ENERGY
·
2025
·
IF 9.4
Ruihan Dong,Ziyue Tang,Yingquan Chen,Xianhua Wang,Wei Cheng,Qiang Hu,Shusheng Pang,Haiping Yang,Hanping Chen
This study proposes a novel and sustainable approach for the catalytic pyrolysis of microalgae to produce monocyclic aromatic hydrocarbons (MAHs) via algae-based modified biochar catalysts with variant porosity and N content. The effects of introducing of different activators (KOH, KHCO 3 , CH 3 COOK, K 2 CO 3 ) on the physicochemical properties and catalytic performance of the catalysts were systematically investigated. The results indicated that the addition of the activators enhances the specific surface area, porosity, and the abundance of O-/N-containing functional groups with catalytic activity in the biochar catalyst, thereby significantly enhancing the performance of catalyst. Among them, SAC-KOH exhibited a superior porous structure and catalytic effect. The modified biochar catalysts markedly promoted MAHs formation, with benzene, toluene, and xylene identified as the major products. With the addition of the SAC-KOH catalyst, the total relative content of benzene, toluene, and xylene can increase from 8.16 % to 36.53 %. Furthermore, to gain deeper insight into the catalytic conversion mechanism of microalgae to MAHs using modified biochar catalysts, the product transition pathway was explored in depth and comprehensively with soybean protein, sucrose, and peanut oil as the main model compounds of microalgae. These findings demonstrate the feasibility and effectiveness of modified biochar catalysts in enhancing MAHs production from microalgae, providing a promising strategy for aromatic generation.
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Xinmei Qian,Chunxiang Li,Mingyu Zheng,Keqin Deng
A flower-like S, N-codoped carbon nanosheets loaded with hybrid magnetic nanoparticles (HMNPs/S,N-CNSs) by using MOF as precursor was prepared. The morphology, composition, microstructure, and property were evaluated by SEM, HRTEM, EDS, XRD, XPS, magnetic analysis, and cyclic voltammetry. The hybrid nanoparticles were composed of most Fe 3 O 4 , some CoFe alloy, and a few Fe 2 S. The magnetic material showed high magnetism and brilliant electrocatalysis towards the electrochemical reduction of antibiotic nitrofurazone (NFZ). By utilizing screen-printed electrode (SPE) and HMNPs/S,N-CNSs, a disposable electrochemical NFZ sensor (HMNPs/S,N-CNSs/SPE) was fabricated by magnetic control. The current signal of NFZ at HMNPs/S,N-CNSs was 6.38 times higher than that of bare SPE. It displayed a wide detection range of 0.01–50 μM with a detection limit of 4.2 nM (S/N = 3). The practical applicability of the sensor in real samples presented satisfactory results. The disposability, low cost, high sensitivity, low consumption volume in analyses, and good selectivity make the proposed sensor a promising tool for NFZ detection.
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Analytical Methods
·
2026
·
IF 3
Ying Wang,Xuyuan Sun,Minmin Liu,Zhengyuan Dai,Xiaoyu Yang,Li Li,Yaping Ding
As a core medication for the prevention and treatment of cerebral vasospasm, especially after aneurysmal subarachnoid hemorrhage, real-time monitoring of nimodipine (NMD) concentration helps evaluate the adequacy of drug therapy and holds great significance for ensuring patient life and health. Herein, based on dual functional monomers, a molecularly imprinted electrochemical sensor (MIECS) for the detection of NMD with nitrogen-doped multi-walled carbon nanotubes (N-CNTs) and Fe-MOFs was developed. Fe-MOFs provided a large specific surface area, offering more space for generating imprinting sites, while N-CNTs enhanced the conductivity of the electrode. 2-Amino-5-mercapto-1,3,4-thiadiazole (AMT) and o-phenylenediamine (o-PD) served as dual functional monomers and NMD as the template molecule. A molecularly imprinted polymer (MIP) membrane was prepared on the electrode surface by electropolymerization. Compared to single functional monomers, the dual functional monomers exhibited better selectivity and specificity in NMD recognition. Under optimal experimental conditions, the response of the MIECS to NMD showed a linear relationship ranging from 10−14 M to 10−8 M, with a detection limit of 2.97 × 10−15 M. Satisfactory recovery rates were obtained in the detection of human serum and tablets. This multi-parametric enhancement establishes a new paradigm for therapeutic drug monitoring in clinical neurology and pharmaceutical quality control.
