Scientific Reports
·
2025
·Vol. 15
·期 1
·1-11
·
IF 3.9
Zhu Huanle,Qi Yuchen,Hua Shiyuan,Huang Rongrong,Chen Lumin,Zhou Xiaoxuan,He Jian,Hu Hongjie,Niu Zhongfeng
Inorganic nanoparticles play important roles in cancer treatment, but the issues of biodegradable properties, and tumor penetration restricted further clinical application. Aiming at the low efficiency and toxic side effects problems existing in the current clinical treatment of cancer, a biodegradable mesoporous silica nanoparticle (MSN) platform integrating pH-responsive drug release and synergistic chemo-radiotherapy was developed. The doxorubicin hydrochloride (DOX) was loaded in MSNs via electrostatic interactions, with ultra-small hafnium sulfide (HfS 2 ) nanodots were anchored to the surface of MSN. At physiological pH, HfS₂ reinforces DOX retention through steric and electrostatic effects, while in acidic tumor microenvironments, it triggers DOX release. Concurrently, dissociated HfS 2 acts as a radiosensitizer, enhancing X-ray-induced cytotoxicity and promoting deep tumor penetration. Both the in vitro cellular and in vivo animal level results confirmed synergistically enhanced chemoradiotherapy efficiency. Therefore, this research, we believed, will bring a new train of thought and scientific support for more safety and more efficiency in cancer therapy.
研究领域:
纳米医学
·
癌症治疗
·
药物递送
·
放射肿瘤学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RENEWABLE ENERGY
·
2024
·
IF 9
Xian Shi,Xinyi Xing,Wanni Liu,Mengya Ruan,Ying Guan,Gaojin Lyu,Hui Gao,Siquan Xu
The efficient catalytic conversion of cellulose to 5-hydroxymethylfurfural (HMF) can provide a valuable reference for the high-value utilization of biomass. In this work, a series of simple phosphate-doped hafnium oxide catalysts (x-P-HfO 2 ) were prepared, and their physicochemical properties were analyzed by ICP-OES, XRD, XPS, FTIR, SEM-EDX, N 2 adsorption-desorption isotherms, NH 3 -TPD and Py-FTIR characterizes. Detailed evaluation of the reaction conditions demonstrated the ideal catalytic performance of the x-P-HfO 2 catalysts, and the HMF yield from cellulose reached a satisfactory 61% in the water (NaCl) /tetrahydrofuran biphasic reaction system. Based on the captured intermediates and detected by-products, possible catalytic pathways are summarized. Meanwhile, the hydrothermal stability of the catalyst was also investigated, and the reason for its performance degradation after five cycles was determined to be the loss of useful Brønsted active sites. In addition, the effects of the phosphating and sulfating modification approaches on the catalyst activity were also compared, verifying that the introduction of phosphate is more conducive to the catalyst expressing high activity for the formation of HMF from cellulose.
研究领域:
催化
·
生物质转化
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2024
·
IF 3.8
Li Haiyin,Wang Zhixin,Li Feng,Gai Panpan
Exploring the construction of an interface with bright emission, fabulous stability, and good function to develop high-performance electrochemiluminescence (ECL) biosensors for tumor biomarkers is in high demand but faces a huge challenge. Herein, we report an oriented attachment and in situ self-assembling strategy for one-step fabrication of CdTe QD-encapsulated Hf polymer membrane onto an ITO surface (Hf-CP/CdTe QDs/APS/ITO). Hf-CP/CdTe QDs/APS/ITO is fascinating with excellent stability, high ECL emission, and specific adsorption toward ssDNA against dsDNA and mononucleotides (mNs). These interesting properties make it an ideal interface to rationally develop an immobilization-free ECL biosensor for cancer antigen 125 (CA125), used as a proof-of-concept analyte, based on target-aptamer recognition-promoted exonuclease III (Exo III)-assisted digestion. The recognition of ON by CA125 leads to the formation of CA125@ON, which hybridizes with Fc-ssDNA to switch Exo III-assisted digestion, decreasing the amount of Fc groups anchored onto the electrode’s surface and blocking electron transfer. As compared to the case where CA125 was absent, significant ECL emission recovery is determined and relies on CA125 concentration. Thus, highly sensitive analysis of CA125 against other biomarkers was achieved with a limit of detection down to 2.57 pg/mL. We envision this work will provide a new path to develop ECL biosensors with excellent properties, which shows great potential for early and accurate diagnosis of cancer.
