JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
·
2021
·Vol. 102
·期 1
·109-116
·
IF 1.633
Ma Mingfang,He Zirui,Zhou Shumin,Liu Xuyan,Zhao Min,Wang Xinyan,Liu Huan,Hao Aiyou
Abstract Even through gels based on the polymer modified with β-cyclodextrin have been researched widely, there are only few studies focus on gels based on β-cyclodextrin directly. In this study, we report a novel smart responsive β-cyclodextrin/graphene oxide hybrid gel. Graphene oxide can be loaded into the network of β-cyclodextrin gel successfully by co-assembly method, which can be supported by transmission electron microscope and scanning electron microscope. Hydrogen bonding is the main driving force in gel formation from fourier transform infrared spectroscopy and X-ray diffraction analysis. More interesting is that β-cyclodextrin/graphene oxide hybrid gel can respond to multiple stimuli sensitively. The change of temperature can induce the formation and deformation of gel reversibly. Besides, gel will collapse with the addition of different metal ions including Na + , K + , Zn 2+ , Ba 2+ and Fe 3+ . Hence, this composite gel is a smart responsive material, may have great potential applications in intelligent material fields. Graphic Abstract
In this study, we report a
novel smart responsive β-cyclodextrin/graphene oxide hybrid gel. Graphene oxide
can be loaded into the network of β-cyclodextrin gel successfully by
co-assembly method, which can be supported by transmission electron microscope
and scanning electron microscope. Hydrogen bonding is the main driving force in
gel formation from fourier transform infrared spectroscopy and X-ray
diffraction analysis. More interesting is that β-cyclodextrin/graphene oxide
hybrid gel can respond to multiple stimuli sensitively. The change of
temperature can induce the formation and deformation of gel reversibly.
Besides, gel will collapse with the addition of different metal ions including
Na + , K + , Zn 2+ , Ba 2+ and Fe 3+ .
Hence, this composite gel is a smart responsive material, may have great
potential applications in intelligent material fields.
研究领域:
材料科学
·
化学
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DOI
高影响因子
Food Science & Nutrition
·
2018
·Vol. 6
·期 4
·1053-1064
·
IF 1.521
Shuang Ma,Xu Yang,Changhui Zhao,Mingruo Guo
Effect of ultrasound treatment on the physicochemical properties and structure of β-lactoglobulin were investigated. β-Lactoglobulin was treated with ultrasound at different amplitudes, temperatures, and durations. The surface hydrophobicity and free sulfhydryl group of β-lactoglobulin were significantly increased after ultrasound treatment ( p < .05). The maximal surface hydrophobicity and free sulfhydryl group were 5,812.08 and 5.97 μmol/g, respectively. Ultrasound treatment changed the physicochemical properties of β-lactoglobulin including particle size (from 1.21 ± 0.05 nm to 1.66 ± 0.03 nm), absolute zeta potential (from 15.47 ± 1.60 mV to 27.63 ± 3.30 mV), and solubility (from 84.66% to 95.17%). Ultrasound treatment increased α-helix and β-sheet structures of β-lactoglobulin. Intrinsic fluorescence intensity of ultrasound-treated β-lactoglobulin was increased with shift of λ max from 334 to 329 nm. UV absorption of β-lactoglobulin was decreased with shift of λ max from 288 to 285 nm after ultrasound treatment. There were no significant changes in high-performance liquid chromatography and protein electrophoretic patterns. These findings indicated that ultrasound treatment had high potential in modifying the physiochemical and structural properties of β-lactoglobulin for industrial applications.
