JOURNAL OF PHYSICAL CHEMISTRY B
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2015
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IF 3.302
Mei Huang,Shuai He,Wenhong Liu,Yunjin Yao,Shiding Miao
Studies on the configuration of dye molecules are of great importance in revealing origins of the electronic bands as well as understanding their transitions. In this work, we utilized dye molecules named Nile blue A, which are a type of oxazine dyes, to study the molecular configurations when they are transferred from solutions to a solid surface. The Langmuir–Blodgett (LB) technique was employed to construct such an interface where the interaction between the dye molecules and solid supports can be pursued. Hybrid films were prepared via the LB depositions, and the dye molecules were assembled on the elementary clay sheets (laponite, saponite). The configuration of Nb reflected by the molecular orientation, packing density, phase behavior, and variances of the surface tension has been derived. The ex situ spectroscopy characterizations such as UV–vis absorption, fluorescence emission, and excitation spectra were carried out on these LB films to reveal the fact that the adsorbed Nb molecules are mainly assembled in two types of configurations. Adsorbed state I was found to be achieved at high concentrations (1–10 ppm) of clay dispersions and low surface pressure (∼5 mN/m). In this state the anionic oxazine rings of Nb are adsorbed on clay sheets sharing a large lift-off area. This configuration gives allowable fluorescence (λ = 550 nm). Lower clay concentration (<1 ppm) and high surface pressure (10–30 mN/m) yield the adsorbed state II in which the oxazine chromophores were arranged in a side-by-side style, and the dye molecules stand perpendicularly to the clay sheets. This conformation exhibits no photoluminescence.
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Journal of Materials Chemistry B
·
2015
·Vol. 3
·期 45
·8832-8841
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IF 4.726
Huihui Wang,Hao Wu,Hujun Shen,Shaote Geng,Beibei Wang,Yanfang Wang,Xiaojun Ma,Guohui Li,Mingqian Tan
The combination of complementary MRI and NIR imaging methods evolved to provide an even more powerful bioimaging tool. Herein, a novel bimodal MRI/NIR nanoprobe GCF-HDA was prepared via a facile self-assembly approach of three types of amphiphilic structures in aqueous solution. The Stokes shift of the NIR moiety increased from 30 to 150 nm and fluorescence quantum yield increased from 1.5 to 8% after conjugation with electron-rich hexadecylamine (HDA) to organic dye Cy7. The photostability of the nanoprobe GCF-HDA was dramatically improved after involving the newly synthesized dye. Molecular dynamics simulation demonstrated that the GCF-HDA is composed of 2.0–3.5 nm clusters and in each cluster the head groups of the amphiphilic molecules assemble together and the tail groups point outwards. The r1 and r2 relaxivities of GCF-HDA were found to be 11.87 and 19.91 mM−1 s−1 per Gd(III) chelate at 0.5 T, respectively. In vitro cellular imaging with human glioma U-87 MG cells showed that the GCF-HDA was able to enter the cells and accumulate in the cytoplasm. The targeted GCF-HDA resulted in higher MR contrast enhancement and stronger fluorescence intensity than the corresponding non-targeted probe GC-HDA in the tumor tissue 96 hours post injection. Ex vivo fluorescence imaging and histological analysis of the tumor tissue further confirmed the specific binding ability of the GCF-HDA.