研究领域:
分析化学
·
生物传感
·
纳米技术
·
癌症诊断
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INORGANIC CHEMISTRY
·
2024
·
IF 4.3
Mei Yan,Ru-Ling Tang,Wei Xu,Wenlong Liu,Sheng-Ping Guo
Zirconium/hafnium fluorides have recently been recognized as potential nonlinear optical (NLO) materials with short ultraviolet (UV) cutoff edges, which is significant in laser science and industry. The synthesis of noncentrosymmetric (NCS) materials based on centrosymmetric (CS) compounds by an isovalent cation substitution-oriented design is an emerging strategy in the NLO territory. Here, two isostructural and novel fluorides, CaBaMF8 (M = Zr (1), Hf (2)), have been synthesized through the combination of alkaline earth metals, zirconium/hafnium, and fluorine elements. They feature zero-dimensional and CS structures composed by an isolated MF8 (M = Zr, Hf) dodecahedron and dissociative Ca2+ and Ba2+ cations, and they display short UV cutoff edges (<200 nm) as well. Two three-dimensional fluorides Li2CaMF8 (M = Zr (3), Hf (4)) are obtained by replacing Ba with alkali metal Li atom, which not only represent phase-matchable second-harmonic-generation activities (0.36, 0.30× KH2PO4 (KDP)) at 1064 nm but also maintain short UV cutoff edges with high reflectance. This work has largely enriched the family of NCS zirconium/hafnium fluorides reaching the short UV region.
研究领域:
材料科学
·
无机化学
·
光学材料
·
晶体工程
·
非线性光学
✓ 已验证
DOI
高影响因子
Advanced Healthcare Materials
·
2024
·
IF 10
Zede Wu,Qiuyu Li,Kai Zhu,Shuting Zheng,Honglei Hu,Meirong Hou,Li Qi,Siwen Chen,Yikai Xu,Bingxia Zhao,Chenggong Yan
Immunotherapy has emerged as an innovative strategy with the potential to improve outcomes in cancer patients. Recent evidence indicates that radiation-induced DNA damage can activate the cyclic-GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway to enhance the antitumor immune response. Even so, only a small fraction of patients currently benefits from radioimmunotherapy due to the radioresistance and the inadequate activation of the cGAS-STING pathway. Herein, this work integrates hafnium oxide (HfO 2 ) nanoparticles (radiosensitizer) and 7-Ethyl-10-hydroxycamptothecin (SN38, chemotherapy drug, STING agonist) into a polydopamine (PDA)-coated core-shell nanoplatform (HfO 2 @PDA/Fe/SN38) to achieve synergistic chemoradiotherapy and immunotherapy. The co-delivery of HfO 2 /SN38 greatly enhances radiotherapy efficacy by effectively activating the cGAS-STING pathway, which then triggers dendritic cells maturation and CD8 + T cells recruitment. Consequently, the growth of both primary and abscopal tumors in tumor-bearing mice is efficiently inhibited. Moreover, the HfO 2 @PDA/Fe/SN38 complexes exhibit favorable magnetic resonance imaging (MRI)/photoacoustic (PA) bimodal molecular imaging properties. In summary, these developed multifunctional complexes have the potential to intensify immune activation to realize simultaneous cancer Radio/Chemo/Immunotherapy for clinical translation.
研究领域:
癌症研究
·
纳米技术
·
免疫治疗
·
放射肿瘤学
·
分子成像
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Chengqiang Hu,Hongru Zhao,Ruiyi Sun,Xiumin Yang,Junlian Wang
Deep separation of Zr and Hf has always been a great challenging due to their very similar physicochemical properties. In this study, we established a method to synthesize two novel extraction chromatographic resins which graft dialkylphosphinic acid groups through amide group. The dialkylphosphinic acid modified resins were characterized by FT-IR, EA, SEM-EDS, XPS, and BET. Their adsorption and separation behaviors for Zr and Hf were investigated, and the adsorption mechanism was studied. The Zr and Hf adsorption onto Mer-CON-POOH-272 and Mer-CON-POOH-HYY2 both fit pseudo-second order model and Langmuir isotherm model. Mer-CON-POOH-HYY2 has stronger affinity to Zr and Hf than Mer-CON-POOH-272. Mer-CON-POOH-272 has a theoretical maximum loading capacity of 5.663 mg·g −1 Zr and 11.111 mg·g −1 Hf, while Mer-CON-POOH-HYY2 has a higher theoretical maximum loading capacity of 8.376 mg·g −1 Zr and 13.157 mg·g −1 Hf. Dialkylphosphinic acids are the functional groups of Mer-CON-POOH-272 and Mer-CON-POOH-HYY2 that interact with Zr and Hf during adsorption. They adsorb Zr and Hf through cation exchange mechanism, which can be expressed as M(SO 4 ) 3 2– + 2HL ⇌ M(SO 4 )L 2 +. 2H + + 2SO 4 2- . With increasing H 2 SO 4 concentration, the Zr and Hf extraction percentages and their separation efficiency reduce. The DFT calculation reveals that the adsorption process is accompanied by charge transfer. Adsorption occurs mainly at P = O and P-O positions. The affinity of the two resins for Hf is higher than that of Zr, which is the reason why the resin preferentially adsorbs Hf.
