JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2017
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IF 2.323
Qingsong Li,Midong Shi,Liping Wang,Gaoyin He,Fan Gan
The liquid–liquid equilibrium (LLE) experiments for n-butanol + n-hexane + ethylene glycol were carried out and LLE data were measured at 298.15, 303.15, 308.15, 313.15, and 323.15 K under atmospheric pressure. The analysis results of the effects of n-butanol content and temperature on extraction showed that high n-butanol content was not favorable for extraction, and temperature had little effect on extraction. Moreover, the NRTL and UNIQUAC models were applied to correlate the LLE data, and the correlated data indicated that the UNIQUAC model showed a better correlation performance.
研究领域:
化学工程
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物理化学
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DOI
高影响因子
FLUID PHASE EQUILIBRIA
·
2017
·
IF 2.473
Rui Zhao,Miao Yu,Peng-shuai Zhang,Tao Li,Bao-zeng Ren
Capecitabine is a widely used anticancer prodrug of 5-fluorouracil, but up to the present time there is no solubility data reported other than in supercritical carbon dioxide . In this paper, by the polythermal method, the solubility data of capecitabine in fifteen pure lower alcohols and water with methanol mixture solvents were measured from 278.15 K to 323.15 K under atmospheric pressure. The results show that the solubility of capecitabine in linear lower alcohols are bigger than that in corresponding branch chain lower alcohols, and decrease with the increasing of carbons in alkyl of alcohols. Moreover, the solubility of capecitabine increases with the increasing of temperature and mole fraction of methanol in the binary solvent mixtures of water + methanol. To expand industrial application of experimental solubility data of capecitabine in recrystallization, the values measured in selected pure lower alcohols are correlated using the modified Apelblat equation, the Buchowski-Ksiazczak-pletrzyk equation, the van't Hoff equation, the Wilson model and the NRTL model; And for the binary solvent system, the modified Apelblat equation and Jouyban-Acree model are used to correlate the solubility data. By evaluating the deviations between experimental and correlated data, all the correlated data by six models used in this research show comparable precision to those attained by careful experimental measurement. Moreover, some apparent thermodynamic quantities (Δ S d o , Δ H d o , Δ G d o , % ζ H and % ζ TS ) of the dissolution processes of capecitabine in selected solvents and temperature range studied were calculated by the parametric van't Hoff equation. According to the calculation, the dissolution of capecitabine in lower alcohols and water with methanol mixture solvents is an endothermic and entropy-driven process. The solubility and apparent dissolution characteristics of capecitabine in this paper would provide basic support for industrial design and further studies.
研究领域:
药学
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化学
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DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2021
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IF 3.764
Baoyou Liu,Jie Tian
The efficient and environmentally friendly recovery and separation of ammonia (NH3), as a toxic substance in the environment and an indispensable chemical raw material, has always been a challenge. In the present work, natural deep eutectic solvents (DESs) based on dual solid components of glycolic acid (GA) and xylitol (XYL) were designed and synthesized as absorbents to capture ammonia efficiently and reversibly. The results showed that DESs exhibited ideal physical properties, high NH3 absorption capacity, and high NH3/CO2 selectivity. At 303.15 K and 101.33 kPa, the absorption capacity of GA+XYL (3:1) for NH3 is as high as 0.225 g NH3·(g DES)−1, which is much higher than those of ionic liquids and DESs reported so far. DES absorbs NH3 with high reversibility and can represent high absorption performance after five absorption–desorption cycles. In addition, the intrinsic absorption mechanism was analyzed using spectral characterization and quantum chemical calculation. These protic DES-based GA and XYL with high efficiency and reversible NH3 capture are expected to be promising substitutes for ammonia absorbents.
