INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2018
·
IF 3.862
Qilong Wang,Qiuxuan Yang,Xia Cao,Qiuyu Wei,Caleb K. Firempong,Min Guo,Feng Shi,Ximing Xu,Wenwen Deng,Jiangnan Yu
[6]-Shogaol, an alkylphenol compound purified from the root and stem of ginger ( Zingiber officinale ), has attracted considerable interest due to its potential anticancer, antioxidative and antirheumatic properties. However, the oral bioavailability of [6]-shogaol has been severely limited because of its poor solubility. In this study, a significant quantity of high-purity [6]-shogaol (yield: 3.6%; purity: 98.65%) was extracted and encapsulated in solid lipid nanoparticles (SLNs) via high-pressure homogenization (encapsulation efficiency: 87.67%) to improve its solubility and oral bioavailability. The resulting [6]-shogaol-loaded solid lipid nanoparticles (SSLNs) were stable, homogeneous and well-dispersed. Its mean particle size and zeta potential were 73.56 ± 5.62 nm and −15.2 ± 1.3 mV, respectively. Importantly, the in vitro release profile and in vivo oral bioavailability of SSLNs were significantly improved compared with the free drug. Furthermore, the SSLNs could remarkably lower the uric acid level via inhibiting the activity of xanthine oxidase and reduce the production of interleukin-1β (IL-1β) and tumor necrosis factor (TNF-α) in the hyperuricemia/gouty arthritis rat model, when compared to the free [6]-shogaol. Collectively, SLNs could serve as a promising drug delivery system to improve the oral bioavailability of [6]-shogaol for effective treatment of gouty arthritis.
研究领域:
药剂学
·
生物化学
·
纳米医学
✓ 已验证
DOI
高影响因子
CRYSTENGCOMM
·
2012
·Vol. 14
·期 10
·3380-3386
·
IF 3.842
Lixian Han,Jie Liu,Zhengjun Wang,Kun Zhang,Hui Luo,Bo Xu,Xing Zou,Xiao Zheng,Bin Ye,Xibin Yu
Monodisperse ZnSn(OH)6 (ZHS) microcrystallites (MCs) with two morphologies have been prepared through a facile preparation method without complicated steps, or advanced experimental conditions or equipments. The morphology and compositional characteristics of the 3D hierarchitectures (HAs) of ZHS MCs were investigated by various techniques such as XRD, FESEM, TEM, UV-vis spectra, BET, XPS and EPR. In the reaction system the morphology evolution from cube to sphere was controlled by adding a different concentration of NH4OH. Meanwhile, the formation mechanisms of the two ZHS MCs were studied via a series of time-dependent experiments. Interesting, ZHS MCs were self-assembled from irregular-shaped nanoparticles (5–10 nm). The XPS and EPR tests demonstrated oxygen vacancy defects existed in the ZHS MCs. The gas sensors based on ZHS presented a good sensor performance towards HCHO. However, the gas sensors based on of ZHS spherical MCs exhibited a higher response, shorter recovery time and good reproducibility towards HCHO than those of ZHS cubic MCs. More importantly, the best gas sensing properties were found coming from the ∼600 nm spherical ZHS MCs owing to more oxygen vacancy defects, lower band gap energy, and larger active surface area.
研究领域:
材料科学
·
化学
✓ 已验证
DOI
高影响因子
POLYMER ENGINEERING AND SCIENCE
·
2024
·Vol. 64
·期 6
·2724-2735
·
IF 3.2
Weihua Ye,Yanchao Yuan,Xing Liu,Shumei Liu,Jianqing Zhao
Polyamide 6 (PA6) is a widely used thermoplastic engineering polymer, and the toughening modification for PA6 is always a main research topic. Meanwhile, the rigidity and heat resistance of PA6 usually deteriorate. To address this conflict, an epoxy compound (EGDE-GA) was designed and synthesized and used to modify PA6 by dynamic vulcanization in twin-screw extruder. EGDE-GA is a linear molecule with a flexible molecular structure, which is favorable to toughening of PA6, and epoxy groups of EGDE-GA can form local cross-linked structure to improve the rigidity and retain the heat resistance of PA6. At the loading of 20 wt% of EGDE-GA, the modified PA6 (PA6/EGDE-GA 20) exhibited very high elongation at break and notched impact strength, which were increased by 413% and 520%, respectively, compared to those of PA6. The tensile strength was 61.4 MPa, which was higher than that of PA6. The heat deflection temperature remained almost unchanged. The results showed that the modified polymers may possess the high toughness without sacrificing the original rigidity by building the local crosslinked structure using dynamic vulcanization. The findings provide a feasible method for reusing and upcycling PA6 and other polymers with higher value and wider use in the industry. Highlights The polyamide 6 (PA6) is toughened via dynamic vulcanization. The toughness of modified PA6 is increased by 520% compared with pure PA6. The toughened PA6 exhibits higher tensile strength than that of pure PA6. The toughened PA6 maintains its rigidity and heat resistance.