研究领域:
食品科学
·
蛋白质化学
·
生物物理学
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DOI
PubMed
高影响因子
INTERNATIONAL IMMUNOPHARMACOLOGY
·
2025
·
IF 4.7
Lulu Peng,Zhengwei Zou,Lin Zhou,Lincai Li,Wenming Lu,Cixiang Chen,Yan Xu,Yuyue Liu,Jing Lin,Junsong Ye
Hepatic fibrosis (HF) is a leading cause of death worldwide, yet there is currently no safe and effective treatment available. Canagliflozin, a novel glucose-lowering drug, has been shown to improve non-alcoholic steatohepatitis (NASH). However, its therapeutic effects on HF and the underlying molecular mechanisms remain unclear. In this study, HF was induced in mice via intraperitoneal injections of CCl 4 . Additionally, immortalized hepatic stellate cells (HSCs), including HSC-T6 and LX-2 cells, were used for in vitro experiments. Our findings revealed that Canagliflozin inhibited the activation and proliferation of HSCs, thereby downregulated the expression levels of fibrotic markers (α-SMA and Collagen I), ultimately alleviating HF. Further investigations demonstrated that Canagliflozin inhibits protein phosphatase 2 A (PP2A) activity in HSCs, which in turn prevents PP2A-mediated dephosphorylation of β-catenin and attenuates Wnt/β-catenin signaling. While the Wnt/β-catenin signaling is considered a key mechanism that promote the activation and proliferation of HSCs, it is also a crucial pathway in the development of HF. Moreover, increased activity of PP2A was found to promote the expression of fibrotic markers (α-SMA and Collagen I) in HSCs. In conclusion, our study indicates that Canagliflozin ameliorate HF via inhibiting PP2A-mediated dephosphorylation of β-catenin in HSCs. The inhibition of PP2A in HSCs may represent a potential therapeutic target not only for cancer treatment but also for the management of HF.
研究领域:
药理学
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分子生物学
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肝病学
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细胞生物学
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF ENERGY RESEARCH
·
2019
·Vol. 43
·期 6
·2162-2171
·
IF 3.343
Wei Li,Shu-ao He,Xiao Wang,Qiong Ma,Chen-hui Zhao
Summary β-iron oxide hydroxide (β-FeOOH) had been proven to be an effective co-catalyst during H 2 evolution reaction (HER) process. In this research, a BiOCl/β-FeOOH heterojunction was successfully synthesized by a solid-state doping method. Then, the structure, composition, and photo-electrochemical properties of the prepared photocatalysts were studied. For the superior HER photocatalytic activity of ultrasmall β-FeOOH nanoparticles (NPs) and the formation of the BiOCl/β-FeOOH heterojunction, this heterojunction photocatalyst exhibited very superior photocatalytic performance in the HER process. Especially, when the amount of incorporated β-FeOOH NPs was appropriate, the BFOH-2 possessed the highest photocatalytic activity in HER process, and the HER rate was about 16.64 mmol·g −1 ·h −1 during illuminated time of 6 hours under visible light. When appropriate, ultrasmall β-FeOOH NPs were implanted into the structure of BiOCl, the BiOCl/β-FeOOH heterojunction interfaces would form for the existence of interfacial interactions. Therefore, this BiOCl/β-FeOOH heterojunction exhibited superior visible-light response, fast photo-carrier migration, and high-efficient separation of photo-carriers, so that the BFOH-2 heterojunction possessed high-efficient hydrogen evolution reaction (HER) photocatalytic activity.
研究领域:
材料科学
·
光催化
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DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2021
·
IF 7.312
Chengyu Duan,Jianyu Wang,Qikai Liu,Yi Zhou,Yanbo Zhou
Salbutamol (SAL) and Atenolol (ATL), two common medical ingredients acting on adrenal receptor, are often used for treating chronic illnesses. However, the incomplete metabolism in organism and widespread utilization lead to unneglected problems of water pollution, which the traditional treatment plant cannot satisfactorily deal with. For efficient removal of SAL and ATL, a kind of silanized β-cyclodextrin compound adsorbents (GD-EDTS) was designed based on the ionization features of two pollutants. Through an introduction of rich carboxyl groups by N-[(3-Trimethoxysilyl)propyl]ethylenediamine triaceticacid trisodium salt (EDTS), GD-EDTS surface obtains an appropriate electronegativity to meet different forms of IOCs and maintain a good adsorption performance in a wide pH range. The maximum adsorption capacities of SAL and ATL are 140.24 mg/g and 236.92 mg/g, respectively. And a remarkable rise is known from the adsorption capacity of SAL and ATL increasing to 162% and 706%, respectively, after EDTS modification. Adsorption data fit the Sips adsorption isotherms and the pseudo second-order kinetic model, and a weak competitive behavior between SAL and ATL indicates two pollutants can be removed simultaneously by GD-EDTS in their binary system. In this work, GD-EDTS is suggested to be an efficient adsorbent in the removal of SAL and ATL.