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ACS Applied Materials & Interfaces
·
2026
·
IF 8.2
Wan-Ting Lin,Chang Liu,Xiao-Wei Luo,Wan-Long Li,Zi-Lu Zhang,Si-Yuan Zhang,Zhi-Kang Xu,Ling-Shu Wan
Separation under high temperature is a crucial challenge for polymer nanofiltration (NF) membranes. Polyamide NF membranes with favorable compactness and pore size distribution are promising for boosting their thermal stability and high-temperature separation performance. Despite recent strategies to improve thermal stability, the effect of polyamide membrane compactness on structural changes and separation performance at high temperatures remains insufficiently explored. Herein, we propose a straightforward and effective concentration regulation strategy to address this challenge in the classic piperazine-trimesoyl chloride (PIP-TMC) interfacial polymerization system, focusing on the precise tuning of the polyamide network structure and the high-temperature NF performance through the controlled adjustment of monomer concentration and the relative ratios. Polyamide layer fabricated with a PIP/TMC ratio of 30:1.5 exhibits higher cross-linking degree than that with a PIP/TMC ratio of 2:1.5, and the NF membrane exhibits exceptional thermal stability, with MgSO4 rejection remaining >98.5% at 85 °C. Molecular dynamics simulations reveal that denser polyamide network possesses significantly weaker segmental motion, along with smaller changes in pore size distribution and fractional free volume at elevated temperatures. This concentration regulation strategy effectively enhances the intrinsic thermal stability without complex modifications and provides critical insights into polyamide segment evolution at high temperature.
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ACS Applied Nano Materials
·
2026
·
IF 5.5
Yun Ye,Minqing Chen,Qianlin Wang,Yuhao Huang,Xvjing Xv,Ziwen Chen,Chenlong Zhou,Hui Long,Yu Zhao,Lili Tao
Ultrafast lasers have extensive and important applications in precision processing, biomedicine, ultrafast spectroscopy research, and communication fields. Saturable absorber materials are key components in obtaining ultrafast lasers. However, at high mode-locked pump power, the saturable absorber is easily damaged, greatly reducing its operational stability and service life. Here, we report the synthesis of uniform tellurium quantum dots with an average size of ∼3 nm and stable traditional soliton mode-locked fiber laser achieved at an extremely low pump power of 30 mW, with an output pulse width of 700 fs based on the tellurium quantum dot saturable absorber. As the pump power further increased, the output pulse width was compressed to 578 fs at 150 mW. Even more interestingly, by adjusting the pump power, the phenomenon of bound soliton mode-locked was also discovered. The experimental results demonstrate that the synthesized uniform tellurium quantum dots exhibit an ultralow mode-locked threshold, enabling ultrafast laser operation at low pump powers. This material represents a promising saturable absorber with unique application potential.
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INDUSTRIAL CROPS AND PRODUCTS
·
2026
·
IF 6.4
Penghua Shu,Wenhao Zou,Yu Meng,Jiaqi He,Tingting Guo,Xinfeng Fan,Di Hu,Hao Yin,Shuxian Fan,Na Wang,Simin Liu,Lu Lv,Si Chen,Xialan Wei,Jihong Huang
Astragali complanati Semen (ACS) is frequently used as Chinese medicines and functional foods. Complanatoside A (CA), a key bioactive phytochemical isolated from ACS, exhibits broad-spectrum pharmacological properties. This investigation systematically formulated sixteen natural deep eutectic solvent (NADES) systems by combining three hydrogen-bond acceptors with eleven hydrogen-bond donors at varying molar ratios. These NADES formulations were subsequently employed in tandem with ultrasonic-assisted extraction to isolate CA. Optimization studies identified the following parameters as most effective for extraction using the L -proline/levulinic acid-based NADES (molar ratio 1:2): 60℃, 30 min, 40 % water content, liquid-solid ratio 25 mL/g, achieving an extraction yield of 1.57 %. The adsorption and desorption conditions were optimized employing a macroporous resin for the recovery of CA, while the reusability of the NADES solvent was thoroughly evaluated throughout the extraction process. The CA extract exhibited significant tyrosinase and α-glucosidase inhibitory activity. These findings establish ultrasound-assisted NADES extraction as a sustainable methodology for efficient extraction of CA from ACS, providing valuable insights for eco-friendly extraction and pharmacological exploitation of plant-derived bioactives.
