MOLECULES
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2024
·Vol. 29
·期 9
·1971
·
IF 4.2
Hong-Li Huang,Shan Li,Yong-Zheng Lv,Ya-Qian Shi,Tian-Tian Pang,Ru-Fen Zhang,Wenjing Huang,Jianhui Yin,Fei Gao
A novel and efficient method for functionalizing organosulfones has been established, utilizing a visible-light-driven intermolecular radical cascade cyclization ofα-allyl-β-ketosulfones. This process employsfac-Ir(ppy)3as the photoredox catalyst andα-carbonyl alkyl bromide as the oxidizing agent. Via this approach, the substrates experience intermolecular addition ofα-carbonyl alkyl radicals to the alkene bonds, initiating a sequence of C-C bond formations that culminate in the production of organosulfone derivatives. Notably, this technique features gentle reaction conditions and an exceptional compatibility with a wide array of functional groups, making it a versatile and valuable addition to the field of organic synthesis.
研究领域:
有机化学
·
合成化学
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DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2022
·
IF 9.231
Songjie Li,Weimin Zhang,Ruimin Wang,Congfa Li,Xue Lin,Lu Wang
Partridge leaves ( Mallotus furetianus Muell-Arg.) have long been consumed as popular folk substitute tea for treating hyperglycemia in China. In this study, the inhibiting effects of partridge tea extracts on α -glucosidase and α -amylase were investigated, and then effect of partridge tea aqueous extracts (PTAEs) on glucose consumption capacity of 3 T3-L1 preadipocytes cells was determined. Results verified that PTAEs showed excellent anti- α -glucosidase and anti- α -amylase effects. In addition, the PTAEs evidently promoted glucose consumption capacity of 3T3L1 preadipocytes cells. To this end, a combined method of affinity ultrafiltration and HPLC-ESI-qTOF-MS/MS was used for rapidly screening and identifying the potential inhibitors in the PTAEs. Catechin, epicatechin, rutin, ferulic acid, and kaempferitrin with high affinity capacity indicated strong inhibiting effect on α -glucosidase and α -amylase. Docking studies revealed the potential interactive mechanisms between these major inhibitors and two digestive enzymes. This research shows that partridge tea is effective in preventing and treating post hyperglycemia.
研究领域:
药理学
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生物化学
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营养学
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分子生物学
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植物科学
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产品关联
DOI
PubMed
高影响因子
ACS Biomaterials Science & Engineering
·
2025
·
IF 5.5
Tianhui Liu,Qingshuang Wang,Wenxin Geng,Xue Jiang,Changshun Lu,Zhe Zhang,Xiangru Feng
The cancer-associated fibroblasts (CAFs) in tumor stroma present substantial barriers to drug penetration, resulting in tumor resistance and progression. One promising strategy is to reprogram CAFs into a quiescent state, which necessitates novel approaches. Our study introduces a sequential treatment strategy using chitosan thermosensitive hydrogels loaded with α-Mangostin (α-M), a small molecule drug with antifibrotic properties, aimed at reprogramming CAFs within the breast cancer tumor microenvironment (TME). We developed glutathione (GSH)-responsive nanoparticles (NPc) that carry the chemotherapeutic drug doxorubicin (DOX). Treatment with α-M results in the downregulation of CAF-specific biomarkers and a remodeled TME, which improves the penetration of NPc/DOX deep into the tumor tissue. This strategy holds great promise in enhancing cancer therapeutic outcomes in tumors rich in CAFs, particularly in the case of breast cancer.