研究领域:
环境科学
·
药物化学
·
吸附材料研究
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DOI
高影响因子
Food & Function
·
2022
·Vol. 13
·期 7
·3917-3930
·
IF 6.317
Yan Qiao,Xianfeng Ye,Lingli Zhong,Chengyao Xia,Lei Zhang,Fan Yang,Yongkai Li,Xiaodong Fang,Lei Fu,Yan Huang,Hui Cao,Zhoukun Li,Zhongli Cui
The β-glucan from Saccharomyces cerevisiae is a potent adjuvant that exhibits a broad spectrum of biological activities and health benefits, and different processes have been established to prepare active β-glucan from yeast. However, studies concerning the effect of β-1,6-glucanase enzymolysis on the structure and immunomodulatory activity of yeast β-1,3-glucan are scarce. In this study, we aim to develop a novel enzymatic process for the preparation of immunologically active β-glucan (BYG) from baker's yeast using a β-1,6-glucanase GluM. The β-1,6-glucan in fungal cell wall was specifically hydrolyzed by GluM, and resulted in cell wall decomposition and β-glucan release. Batch production of BYG was realized with 17.8% yield, 85.3% purity and 75.4% recovery rate. Structural characterization indicated that BYG exhibits rod-like structures with natural triplex and nanoparticle-like substructures compared with the commercial Glucan 300. BYG ameliorated inflammation in a DSS-induced mouse model of colitis through inhibiting oxidative stress (NO, MDA and MPO), inflammatory mediators (NLRP3, ASC, caspase-1, iNOS and COX-2), and pro-inflammatory cytokines (IL-1β, IL-6, TNF-α, IFN-γ), increasing the expression levels of tight junction proteins (ZO-1, occludin and claudin-1) and modulating the production of gut microbiota-synthesized SCFAs compared to the control. Our results showed that yeast β-1,3-glucan prepared with β-1,6-glucanase exhibits structural integrity that is responsible for its favorable immunomodulatory activity.
研究领域:
微生物学
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免疫学
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生物技术
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药理学
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DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2019
·
IF 3.571
Hui Niu,Weijun Chen,Wenxue Chen,Yonghuan Yun,Qiuping Zhong,Xiong Fu,Haiming Chen,Gang Liu
β-Cyclodextrin (β-CD) was modified using octenyl succinic anhydride (OSA) to introduce amphiphilic groups (hydrophilic carboxyl and lipophilic octenyl chains) by esterification under alkaline conditions. The FT-IR results indicated that the OSA-modified β-CD (OCD) showed new absorption peaks of an ester bond and a carboxylate (RCOO–) at 1724 and 1570 cm–1, respectively, confirming the successful preparation of OCD. Then the embedding effects of β-CD and OCD on β-carotene and the emulsifying and antioxidant properties of their inclusion complexes were evaluated. The results of XRD showed that the β-CD (or OCD)/β-carotene inclusion complexes were converted from a cage-type structure to a channel-type structure. AFM and SEM showed that the crystal characteristics and surface morphologies of the inclusion complexes were different from those of the physical mixture. The emulsion stabilized by OCD exhibited smaller droplet sizes and larger zeta-potentials than that stabilized by β-CD. In addition, the inclusion complexes-prepared emulsion exhibited lower POV values and TBARS contents than did the physical mixture. OCD/β-carotene inclusion complexes can improve the physical and oxidative stability of the emulsion, which is of great significance to the food industry.
