Advanced Science
·
2023
·
IF 15.1
Qiao Chen,Xinmei Duan,Yao Yu,Rongrong Ni,Guojing Song,Xu Yang,Li Zhu,Yuan Zhong,Kun Zhang,Kai Qu,Xian Qin,Wei Wu
Multifunctional nanomedicines have been used in atherosclerosis theranostics. Herein, phosphatidylserine-specific peptide CLIKKPF-functionalized carbon-dots nanozymes (pep-CDs) are reported for specific and efficient noninvasive theranostic of atherosclerosis. Surprisingly, pep-CDs are discovered to not only inherit the inherent properties of carbon dots (CDs), including deep-red fluorescence emission, photoacoustic response, and superoxide dismutase-like antioxidant, and anti-inflammatory activities but also possess the ability to target recognition on foam cells and target localization on plaques due to the specific interaction of CLIKKPF with phosphatidylserine on the membrane outer surface of foam cells. Furthermore, the target localization effect of pep-CDs vastly promotes the efficient accumulation of CDs in plaque, thus maximizing AS theranostic of CDs. Interestingly, pep-CDs could be developed to image plaque for monitoring atherosclerosis pathological progression in real-time resulting from the different content of foam cells. This work on the one hand proposes a simple and feasible strategy to construct theranostic nanoplatform employing only a single functional unit (i.e., multifunctional CDs) to simplify the fabrication procedure, on the other hand, highlights the advantages of the active target auxiliary mode for atherosclerosis theranostic applications.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Zehao Chen,Ting Zhao,Qing Tan,Jihao Zuo,Shouping Xu,Yunjun Nong,Xiufang Wen,Pihui Pi
The crude oil spillage and large-scale industrial release of oily effluents has led to significant ecological degradation and resource wastage. Traditional superwetting materials encounter intractable challenges for treating surfactant-stabilized oil–water emulsions, including trade-off effect of permeation flux and separation efficiency, and low emulsion processing life. These issues considerably impede advancements in oil–water separation industry. In order to enhance the demulsification durability of materials while ensuring high separation efficiency and flux, this work doped perfluorooctanoic acid (PFOA) onto the modified sponge surface with superhydrophilic charged surface, and a unique in-air superhydrophilic-oleophobic sponge was prepared. This special surface allows rapid water phase permeation yet offers remarkably more stable oleophobicity compared with traditional underwater oleophobic materials when processing a large amount of emulsions. The intrinsic oleophobicity endows the sponge outstanding fouling resistance and greatly increases the one-cycle emulsion treatment amount up to 1695 L·m −2 . Moreover, the sponge's inherent long permeation channels and surface charge maintain a high separation efficiency of over 97 %. The large pores of the sponges and superhydrophilic surface provide a high permeation flux exceeding 40,000 L·m −2 ·h −1 . The sponge with high separation efficiency, flux, and capacity marks a significant advancement, offering a promising strategy for superwetting material applications in oil-in-water emulsion separation fields.
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Materials Today Communications
·
2023
·
IF 3.8
Yanyan Yu,Guopeng Xu,Peijian Zhao,Jie Zhang
Wound dressings, an effective tool for repairing injured skin and protecting it from secondary damage, have been widely manufactured. However, the design of wound dressings with waterproofness, breathability, mechanical robustness, and excellent biocompatibility remains a challenge due to the imbalance between the multiple desirable properties. Herein, a strategy is proposed to fabricate biocompatible membranes via a facile one-step electrospinning method. Polydimethylsiloxane-based polyurethane is effectively prepared to form durable hydrophobic surfaces , resulting in a high degree of hydrophobicity (141.0° water contact angle). The porous structure is enhanced by adjusting the solution concentration and heat treatment temperature, resulting in an optimal water vapor transmission rate of 8.2 kg·m −2 ·h −1 . Additionally, the membrane exhibits a hydrostatic pressure of 52.3 kPa, which is approximately 14.1 times greater than that of PU fibrous membrane , and an enhanced tensile strength of 6.60 MPa. Moreover, the membrane can be utilized in a wide temperature range from − 123 °C to 160 °C due to its low glass transition temperature and exceptional thermal stability. Significantly, both in vitro and in vivo studies confirmed the remarkable biocompatibility and minimal toxicity to normal cells and mice skin. Our work presents a new approach to designing waterproof and breathable biomaterials with high mechanical strength , thereby enhancing their performance and functionality in the biomedical field, particularly in wound dressing applications.
