Chinese Journal of Natural Medicines
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2016
·
IF 1.382
Feng ZHANG,Liang SUN,Shou-Hong GAO,Wan-Sheng CHEN,Yi-Feng CHAI
Tanreqing injection (TRQ), a well-known traditional Chinese medicine formula, is commonly used to treat respiratory diseases. In the present study, a rapid, selective, and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated to simultaneously determinate the plasma contents of 5 major constituents of TRQ, including chlorogenic acid (CHA), caffeic acid (CFA), baicalin (BA), ursodeoxycholic acid (UDCA) and chenodeoxycholic acid (CDCA) in rats after intravenous administration of TRQ. Chromatographic separation was performed on an Agilent Zorbax SB-C 18 column (3.5 μm, 100 mm × 2.1 mm), with acetonitrile and 0.1% aqueous formic acid as mobile phase at a flow rate of 0.3 mL·min −1 . The calibration curves were linear over the ranges of 27.0–13 333.0 ng·mL −1 for CFA, 30.0–14 933.0 ng·mL −1 for CHA, 50.0–50 333.0 ng·mL −1 for BA, 550.0–55 000.0 ng·mL −1 for UDCA, and 480.0–48 000.0 ng·mL −1 for CDCA, respectively. Intra- and inter-day precisions (relative standard deviations, RSDs) were from 3.11% to 14.08%. The extraction recoveries were greater than 71% and accuracy (relative recovery) was from 89% to 137% for all analytes, except endogenous bile acids. This validated method was successfully applied to the first pharmacokinetic study of CFA, CHA, BA, UDCA and CDCA in rat plasma after intravenous administration of TRQ.
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PHYTOMEDICINE
·
2016
·
IF 2.937
Qin Tang,Fangling Ji,Wenhui Sun,Jingyun Wang,Jianli Guo,Lianying Guo,Yachen Li,Yongming Bao
Background 10-Hydroxy camptothecin (HCPT), a naturally occurring alkaloid, is a clinical drug for cancer chemotherapy . Baicalein (BA) is a flavonoid extracted from the root of Scutellaria baicalensis . The synergistic anti-cancer effect of BA and HCPT has not been reported. Purpose To explore whether and how BA enhances the anti-cancer effect of HCPT in BGC823 cells. Methods Cell viability was measured by MTT assay. Apoptosis and cell cycle were analyzed through flow cytometry and western blotting analysis. DNA damage was determined by a comet assay . The activity of topoisomerase I (Topo I) was detected by the plasmid DNA relaxation assay. The synergistic anti-cancer effect of BA and HCPT in vivo was tested by BGC823 xenografted tumor model. Results BA at non-toxic doses prominently enhanced the anti-cancer activities of HCPT in BGC823, MCF7 and SMMC7721 cells. Combination treatment of BA and HCPT induced BGC823 cells apoptosis mainly via intrinsic rather than extrinsic pathways, and preferentially arresting cell cycle in G1 and G2 phases with the aid of p21 . Of note, p53, the upstream regulator of cell apoptosis and cycle, was increased by 5 folds in combination group. It helped to further trigger DNA damage and inhibit Topo I catalytic activity after combination treatment of BA and HCPT. Moreover, the BGC823 xenografted tumor growth rate in nude mice was repressed in a greater degree ( P < 0.01) in the combinational group than the single-drug group. Conclusion HCPT and BA, a new and effective combination therapy, synergistically target Topo I and up-regulate p53 to induce cell apoptosis and cell cycle arrest.
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CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Jingxuan Zheng,Jingye Liang,Jishuai Xu,Fangying Lu,Hanbin Yu,Yong Liu,Run Wang
Hydrogel electrolytes, with high ionic conductivity, flexibility, and tunable mechanical properties, are widely applied in flexible strain sensors and supercapacitors. However, the fabrication of hydrogel electrolytes with anti-freezing, self-healing and adhesion in extreme environmental condition remains a challenge. In this study, a zwitterionic hydrogel electrolyte is prepared by introducing betaine, borax, and zinc ions into a poly(vinyl alcohol) and polyacrylic acid double-network hydrogel. The prepared multifunctional hydrogel electrolytes exhibit excellent stretchability (980.0 %), anti-freezing capacity (−28.9 °C), self-healing ability, self-adhesion (22.5 kPa for metal), and ionic conductivity (4.56 S m −1 ). Under applied strain, the resistance of the hydrogel changes, which can be monitored as a variation in the electrical signal to detect strain. Moreover, the flexible strain sensor assembled from the hydrogels is capable of monitoring human movement and transmitting information. Impressively, the zinc-ion supercapacitor based on zwitterionic hydrogel electrolytes demonstrates a high energy density of 19.5 Wh kg −1 , and a high power density of 696.0 W kg −1 . This work offers an effective strategy to design hydrogel electrolytes for flexible electronic devices toward wearable sensing, power supply, and energy storage.