研究领域:
肿瘤学
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药剂学
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生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PHYSICA E-LOW-DIMENSIONAL SYSTEMS & NANOSTRUCTURES
·
2019
·
IF 3.176
Zunlan Hu,Wenlong Huo,Tianbin Zhu,Jian Liu,Zhipeng Xie
In this paper, a new nanomaterial , α-Si 3 N 4 nanobelts assembled by high density nanorods were prepared via the crystallization of amorphous Si 3 N 4 at 1450 °C for 12 h. The as-synthesized nanobelts exhibited a width of ∼900 nm and a thickness of ∼150 nm, and a depressed linear region in the central. α-Si 3 N 4 nanorods on the nanobelts had a width of 8–16 nm and a length of 400–450 nm. The nanorods were single-crystal, growing along (101) plane. The nanobelt appeared to be initiated by α-Si 3 N 4 nanorods constantly growing on the both sides of a nanowire which was caused by secondary nucleation and the growth of Si 3 N 4 microcrystals . Growth mechanism related to the formation of the nanobelts was analyzed in detail on the basis of vapor-solid mechanism and secondary nucleation. The current work would provide new insights into α-Si 3 N 4 nanobelts assembled by nanorods which play an important role in nanoscale devices and show widespread potential applications due to their special morphology.
研究领域:
材料科学
·
纳米技术
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产品关联
DOI
高影响因子
ACS Omega
·
2020
·
IF 2.87
Ruida Zhao,Puke Mi,Sheng Xu,Suqin Dong
In this paper, poly-α-olefins (PAO) containing quaternary carbon centers were prepared by two-step oligomerization using a metallocene catalyst followed by a Ziegler–Natta catalyst. First, the 1-decene dimer was oligomerized with [t-BuN(Me)2C(η5-C5H4)]ZrCl2, and the effects of the oligomerization temperature, Al/Zr molar ratio, and catalyst loading on the oligomerization were investigated. In the second step, the obtained 1-decene dimers were copolymerized with 1-decene with TiCl4/Et2AlCl, and the effects of the catalysts, monomer/dimer ratio, and α-olefin species on the copolymerization were investigated. The composition and structure of the dimers and copolymerization products were characterized by gas chromatography (GC) and 1H NMR and 13C NMR spectroscopy. The results of GC and 13C NMR analyses indicated that the metallocene catalyzed the formation of the 1-decene oligomerization product, resulting in the branched olefin dimer being the major product, and the existence of quaternary carbons in the 1-decene/1-decene dimer copolymerization product could also be found. The polymerization mechanism for the formation of the quaternary carbon centers is proposed. The 1-decene/1-decene dimer copolymerization product containing quaternary carbon centers has a kinematic viscosity of 10.8 mm2/s at 100 °C, a viscosity index of 165, and a pour point of −52 °C; thus, the product with quaternary carbon centers has a better viscosity–temperature performance and low-temperature fluidity than those of the 1-decene oligomerization product and typical PAO products, but the kinematic viscosity is similar.
研究领域:
材料科学
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化学工程
✓ 已验证
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2024
·Vol. 48
·期 10
·4580-4588
·
IF 2.7
Ningning Ji,Fengli Yu,Bing Yuan,Congxia Xie,Shitao Yu
A series of low-cost Lewis acidic deep eutectic solvents (DESs) was synthesized and applied for the first time for catalyzing the polymerization of α-pinene to produce terpene resins. The DES catalyst of [AlCl3]3[CPL] prepared via the self-assembly of AlCl3 and caprolactam (CPL) exhibited the highest catalytic activity, and polymerization conditions were optimized by a single-factor method: 15 g α-pinene, 3 g catalyst, 1 g initiator, −5 °C reaction temperature, and 4 h reaction time. Under these conditions, the softening point of the terpene resin reached (annular spheroid method) 118.3 °C, the acid value was 0.22 mg KOH g−1, and the depth of color (Fe–Co method) was 5. The structure of [AlCl3]3[CPL] was characterized using FT-IR, 1H-NMR, and UV-vis spectroscopy. GPC measure showed that the number-average molecular weight of the terpene resin was 510, the weight-average molecular weight was 776, and the polydispersity index was 1.523. TG results indicated that the terpene resin had favorable thermal stability. After the reaction, the product and the catalyst could be automatically divided into two phases, which was beneficial for recycling the catalyst. The results revealed that [AlCl3]3[CPL] exhibited good recyclability.