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Foods
·
2026
·Vol. 15
·期 5
·
IF 6
Zhiyuan Lin,Mei Chen,Bo Zhou,Junfeng Tan,Liang Zeng,Zhi Lin,Jinchi Tang,Weidong Dai
(1) Background: Primary metabolism is essential for tea quality formation, however systematic analysis of tea primary metabolites remains limited; (2) Methods: An orthogonal design was used to optimize the pre-column derivatization reaction conditions for the tea matrix. Using the optimized method, gas chromatography–mass spectrometry (GC–MS) was employed to analyze Longjing green tea (LJGT) samples from different processing stages and regions; (3) Results: Optimal derivatization was achieved with 75 μL of methoxamine hydrochloride pyridine solution at 30 °C for 1.5 h. A total of 52 primary metabolites were identified in LJGT. Processing analysis showed that 8 metabolites associated with carbohydrate metabolism significantly decreased during spreading. Five reducing sugars significantly decreased, while sucrose, turanose, and quinic acid significantly increased due to the thermal action during pan-fixation. Additionally, 15 key differential compounds were identified among three regions (Xihu, Qiantang, and Yuezhou) of LJGT. Quantitative analysis revealed that shikimic and quinic acid contents were significantly higher in the Xihu region compared to other regions; (4) Conclusions: This study established a pre-column derivatization GC-MS method for primary metabolite profiling, elucidated metabolic regulation during LJGT processing, and identified differences in primary metabolite content among LJGT from different geographical origins.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Weimin Fang,Wei Zeng,Yalan Huang,Anqi Chen,Yanbin Guo,Guanxi Wen,Jiayu Ye,Jinfeng Xu,Yingying Liu
Macrophage-driven oxidative stress and chronic inflammation play pivotal roles in the progression of atherosclerosis. Given the overactivation of poly (ADP-ribose) polymerase (PARP) in atherosclerosis, PARP inhibitors have potential therapeutic potential, but their efficacy is limited due to poor in vivo targeting. Platelet-rich plasma-derived extracellular vesicles (PEVs), which inherently target inflammatory sites and mitigate oxidative stress, offer a promising delivery platform. Here, we developed NGPPEVs, a nanoplatform that employs PEVs to deliver niraparib, a PARP inhibitor, followed by encapsulation of Ca(HCO₃)₂ to generate gas within cells, thereby combining targeted therapy with ultrasound imaging capabilities. In vitro, NGPPEVs significantly scavenged intracellular reactive oxygen species (ROS) and suppressed pathways related to oxidative stress and cholesterol metabolism. Mechanistically, NGPPEVs suppressed foam cell formation by inhibiting the PARP1–IL-6–CD36 axis, leading to significant downregulation of the key scavenger receptor CD36. In apolipoprotein E-deficient mice fed a high-fat high-cholesterol diet, NGPPEVs demonstrated superior therapeutic efficacy, effectively reducing atherosclerotic plaque area and enhancing plaque stability. Collectively, NGPPEVs have great potential in the precise diagnosis and treatment of atherosclerosis.
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Food Bioscience
·
2026
·
IF 6.2
Wanqi Zhang,Lu Han,Yanhao Yin,Yaoting Mou,Yuhang Tian,Zhicong Sun,Yanfang Wu,Dongfei Chen,Yemin Guo,Xia Sun,Falan Li
Excessive streptomycin (STR) residues pose significant risks to dairy product quality and safety. Thus, developing highly sensitive detection methods for STR is essential to safeguard dairy safety and public health. In this study, we present a dual signal amplification lateral flow strip (LFS) using enzyme-assisted cycling and composite probe composed of multiple gold nanoparticles (AuNPs) for STR detection. Through targeted mutation, an optimized aptamer (Apt52-0) with both high affinity for STR and recognition by nicking endonuclease was developed, exhibiting enhanced binding to STR with a K d value of 6.87 nM, compared to the original Apt52. Enzyme-assisted amplification was achieved using the hairpin structure of the Apt52-0, Vent (exo-) DNA polymerase, and Nt.Alwl nicking endonuclease, enabling dual cycling of the target and double-stranded DNA (dsDNA). The cyclic products were then isothermally amplified, and composite probe composed of multiple AuNPs was utilized to construct a dual signal amplification lateral chromatography sensor for STR detection. This aptamer-based LFS achieved a visual limit of detection (LOD) of 25 nM, and a LOD of 17.6 nM analyzed via ImageJ software. The test strip demonstrated promising sensing performance in practical application, with STR recovery rates of 95.8%–103.9% in milk samples. This dual signal amplification-based LFS offers an inexpensive, rapid and sensitive approach to STR detection.