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Environmental Technology & Innovation
·
2026
·
IF 7.3
Jiangtao Yu,Rui Wang,Mei Chen,Hongwei Guo,Yang Zhao
Reagent-free thermal regeneration restores ~99% flux in oil-fouled membranes. • A 400 °C treatment removes pore-associated residues without observable collapse. • Al 2 O 3 membranes retain ~97% FRR and ~98% O/W emulsion rejection after five cycles. • Thermal treatment restores membranes after repeated alkaline-cleaning failure. • Direct-input comparison shows ~11% cost and ~13% electricity input. Severely oil-fouled ceramic membranes that lose recoverability after conventional cleaning represent a replacement-prone but underutilized inorganic separation resource. Here, we demonstrate a reagent-free thermal regeneration strategy for restoring oil-fouled Al 2 O 3 ceramic membranes and examine its applicability to SiC membranes. Under optimized conditions of 400 °C for 30 min, the regenerated Al 2 O 3 membrane achieved an initial flux recovery ratio of nearly 99% and retained ~97% flux recovery after five fouling-regeneration cycles, while the emulsified-oil rejection remained ~96–98%. Repeated alkaline cleaning led to substantial irreversible flux loss, whereas subsequent thermal regeneration restored the flux recovery to ~96%, highlighting its value for membranes after repeated alkaline-cleaning failure. Structural and thermal analyses indicate that thermal treatment promotes the transformation and removal of oil-emulsion-derived organic residues from the fouled surface and pore-associated regions, thereby reopening transport pathways while preserving the ceramic pore architecture and crystal phase. The direct-input comparison shows that thermal regeneration requires ~11% of the direct-input cost and ~13% of the electricity input associated with pristine membrane fabrication. This work provides a practical basis for restoring severely oil-fouled ceramic membranes before replacement in oily wastewater treatment. Download: Download high-res image (277KB) Download: Download full-size image
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ACS Applied Polymer Materials
·
2023
·
IF 5
Jing Li,Yining Sun,Xiaodong Yang,Zhuan Fu,Xiangxiang Zhu,Hui Sun,Bin Yu
The superwetting membrane with superhydrophilic/underwater superoleophobic properties is one of the ideal materials for treating oily wastewater. We combined a catechol/silane biomimetic composite coating system and a metal-phenolic network structure to co-deposit a dopamine-like superhydrophilic coating on polypropylene nonwoven fabrics. The modified fabric separated oil–water mixtures with a filtration efficiency of up to 99%. Besides, the as-prepared material has the property of nonstick oil underwater and outstanding stability. After 30 cycles of separation tests, the pure water flux can be restored to 94.5% of the initial value after rinsing with deionized water. It maintained underwater superoleophobic properties after being immersed in a harsh environment of pH 1 or 13 for 1 h. Compared with dopamine hydrophilic modification, this method was more economical and time-consuming and could fabricate a full-scale separation material.
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Journal of Coatings Technology and Research
·
2023
·
IF 2.3
Liu Yalong,Kong Fangyuan,Xin Binjie,Chen Zhuoming,Xu Yingqi,Liu Yan,Li Lifeng,Newton Md All Amin
The efficient separation of oil and water is significant in addressing oil–water pollution issues. In this study, we developed a poly(vinylidene fluoride)/graphite (PVDF/GE) multiscale heterogeneous porous carbon nanofiber composite mat (MHPCM) through a two-step electrospinning method for enhanced oil–water separation. The mat was prepared by incorporating PVDF nanospheres, GE flakes, and carbon nanofibers, taking advantage of their inherent oil-repellent and water-attracting properties. MHPCM-4 demonstrates superhydrophobicity (WCA≈154.1°) and superoleophilicity (OCA≈0°). The separation efficiency for 1–14 μm carbon tetrachloride-in-water emulsions exceeds 99.9%. After 25 cycles, MHPCM-4 maintains its oil flux at 92.25% of the initial value. Additionally, even after 25 cycles, MHPCM-4 retains a separation efficiency of 99.8% for immiscible oil-in-water mixtures and a separation efficiency of 99.7% for water-in-oil emulsions. Thus, this material has great potential for efficient oil–water separation in various circumstances.