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FOOD RESEARCH INTERNATIONAL
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2025
·
IF 8
Jingbo Liu,Yang Liu,Shanglin Li,LongJiang Tian,Yajuan Li,Chunmei Liu,Sitong Ma,Ting Zhang,Meng Yang,Zhiyang Du
Efficient oral coassembly strategies have attracted increasing attention for the preferable co-delivery of multiple nutraceuticals. Inspired by superior transport tendencies of the intestinal glucose transporter 2 (GLUT2) to fructose-modified biopolymers, this study fabricated the coassemblies consisting of fructose-modified chitosan (Fru-CS) shell and disulfonic acid-modified γ-cyclodextrin (BA-γ-CD) core to effectively co-deliver hydrophilic egg white oligopeptides (EWOP) and hydrophobic curcumin (Cur). The non-covalent interactions-driven coassemblies exhibited the admirable nanoscale colloidal features and nutraceuticals (EWOP/Cur) co-loading capacity (20.6–25.5 > > 10 %). Besides, the coassemblies introduced the outstanding application synergism (> 15 % enhancement) to nutraceuticals under multi-dimensional scenarios ( e.g. , digestion, heat, UV-light, and antioxidant). Notably, the outer Fru-CS-coated coassemblies could dramatically improve the intact absorption efficiency (2.5–7.9 times) of nutraceuticals mainly via GLUT2-oriented transcytosis and cooperate with BA-γ-CD to achieve better gastrointestinal retention and mucus permeation. This work offers a facile and effective co-assembly strategy for oral co-delivery of nutraceuticals for food processing and healthcare.
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Materials
·
2018
·Vol. 11
·期 1
·89
·
IF 2.467
Yun Zhang,Bo Pang,Sen Yang,Wei Fang,Sheng Yang,Tong-Qi Yuan,Run-Cang Sun
Polyvinyl acetate emulsion adhesive has been widely used due to its good bonding performance and environmentally friendly properties. Indeed, the bonding performance can be further improved by copolymerizing with other monomers. In this study, the effect of the adjunction of redox initiator (hydrogen peroxide–tartaric acid, H2O2–TA) on the properties of the poly (vinyl acetate-butyl acrylate) (P (VAc–BA)) emulsion adhesive was investigated. With increasing dosage, the reaction became more complete and the obtained film was more compact, as identified via SEM. The core-shell structure of the emulsion particles was confirmed via TEM. Results indicate that while the initiator content increased from 0.5 to 1.0%, a clearer core-shell structure was obtained and the bonding strength of the plywood improved from 2.34 to 2.97 MPa. With the further incorporation of H2O2–TA (i.e., 1.5%), the bonding performance deteriorated. The optimum wood bonding strength (2.97 MPa) of the prepared P (VAc-BA) emulsion adhesive was even better than that (2.55 MPa) of a commercial PVAc emulsion adhesive, suggesting its potential application for the wood industry.Keywords:poly (vinyl acetate-butyl acrylate);redox initiator;emulsion polymerization;core-shell structure
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2018
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IF 3.909
Nan Wu,Siming Wang,Ye Yang,Jiayi Song,Ping Su,Yi Yang
A novel type of trypsin capillary microreactor was developed based on a DNA-directed immobilization (DDI) technique applied to a fused-silica capillary modified with polyamidoamine (PAMAM) dendrimers. Trypsin binding to the inner wall of the capillary was confirmed by confocal laser scanning microscopy. The properties of the trypsin–DNA conjugated, PAMAM-modified capillary microreactor were investigated by monitoring hydrolysis of N α-benzoyl- L -arginine ethyl ester. Through the hybridization and dehybridization of the DNA, the inner wall of the capillary functionalized with trypsin can be regenerated, thus indicating the renewability of this enzyme microreactor. In addition, these results demonstrated that introduction of PAMAM enabled higher amounts of trypsin to be immobilized, markedly improving the enzymolysis efficiency, compared with traditional modified capillaries. The digestion performance of the trypsin capillary microreactor was further evaluated by digesting cytochrome C, and a peptide numbers of 8, and a sequence coverage of 59% were obtained. This renewable and efficient immobilized trypsin capillary microreactor combines advantages of both DDI technology and PAMAM, and is potentially adaptable to high-throughput enzyme assays in biochemical and clinical research.
