FOOD CHEMISTRY
·
2024
·
IF 8.5
Xiang Luo,Yuanyuan Chen,Zhe Jiang,Hongze Wu,David Julian McClements,Chang Zhang,Yanyan Zhou,Hongliang Fu,Xuguang Yin,Wenna Huang,Zhixin Wang,Lemao Yu,Xin Tang,Kangli Li,Kewu Zhu
A new multifunctional emulsifier was synthesized by coupling maltodextrin with a dextrose equivalent of 19 to vitamin E succinate. Two emulsifiers with varying degrees of vitamin E succinate substitution were prepared based on different mass ratios of vitamin E succinate to maltodextrin. The molecular structure and purity of these emulsifiers were analyzed. Nanoemulsions were prepared using octenyl succinic anhydride modified starch as a control to investigate the physical stability, antioxidant capacity, oxidative stability, and in vitro simulated digestive properties of the nanoemulsions. The emulsifying and antioxidant activity of the maltodextrin-vitamin E succinate conjugate was significantly superior to that of octenyl succinic anhydride modified starch, demonstrating good physical and oxidative stability. Additionally, they were rapidly digested under simulated small intestinal conditions. This new emulsifier shows broad application potential for the encapsulation, protection, and delivery of hydrophobic bioactive substances in the fields of medicine, food, and healthcare products.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
International Journal of Peptide Research and Therapeutics
·
2017
·Vol. 25
·期 1
·161-168
·
IF 0.904
Yu Zhiliang,Zhang Ling,Qin Wangrong,Yin Jianhua,Qiu Juanping
Polymyxin E (colistin) has been considered as an important peptide antibiotic for clinical treatment of Gram-negative pathogens by selectively targeting lipopolysaccharide on the outer membrane. Recent reports showed that colistin can also kill Gram-positive bacteria, but the mechanism of colistin against Gram-positive bacteria remains unclear. In this study, we found that colistin can kill its producer Paenibacillus polymyxa , a Gram-positive bacterium, by both disrupting its cell integrity and inducing oxidative stress. Enhancement of the cell permeability is the major action of colistin against P. polymyxa . In relative, colistin-induced oxidative stress plays an associated role in killing of P. polymyxa . Notably, we, for the first time, found that exogenous catalase is able to intensify the colistin-induced killing by inhibiting the intracellular catalase activity and thus increasing oxidative stress. Our findings would shed light on a not yet clearly described bactericidal mechanism of colistin against Gram-positive bacteria. More importantly, our findings pave the road for the future to lower clinical use of colistin for avoiding bacterial resistance.
✓ 已验证
产品关联
DOI
高影响因子
Cell Metabolism
·
2025
·
IF 30.9
Yu-Zhang Wang,Wei-Hai Chen,Zi-Yi Han,Shi-Man Zhang,Ping Ji,Cheng Zhang,Jun-Long Liang,Xian-Zheng Zhang
Bacteria-based metabolic therapy has been acknowledged as a promising strategy for tumor treatment. However, the insufficient efficiency of wild-type bacteria severely restricts their therapeutic efficacy. Here, we elaborately develop an ʟ-cyst(e)ine-addicted bacteria-nanodrug biohybrid for metabolic therapy through a dual-selection directed evolution strategy. Our evolved strain exhibits a 36-fold increase in ʟ-cystine uptake and a 23-fold improvement in total activity of cysteine desulfhydrases compared with the wild-type strain. By conjugating with DMXAA-loaded liposomes, the engineered bacteria-nanodrug biohybrid not only prevents the influx of nutrients into the tumor by blocking neovasculature but also achieves efficient and durable CySS catabolism locally. The unavailable of Cys species disrupts redox homeostasis and strikingly increases intracellular ROS level, achieving favorable therapeutic outcomes in multiple tumor models. Our study not only highlights the promise of directed evolution strategy in enhancing the stability and efficiency of bacteria-based living biocatalyst but also provides new opportunities for antitumor metabolic therapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Chen Tang,Mengying Liu,Yufei Tang,Pengjiao Chong,Lei Dong,Jiayi Ye,Xiaohang Yang,Jiaju Meng,Weiyan Wang,Zhaowei Liu,Kang Zhao