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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
·
2023
·
IF 6.2
Pei Feng,Peizhuo Pang,Zehang Sun,Zhongyu Xie,Tingting Chen,Shan Wang,Qian Cao,Rujia Mi,Chenying Zeng,Yixuan Lu,Wenhui Yu,Huiyong Shen,Yanfeng Wu
Background Mesenchymal stem cells (MSCs) are pluripotent stem cells capable of differentiating into osteocytes, adipocytes and chondrocytes. However, in osteoporosis, the balance of differentiation is tipped toward adipogenesis and the key mechanism is controversial. Researches have shown that, as upstream regulatory elements of gene expression, enhancers ar involved in the expression of identity genes. In this study, we identified enhancers-mediated gene FOXO3 promoting MSC adipogenic differentiation by activating autophagy. Methods We integrated data of RNA sequencing (RNA-seq), chromatin immunoprecipitation sequencing (ChIP-seq) and ATAC-sequencing (ATAC-seq) to find the identity gene FOXO3. The expression of FOXO3 protein, adipogenic transcription factors and the substrate of autophagy were measured by western blotting. The Oil Red O (ORO) staining was used to visualize the adipogenesis of MSCs. Immunohistochemistry was used to visualize the FOXO3 expression in adipocytes in bone marrow. Immunofluorescence was used to detect the expression of PPARγ and LC3B. Results During adipogenesis, enhancers redistribute to genes associated with adipogenic differentiation, among which we identified the pivotal identity gene FOXO3. FOXO3 could promote the expression of the adipogenic transcription factors PPARγ, CEBPα, and CEBPβ during adipogenic differentiation, while PPARγ, CEBPα, and CEBPβ could in turn bind to FOXO3 and continue to promote FOXO3 expression to form a positive feedback loop. Consistently elevated FOXO3 expression promotes autophagy by activating the PI3K-AKT pathway which mediates adipogenic differentiation. Conclusions Pivotal identity gene FOXO3 promotes autophagy by activating PI3K-AKT pathway, which provokes adipogenic differentiation of MSCs. Enhancer-regulated adipogenic identity gene FOXO3 could be an attractive treatment for osteoporosis.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Zhecun Wang,Hanzhen Li,Min Guan,Xin Yang,Jing Guo,Shenghai Li,Yaohan Chen
Janus porous membranes with anisotropic interfaces exhibiting directional liquid transport properties have emerged as important tools for addressing real-world issues, such as oil-spill cleanup and fog collection. Here, a single-layered Janus mesh membrane with asymmetric wettability and a well-tuned hydrophilization depth is prepared using an ethanol-assisted floating method. Consequently, the well-regulated hydrophilization depth combined with a water-assisted strategy achieves controllable and efficient directional water transport properties, which also gives rise to a high anisotropic critical breakthrough pressure. In addition, the water-assisted controllability can form an on–off gate capable of allowing or blocking water to pass through upon request. Moreover, we theoretically and experimentally determine the changeable contact area as important in directional water transport properties. Controllable directional water transport behavior with a high pressure difference has been demonstrated in on-demand oil–water separation and intravenous infusion, whereas the efficient directional water transport properties have potential applications in fog collection. Overall, this work provides a new idea for the preparation of a single-layered multifunctional Janus mesh membrane with a high anisotropic critical breakthrough pressure and opens an avenue for controllable and efficient directional water transport properties for diverse applications.
