Liver Research
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2025
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IF 2.1
Qian Zeng,Yina Sun,Mengzhen Lei,Zihan Liu,Xijing Yan,Rong Li,Jun Zheng,Jiandong Zha,Lijun Zhang,Xiaoling Guan,Jia Yao
Background and aims Hepatic ischemia-reperfusion injury (HIRI) is a major contributor to liver dysfunction and failure, particularly in the context of liver transplantation. Its pathogenesis is primarily driven by ferroptosis, oxidative stress, and mitochondrial dysfunction. Given the interplay among these mechanisms through redox imbalance and disrupted energy metabolism, nicotinic acid (NA)—recognized for its antioxidative and metabolic regulatory properties—emerges as a promising therapeutic candidate. This study aims to investigate the protective effects of NA on HIRI and elucidate its underlying mechanisms. Methods An HIRI model in mice and a hypoxia/reoxygenation (H/R) model in primary hepatocytes were established to evaluate the effects of NA treatment on oxidative stress. NA was administered prior to model induction. N-acetylcysteine (NAC) was used as a comparator. Comprehensive assessments of ferroptosis, oxidative stress, mitophagy, and mitochondrial biogenesis markers were conducted using Western blotting, immunohistochemistry, immunofluorescence, and biochemical assays. Results NA pretreatment reduced serum alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase (LDH) levels, suppressed inflammation by decreasing neutrophil infiltration and macrophage activation, and mitigated oxidative stress by lowering reactive oxygen species (ROS) and malondialdehyde (MDA) levels. It enhanced antioxidant defenses, inhibited ferroptosis, and improved mitochondrial health through increased mitophagy, mitochondrial biogenesis, and mitochondrial permeability transition pore (mPTP) stabilization, leading to enhanced ATP production and mitochondrial function in HIRI. Conclusions NA improves mitochondrial function by promoting mitophagy and mitochondrial biogenesis, which reduces ferroptosis and oxidative stress, thereby alleviating HIRI.
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PubMed
高影响因子
RENEWABLE ENERGY
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2025
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IF 9.1
Yu Zhang,Runzhe Li,Jingde Luan,Longde Jiang,Wengang Liu,Zheng Yan,Yu Bai
Photocatalytic hydrogen evolution from seawater splitting was a sustainable energy technology, alleviating the overuse of limited freshwater resources. The exogenous carbon was successfully doped into the framework of graphite carbon nitride via ultrasonic peeling and secondary calcination, replacing the bridging N atoms within the heptazine skeleton. This approach effectively regulated the chemical structure of g-C 3 N 4 , and the photocatalytic hydrogen yield of as-prepared CN-NA45 in water reached 7.15 mmolg −1 h −1 . In artificial seawater, the hydrogen yield of CN-NA45 increased to 10.80 mmolg −1 h −1 , which was attributed to the larger specific surface area, reduced band gap and more negative band edge. The presence of bridging carbon facilitated the transfer of electrons from the heptazine ring to the region near the bridging position, enhancing the local delocalization of π electrons. In artificial seawater, the adsorption of Na + ions on the catalyst surface were superior to other ions, facilitating the electron enrichment and providing more electrons for the photocatalytic reduction reaction. This work provided an insight into the construction of photocatalytic materials for marine environmental applications and the impact of electrolyte ions on hydrogen evolution performance.
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高影响因子
TALANTA
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2015
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IF 3.545
Xiao-Dong Cheng,Yan-Hong Hao,Xi-Tian Peng,Bi-Feng Yuan,Zhi-Guo Shi,Yu-Qi Feng
The present study described the preparation and application of zwitterionic stationary phases (ACS) with controllable ratio of positively charged tertiary amine groups and negatively charged carboxyl groups. Various parameters, including water content, pH values and ionic strength of the mobile phase , were investigated to study the chromatographic characteristics of ACS columns. The prepared ACS columns demonstrated a mix-mode retention mechanism composed of surface adsorption, partitioning and electrostatic interactions . The elemental analysis of different batches of the ACS phases demonstrated good reproducibility of the preparation strategy. Additionally, various categories of compounds, including nucleosides , water-soluble vitamins, benzoic acid derivatives and basic compounds were successively employed to evaluate the separation selectivity of the prepared ACS stationary phases. These ACS phases exhibited entirely different selectivity and retention behavior from each other for various polar analytes, demonstrating the excellent application potential in the analysis of polar compounds in HILIC .
