Nature Sustainability
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2024
·
IF 25.7
Zhao Ziming,Li Tianyu,Zhang Changkun,Zhang Mengqi,Li Shenghai,Li Xianfeng
The growing global capacity for renewable energy generation necessitates the deployment of energy storage technologies with a combination of low cost, good performance and scalability. With these advantages, aqueous organic flow batteries have the potential to be the system of choice because they could store energy from organic redox-active molecules. Here we report naphthalene derivatives as organic redox-active molecules that exhibit high solubility (~1.5 M) and a stable redox-active framework with no obvious capacity decay over 40 days (50 Ah l −1 ) in an air atmosphere in flow batteries. We report a battery that runs smoothly even under continuous airflow without obvious capacity decay for ~22 days (more than 600 cycles). A series of spectral analyses and theoretical calculations reveal that the dimethylamine scaffolds improve the water solubility and protect the active centre, ensuring the stability of the molecules during the charge and discharge process. Owing to the success in kilogramme-scale molecular synthesis, pilot-scale stack expansion with notable cycling stability over 270 cycles (~27 days) is attained. The cost benefit evidenced by technoeconomic analysis together with the stability even under open-air conditions indicates the practical value of the present molecular system in grid-scale energy storage.
研究领域:
能源化学
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材料科学
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高影响因子
Crystals
·
2024
·Vol. 14
·期 12
·1104
·
IF 2.4
Xian-Rui Zhang,Bao-Lin Wu,Jing-Jing Han,Jin-Qing Li
Naproxen (NAP) is a non-steroidal anti-inflammatory drug (NSAID) that belongs to the arylpropionic acid class. Classified as a Biopharmaceutical Classification System (BCS) class II drug, NAP exhibits low water solubility, thus resulting in restricted oral bioavailability. This study aimed to evaluate the effectiveness of pharmaceutical salts in enhancing the solubility and oral bioavailability of NAP. Two novel NAP salts, specifically naproxen-ethylenediamine (NAP-EDA) and naproxen-trometamol (NAP-TRIS), were synthesized using a 2:1 and 1:1 stoichiometric ratio, respectively. The NAP-EDA and NAP-TRIS powders were thoroughly characterized using single-crystal X-ray diffraction (SXRD), powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC), providing a comprehensive understanding of their structural and thermal properties. Additionally, the solubilities and dissolution rates of NAP-EDA and NAP-TRIS salts were assessed in water and a pH 6.86 phosphate buffer. Notably, the solubility of NAP-TRIS salt increased markedly, by 397.5-fold in water and 6.2-fold at pH 6.86. Furthermore, in vivo pharmacokinetic studies in rats revealed that NAP-TRIS salt displayed faster absorption and higher peak blood concentrations compared to NAP. These results indicate that the NAP-TRIS salt effectively enhanced the solubility and oral bioavailability of naproxen. In conclusion, this study underscores the potential of pharmaceutical salts, particularly NAP-TRIS, in improving the solubility and oral bioavailability of drugs with low aqueous solubility, presenting a promising avenue for advancing drug delivery and therapeutic outcomes.
研究领域:
药学
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药物递送系统
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生物药剂学
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DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2024
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IF 8.1
Zhengkang Peng,Xun Gong,Zijian Zhou,Shiwei Dong,Wei Hu,Hanxiao Liu,Jingying Xu
The removal of naphthalene is important but deficient, so that the available V-W/Ti catalysts (1.0 wt% V 2 O 5 /TiO 2 ) were prepared for its efficient abatement in this work. Especially, influences of different existence status of vanadium species on naphthalene elimination were investigated via changing the pH value of precursor solution. With the increase of precursor solution acidity, more highly polymeric vanadium species were formed on the catalyst surface. The redox capability was enhanced markedly as a consequence of the stronger electron transfer between V/W and Ti that induced more surface active oxygen and V 5+ , whereas the catalytic activity was obviously boosted and almost 90 % conversion of naphthalene was achieved at 293 °C. Moreover, the weaker chemisorption between naphthalene and V-W/Ti catalyst allowed the deeper conversion to CO x . GC–MS manifested that naphthalene seemed to be an organic component that was difficult to be totally degraded. Naphthalene oxidation was in the following pathway of naphthalene → 1,4-naphthoquinone → phthalic anhydride → phthalates → benzene → benzoquinone → maleic anhydride → CO x /H 2 O. The opening of aromatic ring in phthalic anhydride and benzene ring in benzene were proven to be the rate-controlling step based on in-situ DRIFTS results. The key of naphthalene oxidation was the complete degradation of various intermediates.
