Journal of Materials Chemistry B
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2021
·Vol. 10
·期 14
·2584-2596
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IF 6.331
Qin Yao,Binghai Chen,Jiaxiang Bai,Wenbo He,Xu Chen,Dechun Geng,Guoqing Pan
Urinary tract infection (UTI) represents one of the most common nosocomial infections, which is mainly related to indwelling catheters or stents. In addition to the formation of biofilms to reduce antibiotic sensitivity, the urease-producing bacteria can also increase urine pH, causing Ca2+ and Mg2+ deposition and finally catheter obstruction. The prevention of UTIs and its complication (i.e., encrustation) thus is a great challenge in design of catheters and ureteral stents. In this work, a metal-catechol-assisted mussel chemistry (i.e., dopamine self-polymerization) was employed for surface functionalization of commercially available catheters with antimicrobial peptides (AMP), for the purpose of long-term anti-infection and encrustation prevention. To improve the stability of the polydopamine coating on polymeric stents, we used Cu2+-coordinated dopamine self-polymerization. Then, a cysteine-terminated AMP was introduced on the polydopamine coating through Michael addition. We found that the Cu2+-coordinated polydopamine coating showed improved stability and antibacterial effect. The cytotoxicity test confirmed that the bioinspired antibacterial coating showed good biocompatibility and no obvious toxicity. The results confirmed that the stents with AMP could in situ inhibit bacterial growth and biofilm formation, and finally reduce the deposition of struvite and hydroxyapatite crystals both in vitro and in vivo. We anticipate that this bioinspired strategy would develop a safe, stable and effective antibacterial coating on urinary tract medical devices for long-term bacterial inhibition and encrustation prevention.
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Journal of Materials Chemistry B
·
2021
·Vol. 9
·期 41
·8615-8625
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IF 6.331
Buyun Guo,Rong Fan,Shuwei Shen,Yue Xue,Zhiqiang Zhu,Ronald X. Xu
Accurate delivery of therapeutics to tumor regions and effective sparing of normal tissue structures are important principles for the treatment of widespread metastases or malignant lesions in close proximity to vital organs. However, the currently available drug delivery techniques do not support precise drug release within the identified disease margins. We propose a tailored drug delivery strategy that utilizes a photo-responsive material in combination with tumor margin imaging for automated and tailored release of therapeutics. As a proof of concept, a poly(ethylene oxide)-b-PSPA (PEO-b-PSPA) diblock copolymer is synthesized by spiropyran (SP) polymerization. A photo-responsive membrane (PRM) is formed and irradiated with light sources of different wavelengths. Switching irradiation between ultraviolet light (UV) and green light (Vis) controls the permeability of the PRM in coincidence with the programmed irradiation patterns. The dynamic process of photo-switchable drug permeation through the PRM is modeled and compared with the experimental results. The strategy of tailored drug release is verified using both regular geometric shapes and metastatic cancer images. The therapeutic effect of this tailored drug release strategy is demonstrated in vitro in human breast cancer cells. Our pilot study implies the technical potential of using photo-responsive carriers for image-guided chemotherapy with precisely controlled drug release patterns.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2021
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IF 8.128
Fan Song,Jun Wang,Linlin Zhang,Rongrong Chen,Qi Liu,Jingyuan Liu,Jing Yu,PeiLi Liu,Jizhou Duan
Underwater facilities are often perplexed by severe and ubiquitous biofouling. The widely applied commercial antifouling materials still have several challenges in static applications. Herein, a polymer containing isoborneol and borane (PBABs), the borneol derivative structure and grafted pyridine-triphenylborane (PTPB) as antifouling groups were prepared by radical polymerization. PBABs showed high antibacterial rates for Escherichia coli ( E. coli) and Staphylococcus aureu s ( S. aureus ) of up to 95.1% and 81.1%, respectively, confirming superior antibacterial adhesion propertys. More importantly, PBABs effectively reduced the expression of mussel adhesion protein, indicating superior antifouling propertys, resulting from the synergistic effect of multiple antifouling functional groups on the material’s surface. Therefore, the PBABs have been evaluated as noncytotoxic, low-cost, easily synthesized, and mass-produced, which demonstrates their great potential for actual marine applications.