Hydrogels frequently suffer from low-temperature freezing, high-temperature dehydration, and compromised environmental stability. In contrast, organogels demonstrate superior environmental tolerance and structural designability. Herein, a polyurea organogel (denoted PUA-D x T y ) featuring a trident-chain molecular architecture was synthesized through the polymerization of isocyanate and polyetheramine. By varying the number of functional groups per polyetheramine, dynamic control over crosslinking density and mechanical properties was achieved. The optimized PUA-D 8 T 2 sample exhibited a tensile strength of 178.33 kPa and an ultrahigh elongation of 1838 %, representing 2.3-fold and 4.1-fold enhancements over conventional hydrogels, and significantly surpassing many existing organogels. Besides, this organogel also integrates multifunctional capabilities including strong adhesion to diverse substrates, retention of flexibility/elasticity under harsh conditions, excellent solvent recyclability, and autonomous self-healing enabled by dynamic hydrogen-bond networks. A flexible sensor fabricated by coating the gel surface with a graphene conductive layer accurately monitors multiscale human motions (e.g., finger flexion, wrist rotation) and enables encrypted information transmission via Morse code. This work establishes a novel organogel material platform for environmentally stable flexible electronics, demonstrating significant potential in next-generation electronic skins through its synergistic combination of multifunctional capabilities.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Nano
·
2025
·
IF 16
Kexin Cui,Zhang Fangming,Tianzi Shi,Siyu Zhao,Yixuan Zhou,Xiong Liu,Yong Hu,Zhaoyu Hu,Li Kong,Zhiping Zhang
Ionizable lipids are crucial for the effective delivery of mRNA by using lipid nanoparticles (LNPs). Endowing ionizable lipids with tailored biological properties could potentially augment the therapeutic efficacy of mRNA-based treatments. Herein, a functional vitamin E (VE)-based lipid library with distinct head groups was designed and synthesized. Due to the presence of VE, these lipids inherently exhibited immunomodulatory properties, including the promotion of cellular uptake, dendritic cells maturation, and antigen presentation. Through iterative optimization of the LNP components and the architecture of ionizable lipids, the correlation between the structure of ionizable lipids and their mRNA delivery efficiency has been established, leading to the finding of the most effective delivery formulation. Benefiting from the high mRNA delivery efficiency and the immunomodulatory function of LNPs themselves, VE-based LNPs have demonstrated complete remission in colon cancer by delivering mIL-12, which offered a beneficial combination with immune checkpoint blockade. The proposed functional LNPs were anticipated to furnish potential delivery systems for mRNA-based cancer treatments.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
VACCINE
·
2016
·
IF 3.413
Tengfei Ma,Yongxia Liu,Jia Cheng,Yanhan Liu,Wentao Fan,Ziqiang Cheng,Xudong Niu,Jianzhu Liu
To obtain an effective vaccine candidate against duck Tembusu viral (DTMUV) disease which causes egg-drop and great economical loss in the Chinese duck industry, liposome vaccines containing recombinant E protein were prepared and assessed in this study. The recombinant plasmid (PET28a-E) was constructed and transformed into BL21 (DE3) cells to produce E proteins. The recombinant E proteins were purified and entrapped by liposomes through reverse-phase evaporation. Eighty-four cherry valley ducks were randomly divided into seven groups and inoculated intramuscularly at one- or seven-day-old with liposomes-E protein or Freund's adjuvant-E protein vaccine. Blood samples were collected from the first week to the tenth week for serum antibody , plasma for viremia , as well as oropharyngeal and cloacal swabs for virus shedding analyses after being challenged with a 10 2.4 50% tissue culture infective dose (TCID 50 ) of duck Tembusu virus. Results showed that serum antibody level of the liposomes vaccine was higher than the Freund's adjuvant vaccine, and inoculating twice was superior to once; furthermore, the viremia and virus shedding tests also proved that the liposomes vaccine can provide complete protection against DTMUV challenge. These results demonstrated that the liposomes-E protein vaccine could be used as a potential candidate vaccine to prevent DTMUV infection in ducks.
✓ 已验证
DOI
PubMed
高影响因子
Journal of Applied Spectroscopy
·
2022
·Vol. 89
·期 3
·559-566
·
IF 0.816
Gao Ch.,Du H.