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2018
·
IF 3.141
Jie Tang,Bowen Xu,Zhenhao Xi,Xun Pan,Ling Zhao
Based on retaining the excellent properties of nylon-6 (PA6), nylon-6/66 copolymers (PA6/66) with well-controlled dimensional stability and toughness exhibit more potential applications. In this work, PA6/66 random copolymers were synthesized by melt copolymerization of ε-caprolactam and hexamethylene adipamide salt. The sequence distribution, crystal morphology, crystal forms, and melting and crystallization behavior of PA6/66 copolymers were systematically investigated by quantitative 13C NMR, polarized optical microscopy, wide-angle X-ray diffraction, and differential scanning calorimetry, respectively. The crystallization activation energy increases from −286.43 to −212.43 kJ mol–1 as the co-polyamide bond ratio increases from 0 to 0.22, while the deteriorating sequence regularity does not alter the original crystal morphology and crystal forms of PA6. Significantly, control over the crystallization behavior of PA6/66 copolymer has been obtained through finely regulating its sequence distribution. This work could provide theoretical support and new insights for controllable preparation of PA6 copolymers and ultimately be beneficial to extend their applications.
研究领域:
高分子化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
·
2017
·
IF 2.466
Fan Chen,Dandan Chen,Yubin Zhang,Liang Jin,Han Zhang,Miyang Wan,Tianshu Pan,Xiaochuan Wang,Yuheng Su,Yitao Xu,Junmei Ye
Interleukin-6 (IL-6) signaling is critical for cardiomyocyte hypertrophy, while the role of IL-6 in the pathogenesis of myocardium hypertrophy remains controversial. To determine the essential role of IL-6 signaling for the cardiac development during AngII-induced hypertension, and to elucidate the mechanisms, wild-type (WT) and IL-6 knockout (IL-6 KO) mice were infused subcutaneously with either vehicle or AngII (1.5 μg/h/mouse) for 1 week. Immunohistological and serum studies revealed that the extents of cardiac fibrosis, inflammation and apoptosis were reduced in IL-6 KO heart during AngII-stimulation, while cardiac hypertrophy was obviously induced. To investigate the underlying mechanisms, by using myocardial tissue and neonatal cardiomyocytes, we observed that IL-6/STAT3 signaling was activated under the stimulation of AngII both in vivo and in vitro . Further investigation suggested that STAT3 activation enhances the inhibitory effect of EndoG on MEF2A and hampers cardiomyocyte hypertrophy. Our study is the first to show the important role of IL-6 in regulating cardiac pathogenesis via inflammation and apoptosis during AngII-induced hypertension. We also provide a novel link between IL-6/STAT3 and EndoG/MEF2A pathway that affects cardiac hypertrophy during AngII stimulation.
研究领域:
心脏病学
·
免疫学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2025
·
IF 6.2
Yanbin Feng,Nuanqing Wang,Qianqian Cao,Shang Li,Ying Xu,Xinyu Che,Jinfeng Zhao,Chuanlun Yang,Song Xue
Trehalose 6-phosphate (Tre6P) is a critical metabolic signaling molecule in plants, orchestrating diverse biological processes, including stress resistance and photosynthetic efficiency. Recent advancements highlight its promising role in improving crop yield. However, the efficient synthesis of Tre6P in vitro remains a major challenge. Here, we identified a trehalose-6-phosphate phosphorylase WcTre6PPase from Weissella ceti, the enzyme catalyzes the reversible synthesis of Tre6P from β-glucose 1-phosphate (βGlc1P) and glucose 6-phosphate (Glc6P), with a strong catalytic bias for Tre6P synthesis. The crystal structure of WcTre6PPase resolved in complex with βGlc1P reveals critical molecular determinants for substrate recognition and catalytic efficiency. Binding studies demonstrate a higher affinity of WcTre6PPase for βGlc1P by 1.0 ± 0.2 mM compared to Glc6P by 24.3 ± 7.1 mM. Complementary molecular docking and dynamics simulations provide detailed insights into the catalytic mechanism. Subsequently, by integrating WcTre6PPase into a novel multienzyme cascade, comprising maltose phosphorylase, polyphosphate glucokinase, and AMP/ADP-polyphosphate phosphotransferase, and optimizing reaction conditions, we achieved a remarkable Tre6P yield of 90% from maltose. This study provides molecular insights into the function of WcTre6PPase and establishes a prospective platform for Tre6P production for agricultural applications.