研究领域:
化学工程
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
Biology-Basel
·
2024
·Vol. 13
·期 5
·357
·
IF 3.6
Mingxing Ouyang,Qingyu Zhang,Yiming Zhu,Mingzhi Luo,Bing Bu,Linhong Deng
Simple Summaryα-Catenin mediates cell-matrix interactions while Piezo1 at focal adhesions likely mechanosenses traction force through the matrix hydrogel during cell mechanical communication.AbstractCell-to-cell distant mechanical communication has been demonstrated using in vitro and in vivo models. However, the molecular mechanisms underlying long-range cell mechanoresponsive interactions remain to be fully elucidated. This study further examined the roles of α-Catenin and Piezo1 in traction force-induced rapid branch assembly of airway smooth muscle (ASM) cells on a Matrigel hydrogel containing type I collagen. Our findings demonstrated that siRNA-mediated downregulation of α-Catenin or Piezo1 expression or chemical inhibition of Piezo1 activity significantly reduced both directional cell movement and branch assembly. Regarding the role of N-cadherin in regulating branch assembly but not directional migration, our results further confirmed that siRNA-mediated downregulation of α-Catenin expression caused a marked reduction in focal adhesion formation, as assessed by focal Paxillin and Integrin α5 localization. These observations imply that mechanosensitive α-Catenin is involved in both cell–cell and cell-matrix adhesions. Additionally, Piezo1 partially localized in focal adhesions, which was inhibited by siRNA-mediated downregulation of α-Catenin expression. This result provides insights into the Piezo1-mediated mechanosensing of traction force on a hydrogel. Collectively, our findings highlight the significance of α-Catenin in the regulation of cell-matrix interactions and provide a possible interpretation of Piezo1-mediated mechanosensing activity at focal adhesions during cell–cell mechanical communication.
研究领域:
细胞生物学
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生物力学
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产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 26
·22174-22178
·
IF 3.289
Dezhang Ren,Jun Fu,Lu Li,Yunjie Liu,Fangming Jin,Zhibao Huo
An efficient process for the production of levulinate esters from biomass-derived furfuryl alcohol in liquid alcohol over commercial α-Fe2O3 was firstly investigated. Among the catalysts we tested, α-Fe2O3, a cheap, commercially available and environmentally benign catalyst, exhibited a remarkable catalytic performance for the transformation and gives levulinate esters in good yield compared to the previous studies. The corresponding esters such as methyl levulinate, ethyl levulinate and butyl levulinate were obtained in high yields under optimized reaction conditions. Several influence factors for the formation of levulinate esters were also discussed. A plausible reaction mechanism for the formation of levulinate ester from furfuryl alcohol was proposed. From the viewpoint of practice and economy, the present study provides a potential application for the efficient synthesis of fine chemicals from biomass-derived compounds over cheap, commercially available and environmentally benign catalysts.
研究领域:
化学工程
·
可再生资源利用
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DOI
高影响因子
MOLECULES
·
2015
·Vol. 20
·期 4
·6601-6610
·
IF 2.416
Jie-Tao Pan,Bang-Wei Yu,Yong-Qin Yin,Jie-Hong Li,Li Wang,Li-Bing Guo,Zhi-Bin Shen
Six pentasaccharide resin glycosides fromIpomoea cairica, including four new acylated pentasaccharide resin glycosides, namely cairicoside I–IV (1–4) and the two known compounds cairicoside A (5) and cairicoside C (6), were isolated from the aerial parts ofIpomoea cairica. Their structures were established by a combination of spectroscopic, including two dimensional (2D) NMR and chemical methods. The core of the six compounds was simonic acid A, and they were esterfied the same sites, just differing in the substituent groups. The lactonization site of the aglycone was bonded to the second saccharide moiety at C-2 in1–4, and at C-3 in5–6. Compounds1and5,4and6were two pairs of isomers. The absolute configuration of the aglycone in1–6which was (11S)-hydroxyhexadecanoic acid (jalapinolic acid) was established by Mosher’s method. Compounds1–4have been evaluated for inhibitory activity against α-glucosidase, which all showed inhibitory activities.Keywords:Ipomoea cairica;resin glycoside;simonic acid A;α-glucosidase