研究领域:
化学工程
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环境科学
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DOI
高影响因子
Nutrients
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2022
·Vol. 14
·期 22
·4752
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IF 6.706
Songxia Zhang,Ying Xu,Mengling Ye,Wenli Ye,Jian Xiao,Honghao Zhou,Wei Zhang,Yan Shu,Yun Huang,Yao Chen
People in Eastern countries hold a tradition of soaking herbal medicine in wine; however, the efficacy and safety of herbal wine have not been rigorously assessed. By assessing the efficacy of resveratrol (RSV) in ethanol against alcoholic liver disease (ALD) in mice, we aimed to offer a perspective on the use of herbal wine. To simulate the behaviour of herbal wine users, RSV (15 mg/kg) soaked in ethanol (RSV-alcohol) was administrated via gavage to the mice, here with alcohol consumption-induced ALD. RSV soaked in water (RSV-water) was the treatment control. The efficacy and safety of RSV on ALD were evaluated. Compared with the RSV-water group, a higher rate of mortality was found in the RSV-alcohol group (50.0% vs. 20.0%), which also exhibited more severe liver injury. RSV significantly increased the exposure of alcohol by 126.0%, which was accompanied by a significant inhibition of the ethanol metabolic pathway. In contrast, alcohol consumption significantly reduced exposure to RSV by 95.0%. Alcohol consumption had little effect on the expression of drug-metabolizing enzymes in RSV; however, alcohol seemed to reduce the absorption of RSV. RSV in liquor exacerbates alcoholic liver injury and has a reduced therapeutic effect, suggesting that the habit of herbal wine use without supervision is risky.Keywords:herbal wine use;resveratrol;ethanol;concomitant administration;liver injury
研究领域:
药理学
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肝病学
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毒理学
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DOI
PubMed
高影响因子
Polymers
·
2023
·Vol. 15
·期 2
·413
·
IF 5
Jialin Xu,Kuo Zhou,Linlin Qin,Zaiming Tan,Shijing Huang,Peigao Duan,Shimin Kang
The chemical recycling of end-of-life polylactic acid (PLA) plays roles in mitigating environmental pressure and developing circular economy. In this regard, one-pot tandem alcoholysis and hydrogenation of PLA was carried out to produce 1,2-propanediol, which is a bulk chemical in polymer chemistry. In more detail, the commercially available Raney Co was employed as the catalyst, and transformation was conducted in ethanol, which acted as nucleophilic reagent and solvent. Single-factor analysis and Box–Behnken design were used to optimize the reaction conditions. Under the optimized condition, three kinds of PLA materials were subjected to degradation. Additionally, 74.8 ± 5.5%, 76.5 ± 6.2%, and 71.4 ± 5.7% of 1,2-propanediol was yielded from PLA powder, particle, and straws, respectively, which provided a recycle protocol to convert polylactic acid waste into value-added chemicals.Keywords:polylactic acid;alcoholysis;hydrogenation;1,2-propanediol;PLA straws
研究领域:
化学工程
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环境科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
FLUID PHASE EQUILIBRIA
·
2023
·
IF 2.6
Xiaomin Qiu,Huaqing Qi,Mengjin Zhou,Zhaoyou Zhu,Yinglong Wang,Jingwei Yang,Hengjun Gai
Sufficient and accurate physical property data is the basis for thermodynamic analysis and process simulation analysis. Reliable thermodynamic model data is essential for the study of extractive distillation separation of azeotropic mixtures. The vapor-liquid equilibrium data of 2-butanol alcohol-ethylene glycol and cyclohexane-butyl butyrate were measured by using a reliable experimental device, namely a modified Rose vapor-recirculating-type equilibrium still. The effects of 12 solvents on the relative volatility of the azeotrope of cyclohexane, 2-butanol alcohol and water were calculated, and ethylene glycol was selected as the best solvent. On this basis, the contribution of different atom pairs and atoms to the interaction between ethylene glycol and cyclohexane/2-butyl alcohol/water was compared and studied, and the reason why ethylene glycol can separate cyclohexane-2-butyl alcohol-water was analyzed. The thermodynamic model parameters obtained from the vapor-liquid equilibrium experiment were used to simulate the extractive distillation process, and total annual cost optimization was performed to improve the process accuracy. Overall, this study improves the application potential of phase equilibrium data in azeotropic separation technology, and establishes a reliable data and model foundation for the sustainable development of 2-butyl alcohol and cyclohexane.