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BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
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2025
·Vol. 136
·期 5
·e70027
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IF 3.3
Mengjie Guo,Han Meng,Yi Sun,Lianxin Zhou,Tingting Hu,Tianyi Yu,Haowen Bai,Yuanjiao Zhang,Chunyan Gu,Ye Yang
Multiple myeloma (MM) is an incurable hematologic malignancy, driving significant interest in the discovery of novel therapeutic strategies. Bruceine A (BA), a tetracyclic triterpene quassinoid derived from Brucea javanica , has shown anticancer properties by modulating multiple intracellular signalling pathways and exhibiting various biological effects. However, the specific pharmacological mechanisms by which it combats MM remain unclear. In this study, we identified USP13 as a potential target of BA. We observed a significant increase in USP13 expression in patients with MM, which was strongly associated with a poorer prognosis. Furthermore, enhanced USP13 expression can stimulate MM cell proliferation both in vitro and in vivo. Mass spectrometry analysis, combined with co-immunoprecipitation and in vitro ubiquitination experiments, revealed PARP1 as a critical downstream target of USP13. USP13 can stabilize PARP1 protein through deubiquitination, promoting PARP1-mediated DNA damage repair (DDR) and facilitating MM progression. Notably, we utilized MM cell lines, an MM Patient-Derived Tumour Xenograft model, and a 5TMM3VT mouse model to determine the anticancer effects of BA on MM progression, revealing its potential to target USP13/PARP1 signalling and disrupt DDR in MM cells. In conclusion, these findings suggest that BA inhibiting USP13/PARP1-mediated DDR might be a promising therapeutic strategy for MM.
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INORGANIC CHEMISTRY
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2012
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IF 4.601
Wenlong Yin,Wendong Wang,Lei Bai,Kai Feng,Youguo Shi,Wenyu Hao,Jiyong Yao,Yicheng Wu
The 12 new rare-earth tellurides Ba2MLnTe5 (M = Ga and Ln = Sm, Gd, Dy, Er, Y; M = In and Ln = Ce, Nd, Sm, Gd, Dy, Er, Y) have been synthesized by solid-state reactions. The two compounds Ba2GaLnTe5 (Ln = Sm, Gd) are isostructural and crystallize in the centrosymmetric space group P1̅, while the other 10 compounds belong to another structure type in the noncentrosymmetric space group Cmc21. In both structure types, there are one-dimensional anionic 1∞[MLnTe5]4– chains built from LnTe6 octahedra and MTe4 (M = Ga, In) tetrahedra, but the connectivity between the LnTe6 octahedra and MTe4 tetrahedra is different for the two structure types. On the basis of the diffuse-reflectance spectra, the band gaps are around 1.1–1.3 eV for these compounds. The Ba2MLnTe5 (M = Ga and Ln = Gd, Dy; M = In and Ln = Gd, Dy, Er) compounds are paramagnetic and obey the Curie–Weiss law, while the magnetic susceptibility of Ba2InSmTe5 deviates from the Curie–Weiss law. In addition, electronic structure calculation on Ba2MYTe5 (M = Ga, In) indicates that they are both direct-gap semiconductors with large nonlinear-optical coefficients.
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INORGANIC CHEMISTRY
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2012
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IF 4.601
Wenlong Yin,Kai Feng,Wendong Wang,Youguo Shi,Wenyu Hao,Jiyong Yao,Yicheng Wu
The twelve quaternary rare-earth selenides Ba2MLnSe5 (M = Ga, In; Ln = Y, Nd, Sm, Gd, Dy, Er) have been synthesized for the first time. The compounds Ba2GaLnSe5 (Ln = Y, Nd, Sm, Gd, Dy, Er) are isostructural and crystallize in a new structure type in the centrosymmetric space group P1̅ of the triclinic system while the isostructural compounds Ba2InLnSe5 (Ln = Y, Nd, Sm, Gd, Dy, Er) belong to the Ba2BiInS5 structure type and crystallize in the noncentrosymmetric space group Cmc21 of the orthorhombic system. The structures contain infinite one-dimensional anionic chains 1∞[GaLnSe5]4– and 1∞[InLnSe5]4–, and both chains are built from LnSe6 octahedra and MSe4 (M = Ga, In) tetrahedra in the corresponding selenides. As deduced from the diffuse reflectance spectra, the band gaps of most Ba2MLnSe5 (M = Ga, In; Ln = Y, Nd, Sm, Gd, Dy, Er) compounds are around 2.2 eV. The magnetic susceptibility measurements on Ba2GaGdSe5 and Ba2InLnSe5 (Ln = Nd, Gd, Dy, Er) indicate that they are paramagnetic and obey the Curie–Weiss law, while the magnetic susceptibility of Ba2InSmSe5 deviates from the Curie–Weiss law as a result of the crystal field splitting. Furthermore, Ba2InYSe5 exhibits a strong second harmonic generation response close to that of AgGaSe2, when probed with the 2090 nm laser as fundamental wavelength.