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ACS Applied Materials & Interfaces
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2015
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IF 6.723
Xiaosong Guo,Yulu Chen,Ming Su,Dong Li,Guicun Li,Chengdong Li,Yu Tian,Chuncheng Hao,Qingquan Lei
Titanium dioxide and Nb-doped titanium dioxide microspheres with the same size were fabricated by a simple sol–gel method, and the formation mechanism of Nb-doped titanium dioxide microspheres was proposed. Titanium dioxide and Nb-doped titanium dioxide microspheres were adopted as dispersed materials for electrorheological (ER) fluids to investigate the influence of the charge increase introduced by Nb doping on the ER activity. The results showed that Nb doping could effectively enhance the ER performance. Combining with the analysis of dielectric spectroscopy, it was found that the interface polarization of Nb-doped TiO2 ER fluid was larger than that of TiO2 ER fluid, which might be caused by more surface charges in Nb-TiO2 microspheres due to Nb5+ doping and resulting in enhancement of electric field force and strengthening of fibrous structure. In addition, by comparing and analyzing the permittivity curves of Nb-TiO2/LDPE solid composite and Nb-TiO2/silicone-oil fluid composite, it could be concluded that the enhancement of permittivity at low frequency resulted from the increase of the order degree of dispersed particles in ER fluid rather than from the quasi-dc (QDC) behavior. Moreover, the absolute value of slope of permittivity curves (K) at 0.01 Hz could be utilized as the standard for judging the ability to maintain the chainlike structure. The relationships between polarizability of dispersed particles, dielectric spectrum, parameter K, and ER properties were discussed in detail.
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EUROPEAN POLYMER JOURNAL
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2014
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IF 3.242
Chanjuan Tan,Jun Peng,Weihong Lin,Yuxiu Xing,Kai Xu,Jiancheng Wu,Mingcai Chen
Cellulose nanocrystals (CNCs), surface-modified by grafting long alkyl chain amine onto carboxylated CNCs, have been applied as novel nanofillers to prepare nanocomposite films of poly(ethylene-co-vinylacetate) (EVA) through solution casting technique. The robust amide linkages imparted hydrophobicity to the nanocrystal surface and allowed for a better dispersion of CNCs within the EVA matrix. Atomic force microscopy (AFM) surface images and polarized optical micrographs showed that the nanocrystals were randomly oriented in the plane of the EVA film. To achieve the alignment of anisotropic nanofillers, we carried out mechanical shear experiments at an elevated temperature well above the glass-transition temperature of matrix polymer. Hot-pressing and hot-stretching resulted in preferential reorientation of nanocrystals, but not along the shear direction, which is related to the combined actions between the external tension and intermolecular interaction of amide-modified CNC during shear processing. As a result, external mechanical stress transferred from the matrix to the particles, leading to a preferential orientation of the latter. Mechanical and water vapor barrier properties were found to be drastically enhanced. The amide-based CNC/EVA showed high level of elongation at break (up to 85% retention of the initial values). These enhancements were tentatively attributed to the strong interaction occurring at the interface between CNC amide and the EVA polymer.
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ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Ye Zhang,Congjun Zhang,Jing Chen,Li Liu,Mengyue Hu,Jun Li,Hong Bi
Multidrug resistance (MDR) has been recognized as a major obstacle to successful chemotherapy for cancer in the clinic. In recent years, more and more nanoscaled drug delivery systems (DDS) are constructed to modulate drug efflux protein (P-gp) and deliver chemotherapeutic drugs for overcoming MDR. Among them, d-α-tocopheryl polyethylene glycol succinate (TPGS) has been widely used as a drug carrier due to its capability of inhibiting overexpression of P-gp and good amphiphilicity favorable for improving permeation and long-circulation property of DDS. In the present work, a novel kind of mitochondria-targeting nanomicelles-based DDS is developed to integrate chemotherapeutics delivery with fluorescence imaging functionalities on a comprehensive nanoplatform. The mitochondria-targeting nanomicelles are prepared by self-assembly of triphenylphosphine (TPP)-modified TPGS and fluorescent carbon quantum dots (CQDs) in an n-hexane/H2O mixed solution, named CQDs-TPGS-TPP. Notably, although the drug loading content of doxorubicin (DOX) in the as-prepared nanomicelles is as low as 3.4%, the calculated resistant index (RI) is greatly decreased from 66.23 of free DOX to 7.16 of DOX-loaded nanomicelles while treating both parental MCF-7 cells and drug-resistant MCF-7/ADR cells. Compared with free DOX, the penetration efficiency of DOX-loaded nanomicelles in three-dimensional multicellular spheroids (MCs) of MCF-7/ADR is obviously increased. Moreover, the released DOX from the nanomicelles can cause much more damage to cells of drug-resistant MCs. These results demonstrate that our constructed mitochondria-targeting nanomicelles-based DDS have potential application in overcoming MDR of cancer cells as well as their MCs that mimic in vivo tumor tissues. The MDR-reversal mechanism of the DOX-loaded CQDs-TPGS-TPP nanomicelles is also discussed.
