Catalysts
·
2024
·Vol. 14
·期 12
·880
·
IF 3.8
Yaohui Xu,Qin Wang,Yuting Li,Zhao Ding
Based on the photocatalytic activity and magnetic nature of magnetite and goethite, as well as the oxygen storage characteristic of cerianite, a magnetic ternary hybrid composite including cubic CeO2, cubic Fe3O4and orthorhombic FeOOH, designated as Fe3O4/FeOOH/CeO2, was successfully synthesized with different Ce:Fe molar ratios using a simple hydrothermal route without subsequent calcination process, and employed as photocatalysts for the degradation of Acid Orange 7 (AO7) dye. The absorption range of light by the Fe3O4/FeOOH/CeO2composites was broadened, and the intensity was enhanced. Furthermore, there existed a possibility of hybridization and doping among the three crystalline structures, with the elements Ce, Fe and O exhibiting a uniform distribution, significantly enhancing the photocatalytic efficiency of the Fe3O4/FeOOH/CeO2composites in promoting the photodegradation of AO7. The magnetic response behaviors of hybrid composites synthesized with different Ce:Fe molar ratios were investigated. The adsorptive degradation of AO7 in darkness and the photocatalytic degradation of AO7 under UV light illumination were evaluated. Moreover, ten cycling runs of the photocatalytic degradation of AO7 under simulated UV illumination of Fe3O4/FeOOH/CeO2synthesized with a Ce:Fe molar ratio of 1:15 were performed. The hybrid ternary composites were proved to have excellent magnetic sensitivity, exhibited outstanding photocatalytic activities and demonstrated remarkable stability. It is anticipated that magnetic Fe3O4/FeOOH/CeO2ternary hybrid composites may have potential applications in the treatment of organic dye sewage.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Tao Chen,Changdong Lin,Weihang Lu,Shuo Wang,Cheng Shen,Juyuan Luo,Yulin Li
In the present study, six 7- O -glycosyl acylation of flavonoids derived from lutonarin and saponarin were obtained from barley seedlings by medium-pressure LC, high-speed counter-current chromatography and preparative HPLC guided by UPLC-QTOF-MS/MS. Their inhibitory effects on α-glucosidase were investigated. Structure–activity relationship showed 7- O -glycosyl acylation enhanced inhibitory effect on α-glucosidase with coumaroyl > feruloyl > hydroxybenzoyl > sinapoyl. The IC₅₀ values for saponarin and its four acylated products were 802.4 ± 0.48 μg/mL, 374.6 ± 0.16 μg/mL, 461.6 ± 0.27 μg/mL, 523.8 ± 0.24 μg/mL and 585.8 ± 0.42 μg/mL, respectively. Steady-state fluorescence spectroscopy revealed 7- O -glycosyl acylation enhanced the fluorescence quenching rate of α-glucosidase. Molecular docking revealed 7- O -glycosyl acylation formed more hydrogen bonds and hydrophobic interactions with α-glucosidase. Synchronous fluorescence spectroscopy showed all compounds altered the hydrophobic microenvironment surrounding the tryptophan residues in α-glucosidase. Circular dichroism spectroscopy indicated 7- O -glycosyl acylation modified the conformation and secondary structure of α-glucosidase.
研究领域:
植物化学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2020
·Vol. 8
·期 38
·13328-13335
·
IF 7.059
Jiaqiang Liu,Xizhuang Yue,Zhuopeng Wang,Xia Zhang,Yan Xu
Developing a highly reliable non-contact optical thermometer probe with excellent sensitivity and multi-mode temperature sensing behaviours is always a great challenge. Here, dual-emitting luminescent composites fabricated using a europium-based metal–organic framework (Eu-MOF) and surface-immobilized molecular dye (Coumarin 7) were successfully prepared by a simple solvothermal method, followed by a post-modification strategy. Benefiting from the linear response in fluorescence intensity ratios (FIRs) of Eu3+ to Coumarin 7 dye molecules in the temperature range from 10 °C to 90 °C, the composite demonstrated the maximum relative temperature sensitivity (Sr) of 0.50% °C−1 at 90 °C. Moreover, the observed red-shift of Coumarin 7 emission with the temperature readout suggests a dual-mode optical thermal sensing mechanism in the dye-immobilized MOF composite. Their excellent reusability and temperature sensing mechanisms have been also investigated. These results demonstrate the potential of the Coumarin 7 functionalized Eu-MOF composite as a dual-mode optical thermometer for temperature sensing applications.