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ACS Omega
·
2021
·
IF 3.512
Rui Wang,Weiwen Gu,Ziling Liu,Yunyu Liu,Guocong Ma,Jianfei Wei
Carbonized polymer dots (CPDs) have attracted widespread attention owing to their unique properties and are usually prepared from monomers of polymers or polymers. To reduce the waste of high-value petropolymers and environmental pollution, a simple and green method for the preparation of CPDs using a hydrothermal technique based on the cross-linking enhanced emission effect was proposed, in which nylon 66 waste fibers were used as a precursor and glutaraldehyde as a cross-linking agent. The as-prepared CPDs possessed polymer/carbon hybrid structures with a 3.5 nm average diameter, and hydroxyl (−OH), carboxyl (−COOH), and amino (−NH2) groups were present on the surface of CPDs. It can be found that the as-prepared CPDs display excitation-dependent photoluminescence emission, which is mainly attributed to the molecular state luminescence center. Because the molecular state fluorescence of CPDs could be affected by the presence of Fe3+ and the change of pH values, the as-prepared CPDs can be used as a probe for the detection of the concentration of Fe3+ and the pH variations of solution. The fluorescence intensity of CPDs was selectively quenched by Fe3+ in the range from 1 to 145 μM. In virtue of the static quenching of CPDs by Fe3+, a sensing system was fabricated for the quantitative detection of Fe3+, and its limit of detection was 0.1 μM. Based on the electrostatic doping/charging of CPDs, a pH sensor was fabricated. It showed that the fluorescence intensity of CPDs decreased along with the increase of pH from 2.60 to 12.6. What is more, the CPDs were found to be an alternative to traditional fluorescent inks for encryption and information storage.
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JOURNAL OF DENTISTRY
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2021
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IF 4.379
Rui Guo,Wenan Peng,Hongye Yang,Chenmin Yao,Jian Yu,Cui Huang
Objectives This paper aimed to evaluate the influence of resveratrol-doped adhesive on the durability and antibiofilm capability of dentin bonding . Methods Experimental adhesives were prepared by incorporating resveratrol into a universal adhesive at concentrations of 0 (control), 0.1, 1, and 10 mg/mL. The microtensile bond strength, fracture modes, and adhesive–dentin interface nanoleakage were assessed after 24 h of water storage, 10,000 times of thermocycling or 1-month of collagenase ageing. Relevant antibiofilm capability on Streptococcus mutans ( S. mutans ), in situ zymography , degree of conversion, and cytotoxicity of resveratrol-doped adhesives were also determined. Results Irrespective of thermocycled or collagenase ageing, the resveratrol-doped adhesive (1 mg/mL) maintained the bond strength and reduced the nanoleakage expression. Meanwhile, the inhibitory ability on endogenous protease activity and S. mutans biofilm formation with acceptable biocompatibility were obtained. Conclusions This study suggested that the resveratrol-doped adhesive achieved effective improvement on dentin bond durability and secondary caries management. Clinical significance The application of the resveratrol-doped adhesive indicates promising benefits to increase the lifetime of composite restorations.
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Advanced Composites and Hybrid Materials
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2021
·Vol. 4
·期 4
·1292-1301
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IF 5.693
Zhang Pengxiang,Zhang Xihua,Li Bin,Xu Lingan,Dang Feng,Li Bao-Wen
Improving the interfacial impedance matching and attenuation ability of a microwave absorber is an important strategy to obtain excellent microwave absorbing performance. Here, we prepared an ultralight, hierarchical porous single-atom Co–N–C microwave absorber, in which evenly distributed single-atom Co is anchored in a porous N-doped carbon framework by N–Co bond via a facile bio-inspired method. These doped single atoms provide abundant highly active atomic absorption sites on the carbon skeleton, and considerable defects including pyridinic-N, pyrrolic-N, oxidized N, and so forth are introduced into the carbon framework owing to single Co atom doping. These doped single Co atoms and introduced defects act together as strong dipolar/interfacial polarization units, which lead to better impedance matching and a significant increase in attenuation capability of the absorber. The metal Co exists in form of a single atom, benefiting light weight of the absorber. Therefore, an extremely strong reflection loss (RL) value of − 60.9 dB is achieved at a lower filler content of 10 wt% with the absorber thickness of 2.5 mm, and the effective frequency bandwidth covered from 10.4 to 15.1 GHz with a thickness of 2.0 mm at a low filler content of 10 wt%. This research offers a novel route for designing a microwave absorber to improve microwave absorption performance and is expected to a wider range of absorbing materials with different structures. Graphical abstract