研究领域:
材料科学
·
化学工程
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
Nanomaterials
·
2022
·Vol. 13
·期 1
·39
·
IF 5.719
Yuan-Dong Xu,Yan-Ping Jiang,Xin-Gui Tang,Qiu-Xiang Liu,Zhenhua Tang,Wen-Hua Li,Xiao-Bin Guo,Yi-Chun Zhou
Resistive random-access memory (RRAM) is a promising candidate for next-generation non-volatile memory. However, due to the random formation and rupture of conductive filaments, RRMS still has disadvantages, such as small storage windows and poor stability. Therefore, the performance of RRAM can be improved by optimizing the formation and rupture of conductive filaments. In this study, a hafnium oxide-/aluminum-doped zinc oxide/hafnium oxide (HfO2/Al-ZnO/HfO2) tri-layer structure device was prepared using the sol–gel method. The oxygen-rich vacancy Al-ZnO layer was inserted into the HfO2layers. The device had excellent RS properties, such as an excellent switch ratio of 104, retention of 104s, and multi-level storage capability of six resistance states (one low-resistance state and five high-resistance states) and four resistance states (three low-resistance states and one high-resistance state) which were obtained by controlling stop voltage and compliance current, respectively. Mechanism analysis revealed that the device is dominated by ohmic conduction and space-charge-limited current (SCLC). We believe that the oxygen-rich vacancy concentration of the Al-ZnO insertion layer can improve the formation and rupture behaviors of conductive filaments, thereby enhancing the resistive switching (RS) performance of the device.
研究领域:
材料科学
·
电气工程
·
纳米技术
·
半导体器件
✓ 已验证
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2023
·
IF 9.9
Yan Ma,Haitao Wu,Qinglong Guo,Xingliang Dai,Peisan Wang,Wei Zhang,Dongdong Liu,Xulin Chen,Haisheng Qian,Xianwen Wang
Photothermal therapy (PTT) effectively suppresses tumor growth with high selectivity . Nevertheless, PTT may cause an inflammatory response that leads to tumor recurrence and treatment resistance, which are the main disadvantages of PTT. Herein, monodisperse hafnium carbide nanoparticles (HfC NPs) were successfully prepared for noninflammatory PTT of cancer. HfC NPs possessed satisfactory near-infrared (NIR) absorption, good photothermal conversion efficiency (PTCE, 36.8 %) and photothermal stability. Furthermore, holding large surface areas and intrinsic redox-active sites, HfC NPs exhibited excellent anti-inflammatory properties due to their antioxidant and superoxide dismutase (SOD) enzymatic activities . In vitro and in vivo experiments confirmed that HfC NPs converted light energy into heat energy upon NIR laser irradiation to kill cancer cells through PTT and achieved a better therapeutic effect by anti-inflammatory effects after PTT. This work highlights that multifunctional HfC NPs can be applied in noninflammatory PTT with outstanding safety and efficacy.
研究领域:
纳米技术
·
癌症治疗
·
光热疗法
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMATERIALS
·
2024
·
IF 12.8
Jia-Wei Wang,Ping Ji,Jin-Yue Zeng,Jun-Long Liang,Qian Cheng,Miao-Deng Liu,Wei-Hai Chen,Xian-Zheng Zhang
Hypoxia and lactate-overexpressed tumor microenvironment always lead to poor therapeutic effect of radiotherapy. Here, platinum nanoparticles-embellished hafnium metal-organic framework (Hf-MOF-Pt NPs) were elaborately integrated with Shewanella oneidensis MR-1 (SO) to construct an engineered biohybrid platform (SO@Hf-MOF-Pt) for enhancing radiotherapy. Benefiting from the tumor-targeting and metabolic respiration characteristics of SO, SO@Hf-MOF-Pt could enrich in tumor sites and continuously metabolize the overexpressed lactate, which specifically downregulated the expression of hypoxia-inducible factor (HIF-1α), thereby relieving the radiosuppressive tumor microenvironment to some extent. Moreover, SO@Hf-MOF-Pt would react with tumor-overexpressed hydrogen peroxide (H 2 O 2 ) to generate oxygen (O 2 ) and further inhibit the expression of HIF-1α, resulting in the downregulation of lactate dehydrogenase (LDHA) and subsequently reducing the lactate production. Under these multiple cascaded effects, the radiosuppressive tumor microenvironment was significantly reshaped, thus potentiating the radiosentization of SO@Hf-MOF-Pt and remarkably amplifying the therapeutic outcomes of radiotherapy. The designed biohybrid SO@Hf-MOF-Pt represented promising prospects in sensitizing radiotherapy via bacterium-based metabolic regulation.