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ACS Nanoscience Au
·
2024
·
IF 4.8
Dan Luo,Zhiheng Xie,Shuangqun Chen,Tianyi Yang,Yalin Guo,Ying Liu,Zhouhao Zhu,Liyong Gan,Lingmei Liu,Jianfeng Huang
Electrochemical semihydrogenation (ESH) of alkynes to alkenes is an appealing technique for producing pharmaceutical precursors and polymer monomers, while also preventing catalyst poisoning by alkyne impurities. Cu is recognized as a cost-effective and highly selective catalyst for ESH, whereas its activity is somewhat limited. Here, from a mechanistic standpoint, we hypothesize that electron-deficient Cu can enhance ESH activity by promoting the rate-determining step of alkene desorption. We test this hypothesis by utilizing Cu–Ag hybrids as electrocatalysts, developed through a welding process of Ag nanoparticles with Cu nanowires. Our findings reveal that these rationally engineered Cu–Ag hybrids exhibit a notable enhancement (2–4 times greater) in alkyne conversion rates compared to isolated Ag NPs or Cu NWs, while maintaining over 99% selectivity for alkene products. Through a combination of operando and computational studies, we verify that the electron-depleted Cu sites, resulting from electron transfer between Ag nanoparticles and Cu nanowires, effectively weaken the adsorption of alkenes, thereby substantially boosting ESH activity. This work not only provides mechanistic insights into ESH but also stimulates compelling strategies involving hybridizing distinct metals to optimize ESH activity.
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CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Ding Zhang,Renkun Zhang,Qiuying Zhao,Haiyan He,Huajie Huang,Lu Yang,Yuanping Xu
Flexible sensors capable of real-time monitoring pressure across wide frequency range have garnered significant interest in line with the explosive exploitation of wearable technology and the Internet of Things (IoT). However, it remains a challenge to enable high yet linearized sensitivity over broad pressure range across full-spectrum frequency for the practical application of flexible pressure sensors. Herein, a novel flexible pressure sensor, featured with both high sensitivity and linearity over wide pressure range across full-spectrum frequency, is proposed by assembling micro-structured polyurethane (PU) based piezoresistive layer and poly(vinylidene fluoride) (PVDF) based piezoelectric layer. By synergizing the nanocomposites and topological structure approaches, notably amplified yet linearized sensing performances can be obtained in piezoresistive and piezoelectric layers, respectively. The subsequent coupling of laminated layers permits highly linearized ( R 2 > 0.982) piezoelectric sensitivity of 0.0346 V/kPa over 0–1300 kPa for dynamic pressures monitoring while a piezoresistive sensitivity of 0.0098 kPa −1 (R 2 = 0.960) over 0–100 kPa for static and low frequency (< 4.0 Hz) pressures detecting. Furthermore, the extraordinary sensing capability of sensor permits its viability in real-time capturing physiological signals and aircraft wings motion, highlighting its great applicability in diverse applications.
