JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
·
2015
·
IF 3.564
Zhi-bo Zhang,Qiang Lu,Xiao-ning Ye,Wen-tao Li,Ying Zhang,Chang-qing Dong
A new technique was proposed to selectively produce 4-ethyl phenol (4-EP) from low-temperature catalytic fast pyrolysis of certain herbaceous biomass, while 4-vinyl phenol (4-VP) could be selectively produced from non-catalytic fast pyrolysis process. In this study, Pd/SBA-15 catalysts were prepared, and pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS) technique was applied for both ex situ and in situ catalytic fast pyrolysis of bagasse . The results indicated the 4-EP could be selectively produced from both catalytic methods. During the ex situ catalytic pyrolysis process, the bagasse would decompose to form 4-VP which was then hydrogenated by the Pd/SBA-15 catalyst to be 4-EP. During the in situ catalytic pyrolysis process, the Pd/SBA-15 catalyst would catalyze the decomposition and hydrogenation of bagasse to directly produce 4-EP. Certain pyrolytic products would serve as the hydrogen-donors (H-donor) for the formation of 4-EP. The selectivity of the 4-EP from the ex situ catalytic process was a little better than that form the in situ catalytic process. The highest 4-EP yield from ex situ catalytic pyrolysis of bagasse was around 2.0 wt%, obtained at the pyrolysis temperature of 350 °C and catalyst-to-biomass ratio of 1.5.
研究领域:
能源与环境科学
·
化学工程
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DOI
高影响因子
DALTON TRANSACTIONS
·
2014
·Vol. 43
·期 26
·10057-10063
·
IF 4.097
Xin Yang,Junhai Wang,Dongyue Su,Qingdong Xia,Fang Chai,Chungang Wang,Fengyu Qu
Rapid and sensitive detection of 2,4,6-trinitrotoluene (TNT) and 4-nitrophenol (4-NP) has attracted considerable attention due to their wide applications as nitroaromatic explosive materials. A novel fluorescence method for TNT and 4-NP based on bovine serum albumin functionalized fluorescent gold nanoclusters (BSA Au-NCs) has been developed. The detection probe BSA Au-NCs can be used as a fluorescent probe for the sensitive and selective detection of TNT and 4-NP simultaneously. A good linearity of fluorescence detection using BSA Au-NCs as a fluorescent probe was observed for TNT and 4-NP concentrations in the range of 10−8–5 × 10−5 M and 10−9–5 × 10−5 M, with a detection limit of 10 nM and 1 nM, respectively. The high specificity of TNT and 4-NP with BSA Au-NCs interactions provided excellent selectivity towards detecting TNT and 4-NP over other relevant nitroaromatic compounds. This system can be applied to test strips to detect TNT and 4-NP with high sensitivity and selectivity. The vapour of TNT and 4-NP can be detected using BSA Au-NCs test paper within 1 min with a detection limit of 10 pM and 1 pM.
研究领域:
分析化学
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环境科学
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材料科学
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DOI
PubMed
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2016
·Vol. 408
·期 9
·2319-2327
·
IF 3.125
Chen Yanrong,Wang Kan,Liu Zongrui,Sun Rongjin,Cui Daxiang,He Jinghua
Rapid and quantitative detection of biomarkers with high sensitivity and specificity has become a common practice in the clinical diagnosis and treatment of cancer. Herein, a quantitative lateral flow immunoassay (LFIA) based on superparamagnetic nanoparticles (SPMNPs) was developed for detection of carbohydrate antigen 72-4 (CA72-4) in human serum. This direct and rapid method did not involve any sample preparation and was accomplished using a test strip in which a sandwich reaction was performed. Probes on the conjugate pad were prepared by coupling monoclonal antibody CC49 specific to CA72-4 onto SPMNPs. Coupled monoclonal antibody B72.3 and goat anti-mouse IgG were loaded onto a nitrocellulose (NC) membrane, serving as the test and control lines, respectively. Initially, results were evaluated by macroscopic observation. Afterwards, the magnetic signal strength of the reaction area was quantified using a magnetic assay reader (MAR). Several parameters that may influence the detection sensitivity were studied and optimized. Under optimal conditions, the proposed method was capable of detecting as low as 0.38 IU/mL of CA72-4 in 20 min and had a wide detection linearity range (0–100 IU/mL). We evaluated 100 clinical samples (70 positive and 30 negative) to assess the validity of these test strips, which exhibited high sensitivity (99 %) and specificity (97 %). The results indicated a high rate of accuracy (98.4–102 %) and a low relative standard deviation according to the average recovery test. In conclusion, the test strips based on SPMNP probes are a rapid, sensitive, and quantitative method for the detection of CA72-4 and possess great potential in point-of-care testing (POCT).