研究领域:
材料科学
·
光学
·
化学
✓ 已验证
DOI
高影响因子
DYES AND PIGMENTS
·
2020
·
IF 4.613
Guangliang Hou,Shenxi Min,Yuhan Zhao,Bin Dong,Lina Zhang,Dahua Li,Weichun Wu,Huifang Zhu,Bo Song
In this study, we synthesized an amphiphilic α-cyanostilbene derivative ( E -form)-1-(12-(2-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)-5-(diethylamino)phenoxy)dodecyl)pyridin-1-ium bromide (denoted by BCPB). As being dissolved in aqueous solution, BCPB shows strong emission of excimers at around 660 nm due to the formation of aggregates. Addition of different amount of CB[7] into the solution leads to the emission shift from 660 nm, firstly to 540 nm and then to 588 nm. The emission shift is attributed to the two-step assembly driven by the concentration of CB[7], and the molar ratios of CB[7]/BCPB (denoted by R m ) play a critical role for the shift. As R m ≤ 4, CB[7] mainly interacts with the cationic pyridinium group of BCPB to form BCPB@CB[7] complex. As R m > 4, another CB[7] binds to the diethylamino group at one end of α-cyanostilbene to form BCPB@CB[7] 2 complex. The two-step assembly well explains the emission shift of BCPB.
研究领域:
超分子化学
·
材料科学
·
光化学
✓ 已验证
产品关联
DOI
高影响因子
Molecular Medicine Reports
·
2017
·Vol. 16
·期 2
·1864-1870
·
IF 1.692
Chao Weng,Man Ding,Shanghua Fan,Qian Cao,Zuneng Lu
Transcription factor 7 like 2 (TCF7L2, also termed TCF4), is a Wnt effector induced transiently in the oligodendroglial lineage. The current well accepted hypothesis is that TCF7L2 inhibits oligodendrocyte differentiation and remyelination through canonical Wnt/β‑catenin signaling. However, recent studies indicated that TCF7L2 activity is required during oligodendrocyte differentiation and remyelination. In order to clarify this, in situ hybridization, immunofluorescence and western blot analysis using in vivo TCF7L2 conditional knockout mice, were performed and it was found that TCF7L2 promotes oligodendrocyte differentiation during myelin formation and remyelination. Furthermore, it was established that TCF7L2 does not affect oligodendrocyte precursor cells during remyelination. These data are of important clinical significance to develop novel therapeutic targets to overcome multiple sclerosis and other demyelinating diseases.
研究领域:
神经科学
·
分子生物学
·
细胞生物学
·
神经病学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Lei Zou,Jiajun Ren,Fangdong Ning,Xianmei Ma,Matthew J. Webber,Yongjun Zhang
Slide-ring hydrogels have been shown to have exceptional toughness and stretchability. Current designs typically rely on polyrotaxane architectures of cyclodextrin (CD) macrocycles treaded onto polyethylene glycol (PEG) chains. The use of alternative macrocycles to prepare slide-ring hydrogels remains largely unexplored. In this study, we present a cucurbit[7]uril (CB[7]) slide-ring hydrogel prepared from multiblock PEG polymers segmented with guest moieties of varying affinity for binding to CB[7]. Following threading with allyl-modified CB[7] to form pseudopolyrotaxane structures, the side-chains are then covalently cross-linked to yield the slide-ring architecture. The resulting hydrogels exhibit unique mechanical properties modulated by host–guest binding affinity and dynamics. Given the exceptional molecular recognition capabilities of the CB[n] family of macrocycles for diverse guests, using these as alternatives to CDs offers an opportunity to expand the design space for slide-ring hydrogel architectures.