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CELLULOSE
·
2024
·
IF 4.9
Zheng Jiaojiao,Cao Tianyu,Wang Jianxiao,Xu Wenhao,Qu Yihan,Wang Jiafen,Wu Yunlong,Song Yanyan,He Lizhong,Chen Xudong,Yang Jie,Qu Yinhu
Engineering the active layer of pressure sensors with micro-nano structures is increasingly important in improving their sensing properties, such as sensitivity and detection range. However, existing structures based on template methods continue to face manufacturing challenges and uncontrolled structures, making it difficult to optimize sensing performance. To address the aforementioned shortcomings, this study proposes highly tunable metallic silver copper micro-nano structures adapted on cotton fabric (AgCu/cotton) to adjust the interfacial contact sites and optimize the sensing properties. The shape, size, and distribution of the metallic AgCu nano structures are precisely regulated, and various distinctive morphologies including two-dimensional (2D) nanosheet stacking, three-dimensional (3D) irregular protrusions, and nanoparticle aggregation were obtained. Specifically, the 3D irregular protrusions of varying heights and shapes (nanosheets, nanoparticles, and so on), encouraging multiple deformations and enhanced interfacial contact sites. On the other hand, the hierarchical porous structure of cotton fabric enhances structural compressibility. Collectively, the synergistic results of the 3D irregular protrusions and the hierarchical porous structure allow for a high sensitivity (115.65 kPa −1 ), a quick response time (500 ms), and outstanding stability (2000 cycles). The above sensing properties enable the pressure sensor to be successfully applied in joint movement detection and swallowing recognition. The discovery could pave the way for a more cost-effective and widespread approach to a controlled and improved piezoresistive pressure sensor. Graphical abstract We herein develop a highly morphology-controlled AgCu/cotton flexible pressure sensor with an economical strategy toward superior sensing performance. Such regulated morphology is responsible for optimized contact sites and structural deformation, resulting in a high sensitivity of 115.65 kPa −1 over 2–7.5 kPa, and showing great potential in various human motion detections.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2025
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IF 8.3
Yanze Wang,Zhenyu Liu,Wenxuan Wang,Junxiao Tang,Rongjie Wang,Jingjing Xie,Zhengyi Fu
Accelerating charge transport and avoiding recombination are promising strategies for establishing highly efficient artificial photosystems. Herein, an S-scheme heterostructure consisting of Zn x Cd 1− x S and TiO 2 is fabricated via the in situ crystal growth method. The refined structure significantly enhances the transport of photogenerated charges, thereby improving photocatalytic hydrogen production efficiency. The optimized TiO 2 −Zn x Cd 1− x S composite, incorporating 60% TiO 2 with Zn 0.4 Cd 0.6 S, exhibits a robust H 2 evolution rate of 50.96 mmol g −1 h −1 with continuous release of H 2 bubbles. It is worth noting that the hydrogen production rate in seawater is as high as 26.22 mmol g −1 h −1 . The strong interfacial interaction and staggered band alignment between TiO 2 and Zn x Cd 1− x S result in the formation of a built-in electric field and high-content oxygen vacancies, which can drive the directional migration of photoelectrons with high redox ability and high speed. The designed photocatalyst with S-scheme and rich Oxygen vacancies at the interface provides a new approach for fabricating high-efficiency photocatalysts.
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ACS Nano
·
2025
·
IF 16
Ximu Li,Mengyao Ma,Ni An,Xiaoxuan Yao,Guzailinuer Yasen,Mingyuan Zhong,Zheng Jin,Zhonggui He,Yongjun Wang,Hongzhuo Liu
Antidrug antibodies (ADAs) against biologics present a major challenge for sustained biotherapy, including enzyme replacement therapies and adeno-associated virus (AAV) gene therapies. These antibodies arise from undesirable immune responses, leading to altered pharmacokinetics, reduced efficacy, and adverse reactions. In this study, we introduced a rationally designed lipid-rapamycin (Rapa)-based nanovaccine to restore immune tolerance to biologics and overcome drug resistance. The nanovaccine significantly decreased ADA responses when used in a tolerogenic regimen with keyhole limpet hemocyanin (KLH), uricase, pegylated uricase, and AAV8 vector gene therapy. This approach facilitated three rechallenges with pegylated uricase after a 5 week rest from the nanovaccine, thereby enhancing its urate-lowering efficacy. Furthermore, the nanovaccine allowed for the successful intravenous readministration of AAV8 vector expressing secreted embryonic alkaline phosphatase (AAV8-SEAP), achieving sustained viral DNA and transcript levels in target tissues. The nanovaccine prompted antigen-presenting cells (APCs) in the liver to exhibit dynamic changes in CD80, CD86, MHCII, and PD-L1, which promoted the development of immunoregulatory T cells in response to biologic challenges. Notably, the nanovaccine exerted a minimal impact on CD8+ T cells, natural killer (NK) cells, and NK T cells, preserving the body’s normal immune response to pathogens and tumors. Overall, the universal nanovaccine addressed biologic resistance by mitigating ADA-related issues, thereby enabling a prolonged therapeutic efficacy for antibodies, proteins, and gene therapies.