研究领域:
结构生物学
·
生物化学
·
植物代谢
·
酶学
·
生物催化
·
农业生物技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER SCIENCE SERIES B
·
2022
·Vol. 64
·期 4
·402-410
·
IF 1.023
Xubo Huang,Fan Junwei,Liu Zhaogang,Zhao Jingang,Chen Mingguang,Hu Yanhong,Wu Jinxiu
Abstract Rare earth thermal stabilizers are a kind of newly discovered stabilizers, which are considered as a series of very promising stabilizers for inhibiting the degradation of PVC in the application and processing. Therefore, the continued exploration of new rare earth heat stabilizer is very necessary for scientific research and practical application. In this work, a new rare earth thermal stabilizer lanthanum cerium 6-methyluracil (LCMUA) was successfully synthesized via using cerium nitrate, lanthanum nitrate, 6-methyluracil (MUA) and aqueous ammonia as raw materials. And it was characterized by elemental analysis, FTIR, TG and other methods, the molecular formula of lanthanum cerium 6-methyluracil is confirmed as: La 0.35 Ce 0.65 (C 5 H 4 N 2 O 2 )NO 3 ⋅2H 2 O. Subsequently, congo red tests and thermal aging tests of pristine LCMUA and LCMUA with calcium stearate (CaSt 2 ), zinc stearate (ZnSt 2 ), and pentaerythritol (PE) composite samples were performed, when LCMUA/CaSt 2 /PE is compounded with mass ratio of 3 : 1 : 1, the heat stabilization time reached 70 min, and the heat stabilization performance was the best, which is better compared to those of commercial CaSt 2 and ZnSt 2 . The excellent experimental results can be attributed to the special absorption effect of LCMUA for hydrogen chloride gas derived from the thermal decomposition of PVC, thereby removing in time hydrogen chloride gas to restrain the PVC self-decomposition process caused by HCl gas.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
AAPS PHARMSCITECH
·
2018
·Vol. 19
·期 8
·3661-3669
·
IF 2.666
Wei Qiuyu,Yang Qiuxuan,Wang Qilong,Sun Congyong,Zhu Yuan,Niu Ya,Yu Jiangnan,Xu Ximing
In this study, an optimized nanostructured lipid carriers (NLCs) were developed and investigated for improving the solubility and oral availability of 6-Gingerol (6G), an active and abundant component of ginger with limited applications due to its poor water solubility plus oral biological availability. The NLCs consisted of a solid lipid (glyceryl monostearate), another liquid lipid (decanoyl/octanoyl-glycerides) and mixed surfactants (Tween 80 and Poloxamer 188), and was prepared by high pressure homogenization method. The optimal 6G-NLC formulation was evaluated through physical properties such as appearance, mean particle size, zeta potential, encapsulation efficiency, and in vitro drug release, alongside techniques viz. , transmission electron microscopy (TEM), differential scanning calorimetry (DSC), as well as powder X-ray diffraction (XRD). Pharmacokinetics were also evaluated in rats. The 6G-NLCs prepared with optimal formulation exhibited a homogenous spherical shape with mean particle size and zeta potential of 63.59 ± 5.54 nm and − 12.18 ± 1.06 mV. Encapsulation efficiency and drug loading were 76.71 ± 1.11 and 1.17 ± 0.35%, respectively. In vitro release profile of 6G from NLCs was sustained and fitted with Weibull equation. After oral administration of the 6G-NLCs, drug concentrations in serum, MRT, and AUC 0-t were significantly higher as compared with the free 6G suspension. All these results indicated that the developed NLC formulation could be effective and promising drug carriers to improve the water solubility of 6G while sustaining the drug release as well as prolonging in vivo acting time of the drug coupled with oral bioavailability enhancement.
研究领域:
药剂学
·
药物递送
·
生物医学工程
✓ 已验证
DOI
高影响因子
RESEARCH ON CHEMICAL INTERMEDIATES
·
2024
·Vol. 50
·期 8
·3821-3841
·
IF 2.8
Zhai Chenghan,Ma Zhengxiang,Wang Yanji
The preparation of caprolactam (CPL) from biomass as raw material is a very hot topic of current concern. In this paper, a new way to synthesize CPL from 5-hydroxymethylfurfural (HMF) was proposed, and the catalytic reaction of cyclization of the intermediate 6-hydroxycaproamide (6-HCM) was studied to provide a basis for the synthesis of bio-based CPL. A bimetallic catalyst, Ru–Co/TiO 2 , was prepared using the impregnation method and characterized using XRD, XPS, H 2 -TPR, and TEM. The investigation delves into the impact of various parameters, including metal loading, choice of solvent, solvent ratio, catalyst dosage, and reaction time, on the yield of the final product. The findings demonstrate a significant synergistic effect between Ru and Co in the bimetallic Ru 5 Co 6 /TiO 2 catalyst, leading to improved catalytic performance. Under the optimized reaction conditions (250 °C, 1 MPa N 2 , 1,4-dioxane: NH 3 ·H 2 O = 2:1 as the solvent ratio), the conversion rate of 6-HCM reaches 99.0%, with CPL yield of 62.2%.