研究领域:
材料科学
·
高分子化学
·
超分子化学
·
材料力学性能
✓ 已验证
产品关联
DOI
高影响因子
Scientific Reports
·
2024
·Vol. 14
·期 1
·1-12
·
IF 3.8
Gao Kexin,Liu Yancui,Sun Cheng,Wang Ying,Bao Hongrong,Liu Guoyang,Ou Jinrui,Sun Ping
Pyroptosis is a gasdermin-mediated pro-inflammatory form of programmed cell death (PCD). Tumor necrosis factor-ɑ (TNF-ɑ) is an inflammatory cytokine, and some studies have shown that TNF-ɑ can cause pyroptosis of cells and exert anti-tumor effects. However, whether TNF-ɑ exerts anti-tumor effects on breast cancer cells by inducing pyroptosis has not been reported. In this study, to explore the impact of TNF-ɑ on pyroptosis in breast cancer cells, we treated MCF-7 cells with TNF-ɑ and found that TNF-ɑ induced cell death. Moreover, we observed that the dead cells were swollen with obvious balloon-like bubbles, which was a typical sign of pyroptosis. Further studies have found that the anti-tumor effect of TNF-ɑ on breast cancer cells in vitro was achieved through the canonical pyroptosis pathway. In addition, TNF-ɑ-induced pyroptosis in MCF-7 cells was associated with mitochondrial dysfunction, in which mitochondrial membrane potential was decreased and mitochondrial ROS production was increased. After inhibiting ROS production, the activation effect of TNF-ɑ on NLRP3/Caspase-1/GSDMD pathway was weakened, and the inhibitory effect of TNF-ɑ on the growth of MCF-7 cells in vitro was also decreased, further confirming the involvement of ROS in TNF-ɑ-induced pyroptosis. Overall, our study revealed a new mechanism by which TNF-ɑ exerts an anti-tumor effect by inducing pyroptosis in MCF-7 cells through the ROS/NLRP3/Caspase-1/GSDMD pathway, which may provide new therapeutic ideas for the treatment of breast cancer.
研究领域:
肿瘤学
·
细胞生物学
·
免疫学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS LETTERS
·
2015
·
IF 2.489
Dongdong Lv,Dafeng Zhang,Xipeng Pu,Meichao Gao,Huiyan Ma,Huaiyong Li,Tongtong Zhang
Li 8 Bi 2 (MoO 4 ) 7 was synthesized by a one-step combustion method. The structure, morphology, adsorbance, optical and photocatalytic properties of as-obtained sample were studied by X-ray powder diffraction, scanning electron microscopy, ultraviolet–visible spectrophotometry. The experimental results show that the formation of tetragonal Li 8 Bi 2 (MoO 4 ) 7 was one-pot achieved. The sample exhibits a irregular particle morphology with an average size of ~0.6 μm. The direct energy band gap calculated from the diffuse reflectance spectrum is 3.25 eV. Compared with TiO 2 (P25), as-synthesized Li 8 Bi 2 (MoO 4 ) 7 shows better visible light photodegradation performance for MB, which can be attributed to its excellent adsorbability.
研究领域:
材料科学
·
光催化
·
化学
✓ 已验证
DOI
高影响因子
TETRAHEDRON
·
2023
·
IF 2.1
Jianping Zhang,Jinming Liu,Gengwen Yin,Wenlong Hou,Haiquan Zhang
Nucleophilic substitution reaction of 1,7-dibromo-perylene diimide derivatives can expend the chemical structure and photophysical properties of perylene diimide. Here, we reported firstly the synthesis and mechanism of 1-bromo-7-hydroxyl perylene diimide derivative by the 1,7-dibromo-perylene diimide derivative in electron donor solvents (such as, NMP, DMF and etc) and under visible light irradiation . The structure of 1-dibromo-7-hydroxyl perylene diimide was confirmed by HR-MS, UV–Vis absorption spectra and comparison of UV–Vis absorption spectra with product from the heating chemical reaction. Furthermore, the 1-bromo-7-hydroxyl-perylene diimide derivative showed a higher optical response to some metal ions , such as Fe 3+ , Cu 2+ and etc.
