LANGMUIR
·
2022
·
IF 4.331
Yang Yang,Li Wang,Xiaojiang Li,Dan Liu,Shanshan Dai,Hongsheng Lu
Phase-selective organogelators (PSOGs) have recently attracted more attention because of their advantages in handling oil spills and leaked organic solvents. However, it is difficult to separate and recover the organic phase and PSOGs from organic gels due to the strong interaction between them. Aiming to enhance the separation and recovery performance of the organic phase and PSOGs, we synthesized a series of pH-responsive PSOGs by using itaconic anhydride and fatty amines with carbon chain lengths of C12–C18. Here, PSOGs have an excellent gelation ability in that amounts of organic solvents and fuel oil can be solidified at a low concentration (<3 wt %). It is worth noting that these gels are stronger, which is more convenient for removal by a salvage operation. More importantly, compared with traditional organogelators, pH-responsive PSOGs can easily recover the organic phase and fuel oil with an adjustment of the pH without extraction or distillation. Because of the transformation between the hydrophilicity and hydrophobicity of PSOGs by pH stimulation, 83.15% PSOGs are recovered in three-cycle experiments. In addition, the recycled PSOGs can be used to realize the removal of the organic phase again. Herein, we find that pH-responsive PSOGs could be used as promising and sustainable materials for separating and recovering organic solvents/oils and PSOGs.
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高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2022
·Vol. 32
·期 31
·2203492
·
IF 19.924
Min Hao,Dapeng Zhang,Wenhan Wang,Zhijian Wei,Jiazhi Duan,Jianlong He,Xiaohong Kong,Yuanhua Sang,Shiqing Feng,Hong Liu
Limitations such as the cell life span, cellular activity, and cellular diffusion outside the lesion make the direct repair of spinal cord injury (SCI) by neural stem cell (NSC) transplantation challenging. Here, an injectable hydroxyapatite (HAp) thermosensitive nanohydrogel is proposed to achieve stem cell storage and release, as well as fate regulation, for therapy. The cavities formed in situ functioned as brood pouches for cell proliferation. The enzyme-induced collapse of cavities released mouse NSCs (mNSCs) gradually and continuously. The endocytosis of HAp nanorods by encapsulated mNSCs enhanced the property of mNSC neuronal differentiation. The HAp thermosensitive nanohydrogel with mNSCs exert an inspiring therapeutic effect on a complete transected SCI model and has prospects in material design to improve SCI therapy with stem cells.
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MACROMOLECULAR MATERIALS AND ENGINEERING
·
2022
·Vol. 307
·期 8
·2200127
·
IF 4.402
Xiaomin Luo,Rong Qin,Jianyan Feng,Peng Zhang,Wenqi Wang,Huijun Ren,Hui Kong,Wenjie Hu
Superhydrophobic and self-cleaning materials have attracted tremendous attention because of their broad applications. However, it is still challenging to develop excellent films exhibiting both reparable superhydrophobic and robust mechanical properties by an environmentally friendly method. Inspired by a natural nacre structure, the novel multi-layered inorganic-organic films consisting of n-octadecylamine-modified graphene oxide (NGO) and solvent-free self-healing polyurethane synthesized by Diels-Alder reaction (SFPU-DA) are demonstrated. Through the layer-by-layer assembly technology, super-hydrophobic and self-repairing solvent-free polyurethane composite films (NGO/SFPU-DA films) are prepared. The NGO/SFPU-DA composite films exhibit healing of surface creases and cracks within 120 s at 120 °C. Meanwhile, the contact angle and sliding angle of the films can be as high as 151° and 8°, respectively. Noticeably, even after 21 times of rubbing, the superhydrophobicity of the obtained films does not significantly reduce. In addition, the tensile strength and peel strength of NGO/SFPU-DA films can reach 22.6 MPa and 88.6 N/30 mm. Moreover, the steel coated with NGO/SFPU-DA films exhibits lower corrosion current density and better corrosion resistance than the single NGO/SFPU-DA film and uncoated steel. The method may provide an effective way to obtain excellent self-cleaning materials with long service life.
