Ag-30/SiO 2 -4/Cu-20/rice leaf (Ag-30/SiO 2 -4/Cu-20/RL) SERS platform with multiple synergistic electromagnetic enhanced performance. The localized surface plasmon resonance (LSPR) effect was strengthened as the SiO 2 nanolayer generated between Ag and Cu. This SERS platform demonstrated high sensitivity, with a low limit of detection (LOD) of 1 × 10 −10 M for 4-Aminophenylthiophenol (4-ATP) and an enhancement factor (EF) of 3.86 × 10 6 . More importantly, the principal component analysis (PCA) was adopted to analyze the SERS data of three different Traditional Chinese medicine (TCM) pharmacodynamic substances (Orientin, Atractylenolide III and Prim-o-glucosylcimifugin). The K-nearest neighbor (KNN) and Naïve Bayes (NB) achieved classification accuracy of 0.9474 and 0.9649, respectively. The platform provides guidance for the accurate identification of TCM pharmacodynamic substances.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2024
·
IF 8
Yipeng Zhang,Zhangze Yang,Yucheng Zou,Shahzad Farooq,Zeyu Qin,Hui Zhang
Aiming to meet the demand for rapid detection of chlorpyrifos (CPS), a surface-enhanced Raman scattering (SERS) sensor based on a gluten/zein electrospun film (GZEF) was fabricated via electrospraying. The SERS performance was namely improved through metal nanoparticles selection and optimization of loading amounts. Further construction of the AANS@ZIF-8@GZEF sensor was achieved through in-situ growth. Owning to the porous structure of ZIF-8, the trapping ability and enrichment effect of the SERS sensor were enhanced, resulting in a superior SERS enhancement effect of 1.58 times. Moreover, the CPS detection under various concentrations was carried out using the AANS@ZIF-8@GZEF sensor. The concentration-logarithm peak intensity equations were fitted, and the limit of detection (LOD) of CPS was calculated to be 0.981 μg/L. Finally, the detection of CPS residues on the peel of apples was performed using the AANS@ZIF-8@GZEF sensor, and the results showed that the overall recovery rate ranged between 91.18% and 96.83%, with all relative standard deviations being less than 5%. Great potential applications in the rapid and sensitive detection of chlorpyrifos in food are expected for the AANS@ZIF-8@GZEF sensor constructed in this study.
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