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Colloid and Interface Science Communications
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2021
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IF 4.914
Xin-Yu Jiang,Jia-Nan Yan,Yi-Nan Du,Shi-Qi Xu,Hai-Tao Wu
In this communication, the rheological behaviors of hydrolysates from scallop ( Patinopecten yessoensis ) male gonad (SMGHs) combined with eight polysaccharides , including ι -carrageenan, sodium alginate , guar gum , locust-bean gum, pectin, acacia gum, xanthan gum and agar, respectively, were reported. The mixture of SMGHs (5%) and each polysaccharide (0.03–1.25%) was characterized by visual observation and rheological characterization in the concentration ranges where each polysaccharide has visible viscosity and keeps flowing. The addition of ι -carrageenan (0.56%) increased the storage modulus of SMGHs at 0.1 Hz by almost 77-fold, reaching 344.9 Pa. While, when the shear rate was 0.13 s −1 , the mixed-gel viscosity of SMGHs/guar gum and SMGHs/locust-bean gum reached to 137.6 and 129.0 Pa·s, respectively. Moreover, SMGHs have potential application as a gelling agent in the food processing by complexing with a certain polysaccharide.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2021
·
IF 8.128
Qi Zhou,Xuelin Dong,Binbin Zhang,Xinwei Zhang,Kaide Ou,Qin Wang,Yonggui Liao,Yajiang Yang,Hong Wang
In this work, a pH-tunable multicolor luminescent lanthanide-based hydrogel (CS/DEX/CP) was prepared based on lanthanide coordination polymer (CP), dextran aldehyde (DEX) and chitosan (CS). The CP was obtained by the self-assembly of guanosine acid (GMP), ciprofloxacin (CIP), Eu 3+ , and Tb 3+ . As-prepared CS/DEX/CP hydrogel could emit blue, green, and red luminescence of CIP, Tb 3+ , and Eu 3+ , respectively. It was also found that the luminescence of CS/DEX/CP hydrogel exhibited visual color change in the pH range of 5.5 to 8. Such pH-sensitive hydrogel was multicolor-responsive to protons produced by bacterial growth, therefore, it could provide early warning of bacterial infection by naked-eye. In addition, the increased acidity resulted in not only the degradation of acid-labile Schiff base linkages between DEX and CS, but also the fracture of coordination between CIP and lanthanide ions. As a result, the released CIP and CS showed significantly antibacterial activity against both S. aureus and E. coli .
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Advanced Materials Interfaces
·
2021
·Vol. 9
·期 4
·2101727
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IF 6.147
Weiye Zhang,Beibei Wang,Jingmeng Sun,Yanchen Li,Junqi Zhao,Yi Liu,Hongwu Guo
Next-generation flexible electronics must achieve multifunctionality, environmental friendliness and antibacterial activity. Accordingly, organisms in nature are interconnected. Inspired by the honeycomb multilayer porous structure, a wood-nanotechnology-derived flexible membrane circuit is created to meet the abovementioned requirements. The flexible wood (FW) matrix is made of natural balsa wood that underwent a simple top-down chemical treatment. The multiwalled carbon nanotube (MWCNT) acts as a “bridge” between the FW matrix with a porous array structure and the active material (silver nanoparticles (Ag NPs) and poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS). Due to the three-dimensional porous microstructure and highly conductive surface inherited by the wood-nanotechnology-derived flexible membrane (FW/MWCNT/Ag/PEDOT:PSS), it shows a high area capacitance (266.7 mF cm −2 at 20 mV s −1 ) and a good long-term cycling stability 84.3% capacitance retention after 5000 cycles at 5 mA cm −2 when used as a supercapacitor electrode. In addition, it shows an excellent specific electromagnetic shielding efficiency (up to 970 dB cm 2 g −1 ), proving its application potential in the field of electromagnetic shielding. Because of the biocidal property of Ag NPs, the FW/MWCNT/Ag/PEDOT:PSS shows a remarkable antibacterial effect on Escherichia coli and Staphylococcus aureus . This strategy provides a new opportunity for researchers to design biomass-based integrated electronic materials.