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Small
·
2023
·
IF 13.3
Lingya Fei,Liguo Shen,Cheng Chen,Jiujing Xu,Boya Wang,Bisheng Li,Hongjun Lin
Assembling metal-organic frameworks (MOFs) into high-performance macroscopic membranes is crucial but still challenging. MOF-containing hybrid membranes can effectively integrate the advantages of flexible guest materials and MOFs. Nevertheless, the inherent limitations in fully harnessing the distinct characteristics of MOFs persist due to the substantial guest material content necessitated in membrane fabrication. Herein, inspired by the rigid and flexible structures in biological systems, rigid MIP-202(Zr) and defective MIP-202(Zr) (D-MIP-202(Zr)) modified flexible graphene oxide (GO) sheets are synthesized in situ and then assembled into a rigid-flexible coupled MOF-based membrane. The defects in D-MIP-202(Zr) are introduced by using acetic acid as the modulation agent. The obtained GO@MIP-202(Zr) membrane possesses a hierarchical porous structure with a 99 wt% MOF proportion, which is higher than the GO@D-MIP-202(Zr) (75 wt%) membrane with a compact bulge-structured surface. The water permeability of the GO@MIP-202(Zr) membrane attains remarkedly 5762.92 L h −1 m −2 bar −1 , which is 960 and 2.6 times higher than that of the GO membrane and GO@D-MIP-202(Zr) membrane. Additionally, benefiting from the superhydrophilicity and underwater superoleophobicity, the resultant membrane not only demonstrates high rejection for oil-water emulsions but also exhibits exceptional recyclability and anti-fouling ability. These findings provide valuable insights into the assembly of MOFs into high-performance membranes.
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JOURNAL OF MATERIALS SCIENCE
·
2023
·Vol. 58
·期 41
·16002-16018
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IF 4.5
Zhang Yipeng,Jiang Ruohai,Zhang Yujie,Huang Chaozhang,Xiong Xiaopeng
Microsphere polymer material finds a wide range of applications in fields such as adsorbent, drug carrier, catalyst and coating, and receives continuous attention. We here report a novel strategy of quick synthesis of polymethacrylate microsphere via photoinitiated polymerization of methacrylate monomer in a high internal phase emulsion (HIPE). A low cost and environmentally friendly natural product of β-cyclodextrin (β-CD) has been directly used as Pickering emulsifier to stabilize the methacrylate monomer in water to prepare the HIPE. The factors to control the particle size such as the dosage of β-CD, volume fraction of monomer internal phase and amount of inert diluting solvent, have been investigated in detail. Meanwhile, the approach has been validated by using various methacrylate monomers. Our results indicate that using a diluting solvent can not only change the surface morphology but also control the inner microstructure of the microsphere. By using a poor solvent of cyclohexane as diluting agent, porous microsphere other than solid microsphere has been prepared, and it could be directly applied as adsorbent to decolor oil. Moreover, the obtained poly(glycidyl methacrylate) microsphere was post-modified to exhibit satisfactory adsorption efficiencies towards organic dye contaminates in water. Those results indicate powerful platform of the obtained microsphere with reactive groups for further modification to prepare functional materials for desired purposes. Based on the fast synthesis, high yield, low energy cost as well as no harmful waste, the preparation strategy reported in this work could be scalable, and the obtained microsphere may find promising potential applications. Graphical abstract
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Nanoscale Advances
·
2023
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IF 4.7
Chunying Cui,Shuang Zhang,Dandan Li,Danni Liu,Yaoqi Wang,Qi Sun,Ran Sun,Jie Zhang,Xiaoxuan Hong,Ran Huo