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高影响因子
Theranostics
·
2022
·
IF 11.6
Yue Zhou,Lei Xu,Zhangding Wang,Hongwen Liu,Xiang Zhang,Chuanjun Shu,Meng Zhang,Ting Wang,Xinyun Xu,Xiaohong Pu,Jian He,Pin Wang,Yudong Qiu,Guifang Xu,Xiaoping Zou,Yun Zhu,Lei Wang
Rationale : Synergistic treatment strategies for two or more drugs have gradually developed as the main options in clinics for cholangiocarcinoma (CCA) owing to the complicated crosstalk between the tumor and stroma. However, the different synergetic mechanisms pose great challenges to the dosages and order of administration of drugs. Thus, a strategy for exploring and intervening in mutual targets derived from stromal cells and cholangiocarcinoma cells was proposed. Methods : Genes with overexpression patterns in tumors and displaying a significant association with overall survival were identified from RNA-seq data of human CCA patients and CCA mouse models. Western blotting, qRT-PCR, immunofluorescence (IF), colony formation and flow cytometry assays were conducted to determine the biological roles of the key oncogene in cholangiocarcinoma and stromal cells respectively. Additionally, a dual-targeting drug delivery system (AA-HA-ODA) for cancer-associated fibroblasts (CAFs) and tumor cells was constructed to verify the effectiveness of intervening the screened genes in vivo . Results : Polo-like kinase 1 (PLK1) was verified to play vital role in the malignant proliferation of CCA by regulating the cell cycle pathway. PLK1 also decreased stromal production by regulating the CAF phenotype. In addition, a PLK1 inhibitor (Ro3280) loaded dual-targeting drug delivery system (AA-HA-ODA) was prepared and exhibited high affinity for CAFs and cholangiocarcinoma cells. The in vivo distribution pattern and antitumor efficacy of AA-HA-ODA/Ro also verify the effectiveness of inhibiting PLK1 in CCA in vivo . Conclusion : In summary, PLK1 is a mutual target derived from tumor cells and stroma due to its crucial role in the proliferation of tumor cells and stroma regulation in CAFs, which might provide enlightenment for multitarget treatment strategies and guidance for clinical cholangiocarcinoma treatment.
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高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2022
·
IF 5.062
Zimin Cai,Qin Wang,Jinzhuan Xu,Jia Zhou,Zhaohui Jiang,Di Pan,Yanyan Zhang,Ling Tao,Jianqing Peng,Yi Chen,Xiangchun Shen
Emphysema is a type of chronic obstructive pulmonary disease (COPD) usually leading to difficulty breathing. It is highly in need of effective interventions to prevent airspace damage and stretch. Herein, we studied the protective effect of 1,8-cineole (CIN) on porcine pancreatic elastase (PPE)-induced emphysema in mice via quantitative pulmonary administration. To overcome the volatility, instability and poor water solubility of CIN that limits its pharmacological activities in vivo , a hyaluronic acid (HA)-coated liposome was prepared to encapsulate CIN (Lipo/ [email protected] ), which facilitated the delivery of CIN to lung tissue and improved its therapeutic effect for emphysema. A Microsprayer Ⓡ aerosolizer was used to deliver free CIN and its liposomal preparations every other day for four weeks and evaluate the therapeutic effects on emphysema in mice. The results clearly showed that CIN significantly reduced the level of inflammation and oxidative stress, resulting in less lung cell apoptosis. Compared with the free CIN and Lipo/CIN, Lipo/ [email protected] exhibited superior protective effects on mice to prevent the PPE-induced emphysema. Furthermore, the therapeutic mechanisms were verified to be mainly mediated by Nrf2/NQO1 and NF-κB/IκBα pathways. In conclusion, quantitative pulmonary administration of CIN could alleviate the progression of emphysema and the therapeutic effects were further improved by the HA-coated liposome carrier.