Forsythoside E is one of the major secondary metabolites in Forsythia suspensa . The interactions between forsythoside E and two types of cholinesterases, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) were investigated in PBS buffer (pH 7.40) by using multispectroscopic techniques. Forsythoside E increased the fluorescence intensity of AChE but quenched the fluorescence of BChE. Synchronous fluorescence studies showed that forsythoside E mainly acts on tyrosine residues of AChE and tryptophan residues of BChE. It was also proved that the complex between the compound and cholinesterases formed spontaneously at a stoichiometric ratio of 1:1 via multispectral technology. Finally, forsythoside E inhibited the activities of cholinesterases with similar IC 50 values of 1.08 mM for AChE and 0.92 mM for BChE. The results illuminate the details of the interaction between forsythoside E and cholinesterases.
✓ 已验证
DOI
高影响因子
RUSSIAN JOURNAL OF INORGANIC CHEMISTRY
·
2025
·
IF 1.5
Wang L. C.,Ye H. D.,Xu C.,Peng H. N.,Zhang X. L.,Chen F. Y.,Peng S. Y.,Wang S. J.
o-Carborane reacts sequentially with n-butyllithium, sulfur and CpCo(CO)I2 under argon to give the half-sandwich 16-e carborane complex CpCo[S2C2B10H10]. CpCo[S2C2B10H10] reacts with PPh3, P(m-Tol)3, P(p-Tol)3 to afford addition products CpCo(PPh3)[S2C2B10H10] (1), Cp(P(m-Tol)3)Co[S2C2B10H10] (2), CpCo(P(p-Tol)3)[S2C2B10H10] (3), respectively. 1, 2 and 3 have been characterized by chemical analysis, mass-spectrometry, IR and NMR spectroscopy, and single crystal X-ray diffraction (CCDC nos. 2390939 (1), 2390940 (2) and 2390938 (3)).
✓ 已验证
DOI
高影响因子
npj Flexible Electronics
·
2023
·Vol. 7
·期 1
·1-9
·
IF 14.6
Shang Chao,Xu Qunhui,Liang Nengmin,Zhang Jianpeng,Li Lu,Peng Zhengchun
Tactile sensing has been a key challenge in robotic haptics. Inspired by how human skin sense the stress field with layered structure and distributed mechanoreceptors, we herein propose a design for modular multi-parameter perception electronic skin. With the stress field sensing concept, complex tactile signals can be transformed into field information. By analyzing the stress field, the real-time three-dimensional forces can be resolved with 1.8° polar angle resolution and 3.5° azimuthal angle resolution (achieved up to 71 folds of improvement in spatial resolution), we can also detect the hardness of object in contact with the electronic skin. Moreover, we demonstrate random assembly of the sensing arrays and integration of our electronic skin onto differently curved surfaces do not lead to any measurement variation of the stress field. This result reveals that the sensing elements in our electronic skin system can be modularly made and exchanged for specific applications.