Schematic illustration of the strategy for CA72-4 detection and quantification using a superparamagnetic immunochromatographic strip
研究领域:
医学诊断
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生物化学
·
纳米技术
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DOI
PubMed
高影响因子
HIGH PERFORMANCE POLYMERS
·
2023
·
IF 2.1
Jinshui Lu,Jinyuan Zhang,Heng Liu,Weipeng Chen,Jiangrong Luo,Ziqing Wang,Tingting Cui,Yonggang Min,Yidong Liu
In this work, a new diamine was designed by connecting flexible structures such as ether bond and aliphatic carbon chain between benzene rings, and was synthesized and purified through simple reactions such as Suzuki reaction. Finally, a series of polyimide (PI) films were synthesized by copolymerization with 4.4`-diaminodiphenyl ether (ODA)\pyromellitic dianhydride (PMDA) in different proportions. We prepared polyimide films with new monomer copolymerization ratios of 1% (PI-1), 5% (PI-2), 10% (PI-3), and 20% (PI-4). The polyimide films showed excellent glass transition temperatures, which were attributed to their unique bent architectures. The mechanical and thermal properties of the thermosets were studied using tensile testing, static thermomechanical analysis (TMA), and thermogravimetric analysis (TGA). As the results, the films exhibited the optimal glass transition temperatures (317.56°C–381.91°C), and the component with the highest copolymerization ratio has a 15% decrease in glass transition temperature compared to the component without copolymerization. Moreover, PI-1-PI-4 showed good heat resistance in the N2 atmosphere. The temperatures corresponding to a 5% heat loss in the films (T5%) were 458.12 °C–548.75°C, respectively.
研究领域:
材料科学
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高分子化学
·
热分析
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DOI
高影响因子
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
·
2020
·
IF 2.897
Jiao Yang,Qingyi Huang,Huan Liu,Xiong Zhou,Zhuoquan Huang,Quansheng Peng,Chunhong Liu
Environmental endocrine disruptors 4-nonylphenol (NP) and 4-tert-octylphenol (OP) may cast huge harm to human health. We used a rat model to observe the influence of NP or/and OP exposure on anxiety-related behaviors and the underlying mechanisms. Eighty male Sprague-Dawley (SD) rats were randomly divided into 10 groups: control group (corn oil), NP groups [30, 90, 270 mg/kg], OP groups [40, 120, 360 mg/kg] and NO groups [(mixed with the corresponding NP, OP alone exposed low, medium and high dose according to the natural environment exists NP:OP = 4:1]. The rats were orally administered every other day for 30 days. The neurobehaviors of rats were evaluated by open-field test (OFT) and elevated plus-maze test (EPM), and the concentrations of 5-HT, monoamine oxidase (MAOA), serotonin transporter (SERT), vesicular monoamine transporter 2 (VAMT2), 5-hydroxytryptamine 1A (5-HT 1A ), 5-hydroxytryptamine 2A (5-HT 2A )，and 5-hydroxytryptamine 2C (5-HT 2C ) in the rat prefrontal cortex were analyzed by ELISA . OFT and EPM tests showed that NP or/and OP exposure induced anxiety-related behaviors in rats. 5-HT levels were significantly increased compared with the control group. The levels of MAOA, SERT, VAMT2, 5-HT 1A , 5-HT 2A, and 5-HT 2C in the prefrontal cortex reduced in different degrees by high-doses NP or/and OP exposure. In summary, NP or/and OP exposure might cause anxiety-related behaviors in rats through regulating neurotransmitter 5-HT levels by altering the expression of 5-HT decomposition enzyme MAOA, transporters SERT and VMAT2, and 5-HT receptors 5-HT 1A , 5-HT 2A, and 5-HT 2C .