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高影响因子
Lubrication Science
·
2022
·Vol. 34
·期 7
·441-448
·
IF 1.307
Hongxia Ma,Wei Wu,Zeyun Wang
In this work, TiO 2 nanoparticles modified with octadecylamine and dodecyl mercaptan (DDM/ODA@PDA@TiO 2 NPs) are uesd to improve the tribological properties of the white oil. The DDM/ODA@PDA@TiO 2 NPs which are simply prepared by mussel inspired chemistry and the Michael addition reaction can be facilely dispersed in the white base oil. Tribological measurements showed that the dispersion of the white oil containing 3 wt% DDM/ODA@PDA@TiO 2 NPs displays significant reductions in the friction coefficient and wear scar diameter at room temperature and 75°C. Further XPS investigation shows that the favourable tribological properties of DDM/ODA@PDA@TiO 2 NPs are ascribed to the synergistic effect of tribofilm (Fe 2 O 3 , Fe 3 O 4 , FeS 2 , FeS and FeSO 4 ) and TiO 2 nanofluids.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Jie Cao,Yingpeng Chen,Xiujun Wang,Jian Zhang,Ying Li,Shanshan Wang,Xinming Wang,Chunlin Liu
In this article, we prepared Janus sulfonated graphene oxide nanosheets (JSGO) by a facile method for large-scale production. Unlike previous single-sided modifications of graphene oxide (GO), the smart JSGO nanofluid that can automatically find oil was obtained by modifying the double sides of GO. Benefiting from the introduction of sulfonic acid groups, JSGO had outstanding dispersity and stability under extreme conditions. Furthermore, JSGO exhibited excellent interfacial properties due to its amphiphilic characteristic. On the one hand, JSGO can reduce interfacial tension by 71% and form a strong interfacial film at the oil–water contact, achieving piston displacement with high sweep efficiency. On the other hand, JSGO had a strong ability in wettability reversal that can turn the hydrophobic surface into completely hydrophilic. These excellent properties of JSGO nanofluid contributed to obtaining an additional 18.4% recovery factor at low concentration (100 mg/L) and low injection volume (0.3 pore volume). As a result of the simple preparation, high performance, and excellent dispersion stability of JSGO nanofluid, it can be utilized as a chemical agent to enhance oil recovery in the harsh environment of reservoirs.
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高影响因子
Journal of Coatings Technology and Research
·
2022
·Vol. 19
·期 4
·1187-1198
·
IF 2.339
Yuan Jiajia,Yin Xue,Qiu Zelin,Shen Yujie,Fang Lifeng,Liang Zhiying,Kong Qingran,Zhu Baoku
In this work, highly fluorinated acrylate emulsions with reliable stability emulsified by protonated octadecylamine were successfully synthesized. With appropriate protonation, the obtained emulsion showed high monomer conversions up to 90.2% and ultralow surface energy. The ultralow-surface-energy coatings were fabricated via surface enrichment of abundant fluorine and replacing hydrophilic amino groups with hydrophobic groups through the Michael addition reaction. Superhydrophobic and self-cleaning surfaces were prepared on porous substrates through dip coating. When fabricated on porous glass fiber nonwoven mats, surfaces coated with enriching fluorinated side chains and few hydrophilic groups showed remarkable superhydrophobicity with a water contact angle more than 150º and a low sliding contact angle of 4.7°. The usage of fluorinated emulsions was sharply reduced due to the addition of perfluorinated acrylate. Moreover, the Michael acceptors were alternative such as perfluorinaed acrylates, long aliphatic acrylates and crosslinking acrylates, displaying superior hydrophobicity and waterproof properties. All the results conclusively indicated that this practical modified method was promising for potential applications of hydrophobic modifications. Graphical abstract
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高影响因子
Science Advances
·
2022
·Vol. 8
·期 5
·
IF 14.957
Yiting Lei,Yuping Wang,Jieliang Shen,Zhengwei Cai,Chen Zhao,Hong Chen,Xiaoji Luo,Ning Hu,Wenguo Cui,Wei Huang
Introducing hydration layers to hydrogel microspheres (HMs) by coating the surface with liposomes can effectively reduce friction. However, the lubrication can be inactivated when the surface coatings are damaged. To endow HMs with the ability to form self-renewable hydration layers and maintain cellular homeostasis, rapamycin-liposome–incorporating hyaluronic acid–based HMs (RAPA@Lipo@HMs) were created using microfluidic technology and photopolymerization processes. The RAPA@Lipo@HMs improve joint lubrication by using a smooth rolling mechanism and continuously exposing liposomes on the outer surface to form self-renewable hydration layers via frictional wear. In addition, the released autophagy activator (rapamycin)–loaded cationic liposomes can target negatively charged cartilage through electrostatic interactions and maintain cellular homeostasis by increasing autophagy. Furthermore, the in vivo data showed that the RAPA@Lipo@HMs can alleviate joint wear and delay the progression of osteoarthritis. The RAPA@Lipo@HMs can provide efficient lubrication and potentially alleviate friction-related diseases such as osteoarthritis.