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JOURNAL OF APPLIED POLYMER SCIENCE
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2012
·Vol. 127
·期 1
·402-409
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IF 1.289
Haohua Ye,Zhanxiong Li,Guoqiang Chen,Dan Fan
Bis (1H, 1H, 2H, 2H-perfluoro-octyl)methylenesuccinate (FOM)/ethyl acrylate (EA)/methyl methacrylate (MMA) copolymer (FOME) latexes, FOM/butyl acrylate (BA)/MMA copolymer (FOMB) latexes, and FOM/octyl acrylate (OA)/MMA copolymer (FOMO) latexes were synthesized by continuous emulsion polymerization. Solution polymerization was also carried out to prepare FOMB. The influences of fluorine content and curing conditions on the surface properties of polymer films were discussed. The water and oil repellency of cotton fabrics treated with the FOM copolymers was better than that of conventional poly(fluoroalkyl acrylate)s containing the same fluorinated chain. The polymer films or the treated fabrics were characterized by Fourier transform infrared, scanning electron microscope, atomic force microscopy, thermogravimetric analysis, x-ray photoelectron spectrometry, and wide angle x-ray diffraction. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci, 2013
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JOURNAL OF MOLECULAR LIQUIDS
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2025
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IF 5.2
Yusen Chen,Jie Li,Chunshan Li,Yinglong Wang,Jianguang Qi,Zhaoyou Zhu
Trioxane (Tox) is an important source of anhydrous formaldehyde, which is used in large quantities in industrial production resulting in large quantities of low concentration Tox wastewater. Liquid-liquid extraction is one of the commonly used methods for wastewater resource recycling. This study presents a method on the separation of Tox from wastewater using hydrophobic deep eutectic solvents (HDES). Firstly, Thy-BA and Thy-DA were screened from 12 HDES by extraction performance and solubility in water. The effects of different molar ratios of HDES, extraction temperature and addition of acetic acid as impurity on the extraction performance were further investigated. For the measured ternary phase data of HDES-Tox-water, the reliability of the data was verified using the Othmer-Tobias and Hand equations, and the data were fitted using the NRTL model. Quantum chemistry was used to calculate the interaction energy of HDES with Tox and to establish a correlation with the extraction efficiency. Hydrogen bonding was found to be the main force for separating Tox by electrostatic potential and interaction region indicator analysis. Molecular dynamics computing found that Thy was a substance that plays a major role in Thy-BA and Thy-DA. Ultimately, it was discovered that the chosen HDES has great recycling and thermal stability characteristics. This work explores three aspects of phase equilibrium, thermodynamics and microscopic separation mechanism revelation to support the systematic recovery of Tox wastewater.
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Nature Communications
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2025
·Vol. 16
·期 1
·1-10
·
IF 15.7
Jiang Meng,Zhang Qinghua,Zhang Siyuan,Liu Ming,Fu Yuntian,Zhang Zhiyuan,Ai Xin,Mortazavi Bohayra,Wang Lianjun,Zhang Qihao,Makarov Denys,Jiang Wan
Thermoelectric materials offer an exceptional opportunity to convert waste heat into electricity directly, yet their widespread application remains hindered by intrinsic brittleness and poor processability. Here, we introduce a graded ball milling strategy that fundamentally enhances the mechanical robustness and processability of YbZn 2 Sb 2 -based thermoelectrics. By refining grain microstructure, increasing dislocation density, and promoting intermediate-angle grain boundaries, this approach enables the fabrication of crack-free, large-size, disc-shaped, and microscale dices while maintaining excellent thermoelectric performance. Extending this strategy to a broader class of brittle Zintl compounds, including AZn 2 Sb 2 , AMg 2 Sb 2 , and ACd 2 Sb 2 (A = Yb, Mg, Ca, Sr, Ba), we achieve a pre-formation cohesive energy of 9.1 eV atom − 1 and relatively low lattice thermal conductivity of 0.5 W m −1 K −1 in Yb 0.5 Mg 1.3 Zn 1.2 Sb 2 . Integrated with n-type Mg 3.1 Nb 0.1 Sb 1.5 Bi 0.49 Te 0.01 , the thermoelectric module achieves a conversion efficiency exceeding 10% under a 458 K temperature gradient, operating for more than 40 hours steadily. This work establishes a scalable and versatile strategy for reconciling mechanical durability with high thermoelectric performance, paving the way for next-generation thermoelectric devices with enhanced reliability and industrial viability.
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