研究领域:
毒理学
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神经科学
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环境科学
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DOI
PubMed
高影响因子
International Journal of Environmental Research and Public Health
·
2017
·Vol. 14
·期 11
·1414
·
IF 2.101
Yang Du,Wen-Qian Wang,Zhou-Tao Pei,Fahmi Ahmad,Rou-Rou Xu,Yi-Min Zhang,Li-Wei Sun
Ultraviolet (UV)-absorbing chemicals (UV filters) are used in personal care products for the protection of human skin and hair from damage by UV radiation. Although these substances are released into the environment in the production and consumption processes, little is known about their ecotoxicology effects. The acute toxicity and potential ecological risk of UV filters benzophenone-3 (BP-3) and benzophenone-4 (BP-4) onChlorella vulgaris,Daphnia magna, andBrachydanio reriowere analyzed in the present study. The EC50values (96 h) of BP-3 and BP-4 onC. vulgariswere 2.98 and 201.00 mg/L, respectively. The 48 h-LC50of BP-3 and BP-4 onD. magnawere 1.09 and 47.47 mg/L, respectively. The 96 h-LC50of BP-3 and BP-4 onB. reriowere 3.89 and 633.00 mg/L, respectively. The toxicity of a mixture of BP-3 and BP-4 onC. vulgaris,D. magna, andB. rerioall showed antagonistic effects. The induced predicted no-effect concentrations of BP-3 and BP-4 by the assessment factor method were 1.80 × 10−3and 0.47 mg/L, respectively, by assessment factor (AF) method, which were both lower than the concentrations detected in the environment at present, verifying that BP-3 and BP-4 remain low-risk chemicals to the aquatic ecosystem.Keywords:benzophenone-3;benzophenone-4;UV filters;acute toxicity;ecological risk assessment
研究领域:
环境科学
·
毒理学
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产品关联
DOI
PubMed
高影响因子
APPLIED SOIL ECOLOGY
·
2011
·
IF 2.399
Yan Chen,Yao Peng,Chuan-Chao Dai,Qun Ju
Phenolic acid allelochemicals released by decomposing foliage can have negative impacts on growth of plants and microbes in soil. However, these chemicals can potentially be degraded by broad-spectrum endophytic fungi such as, Phomopsis liquidambari (strain B3), which is capable of growing on phenolic 4-hydroxybenzoic acid (4-HBA) as the sole carbon and energy source. In this study, the optimum concentration of 4-HBA supplied in culture as the carbon source was determined to be 600 mg L −1 , with maximum biomass of fungal growth and, 94% and 99% degraded by P. liquidambari in liquid culture and soil conditions, respectively, within 48 h. The fungal metabolic pathway of 4-HBA was investigated using high performance liquid chromatography–mass spectrometry (HPLC–MS) and gas chromatography–mass spectrometry (GC–MS). The results showed that 4-HBA was first hydroxylated to 3,4-dihydroxybenzoic acid, converted to catechol and then oxidated to cis , cis -muconic acid in the tricarboxylic acid (TCA) cycle. The benzene ring was opened through ortho catechol cleavage. During the course of fungal incubation, activities of three main 4-HBA degradation pathway enzymes exhibited a continuous cascading pattern of induction. 4-HBA hydroxylase showed the highest activity after 8 h of incubation, with 3,4-dihydroxybenzoic acid decarboxylase reaching a peak at 24 h and catechol 1,2-dioxygenase peaking at 32 h, which corresponded with changes in corresponding substrate concentrations. These results indicated the bioremediation potential of this endophytic fungus to degrade accumulated phenolic acid allelochemicals in soil to alleviate the effects of their ecological suppression.
研究领域:
环境生物学
·
微生物学
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DOI
高影响因子
JOURNAL OF FLUORESCENCE
·
2015
·Vol. 25
·期 5
·1183-1189
·
IF 1.927
Wu Fuyong,Xu Guangjun,Zeng Xi,Mu Lan,Redshaw Carl,Wei Gang
N , N ′-bis(4-methoxysalicylide)benzene-1,4-diamine ( S1 ) was synthesized from 4-methoxysalicylaldehyde and p -phenylenediamine and it was found to exhibit interesting aggregation-induced emission enhancement (AIEE) characteristics. In aprotic solvent, S1 displayed very weak fluorescence, whilst strong emission was observed when in protic solvent. The morphology characteristics and luminescent properties of S1 were determined from the fluorescence and UV absorption spectra, SEM, fluorescence microscope and grading analysis. Analysis of the single crystal diffraction data infers that the intramolecular hydrogen bonding constitutes to a coplanar structure and orderly packing in aggregated state, which in turn hinders intramolecular C-N single bond rotation. Given that the three benzene rings formed a large plane conjugated structure, the fluorescence emission was significantly enhanced. The absolute fluorescence quantum yield and fluorescence lifetime also showed that radiation transition was effectively enhanced in the aggregated state. Moreover, the AIEE behavior of S1 suggests there is a potential application in the fluorescence sensing of some volatile organic solvents.
研究领域:
有机化学
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材料科学
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DOI
PubMed
高影响因子
JOURNAL OF LUMINESCENCE
·
2024
·
IF 3.3
Weiguang Ran,Zicheng Zhang,Fukai Wang,Huixin Jiang,Yue Shao,Xiaoli Ma,Jiayi Geng,Tingjiang Yan
In this paper, the novel BaY 2 (MoO 4 ) 4 :xSm 3+ phosphors with strong red emission and high thermal stabilization were prepared by a conventional method of high temperature solid state reaction in air atmosphere. Morphology, phase purity, element distribution, UV–Vis–NIR diffuse reflectance spectroscopy (DRS), and luminescence properties were investigated in detail. The crystal structure of the BaY 2 (MoO 4 ) 4 host was refined with the aid of the Rietveld refinement method by the GSAS program. The electronic band structure and phonon dispersion were performed using plane-wave density functional theory (DFT). The prepared BaY 2 (MoO 4 ) 4 :Sm 3+ phosphor exhibits excellent red emission under near-ultraviolet excitation. Strong red emission intensity and high thermal stability suggest potential application in backlighting or phosphor-covered white light-emitting diodes (pc-LEDs).