研究领域:
植物化学
·
药理学
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DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2021
·
IF 6.986
Stanislas Nsanzamahoro,Wei-Feng Wang,Ying Zhang,Cheng-Bo Wang,Yan-Ping Shi,Jun-Li Yang
Designing analytical approaches for enzymatic activity monitoring with high sensitivity and selectivity is of critical value for the diagnosis of diseases and biomedical studies. In this study, we have created a facile one-step synthetic route to prepare orange-red color and yellow fluorescent silicon-containing nanoparticles (Si CNPs) by mixing 3(2-aminoethylamino) propyl (dimethoxymethylsilane) and hydroquinone (HQ) in an aqueous solution. Inspired by the HQ-regulated facile synthetic step and the generation of HQ from α-glucosidase (α-Glu)-catalyzed hydrolysis of 4-hydroxyphenyl-α-d-glucopyranosyl (4-HPαDG), we have designed a straightforward colorimetric and fluorometric α-Glu activity assay using a commercially available 4-HPαDG as the α-Glu substrate. Fluorescent and colorimetric assays for α-Glu activity measurement have been thereby established and exhibited detection limits as low as 0.0032 and 0.0046 U/mL, respectively. Under single excitation at 370 nm, the prepared Si CNPs emitted yellow fluorescence at 520 nm and exhibited an absorbance peak at 390 nm. In addition, the proposed approach reveals various advantages including easy operation, time-saving, and good anti-interference ability. Hence, it could improve the progress of fluorometric and colorimetric enzymatic activity assays with high sensitivity and simplicity. Moreover, the proposed approach was applied for α-Glu inhibitor screening, and its feasibility in real samples was measured by detecting the α-Glu activity in human serum samples.
研究领域:
分析化学
·
生物医学
·
酶学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2023
·
IF 2.6
Xuejuan Wei,Xiaopeng Chen,Linlin Wang,Xiaojie Wei,Jiaqi Liang,Zehui Xiong,Jiezhen Liang
For the isolation and purification of (−)-α-pinene and (−)-limonene from pine resin tapping by spraying ethephon solution on the cutting surface of pine tree, vapor–liquid equilibrium data for (−)-α-pinene and (−)-limonene with ethephon are indispensable. In this work, the isothermal vapor–liquid equilibria of binary system (−)-α-pinene + (−)-limonene and quaternary system (−)-α-pinene + (−)-limonene + water + ethephon were determined using headspace gas chromatography. The thermodynamic consistency of the experimental data was tested by the Van Ness point test and Redlich-Kister area test. The universal quasi-chemical (UNIQUAC) and nonrandom two-liquid (NRTL) models were applied to correlate the experimental data, and the absolute mean deviation of the vapor phase mole fraction and the relative mean deviation of the total system pressure were calculated. The results showed that the UNIQUAC model correlated the system more accurately than the NRTL model. The relative volatility of (−)-α-pinene to (−)-limonene was promoted by adding ethephon solution. In addition, the binding energies of (−)-α-pinene + water + ethephon and (−)-limonene + water + ethephon were calculated by DFT. The results showed that the intermolecular interaction between ethephon solutions with (−)-limonene was greater than that with (−)-α-pinene.
研究领域:
化学工程
·
植物化学
·
热力学
✓ 已验证
产品关联
DOI
高影响因子
Russian Journal of Physical Chemistry A
·
2022
·Vol. 96
·期 12
·2747-2756
·
IF 0.791
Li Xixi,Lu Xinhuan,Jing Run,Zhang Haifu,Wang Chenlong,Zhang Huaxin,Wang Beibei,Zhou Dan,Xia Qinghua
Abstract The MOR supported cobalt complex materials were synthesized by ion exchange method and used to catalyze the epoxidation reaction of α-pinene with air. The liquid phase batch mode of epoxidation reaction was carried out under atmospheric pressure and aerobic conditions. Among the supported [Co(NH 3 ) 6 ] 3+ -zeolites catalysts, [Co(NH 3 ) 6 ] 3+ -MOR exhibited the best catalytic efficiency for the titled reaction, and high reaction conversion as well as epoxidation product selectivity were obtained for α-pinene and α-epoxypinane. Parametric studies were performed to examine the effect factors like the Co content, the solvent, the initiator, the substrate amount and the catalyst amount. The catalyst can be reused at least nine cycles without significant loss in activity towards epoxidation.
研究领域:
化学工程
·
催化材料
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）