研究领域:
环境科学
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催化化学
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DOI
高影响因子
CHINESE CHEMICAL LETTERS
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2021
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IF 6.779
Yuan Liu,Gaojian Yang,Taotao Li,Yan Deng,Zhu Chen,Nongyue He
An improved ssDNA library immobilized systematic evolution of ligands by enrichment (SELEX) was applied to select aptamers against carbaryl. After nine selection rounds, a highly enriched ssDNA pool was obtained. The Apta3 was demonstrated as the optimal aptamer. In order to facilitate the modification of aptamer, the Apta3 was further truncated with the dissociation constant ( K d ) of 0.364 ± 0.055 μmol/L and a fluorescent aptasensor was developed. The linear range for carbaryl was from 100 nmol/L to 1500 nmol/L, with the limit of detection was as low as 15.23 nmol/L. Besides, the biosensor was validated for the carbaryl spiked real samples, and the recoveries were between 97.7% and 107.3%.
研究领域:
生物化学
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分析化学
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DOI
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
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2020
·Vol. 27
·期 17
·21542-21551
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IF 3.056
Bai Rui,Xiao Yong,Yan Weifu,Wang Siqi,Ding Rui,Yang Fan,Li Junpeng,Lu Xiaoquan,Zhao Feng
Naproxen, a widely used nonsteroidal anti-inflammatory drug, has been detected in many environmental matrixes and is regarded as an emerging pollutant. Sulfate radical (SO 4 · - ) -based advanced oxidation processes have attracted wide attention due to their high efficiency and applicability in the removal of emerging contaminants. In this study, CuFe 2 O 4 was used as an efficient catalyst to activate peroxymonosulfate to oxidize naproxen. The results suggested that 92.3% of naproxen was degraded and 50.3% total organic carbon was removed in 60 min in the presence of 0.3 g · L −1 CuFe 2 O 4 and 2 mM peroxymonosulfate. This degradation system showed strong adaptability in a wide pH range from 4.0 to 10.0. Free radical scavenger experiments and electron spin resonance analysis indicated that 1 O 2 , · OH, and SO 4 · - are the main active species. Finally, the potential degradation pathways of naproxen were proposed by detecting and analyzing the degradation products with ultra-high-performance liquid chromatography combined with mass spectrometry. The results of this study suggest that the CuFe 2 O 4 -activated peroxymonosulfate system is a promising technology for the removal of naproxen from natural water.
研究领域:
环境科学
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化学工程
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DOI
PubMed
高影响因子
Frontiers in Chemistry
·
2019
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IF 3.782
Li Zhanyi,Liu Guoguang,Su Qing,Lv Chunyan,Jin Xiaoyu,Wen Xiaoqing
Naproxen (NPX) is one of the most common pharmaceutical and personal care products found in surface water, which is recalcitrant to degradation by biological treatment or complete removal via traditional sewage treatment processes. In this study, nanoscale γ-FeOOH was synthesized and characterized by X-ray diffraction, scanning electron microscopy, surface analysis, and analysis of the forbidden bandwidth. Under UV irradiation, γ-FeOOH had the capacity to rapidly photodegrade NPX. The photodegradation rate of NPX was dependent on the concentration of γ-FeOOH in solution, initial NPX concentration, and pH. By increasing the concentration of γ-FeOOH, the NPX photodegradation rate was increased and then remained stable. Furthermore, the highest photodegradation rate for NPX was observed under acidic conditions. Through the analysis of the active substances (such as h+, e−, OH, 1O2, and O2·-) by electron spin resonance, the photocatalytic mechanism of NPX degradation on γ-FeOOH was determined to be semiconductor photocatalysis.