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JOURNAL OF HAZARDOUS MATERIALS
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2021
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IF 10.588
Ying Liu,Jingfeng Gao,Yuwei Wang,Wanjun Duan,Jie Liu,Yi Zhang,Haoran Zhang,Mingyan Zhao
Antibiotic resistant bacteria (ARB) and the antibiotic resistance genes (ARGs) dissemination via plasmid-mediated conjugation have attracted considerable attentions. In this research, sulfidated nanoscale zerovalent iron (S-nZVI)/peroxymonosulfate (PMS) and S-nZVI/peroxydisulfate (PDS) process were investigated to inactivate ARB ( Escherichia coli DH5α with RP4 plasmid, Pseudomonas . HLS-6 contains sul1 and intI1 on genome DNA sequence). S-nZVI/PMS system showed higher efficiency than S-nZVI/PDS on ARB inactivation. Thus, the optimal condition 28 mg/L S-nZVI coupled with 153.7 mg/L (0.5 mM) PMS was applied to remove both intracellular ARGs (iARGs) and ARB. The oxidative damage of ARB cell was systemically studied by cell viability, intracellular Mg 2+ levels, the changes of extracellular and internal structure, integrity of cell walls and membranes and enzymatic activities. S-nZVI/PMS effectively inactivated ARB (~7.32 log) within 15 min. These effects were greatly higher than those achieved individually. Moreover, removal efficiencies of iARGs sul1 , intI1 and tetA were 1.52, 1.79 and 1.56 log, respectively. These results revealed that S-nZVI and PMS have a synergistic effect against ARB and iARGs. The regrowth assays illustrated that the ARB were effectively inactivated. By verifying the inhibitory impacts of S-nZVI/PMS treatment on conjugation transfer, this work highlights a promising alternative technique for inhibiting the horizontal gene transfer.
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RSC Advances
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2021
·Vol. 11
·期 17
·10121-10129
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IF 3.361
Zhilong Quan,Chunyang Luo,Bitong Zhu,Chungui Zhao,Mingyi Yang,Magnar Bjørås,Kaizheng Zhu,Anna-Lena Kjøniksen
Antibiotic resistance is an emerging threat to public health. The development of a new generation of antimicrobial compounds is therefore currently required. Here we report a novel antimicrobial polymer of chitosan/polypropylene carbonate nanoparticles (CS/PPC NPs). These were designed and synthesized from readily available chitosan and a reactive oligomer polypropylene carbonate (PPC)-derived epoxy intermediate. By employing a simple and efficient functionalized strategy, a series of micelle-like chitosan-graft-polypropylene carbonate (CS-g-PPC) polymers and chitosan–polypropylene carbonate (CS–PPC) microgels were prepared by reacting mono-/bis-epoxy capped PPC with chitosan. The chemical structure, particle size, and surface charge of the newly synthesized polymers were characterized by infrared (IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, dynamic light scattering (DLS), and zeta potential measurements. The antimicrobial activities of these nanoparticles were determined in both Gram-positive bacteria (S. aureus) and Gram-negative bacteria (E. coli). Minimum inhibitory concentration (MIC), the nanoparticle concentration needed to completely inhibit the bacterial growth, was found at 128 μg mL−1 to 1024 μg mL−1, strongly depending both on the nature of the epoxy-imine network formed from the functional groups (mono- or bis-capped epoxy groups reacting with amine groups) and the feed ratio of the functional groups (-epoxy/-NH2) between the functionalized PPC and chitosan. No hemolysis was observed at concentrations well in excess of the effective bacteria-inhibiting concentrations. These findings provide a novel strategy to fabricate a new type of nanoantibiotic for antimicrobial applications.
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SENSORS AND ACTUATORS B-CHEMICAL
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2021
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IF 7.46
Huihui Chai,Feng Chen,Zhaoxi Song,Lulu Xiong,Gang Xiao,Zhisong Lu,Ling Yu
Replica molding is a well-established technique to fabricate surfaces with micro-patterns. Double replica molding of polydimethylsiloxane (PDMS) was developed to fabricate bio-inspired structures though challenged by the cross-linking between PDMS and PDMS. In this paper, we report a novel Wax Assisted Replica Molding (WARM) method to rapidly and precisely copy the microstructures from versatile substrates to PDMS and hydrogels. The low phase transition temperature, hydrophobicity and low surface free energy of wax were utilized to assist transferring patterns from an original master to final replicas. The potential of WARM was demonstrated by generating patters from bio-inspired materials, such as plant leaves and loose fibrous scaffolds, the later was not feasible for direct PDMS replicating. Apart from PDMS, transferring the patterns to materials like hydrogels, sodium alginate, silk fibroin, epoxy glue, and chitosan were also explored. More importantly, the proposed WARM was conducted to fabricate silver nanowire functionalized, microstructure patterned-PDMS specimens, which were further used to construct a flexible electronic skin to monitor human physiological signals, highlighting the potential of WARM in developing biosensors and bioelectronics devices. Neither chemical modification nor special equipment was needed, especially in the favoring of a resource-limited experiment setting.
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危险品化学品经营许可证（带存储）