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ACS Applied Polymer Materials
·
2026
·
IF 5.2
Yu Bai,Yi Ding,Guoquan Liao,Xiangchun Kong,Yucheng Wang,Mingshuo Dai,Yuandu Hu
Photonic microcapsules with dual stopbands hold great potential in sensing and wearable electronics. However, existing systems face limited deformability and responsiveness to physical stimuli. In this study, we fabricated fully deformable dual-stopband photonic microcapsules using microfluidics-enabled core–shell double-emulsion templates. The core and shell parts of the microcapsules were an aqueous suspension of PNIPAM-co-AAC hydrogel particles and a poly(ethylene glycol) phenyl ether acrylate (PEGPEA) resin suspension of silica particles, respectively. Given that the core and shell parts were both deformable components, the resultant photonic microcapsules featured full deformability. Their structural colors can be regulated by tuning the particles’ diameters and volume fractions. The resultant microcapsules exhibited isotropic reflection spectra, overcoming angle dependence, and showed reversible color changes under mechanical compression. This work offers a scalable approach for multifunctional photonic microcapsules, paving the way for applications in microsensors, stress visualization, and adaptive wearable devices.
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Biosensors-Basel
·
2026
·Vol. 16
·期 1
·32
·
IF 5.6
Zhiheng Zhang,Qiyu Fu,Tiantai Wen,Youmin Zheng,Yincong Ma,Shixian Liu,Guozhen Liu
Early detection of high-risk human papillomavirus (HPV), particularly HPV16 E7, is critical for cervical cancer prevention. Here, we report a novel, portable, and instrument-free biosensing platform that integrates recombinase polymerase amplification (RPA) with CRISPR/Cas12a-mediated detection on a microfluidic paper-based analytical device (μPAD) for colorimetric, visual readout of double-stranded DNA (dsDNA). The μPAD features seven functional zones, including lyophilized RPA and CRISPR reagents, and immobilized streptavidin and anti-FAM antibodies for signal generation. Upon target recognition, Cas12a’s trans-cleavage activity releases biotinylated-FAM-labeled reporters that form a sandwich complex with gold nanoparticle (AuNP)-conjugated anti-FAM antibodies, producing a visible red signal at the test zone. The gray value of the colorimetric signal correlates linearly with target concentration, enabling the quantitative detection of HPV16 E7 dsDNA down to 100 pM within 60 min. The assay demonstrated high accuracy and reproducibility in spiked samples. By combining isothermal amplification, CRISPR specificity, and paper-based microfluidics, this platform offers a rapid, low-cost, and user-friendly solution for point-of-care HPV screening in resource-limited settings. This work advances the integration of CRISPR diagnostics with μPAD, paving the way for scalable point-of-care molecular diagnostics beyond HPV.
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NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
·
2026
·
IF 4
Lin Jie,Jin Guoxin,Zhang Ling,Weng Xiu,Wu Kecheng
The short half-life of fibroblast growth factor 21 (FGF21) in vivo limits its clinical application in acetaminophen (APAP)-induced acute liver injury (ALI). This study aimed to construct a novel PLGA-based nanoparticle delivery system for FGF21 and to investigate its protective effects and underlying mechanisms in APAP-induced ALI. PLGA-FGF21 nanoparticles were prepared using a double-emulsion solvent evaporation method and characterized by transmission electron microscopy and Zetasizer Nano for morphology, size, and stability. Their release profile and cytotoxicity were evaluated in vitro using AML12 cells, while hepatoprotective effects were assessed in an APAP-induced ALI mouse model. Histopathology, biochemical assays, immunofluorescence, and Western blot were employed to examine liver function, oxidative stress, and molecular mechanisms. The nanoparticles displayed uniform spherical morphology with an average size of 222.04 ± 1.08 nm and remained stable for 7 days in aqueous suspension. Encapsulation conferred sustained-release properties, and the particles showed no cytotoxicity while maintaining biological activity for at least 28 days. In vivo, PLGA-FGF21 significantly alleviated APAP-induced liver damage, reduced serum ALT and AST, and exhibited superior hepatoprotective efficacy compared with free FGF21. Furthermore, it suppressed inflammatory responses by decreasing TNF-α and MDA levels, while enhancing antioxidant defenses through increased SOD activity. Mechanistically, PLGA-FGF21 activated the PGC-1α/Nrf2/HO-1 signaling pathway, contributing to enhanced anti-inflammatory and antioxidant effects. PLGA-FGF21 nanoparticles provide potent protection against APAP-induced ALI by reducing inflammation and oxidative stress, which may be associated with activation of the PGC-1α/Nrf2 signaling pathway, offering a promising strategy for FGF21-based therapy in liver injury.
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