研究领域:
环境科学
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药学
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DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
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2024
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IF 5.3
Bolun Mei,Yueru Wang,Jianhua Zhou,Xingchuan Yang,Yi Yu,Li Xu,Guoji Liu
To meet the demand of separating and purifying 1-naphthylamine from the reaction production and filling the solubility data gap, the solubility of 1-naphthylamine in twelve pure solvents (acetone, acetonitrile, ethyl acetate, n-butyl acetate, cyclohexane, n-heptane, methanol, ethanol, n-propanol, iso-propanol, n-butanol, and iso-butanol) was experimentally investigated in the range from 273.15 K to 308.15 K. It was found that the solubility of 1-naphthylamine increases markedly with increasing temperature in all solvent systems. The maximum solubility was 0.8978 (in the solvent of acetone, T = 308.15 K) and the minimum solubility was 0.005485 (in the solvent of n-heptane, T = 273.15 K). Then the experimental solubility data was correlated by the modified Apelblat model, Van't Hoff model, NRTL model, Wilson model, and Margules model. ARD% was calculated to assess the accuracy of the five equations and the results indicated that the modified Apelblat model fits optimally with an average ARD% value of 1.62 %. The effects of various physicochemical properties such as solvent polarity, hydrogen bond donor, hydrogen bond acceptor, and cohesive energy density on solute dissolution behavior were explored. In addition, the apparent thermodynamic properties of 1-naphthylamine in different solvents were analyzed based on modified Van’t Hoff model, which indicated the dissolution process of 1-naphthylamine in selected solvents is endothermic and entropy-driving. Finally, the effect of intermolecular interactions on the dissolution behavior was investigated at the molecular scale through molecular dynamics simulation studies, including molecular electrostatic potential surface, solvation free energy and radial distribution function analysis. This work will provide a fundamental guidance for the crystallization, separation, and purification of 1-naphthylamine.
研究领域:
化学工程
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物理化学
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DOI
高影响因子
Journal of Energy Storage
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2020
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IF 3.762
Yi Zhao,Xuelai Zhang,Xiaofeng Xu,Shihua Zhang
According to the temperature requirements of pharmaceutical cold chain logistics, the aim is to develop phase change materials with a phase transition temperature of 2 °C ~ 8 °C. In this study, a mixed solution of tetradecane (TD) and lauryl alcohol (LA) was selected as the base liquid. In view of the low thermal conductivity of organic phase change materials, expanded graphite (EG) was added to TD-LA to improve the thermal conductivity. This study also developed a new type of cold storage equipment for vaccine, which can monitor the temperature of the vaccine in real time on the user's mobile phone. The cold storage equipment is equipped with a special cold storage box of vaccine. The vaccine reagent tube can be placed in the storage hole of the cold storage box. It can ensure that the cold storage agent in the cold storage box releases and transmits the cold quantity more evenly among the goods. Coupling the developed low temperature phase change material with the cold storage equipment can ensure that the vaccine is always in the required low temperature environment in the process of transportation for a long time to ensure its quality.
研究领域:
材料科学
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生物医药工程
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DOI
高影响因子
INORGANIC CHEMISTRY COMMUNICATIONS
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2024
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IF 4.4
Min-Gu Zhou,Long Chen,Jiajun Zhou,Xinpei Zhong,Mao-Sen Yuan
Fluoride ions (F - ) play a significant role in life science and clinical medicine science. A fluorescence probe ( TN-F ) for detecting fluoride ions was synthesized using naphthalimide as the fluorophore and triarylboron as the recognition group. The selectivity and sensitivity to fluoride ions were determined by UV–visible absorption and fluorescence spectroscopy, which can meet the need for rapid detection (90 s) of F - in organic solution. Moreover, this probe exhibited high anti-interference capability and sensitivity with a detection limit of 0.63 μM, achieving efficient and rapid detection of fluoride ions.