研究领域:
材料科学
·
光学
·
理论计算
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DOI
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Feng Wang,Xianhong Bi,Yun Cui,Kewei Lin,Charles Brennan,Soottawat Benjakul,Gengsheng Xiao,Lukai Ma
Toxic compounds in fried food products attract increasing attention, but studies regarding the levels of common toxins, such as malondialdehyde (MDA), 4-hydroxy-2-hexenal (4-HHE), and 4-hydroxy-2-nonenal (4-HNE), in fried starch-based food (FSBF) are scarce. Herein, we investigated the formation and distributions of these aldehydes in FSBF, and the frying oil and FSBF retained higher levels of low-molecular-weight aldehydes. The highest aldehyde concentrations were observed in French fries. Simulated frying experiments revealed that the distributions of the toxic aldehydes in FSBF were mainly determined by the amylose content. Molecular dynamics simulations indicated that amylose interacted strongly with 4-HNE, but its interactions with MDA and 4-HHE were weaker. The migration of MDA, 4-HHE, and 4-HNE into FSBFs was primarily attributed to the interactions between the toxic aldehydes and amylose. This study should provide a novel basis for the control and elimination of toxic aldehydes in fried food.
研究领域:
食品安全
·
分子生物学
·
营养学
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DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Weiyan Luo,Yixin Chen,Ping Hu,Wei Ruan,Yueyuan Ye,Zhifeng Zheng,Shuirong Li,Dechao Wang,Duo Wang
A heterogeneous extracting route of 4-ethylguaiacol is constructed using the intermediate of the reaction between 4-ethylguaiacol and Ca 2+ as the extracting agent. In this work, 4-ethylguaiacol with different concentrations (70, 80, 90, 95%) is prepared using 40 v/v% ethanol aqueous solution as the mother liquor. The extraction parameters optimization, cycle extraction and 4-ethylguaiacol purification are studied, respectively. Extracting parameters investigated are reaction temperature (4–80 ℃), extraction time (5–60 min), and pH value (6.5–13). 4-ethylguaiacol extraction efficiency keeps above 90% at the optimum extracting conditions at the reaction temperature of 4–20 ℃, the extraction time of 30 min, and the pH value of 6.5–10. Further cycle extraction experiments are carried out under the optimal extraction parameters using the intermediate as the extracting agent. After 36 cycle extraction times, the extraction efficiency of 4-ethylguaiacol can still reach 91.7%. Guaiacol has similar physical and chemical properties to 4-ethylguaiacol, thus it is used as an impurity to test the extraction and purification effect of the heterogeneous extracting method. With increasing the cycle extraction times from 1 to 4, 4-ethylguaiacol purity reaches more than 99% for all four mother liquors with different initial concentrations. 4-ethylguaiacol purity of 99.57% is achieved through twice cycle extraction when its initial content in the mother liquor is 95%.
研究领域:
化学工程
·
生物化学
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产品关联
DOI
高影响因子
JOURNAL OF FISH BIOLOGY
·
2021
·Vol. 99
·期 6
·1843-1856
·
IF 2.051
Liping Yang,Shaoyang Zhi,Guokun Yang,Chaobin Qin,Xiao Yan,Mingming Niu,Wenlei Zhang,Mingyu Liu,Mengjuan Zhao,Guoxing Nie
Glucose transporter 4 (GLUT4) is comprehensively investigated in mammals, while the comparative research of GLUT4 in common carp is deficient. To investigate the function of GLUT4, carp glut4 was first isolated. The open reading frame of carp glut4 was 1518 bp in length, encoding 505 amino acids. A high-sequence homology was identified in carp and teleost, and the phylogenetic tree displayed that the carp GLUT4 was clustered with the teleost. A high level of glut4 mRNA was analysed in fat, red muscle and white muscle. After fasting treatment, glut4 mRNA expression was increased significantly in muscle. In the oral glucose tolerance test experiment, glut4 mRNA was also significantly elevated in muscle, gut and fat. Furthermore, intraperitoneal injection of insulin resulted in the upregulation of glut4 gene expression significantly in white muscle, gut and fat. On the contrary, the glut4 mRNA level in the white muscle, gut and fat was markedly downregulated after glucagon injection. These results suggest that GLUT4 might play important roles in food intake and could be regulated by nutrient condition, insulin and glucagon in common carp. Our study is the first to report on GLUT4 in common carp. These data provide a basis for further study on fish GLUT4.
研究领域:
分子生物学
·
鱼类生理学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）