研究领域:
化学
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材料科学
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食品科学
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胶体与表面化学
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产品关联
DOI
PubMed
高影响因子
Small
·
2025
·
IF 12.1
Yunxiang Sun,Nicholas Andrikopoulos,Guofang Zhang,Yuying Liu,Xiufang Liang,Dongjie Li,Xiaoman Suo,Yue Wang,Yuhuan Li,Chuang Wang,Yang Li,Pu Chun Ke,Feng Ding
Senile plaques, comprised of nanosized aggregates of amyloid-β (Aβ) peptides in the brain, are a pathological hallmark of Alzheimer's disease (AD). On the other hand, regular physical exercise is known to significantly reduce the risk of developing AD. Here, it is reported on the transformation and toxicity mitigation of Aβ amyloid aggregation by a spontaneous “corona” of β-endorphin, a major peptide hormone released upon exercise to suppress post-exercise pain. Given that both Aβ and β-endorphin co-localize extracellularly in the brain, it is postulated that β-endorphin may mitigate the toxicity of Aβ aggregation via direct molecular interactions, thereby contributing to an exercise-mediated reduction of AD risk. Combining biophysical characterizations in vitro with atomistic discrete molecular dynamics simulations in silico, a strong interaction is shown between β-endorphin and Aβ, where β-endorphins are located at the periphery to render a corona of their hetero-complexes with Aβ. Cell viability, immunofluorescence and western blotting assays further revealed that the corona shielded cellular exposure to Aβ aggregates and suppressed the toxicity of Aβ in vivo. This work offered a new molecular mechanism for the benefits of physical exercise, which may facilitate a rational design of future therapy and prevention strategies against AD and dementia.
研究领域:
神经生物学
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分子生物学
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医学
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DOI
PubMed
高影响因子
HYDROMETALLURGY
·
2017
·
IF 2.605
Licheng Zhang,Lijuan Li,Dong Shi,Xiaowu Peng,Fugen Song,Feng Nie,Wensheng Han
Lithium recovery from alkaline brines by counter-current method using β-diketone was investigated. By comparing effect of different co-extractants and diluents on lithium extraction, HBTA-TOPO-kerosene system was determined as the extraction system. In extraction process, 0.4 mol/L HBTA and 0.3 mol/L TOPO in kerosene performed as extractant and three theoretical stages were required to reach 95% extraction according to McCabe Thiele diagram. 1 mol/L HCl and 3 mol/L HCl solution were used as scrubbing agent and stripping agent respectively. In regeneration stage, 2 mol/L NaOH was used as regeneration agent to remove free acid entrained in organic phase and exchange H + of hydroxyl. Bench experiments indicated that the respective number of extraction, scrubbing, stripping and regeneration were 3, 1, 2 and 1 stage. A 7-stage extraction process was conducted in a mixer-settler for 30 h to reach stable state, average extraction rate of lithium was 96% and lithium concentration in stripping solution was 15 g/L. Concentration of impurity ions in stripping liquor was < 1 g/L. No third phase or emulsification was observed during the operation. In summary, HBTA-TOPO-kerosene extraction system was verified an effective method to recovery lithium from alkaline brine.
研究领域:
化学工程
·
材料科学
✓ 已验证
DOI
高影响因子
TOXICOLOGY IN VITRO
·
2025
·
IF 2.7
Yuhui Yan,Wenyu Wang,Aiwen Yan,Haonan Zhu,Qiang Meng
Cholestasis, a condition marked by bile acid accumulation in the liver and body systems, leads to liver dysfunction and cirrhosis. Currently, ursodeoxycholic acid (UDCA) and obeticholic acid (OCA) are the only two FDA-approved drugs for Cholestasis. Thus, new therapeutic approaches need to be developed. In this study, we validated the liver-protective properties of β-sitosterol (SIT), a key bioactive element abundant in plants, against hepatic toxicity and cholestasis induced by alpha-naphthylisothiocyanate(ANIT), while elucidating its mechanisms of action both in vivo and in vitro. SIT's FXR activation was confirmed via molecular docking and dual-luciferase assays. In the mechanisms of SIT hepatoprotection, the expression levels of bile salt export pump (Bsep) and multidrug resistance protein2 (Mrp2) which are bile acid efflux transporter, and sulfate transferase 2a1 (Sult2a1) which is a bile acid metabolizing enzyme were all increased by SIT, whereas the expression of uptake transporter sodium taurocholate transporting polypeptide (Ntcp), bile acid synthesis enzyme cholesterol 7α-hydroxylase (Cyp7a1) and oxysterol 12α-hydroxylase (Cyp8b1) was decreased by SIT. In addition, SIT alleviated liver inflammation by suppressing inflammatory factor expression. However, FXR antagonist guggulsterone and FXR siRNA abolished SIT's improvements in liver histology, bile acid transporters, and enzymes. Conclusively, through activating FXR, SIT provides a protective effect against hepatotoxicity and cholestasis. SIT might serve as a new potential therapeutic strategy for the treatment of cholestatic liver diseases.