研究领域:
化学工程
·
催化材料
·
生物质转化
✓ 已验证
产品关联
DOI
高影响因子
CATALYSIS COMMUNICATIONS
·
2008
·
IF 2.394
Yunlai Ren,Zhifei Liu,Shuang Zhao,Xinzhe Tian,Jianji Wang,Weiping Yin,Shebin He
Commercially available and inexpensive ethylenediamine/Cu(OAc) 2 · H 2 O has been found to be a highly effective catalyst system for the cyanation of aryl bromides in the solvent of NMP. At the same time, the highly activated aryl chlorides with NO 2 groups gave corresponding benzonitriles in good yields. Similar to the previous observation, it is not necessary to use an excess of K 4 [Fe(CN) 6 ] in the cyanation reaction (only 20 mol% of K 4 [Fe(CN) 6 ] was used). In other hand, a more remarkable KI-accelerated effect was observed for the cyanation reaction: the addition of KI increased the yield from 6% to 91% in the cyanation of bromobenzene.
研究领域:
有机化学
·
催化化学
✓ 已验证
DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2018
·
IF 3.716
Shengqian Zhou,Jing Lin,Xiaofei Qin,Ying Chen,Congrui Deng
An improved ion chromatographic method including two elution procedures was proposed for the quantitative determination of atmospheric alkylamines in field atmospheric samples involving high levels of inorganic cations by using 18-crown-6 as mobile phase additive. When 18-crown-6 was added to the mobile phase, the retention times increased significantly for Na + , NH 4 + , K + and primary alkylamines but decreased for secondary and tertiary alkylamines due to the complexation with certain cations and interaction with both stationary and mobile phases of 18-crown-6. As a result, the separation of the cations was greatly promoted, which reduced the interference of peak distortion of overloaded inorganic cations on the quantitation of adjacent alkylamines. By using the presented method, five inorganic cations (Na + , NH 4 + , K + , Mg 2+ , Ca 2+ ) and six alkylamines (dimethylamine (DMAH + ), trimethylamine + diethylamine (TMAH + + DEAH + ), propylamine (MPAH + ), triethylamine (TEAH + ), ethanolamine (MEOAH + ) and triethanolamine (TEOAH + )) were effectively separated and determined, and the relative standard derivations (RSDs) of objective cations were all less than 1% for retention time and 3.1% for peak area (n = 9), respectively. The linearity was excellent for each cation (R 2 > 0.993) except for NH 4 + and TEOAH + showing a non-linear response (R 2 > 0.998 for theoretical non-linear fitting), and the detection limit of these cations were 0.03–1.19 ng. The proposed method was successfully used in the determination of both alkylamines and inorganic cations in ambient particulate matters and gaseous alkylamines in ceiling duct exhaust. The annual average concentrations of DMAH + , TMAH + + DEAH + and TEAH + were 15.56, 4.35 and 16.00 ng m −3 in PM 2.5 over Shanghai in 2013. The concentrations of gaseous DMA and TMA + DEA in ceiling duct exhaust reached a maximum of 940.0 and 112.7 μg m −3 , and were positively correlated with the human activity intensity, suggesting that human excreta emissions was a potential important source of atmospheric alkylamines in urban area of Shanghai.
研究领域:
环境科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2022
·Vol. 140
·期 8
·e53501
·
IF 3.057
Chenxi Lou,Xinwen Liu,Cong Yang,Fenxia Ye,Qi Zhou
A one-step method was developed for synthesizing Ag nanoparticles exposed on the chitosan-covered polyamide 6 (CS-Ag@PA6) nanofibers by the in-situ reduction of silver nitrate during the electrospinning process. The bioderived CS was employed as a stabilizer and chelating carrier of Ag 0 /Ag + through its functional groups. CS was also used as a tractive agent to promote the surface migration of Ag atoms owing to its polyelectrolytic properties and immiscibility with PA6. Formic acid was used as the co-solvent for PA6 and CS and the reducing agent for Ag + . It was verified that the Ag nanoparticles (AgNPs) with 31.7% Ag 0 were embedded inside the pure PA6 nanofibers. However, the incorporation of CS achieved the AgNPs with an improved reduction efficiency (i.e., 67.5% of Ag 0 ). In particular, the CS nanolayers were covered on the PA6 nanofiber skeleton, where the AgNPs migrated on the surface of the CS nanolayers. This surface migration of CS and AgNP S endowed a significantly enhanced catalytic activity to the reduction of 4-nitrophenol, where the reduction rate constant ( k ) and turnover frequency (TOF) were an order of magnitude higher than that of the CS-free nanofibers.
研究领域:
材料科学
·
纳米生物学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）