✓ 已验证
DOI
高影响因子
DESALINATION
·
2026
·
IF 9.9
Chuangen Zheng,Liting Luo,Abdul Haleem,Hao Li
A magnetic hollow MOF adsorbent encapsulated with polydopamine was fabricated. • The developed system for efficient and selective gold extraction from E -waste. • The maximum adsorption capacity for gold was 2293.97 mg g −1 at 318 K. • The adsorbent achieves a gold recovery rate of 95.68% from real samples. E -waste recycling has emerged as a sustainable route for gold recovery to alleviate resource shortages. Herein, a polydopamine-encapsulated magnetic hollow MOF (HM-UiO-DMSA) was fabricated via an in-situ growth strategy for selective gold extraction. The adsorbent achieves rapid equilibrium within 600 min and a high adsorption capacity of 1782.84 mg g −1 at pH 4, with adsorption behavior well fitted to the Freundlich isotherm. Benefiting from the abundant amino, thiol and carboxyl groups, HM-UiO-DMSA exhibits outstanding Au(III) selectivity and enrichment capacity. In simulated multi-metal E -waste leachate, the prominent Au(III) distribution coefficient (K d ) and concentration factor (CF) reach 235,258 mL g −1 and 4905.5 mL g −1 , respectively. Notably, benefiting from its intrinsic photothermal effect, HM-UiO-DMSA delivers an exceptional adsorption capacity of 2332.30 mg g −1 under UV irradiation, a value 27.73% greater than its nonmagnetic analogue (H-UiO-DMSA). A high gold recovery efficiency of 95.68% is realized for practical waste circuit board samples with ultra-low Au(III) concentrations, and the final recovered gold exhibits a high purity of 98.20% (23.6 K gold). The excellent gold separation performance originates from the synergistic coordination-reduction effect of heteroatoms and reductive polydopamine/DMSA groups. Furthermore, HM-UiO-DMSA possesses favorable recyclability over six cycles, enabling reliable gold recovery in complex acidic E -waste systems. Download: Download high-res image (115KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
BIOCHEMICAL PHARMACOLOGY
·
2026
·
IF 6.5
Xinyan Li,Liangwen Yan,Kailing Hu,Rongrong Liu,Mengjiao Shi,Jiayi Xu,Gang Wang,Yetong Feng,Pengfei Liu
Disulfidptosis, a recently identified form of regulated cell death driven by toxic intracellular disulfide accumulation and subsequent collapse of the actin cytoskeleton, represents a promising therapeutic vulnerability in hepatocellular carcinoma (HCC), particularly for tumors exhibiting metabolic reprogramming and resistance to conventional apoptosis-based therapies. In this study, we screened eleven representative bioactive constituents derived from Cortex Mori , including stilbenoids, flavonoids, coumarins, and phenolic acids, under glucose deprivation conditions that trigger disulfidptosis, and identified Kuwanon E (KE) as the most potent sensitizer of disulfidptosis in HCC cells. Integrative network pharmacology, RNA sequencing, and untargeted metabolomics revealed that KE preferentially targets the MTOR signaling pathway and autophagic flux. Mechanistically, KE significantly prolonged the half-life of MTOR protein without altering its mRNA expression, leading to MTOR accumulation. This was accompanied by a blockade of autophagic flux at the autophagosome-to-lysosome fusion step, as evidenced by increased p62 and LC3-II protein levels and accumulation of mRFP-GFP-LC3 puncta. This autophagic stagnation resulted in profound depletion of glutathione (GSH) and NADPH, shifting the redox balance toward disulfide formation and promoting non-reducible cross-linking of key cytoskeletal proteins FLNA and DREBRIN, ultimately leading to actin network collapse and cell death. Importantly, co-treatment with the MTOR inhibitor/autophagy inhibitor activator rapamycin or exogenous GSH supplementation effectively rescued KE-mediated disulfidptosis sensitization, confirming the functional centrality of MTOR signaling and GSH metabolism. These findings establish KE as a functional disulfidptosis-sensitizing agent from a natural source and provide a compelling mechanistic rationale for targeting disulfidptosis to overcome metabolic and autophagic resistance in HCC. Download: Download high-res image (228KB) Download: Download full-size image
✓ 已验证
DOI
PubMed
高影响因子
RSC Advances
·
2026
·Vol. 16
·期 30
·27666-27677
·
IF 6.1
Jiahao Teng,Shenggang Huang,Wenkai Zheng,Xuqing Wang,Yingsheng He,Jiye Wang,Yazhou Qin
The illicit use of new psychoactive substances in e-cigarettes has posed severe threats to human health and social security, urgently necessitating the development of targeted rapid and highly sensitive detection methods. In this study, we developed a highly sensitive detection approach for propoxate and isopropoxate, commonly illegally added drugs in e-cigarettes, by integrating deep learning-assisted SERS technology. First, the characteristic spectral peaks of the two isomeric compounds were identified through conventional Raman and SERS analysis of reference standards. Furthermore, DFT calculations were employed to interpret the vibrational modes in the Raman spectra corresponding to their molecular structures. Subsequently, a sample pre-treatment method was developed for spiked e-cigarette samples, enabling trace-level SERS detection of both substances. Finally, an innovative dual-branch deep learning network integrating time-domain and frequency-domain features was developed for high-precision classification and identification of two structurally similar substances, achieving an identification accuracy of 99.73%. This study provides a reference for the detection of structurally similar compounds.
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）