研究领域:
分析化学
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生命科学
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临床医学
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产品关联
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
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2016
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IF 3.42
Xinhua Cao,Na Zhao,Aiping Gao,Haiting Lv,Yuling Jia,Renmiao Wu,Yongquan Wu
Two new gelators containing bis-naphthalimides group were designed and synthesized. The gelator 1b could form gels in DMF and mixed solvent of DMSO/H 2 O (10/1, v/v). The self-assembly processes of 1b in two kinds of solvents were detailedly investigated by UV–vis, fluorescence, infrared spectroscopy, field emission scanning electron microscope (FE-SEM), X-ray diffraction and contact angle experiments. The experiment results showed the hydrogen bonding was the main force for the gel formation. The gel 1b formed in mixed solvent of DMSO/H 2 O (10/1, v/v) possessed of the ability of distinguishing of o -phenylenediamine, m -phenylenediamine and p -phenylenediamine. At the same time, the gelator 1b could selectively and sensitively detect p -phenylenediamine in solution with the detection limit of 8.961 × 10 − 8 M L − 1 . The detection experiment was also confirmed by DFT theoretical calculations. This research would expand the supramolecular self-assembly materials application in sensor field and offer a new detection method for organic amines.
研究领域:
超分子化学
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材料科学
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分析化学
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
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2018
·Vol. 25
·期 26
·26069-26078
·
IF 2.8
Peng Na,Wang Kaifeng,Lin Siwu,Wu Libin
Photolysis of the widely used beta-blocker propranolol (PRO) was investigated in the presence of fulvic acid (FA) and inorganic ions under simulated solar irradiation. PRO undergoes direct photolysis proceeding mainly via degradation of the triplet excited state, 3 PRO*. FA and inorganic ions inhibited photolysis of PRO in the order of FA > Fe 3+ > Cl − > Ca 2+ > Mg 2+ > NO 3 − > K + . An antagonistic effect between FA and inorganic ions toward the suppression of PRO photolysis was exhibited. The binding behaviors of PRO, FA, and inorganic ions were examined through fluorescence quenching experiments, which showed that inorganic ions affected the binding between FA and PRO through competing for the binding sites of FA or PRO. The correlation analysis demonstrated a positive correlation between the binding constant ( K OC ) of FA-PRO and the inhibition rate of FA on PRO photolysis. The observed rate constants of photolysis ( k obs ) have opposite correlations with the concentration of singlet oxygen ( 1 O 2 ). These findings strongly suggest that inorganic ions decrease the inhibition effect of FA on PRO photolysis via restraining the complexation of FA-PRO and production of 1 O 2 .
研究领域:
环境科学
·
药理学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2019
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IF 4.084
Hui Liang,Dandan Chen,Damien Thiry,Wenjiang Li,Minfang Chen,Rony Snyders
High-energy density and low cost magnesium nanoparticles (Mg NPs)-based material are being sought to meet increasing capable of hydrogen (H 2 ) storage demand. Here, a kind of air-stable Mg NPs supported on porous structured multi-walled carbon tubes-polymethyl methacrylate (MWCNTs-PMMA) template is prepared owing to reversible well-distributed, dispersed and small-sized Mg/MgH 2 NPs. The aim is to improve the H 2 storage capacity, hydrogen sorption kinetics and thermodynamics of nano Mg-based system without using catalyst. The organic Mg precursor was directly in-situ reduced to metallic Mg NPs in MWCNTs-PMMA template by lithium naphthalide. The size distribution of reduced Mg nanoparticles is around 3.6 ± 0.2 nm, confirmed by XRD and TEM analyses, which is due to the strong interaction between Mg NPs and MWCNTs-PMMA via PMMA binding Mg 2+ , as well as the confinement of porous template hindered the growth and agglomeration of Mg NPs. Moreover, except H 2 , O 2 and H 2 O molecules can't infiltrate the porous structure of MWCNTs-PMMA resulted in the presence of air stable Mg NPs in the MWCNTs-PMMA. The work provides a new scope to prepare nano metal-based composite for H 2 storage.
研究领域:
材料科学
·
能源存储
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）