研究领域:
生物医学工程
·
癌症治疗
·
纳米技术
·
生物材料
·
肿瘤微环境
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Chun Li,Jiaxun Yao,Jiayi Xu,Huanhuan Yang,Guangfu Luo,Yanhao Yu
Nucleation behavior governs the selectivity of area-selective atomic layer deposition (AS-ALD). Ideally, nontargeted regions should exhibit delayed nucleation or sparse nucleation that can be easily removed by post-treatment. Here, we report a burst nucleation phenomenon during AS-ALD on perfluoroalkyl self-assembled monolayer (SAM)-treated surfaces. Burst nucleation results in discontinuous particle deposition with weak interfacial adhesion on nontargeted regions, in contrast to the progressive nucleation that forms uniform and adherent films on alkyl SAMs. These weakly adhered particles can be completely removed by gentle wiping without affecting the ALD film in targeted areas. The burst window depends on the SAM chain length, the ALD precursor, and the ALD temperature. When applied to Cu/SiO2 substrates, the nucleation control enables 99.9% selectivity after 30 cycles of Al2O3 ALD, while that of alkyl SAMs is 52.2%. The burst nucleation strategy is broadly effective for enhancing the selectivity of AS-ALD oxides (e.g., ZrO2, HfO2, ZnO) and polymers (e.g., polyimide).
研究领域:
材料科学
·
纳米技术
·
薄膜沉积
·
表面化学
·
半导体工艺
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Nano
·
2024
·
IF 15.8
Yuhua Cao,Shuaishuai Ding,Yunping Hu,Lijuan Zeng,Jingrong Zhou,Ling Lin,Xiao Zhang,Qinghua Ma,Ruili Cai,Yu Zhang,Guangjie Duan,Xiu-wu Bian,Gan Tian
cGAS-STING signaling plays a critical role in radiotherapy (RT)-mediated immunomodulation. However, RT alone is insufficient to sustain STING activation in tumors under a safe X-ray dose. Here, we propose a radiosensitization cooperated with cGAS stimulation strategy by engineering a core–shell structured nanosized radiosensitizer-based cGAS-STING agonist, which is constituted with the hafnium oxide (HfO2) core and the manganese oxide (MnO2) shell. HfO2-mediated radiosensitization enhances immunogenic cell death to afford tumor associated antigens and adequate cytosolic dsDNA, while the GSH-degradable MnO2 sustainably releases Mn2+ in tumors to improve the recognition sensitization of cGAS. The synchronization of sustained Mn2+ supply with cumulative cytosolic dsDNA damage synergistically augments the cGAS-STING activation in irradiated tumors, thereby enhancing RT-triggered local and system effects when combined with an immune checkpoint inhibitor. Therefore, the synchronous radiosensitization with sustained STING activation is demonstrated as a potent immunostimulation strategy to optimize cancer radio-immuotherapy.
研究领域:
癌症生物学
·
纳米技术
·
免疫学
·
放射肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small
·
2025
·Vol. 21
·期 21
·2500943
·
IF 12.1
Weizong Wang,Kexuan Jing,He Ma,Kang Liang,Peng Wei,Jiangchuan Liu,Yurong Ren,Qian Zhao,Zhengping Ding
Halide solid-state electrolytes (SSEs) with high ionic conductivity and oxidation stability show significant potentials for the commercialization of all-solid-state batteries (ASSBs). However, their practical applications are limited by poor humidity tolerance and decreased ionic conductivity. Herein, the Li 3/3- x In 1- x M x Cl 5.6 F 0.4 ( M = Hf, Zr, Fe, and Y; x = 0.015, 0.02, 0.025, 0.075, 0.1, 0.125, and 0.15) are synthesized by co-doping Li 3 InCl 6 with M and F ions for high-performance ASSBs. Li 2.98 In 0.98 Hf 0.02 Cl 5.6 F 0.4 achieves the highest ionic conductivity of 1.04 mS cm −1 at room temperature and good humidity tolerance of 87.96% conductivity retention after 24 h exposure. The analysis of experiments combining BVSE and AIMD simulations indicates that it benefits from the enhanced rigid structure that is thermodynamically stable to water caused by Cl − doping with F − and higher Li + vacancies concentration that facilitates Li + conduction generated by In 3+ doping with Hf 4+ . Moreover, an all-solid-state battery ensembled with Li 2.98 In 0.98 Hf 0.02 Cl 5.6 F 0.4 , LiCoO 2 and Li–In alloy, exhibits a high discharge capacity of 83.6 mAh g −1 and 78.6% capacity retention after 100 cycles under 0.5 C at 25 °C. This work provides a reliable strategy for designing advanced halide SSEs for commercial applications in ASSBs by cation–anion co-doping.
研究领域:
材料科学
·
电化学
·
储能技术
·
固态离子学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）