研究领域:
药理学
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分子生物学
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肝脏疾病
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
·
2012
·Vol. 51
·期 6
·1405-1416
·
IF 3.919
Cheng-Guang Mu,Xiao-Dong Fan,Wei Tian,Yang Bai,Zhen Yang,Hao Yao,Heng Chen
We report on the synthesis of an H-shaped polymer bonding β-cyclodextrin (β-CD) at branch points and influences of attached β-CD on physical properties. First, a poly(ethylene glycol)(PEG)-based functional macroinitiator bearing two azidos and four chlorines at chain-ends (PEG-2N 3 (-4Cl)) was prepared via terminal modification reactions. Then, PEG-2N 3 (-4Cl) was applied to initiate the atom transfer radical polymerization of N-isopropylacrylamide, leading to the synthesis of an H-shaped block polymer with PEG as the central chain and poly( N -isopropylacrylamide) (PNIPAM) as side-arms (PEG-2N 3 (-4PNIPAM)). Azido groups were at the branch points of the polymer. Finally, the click reaction between PEG-2N 3 (-4PNIPAM) and alkynyl monosubstituted β-cyclodextrin (β-CD) afforded another H-shaped polymer with two β-CDs bonding at the polymer branch points (PEG-2CD(-4PNIPAM)). The glass transition temperature ( T g ) and lower critical solution temperature (LCST) of the H-shaped polymer increased after the attachment of β-CD. The self-assembly and thermal responsive behaviors, as well as the encapsulation behaviors of PEG-2CD(-4PNIPAM) were also altered. When temperature was below the LCSTs, PEG-2N 3 (-2PNIPAM) dissolved in water molecularly, whereas PEG-2CD(-4PNIPAM) could self-assemble into nano-sized micelles. After the LCST transitions, PEG-2N 3 (-4PNIPAM) aggregated into micron-sized unstable particles, whereas PEG-2CD(-4PNIPAM) transformed into PNIPAM-cored nanomicelles. Besides, PEG-2CD(-4PNIPAM) can encapsulate doxorubicin below its LCST due to the formation of micelles. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2013
研究领域:
高分子化学
·
材料科学
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产品关联
DOI
高影响因子
Materials
·
2025
·Vol. 18
·期 10
·2232
·
IF 3.2
Binbin Fu,Chaoran Wang,Dan Wang
This study investigates the impact of different temperatures and initial Mg2+/Ca2+molar ratios in the solution on the wet-accelerated carbonation of β-dicalcium silicate (β-C2S). The x-ray diffraction (XRD), fourier transform infrared spectroscopy (FT-IR), thermogravimetric analyzer (TGA), and field emission scanning electron microscopy (FE-SEM) analysis results indicated that temperature and the Mg2+/Ca2+molar ratio are key factors in the nucleation of aragonite. Aragonite formed at a temperature above 60 °C, and the high temperature promoted the crystallinity of needle-like aragonite with a length of 1–6 μm and a diameter of ~1 μm. Moreover, 80 °C was the most favorable temperature for the formation of aragonite with a large aspect ratio in the carbonation system of β-C2S. Mg2+had a significant effect on inhibiting the transformation of aragonite to calcite and promoting the stability of aragonite. Aragonite became the dominant CaCO3polymorph instead of calcite when the Mg2+/Ca2+molar ratio was above 1.0, and pure aragonite-style calcium carbonate was formed at a Mg2+/Ca2+molar ratio of 1.5.
研究领域:
材料科学
·
无机化学
·
环境科学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）