研究领域:
有机化学
·
光化学
·
材料科学
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Zhiwei Huang,Xinze Li,Xuanhe Chen,Dedong Yu,Yingzheng Zhao
Ischemia-reperfusion (I/R)-induced acute kidney injury (AKI) triggers ferroptosis through oxidative stress and lipid peroxidation, exacerbating renal cell and tissue damage. 7-Dehydrocholesterol (7-D) was a pro-cholesterol molecule with a unique conjugated 5,7-diene structure that inhibits lipid peroxidation by trapping excessive radicals, thereby attenuating ferroptosis. However, direct administration of 7-D demonstrated limited efficacy in treating AKI. Here, we incorporated 7-D as the anti-ferroptotic agent and prepared it into liposomes (7-D@Lip) for the treatment of AKI. In addition, we added adenosine triphosphate (ATP) into the hydrophilic core of liposomes (7-D@A-Lip) to promote the uptake efficiency by damaged kidney cells. To enhance the distribution and accumulation of 7-D@A-Lip in the injured kidney, we extruded the renal cell membrane into the prepared liposomes (7-D@A-mLip). The results showed that 7-D@A-mLip could be rapidly internalized by hypoxia/reoxygenation-damaged renal cells, effectively inhibiting lipid peroxidation and alleviating ferroptosis-related injury. In addition, post-injection 7-D@A-mLip specifically accumulated in the renal tissues, reduced lipid hydroperoxide production by scavenging reactive oxygen species, and suppressed ferroptosis in the kidney, thereby preserving renal function in the AKI model. This study presented a promising renal-targeted delivery strategy for 7-D to mitigate ferroptosis in kidney disease.
研究领域:
药理学
·
肾脏病学
·
纳米医学
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2022
·Vol. 29
·期 33
·50135-50146
·
IF 5.19
Qin Qingdong,Yan Lu,Liu Zheming,Liu Yahong,Gu Jia,Xu Yan
Morphology optimization of catalysts has been considered as a viable strategy to improve the catalytic efficiency for peroxymonosulfate (PMS) activation by providing high surface area and abundant active sites. In this study, nanotubular Co 3 O 4 (NT-Co 3 O 4 ) was successfully synthesized as a PMS activator for the rapid removal of acid orange 7 (AO7) in aqueous solutions. Characterization results showed that NT-Co 3 O 4 presented as aggregated nanotubes, with an average pore diameter of 10 nm. The specific surface area of NT-Co 3 O 4 was as high as 41.8 m 2 g −1 . Catalytic experiments demonstrated that the degradation rate of AO7 in the NT-Co 3 O 4 /PMS system was 15 times greater than that in commercially available Co 3 O 4 /PMS system. The effects of various experimental parameters, including catalyst dose, PMS dose, pH, and temperature, were comprehensively investigated. The reactive species in the NT-Co 3 O 4 /PMS system were identified as sulfate radical (SO 4 •− ) through both quenching tests and electron paramagnetic resonance (EPR) technology, and ≡CoOH + played an important role in PMS activation. N atoms in the AO7 molecule were found to be preferentially attacked by SO 4 •− . Moreover, the good stability and reusability of NT-Co 3 O 4 were confirmed by a five-cycle AO7 removal experiment. This study provides a broader view of the potential applications of nanotubular materials to achieve highly efficient PMS activation in treating dyes in wastewater.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Future Medicinal Chemistry
·
2022
·Vol. 14
·期 9
·
IF 4.767
Jiao Liu,Xiaoxuan Wang,Yuan Cheng,Yinghua Yu,Maofang Zhao,Jie Huang,Peiquan Yu,Qian Fu,Yilin Song,Yi Liu
Background: H2S is the third gas transmitter affecting the growth, reproduction and survival of cancer cells. However, the H2S anticancer and antitumor mechanism still needs to be further studied. Methods: Here, FHS-1 was synthesized utilizing excited-state intramolecular proton transfer to detect H2S in MCF-7 cells, and investigated the effects of varying concentrations NaHS on apoptosis. Results: The study found that FHS-1 detects H2S levels with high selectivity and pH stability and that H2S may regulate apoptosis in MCF-7 cells through the p53/mTOR/STAT3 pathway. Conclusion: Researching the influence of H2S on apoptosis can serve as a theoretical foundation for future research into H2S-related anticancer medicines, and the H2S probe can be used as an effective cancer screening tool.Graphical abstract
研究领域:
癌症生物学
·
细胞信号传导
·
药物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）