Atherosclerosis is a chronic inflammatory disease, characterized by a lipid accumulated plaque. Anti-oxidative and anti-inflammation as well as lipid metabolism promoting therapeutic strategies have been applied for atherosclerosis treatment. However, the therapeutic effect by a single therapeutic method is limited. Combination of the two strategies could for one thing prevent lipid accumulation cause by inflammation and oxidative stress, for another thing promote lipid efflux from atherosclerotic plaque, to normalize arteries maximumly. Hence, a multifunctional liposome co-encapsulating an antioxidant and anti-inflammatory drug epigallocatechin-3-gallate(EGCG) as well as a lipid-efflux promoting gene miR-223 was established. The system (lip@EGCG/miR-223) could encapsulate miR-223 in core areas of the liposomes to provide an effective protective effect for gene drugs. Moreover, lip@EGCG/miR-223 was smaller in size (91.28±2.28 nm characterized by DLS), making it easier to target to AS lesions which had a smaller vascular endothelial spaces. After internalized into cellular efficiently, lip@EGCG/miR-223 exhibited excellent antioxidant and anti-inflammatory effects in vitro by eliminating overproduced ROS and decreasing the level of inflammatory cytokines (TNF-α, IL-1β and MCP-1), which is due to the effect of EGCG. Besides, the lipid-efflux promoting protein ABCA1 was up-regulated when treated with lip@EGCG/miR-223. By the two therapies mentioned, lip@EGCG/miR-223 could effectively inhibit the formation of foam cells, which is a main component of atherosclerotic plaques. In AS model mice, after intravenous (i.v.) administration, lip@EGCG/miR-223 was effectively accumulated in atherosclerotic plaques, and the distribution of drugs in heart and aorta to that in kidney was significantly increased when compared with free drugs (the ratio was 6.27% for free miR-223 treated group, and was increased to 66.10% for lip@EGCG/miR-223 treated group.). By decreasing inflammation level and lipid accumulation, the arterial vessels in AS were normalized with less macrophages and micro-angiogenesis when treated with lip@EGCG/miR-223. Overall, this study demonstrates lip@EGCG/miR-223 can be developed as a potential system for atherosclerosis treatment by a combined treatment of antioxidant, anti-inflammatory and lipid-efflux promoting effects, which provides a novel strategy for safe and efficient management of atherosclerosis.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Jing Jing,Zhanjian Liu,Xiguang Zhang,Jinyue Yang,Meiling Li,Ruixia Yuan,Guolin Jing,Huaiyuan Wang
Janus membrane with asymmetric wettability are emerging separation materials for the purification of emulsified oil–water mixtures, however, their poor mechanical durability and low-flux without external pressure severely limit their practical application. Herein, a robust superwetting Janus mesh demonstrating a high water contact angle (WCA) difference up to 157° was developed by simply spraying on the stainless steel mesh (SSM), via the superhydrophobic fluorocarbon resin/polyvinylidene fluoride/1H, 1H, 2H, 2H-perfluorodecyltrichlorosilane modified titanium dioxide@carboxylated CNTs (FEVE/PVDF/F-TiO 2 @CNTs) layer and a superhydrophilic layer consisting epoxy resin/ethylene imine polymer/sodium perfluorooctanoate modified bentonite (EP/PEI/F-Bentonite). By carefully adjusting the surface polar-nonpolar molecule repulsion based on the two oppositely bond energy side and incorporating nano/microstructures to form a stable interfacial oiling/hydration layer, the robust Janus mesh achieved interface demulsification and gravity separation of emulsified oil–water mixtures. The prepared Janus SSM exhibited excellent gravity-driven separation performance, achieving a flux up to 1508.6 L m −2 h −1 for water-in-oil (W/O) emulsions, and 843.1 L m −2 h −1 for oil-in-water (O/W) emulsions. Additionally, it exhibited high separation efficiency with water rejection above 99.9 % and oil rejection above 99.7 %. Moreover, the prepared Janus mesh with fine uniform nano/microstructures and functionalized groups demonstrated notable reusability and mechanochemical stability after 10 cycles of O/W and W/O emulsion filtration, 100 cycles of sandpaper abrasion, and strong acid/alkali immersion for 7 d. Overall, this study expected to facilitate the fabrication of a robust asymmetric superwetting Janus mesh with enhanced separation properties for highly efficient oily wastewater treatment.
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危险品化学品经营许可证（带存储）