研究领域:
化学工程
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热力学
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产品关联
DOI
高影响因子
Food Bioscience
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2022
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IF 5.318
Dongmin Liu,Jiating Pi,Bo Zhang,Hongliang Zeng,Changzhu Li,Zhihong Xiao,Fang Fang,Miao Liu,Na Deng,Jianhui Wang
The present study aimed to investigate the regulatory mechanisms of lotus seed core powder phytosterol extract (LSP-PE) on hypercholesterolemia and intestinal microbiota in high-cholesterol diet (HCD)-induced C57BL/6 J mice. Gavage with LSP-PE reduced levels of serum total cholesterol (TC), ratio of low-density lipoprotein cholesterol (LDL-C) to high-density lipoprotein cholesterol (HDL-C), hepatic TC, hepatic triglyceride (TG), hepatic LDL-C, hepatic very low-density lipoprotein (VLDL), fecal TC and fecal total bile acid (TBA), while augmented hepatic HDL-C content. In contrast with HCD group, high-dose LSP triggered significant diminutions of serum ALT , serum AST, hepatic ALT and hepatic AST levels in HCD-fed mice, which were 16.49, 28.94, 43.42, and 44.47%, respectively, thus remarkably ameliorating the pathological changes of liver and small intestine . In-depth genetic research found that LSP was effective in down-regulating the expression of cholesterol metabolism related genes including Niemannpick C1-like protein 1 (NPC1L1), acyl-coA cholesterol acyl-transferase 2 (ACAT2), microsomal triglyceride transporter (MTP) and ATP binding cassette subfamily G member 5 (ABCG5). Moreover, LSP-PE could restore the disorder of intestinal flora via augmenting the Actinobacteria abundance as well as decreasing the Firmicutes / Bacteroidetes ratio and abundances of Proteobacteria and Verrucomicrobia to regulate cholesterol metabolism-related genes. In summary, LSP-PE possessed excellent cholesterol-lowering activity by positively regulating the gut microbiota and the expression levels of genes related to cholesterol absorption and metabolism. Therefore, this work suggested LSP phytosterol as a potential supplement to alleviate the symptoms of hypercholesterolemia.
研究领域:
营养学
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药理学
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微生物学
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分子生物学
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动物科学
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DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2022
·
IF 5.895
Mengxue Diao,Chi Li,Jianxiu Li,Jian Lu,Nengzhong Xie
Sclareol glycol is a key starting material with significant market interest for synthesizing high-value ambroxide, a sustainable substitute for ambergris in high-end fragrances. Sclareol glycol can be obtained by biotransformation of sclareol, a labdane-type diterpene, using Hyphozyma roseonigra. However, the pathway and mechanism of sclareol glycol biosynthesis remain unclear. In this study, the dynamic time course of sclareol biotransformation was explored by resting cell assays and several intermediates produced during biotransformation were detected. The results show that (1) sclareol glycol and sclareolide are not interconverted and are potentially synthesized via different metabolic pathways and (2) several putative intermediates resulting from biotransformation are featured with a labdane carbon backbone, including isomerized and oxidized analogues. A plausible transformation pathway of sclareol in H. roseonigra was proposed based on detected metabolites. This study sheds light on the biosynthetic mechanism of sclareol glycol and paves a way for the future biotechnological production of this promising compound.
研究领域:
生物技术
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化学生物学
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有机化学
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香料科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2022
·
IF 3.119
Hao Li,Fengyi Zhang,Qianlong Zhang,Hongjuan Li,Zhiying Wang,Chunli Li,Jing Fang
For some strongly non-ideal solution systems, there are often errors in predicting the phase equilibrium relationship of a multi-component system using the interaction parameters obtained by the regression of the phase equilibrium data of the binary system. The interaction parameters between the components obtained by directly determining the phase equilibrium of the multivariate system will bring the calculated values closer to the experimental values. Liquid–liquid equilibrium (LLE) data were determined for the system of n-butanol + n-pentanol + n-hexanol + water at 313.15, 323.15, and 333.15K under atmospheric pressure. LLE compositions were determined by gas chromatography. LLE data were correlated by the UNIQUAC model and the non-random two-liquid (NRTL) model. Both models were appropriate for describing the LLE of this quaternary equilibrium system. They provided accurate thermodynamic parameters for the phase equilibrium of C4–6 mixed alcohols in Fischer–Tropsch synthesis water.