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高影响因子
Bioactive Materials
·
2022
·
IF 16.874
Yiting Lei,Xingkuan Wang,Junyi Liao,Jieliang Shen,Yuling Li,Zhengwei Cai,Ning Hu,Xiaoji Luo,Wenguo Cui,Wei Huang
Lipid-based boundary layers formed on liposome-containing hydrogels can facilitate lubrication. However, these boundary layers can be damaged by shear, resulting in decreased lubrication. Here, a shear-responsive boundary-lubricated drug-loaded hydrogel is created by incorporating celecoxib (CLX)-loaded liposomes within dynamic covalent bond-based hyaluronic acid (HA) hydrogels ( [email protected] @HA-gel). The dynamic cross-linked network enables the hydrogel to get restructured in response to shear, and the HA matrix allows the accumulation of internal liposome microreservoirs on the sliding surfaces, which results in the formation of boundary layers to provide stable lubrication. Moreover, hydration shells formed surrounding the hydrogel can retard the degradation process, thus helping in sustaining lubrication. Furthermore, in vitro and in vivo experiments found that [email protected] @HA-gels can maintain anabolic-catabolic balance, alleviate cartilage wear, and attenuate osteoarthritis progression by delivering CLX and shear-responsive boundary lubrication. Overall, [email protected] @HA-gels can serve as shear-responsive boundary lubricants and drug-delivery vehicles to alleviate friction-related diseases like osteoarthritis.
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高影响因子
Nanomaterials
·
2022
·Vol. 12
·期 5
·728
·
IF 5.719
Wei Zhang,Yang Zang,Yanli Lu,Jinghui Han,Qingyun Xiong,Jinping Xiong
In this study. a novel near-infrared fluorescent-driven contrast agent (Ag-doped NaYF4:Yb3+/Er3+@NaYF4:Nd3+@NaGdF4) was synthesized using a coprecipitation-hydrothermal-solvothermal-solvothermal (CHSS) method. The results shows that hexagonal NaYF4:Yb3+/Er3+with a diameter of 300 nm was successfully synthesized by the CHSS method. The new contrast agent was characterized using scanning electron microscopy, fluorescence spectrometry, transmission electron microscopy, energy-dispersive spectrometry and ultraviolet-visible light diffuse reflectance absorption spectroscopy. Even at low concentrations (0.2 M), this proposed contrast agent can be excited by near-infrared light with a wavelength of 980 nm and emits a dazzling green light with a wavelength of 540 nm, and the comparison of the luminescence intensity proves that doping with silver increases the luminescence intensity of the upconverted nanomaterial by nearly 13 times based on the calculated quantum yield. TEM images show the successful preparation of silver nanoparticles with a diameter of 30 nm, and the energy spectrum shows the successful doping of silver nanoparticles and the successful preparation of the core-shell structure of NaYF4:Yb3+/Er3+@NaYF4:Nd3+@NaGdF4. Furthermore, the mechanism of the increased luminous intensity has been studied using simulation calculations. Finally, cytotoxicity tests were used to test material which was modified by 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000] (DSPE-PEG2K), and the biocompatibility was significantly improved, meeting the standard for biological applications.Keywords:upconversion;near-infrared;intensity;in vivo imaging
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高影响因子
Materials Science and Engineering B-Advanced Functional Solid-State Materials
·
2022
·
IF 3.407
Tao Li,Yu Sun,Haiyang Dai,Junjie Liu,Jing Chen,Dewei Liu
Four kinds of polyimide (PI) films were prepared by polycondensation reaction using the pyromellitic dianhydride (PMDA) and 4, 4′-(Hexafluoroisopropylidene) diphthalic anhydride (6FDA）as the dianhydride monomer, the p-phenylenediamine (PDA), 4-4′-diaminodiphenyl ether (ODA) and 4,4′-(Hexafluoroisopropylidene) bis(p-phenyleneoxy) dianiline (HFBDA) as the diamine monomer respectively. The incorporation of trifluoromethyl groups can effectively inhibit the formation of intermolecular and intramolecular charge-transfer complex (CTC), improve the energy gap and increase the free volume in PI, which leads to an improvement in the optical and dielectric properties in different degree for three fluorinated PI films compared with the Kapton film. The maximum transmittance in visible region reaches 90.5% and the dielectric constant at 10 4 Hz is close to 2.0 for PI 6FDA-HFPBDA film. The breakdown strength weakens because of the increase of free volume. The correlation between the dielectric and breakdown characteristics and their free volume has been explained with the help of positron lifetime spectra.
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高影响因子
危险品化学品经营许可证（带存储）