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PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
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2025
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IF 2.5
Yikai Chen,Wen Ye,Wenxin Wang,Nan Miao,Yongqiang Sha,Tao Sun
Major depressive disorder (MDD) is characterized by anhedonia and cognitive deficits. In this study, we investigated the therapeutic effects of nicotinic acid (NA), a nicotinamide adenine dinucleotide + (NAD + ) precursor, in a mouse chronic restraint stress (CRS) model. Behavioral assessments revealed that NA ameliorated depressive-like behaviors, evidenced by restored sucrose preference and reduced immobility in forced swim and tail suspension tests, without affecting motor coordination in the rotarod test. Hippocampal transcriptomic analysis indicated that NA reversed stress-induced gene dysregulation, activated neuroprotective Wnt/β-catenin, cGMP–PKG, and cAMP pathways, and rescued lipid and porphyrin metabolism. In conclusion, NA likely exerts antidepressant effects by remodeling hippocampal gene networks to enhance synaptic plasticity and restore metabolic homeostasis. These findings highlight NA as a promising metabolic antidepressant and support the development of NAD + precursor–based potential therapies for mood disorders.
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高影响因子
TALANTA
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2025
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IF 6.1
Huifang Wu,Qiqi Wang,Lingfeng Zhu,Haoliang Zhang,Lizhong Liu
Anthrax, a fatal infectious disease caused by Bacillus anthracis ( B. anthracis ), poses a significant threat to public health. Herein, a novel type of carbon dots rich in π → π∗ transitions ( R -CDs) was developed to fabricate an R -CDs/Eu 3+ hybrid for the rapid on-site detection of the B. anthracis biomarker dipicolinic acid (DPA). The R -CDs/Eu 3+ hybrid exhibits two distinct fluorescence responses to DPA: (1) quenching of the R -CDs fluorescence due to the internal filter effect, and (2) enhancement of Eu 3+ fluorescence resulting from the antenna effect and the protective role of R -CDs, enabling ratiometric detection of DPA over a range of 0.1–100 μM with excellent selectivity. Furthermore, a portable, cost-effective device based on the hybrid was developed, enabling in-filed detection of DPA in lake water and real-time monitoring of DPA release from bacterial spores, which holds great promise for monitoring pathogenic biomarkers, with significant implications water safety and human health.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2024
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IF 4.3
Rui Cao,Mengyu Zhang,Wen Tang,Jing Wu,Yang Luo,Yi Chen,Zhaodi Liu,Fuying Hao,Liangquan Sheng,Huajie Xu
In this work, a stable ratiometric nanofluorescent probe for the detection of 2,6-dipicolinic acid (DPA), a Bacillus anthracis biomarker, was developed based on confinement-induced emission enhancement of cationic styrylpyridine salt derivative L in MCM-22 molecular sieve pores. The cationic L and the lanthanide Tb 3+ were loaded into the pores of the molecular sieve by electrostatic interaction with the negatively charged AlO 4 tetrahedron unit, and L exhibited enhanced red fluorescence emission as a stable fluorescence reference mark in the nanoprobe platform due to the restricted molecular torsion of L in the pores of MCM-22. At the same time, the characteristic green fluorescence emission of Tb 3+ can be excited by energy transfer due to the “antenna effect” of DPA. The prepared Tb-L@MCM-22 nanoprobe showed specific selectivity and stable fluorescence ratiometric detection of DPA in tap water, lake water, bovine serum and actual bacterial spores. Benefiting from the confinement-induced fluorescence enhancement effect of L in the MCM-22 molecular sieve pores, the obtained Tb-L@MCM-22 can provide a stable reference signal for the fluorescence ratiometric detection of DPA with a limit of detection (LOD) of 78.6 nM and 1.310 × 10 4 spores per mL. More importantly, combining of the Tb-L@MCM-22 based DPA detection test strips with a smartphone app demonstrated a stable, convenient and rapid method for detecting of anthrax biomarkers.
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高影响因子
CRYSTAL GROWTH & DESIGN
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2024
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IF 3.2
Detao Li,Wenqian Chen,Limin Zhou,Li Xu,Feiqiang He,Jerry Y Y Heng,Hamza Shehzad,Jinbo Ouyang
Understanding drug cocrystal formation and its competitive mechanism is important for improving the physicochemical properties of drugs. In this article, the cocrystal formation of polyhydroxy natural products and their competitive mechanisms are discussed through experimental screening and theoretical calculations. The formation conditions and types of cocrystals were determined based on efficient screening experiments of polyhydroxy natural product cocrystals. To investigate the difficulty and stability of cocrystal formation, competitive cocrystal experiments of polyhydroxy natural products were carried out simultaneously. By simulation of the electrostatic potential surface of molecules and the Hirshfeld surface of crystals, the mode of hydrogen bonding within the crystals was determined. The strength of hydrogen bonding was assessed based on the intermolecular interactions and energy framework within the crystal structure. A “substitution model” was constructed based on experimental results and theoretical calculations, which is of great significance for the prediction and design of natural product cocrystals and provides a feasible solution for improving the physicochemical properties of drugs.
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高影响因子
危险品化学品经营许可证（带存储）