研究领域:
化学工程
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热力学
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相平衡建模
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DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2020
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IF 4.939
Chao Hu,Yunong Zhou,Meifang Xiao,Gang Yu
Control of the structure and shape of platinum nanocrystals has recently attracted much attention, mostly due to their specific properties and related catalytic functionalities. However, the realization of platinum nanocrystals with controlled sizes and dominant facet types remains a significant challenge. In this study, platinum nanoparticles with controllable sizes and dominant facets are produced via a simple, organic agent-free, rapid, clean and direct chemical reduction method. The effects of initial solution pH on the sizes and dominant facets of the platinum nanoparticles are investigated and the mechanism for different sizes and facets are examined. Electrocatalytic analyses show that the catalytic activities and stabilities of the synthesized platinum nanoparticles are related to their sizes and dominant facets, and these nanoparticles display great potential as substitutes for commercial Pt/C in the effective catalysis of ethylene glycol , methanol, and ethanol electrooxidation in alkaline medium . Among the present platinum nanoparticles, the nanoparticles synthesized in pH 3 initial conditions, with small average size and (111)-dominant facets, display the best electrocatalytic activity and stability.
研究领域:
材料科学
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化学
·
电催化
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产品关联
DOI
高影响因子
Polymers
·
2018
·Vol. 10
·期 1
·90
·
IF 2.935
Zhenhui Bai,Yun Liu,Tingting Su,Zhanyong Wang
Poly(ethylene succinate) (PES), poly(butylene succinate) (PBS), and poly(hexylene succinate) (PHS), were synthesized using succinic acid and different dihydric alcohols as materials. Enzymatic degradability by cutinase of the three kinds of polyesters was studied, as well as their solid-state properties. The biodegradation behavior relied heavily on the distance between ester groups, crystallinity, and the hydrophilicity-hydrophobicity balance of polyester surfaces. The weight loss through degradation of the three kinds of polyesters with different hydroxyl monomers took place in the order PHS > PBS > PES. The degradation behavior of the polyesters before and after degradation was analyzed by scanning electron microscopy, differential scanning calorimetry, powder X-ray diffraction, Fourier transform infrared spectroscopy, gel permeation chromatography, and thermogravimetric analysis. The decrease in relative intensity at 1800–1650 estedpolyesters were degraded simultaneously. The frequencies of the crystalline and amorphous bands were almost identical before and after degradation. Thus, enzymatic degradation did not change the crystalline structure but destroyed it, and the degree of crystallinity markedly decreased. The molecular weight and polydispersity index only changed slightly. The thermal stability of the three kinds of polyesters decreased during enzymatic degradation.Keywords:poly(ethylene succinate);poly(butylene succinate);poly(hexylene succinate);cutinase;biodegradability
研究领域:
材料科学
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生物化学
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产品关联
DOI
PubMed
高影响因子
FUEL
·
2022
·
IF 8.035
Ning Zhang,Jing Wang,Wen Zhang,Yingxiu Zhao,Zemeng Dong,Zexing Wu,Guang-Rui Xu,Lei Wang
Despite considerable efforts to study direct alcohol fuel cells (DAFCs), the development of efficient bifunctional catalysts for monohydric alcohol and polyhydric alcohols remains a great challenge. This work reports the preparation of self-supported PdNi dendrites on Ni foam (self-supported PdNi DNTs/NF) with a large specific surface area by a simple self-sacrificing template and hydrothermal method. The presence of NF with enrichment of nucleation sites is crucial for the generation of self-supported PdNi DNTs. The as-obtained self-supported PdNi DNTs/NF exhibits an excellent property for ethanol and glycerol electrooxidation with the mass activity of 2375.7 mA mg cat −1 and 2451.6 mA mg cat −1 , the specific activity of 10.07 mA cm −2 and 10.84 mA cm −2 , respectively, in alkaline media, which should attribute to abundant high-index facets and low-coordinated atoms on the edge of branches. Furthermore, the PdNi DNTs/NF exhibits outstanding long-term durability in the current–time test for 7200 s with superior anti-CO poisoning performance, possessing a potential application in DAFCs.
研究领域:
材料科学
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电化学
·
能源技术
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）