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MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 5
·1-13
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IF 5.3
Gao Xue,Liu Lu,Jia Mu,Zhang Hongmei,Li Xuepeng,Li Jianrong
A dual-mode (colorimetric/fluorescence) nanoenzyme-linked immunosorbent assay (NLISA) was developed based on Au-Cu nanocubes generating Prussian blue nanoparticles (PBNPs). It is expected that this method can be used to detect the residues of sulfonamides in the field, and solve the problem of long analysis time and high cost of the traditional method. Sulfadimethoxine (SDM) was selected as the proof-of-concept target analyte. The Au-Cu nanocubes were linked to the aptamer by amide interaction, and the Au-Cu nanocubes, SDM and antibody were immobilized on a 96-well plate using the sandwich method. The assay generates PBNPs by oxidising the Cu shells on the Au-Cu nanocubes in the presence of hydrochloric acid, Fe 3+ and K 3 [Fe (CN) 6 ]. In this process, the copper shell undergoes oxidation to Cu 2+ and subsequently Cu 2 + further quenches the fluorescence of the carbon point. PBNPs exhibit peroxidase-like activity, oxidising 3,3’,5,5’-tetramethylbenzidine (TMB) to OX-TMB in the presence of H 2 O 2 , which alters the colorimetric signal. The dual-mode signals are directly proportional to the sulfadimethoxine concentration within the range 10 − 3 ~10 − 7 mg/mL. The limit of detection (LOD) of the assay is 0.023 ng/mL and 0.071 ng/mL for the fluorescent signal and the colorimetric signal, respectively. Moreover, the assay was successfully applied to determine sulfadimethoxine in silver carp, shrimp, and lamb samples with satisfactory results.
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NEW JOURNAL OF CHEMISTRY
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2024
·Vol. 48
·期 9
·4175-4183
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IF 2.7
Rong Wang,Jin Li,Jia-Jia Chen,Yu Guo,Yue Hu,Xiao-Qi Yu,Ji Zhang
Lipid nanoparticles (LNPs) are the most advanced non-viral platform for nucleic acid delivery, holding enormous potential applications in clinical therapy. However, some shortcomings remain, such as complex synthetic routes, low synthetic yield, and high cost. In this study, a series of lipid molecules with different cationic headgroups and hydrophobic tails were designed and prepared via Passerini reaction, which provided a convenient multi-component one-step synthetic process toward the lipid molecules with variable product structures for structure–activity relationship studies. The LNPs formed from these lipids could compress DNA efficiently and form stable lipoplexes with low cytotoxicity. The gene transfection efficiency was largely affected by the lipid structure including the cationic headgroup and hydrophobic tails. The lipids A3 with equal C14 length tails could induce the highest transfection efficiency, which was up to 25 times higher than Lipo 2000. Compared to the commercial transfection reagent, the efficiency of target LNPs was less negatively affected by serum. Mechanism studies by confocal microscopy and flow cytometry revealed that lipids with equal C14 length tails led to more efficient cellular uptake, which might contribute to their higher transfection efficiency. This study provides a new strategy for the construction of cationic lipid gene vectors for non-viral gene delivery by multi-component Passerini reaction.
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