Analytical Methods
·
2021
·Vol. 13
·期 32
·3561-3568
·
IF 2.896
Lihong Shi,Xiaorui Dong,Guomei Zhang,Yan Zhang,Caihong Zhang,Chuan Dong,Shaomin Shuang
N-doped blue-fluorescence carbon dots (N-CDs) were fabricated via a one-pot hydrothermal method using folic acid and p-phenylenediamine. The obtained N-CDs exhibited strong fluorescence (FL) with a considerable quantum yield (QY) of 21.8% and exceptional optical stability under different conditions. Upon introducing Cr(VI), blue FL of N-CDs was distinctly quenched. On subsequent addition of L-AA, the FL of N-CDs could be partially recovered. The fluorescence changes of N-CDs have been utilized to detect Cr(VI) and L-AA in aqueous solutions with linear ranges of 0.10–150 μM and 0.75–2.25 mM, respectively, as well as limit of detection values of 9.4 nM and 25 μM, respectively. Furthermore, as-obtained N-CDs can be extended to monitor the fluctuation of intracellular Cr(VI) and L-AA. More intriguingly, N-CDs can target lysosomes with a satisfactory Pearson correction coefficient of 0.87, which indicates a promising application prospect in the biomedical field.
研究领域:
材料科学
·
分析化学
·
生物医学工程
·
细胞生物学
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产品关联
DOI
PubMed
高影响因子
Materials Express
·
2020
·Vol. 10
·期 12
·2122-2129
·
IF 1.65
Wei Lai,Wang Jun,Arshad Naila,Wang Jianying
2-Hydroxyethyl methacrylate (HEMA) improved colloids of silica/carbon dots (SiO2/HMCDs) were used by means of new translucent, nontoxic cross-linking centers comprising two non-toxic components, silica colloids and carbon dots. The direct photopolymerization of a mixture
of acrylic acid (AA), HEMA, and SiO2/HMCDs afforded ultrahigh strength and mechanically robust hydrogel. The fabricated fluorescent SiO2/HMCDs-based hydrogels demonstrated stable photoluminescence owing to their outstanding mechanical flexibility. Fluorescent hydrogels
exhibited tensile strength of up to ∼ 13.2 MPa by processing with 1 wt% SiO2/HMCDs content. More importantly, the mechanical properties (stress or strain) could be changed by controlling the content of SiO2/HMCDs and H2O. Relative hierarchical structure
attributed to high mechanical strength.
研究领域:
材料科学
·
生物医学工程
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED POWDER TECHNOLOGY
·
2016
·
IF 2.478
Bin Chen,Shenwen Fang,Ting Chen,Yan Xiong,Ming Duan
Compound poly(methylmethacrylate (MMA)-acrylic acid (AA)-ethyl acrylate (EA))/Fe 3 O 4 superparamagnetic nanoparticles were synthesized successfully by emulsion polymerization and solvothermal reaction methods. The nanoparticles were characterized by transmission electron microscopy (TEM), vibrating sample magnetometer (VSM), Fourier transform infrared spectra (FT-IR), X-ray diffraction (XRD) and thermogravimetry analysis (TGA). P(MMA-AA-EA)/Fe 3 O 4 nanoparticles exhibited superparamagnetic properties with a saturation magnetization value of 20 emu/g. The selective adsorption behaviors of nanoparticles toward dyes were investigated and the function of electronic interaction during the adsorption process was also discussed.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2018
·Vol. 42
·期 16
·13453-13460
·
IF 3.201
Zhangkang Li,Huiyu Bai,Shengwen Zhang,Wei Wang,Piming Ma,Weifu Dong
In this paper, poly(N-isopropylacrylamide) (PNIPPAm), polyacrylic acid (PAA), polyvinyl alcohol (PVA) and cellulose nanocrystals (CNC) were used to prepare double-network hydrogels by the photo-crosslinking technology. The results from mechanical and swelling tests indicated that photo-crosslinked PVA/CNC/P(NIPPAm-co-AA) hydrogels exhibited temperature-sensitive, pH-sensitive behaviors and good mechanical strengths. We prepared DN hydrogels, which combined the advantages of PNIPAAm, PAA and photo-crosslinking collectively in the PVA/CNC system, leading to controllable temperature and pH responses and improvement in physical properties. A simple and green method for the preparation of DN hydrogels was demonstrated, offering photo-crosslinked PVA/CNC/P(NIPPAm-co-AA) hydrogels as excellent prospects for applications in the medical field.
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2019
·
IF 3.131
Guohong Yao,Wendie Bi,Hui Liu
pH-responsive magnetic graphene oxide/poly(N-vinylimidazole-co-acrylic acid) hydrogel (MGO/PNA) was synthesized by random copolymerization of N-vinylimidazole (NVI) and acrylic acid (AA) in the presence of ethylenediamine-modified magnetic graphene oxide (MGO). The resulting hydrogel was systematically characterized by mean of Fourier transform infrared spectrometer, X-ray photoelectron spectroscopy, Raman spectrum, Thermogravimetric analysis, and Scanning electron microscope. The swelling percentage of the hydrogel attained the extremely high value at pH = 2 and pH = 12. The resulting MGO/PNA was used as an easily recyclable adsorbent to remove cationic and anionic dyes, and the effects of solution pH, adsorption time, adsorption temperature, and initial concentration on the adsorption process were systematically investigated. The maximum theoretical adsorption capacities of methyl violet (MV), methylene blue (MB), tartrazine (TZ), and amaranth (AR) were 609.8, 625.0, 613.5 and 609.8 mg/g, respectively. The adsorption behaviors of the hydrogel conformed to Langmuir isothermal model and pseudo-second-order model. The mechanism analysis indicated that the addition of Fe 3 O 4 into the hydrogel not only endowed MGO/PNA with easily recyclable characteristic, but also improved the adsorption capacity of the hydrogel to some degree. MGO/PNA hydrogel could maintain good adsorption effect after five adsorption-desorption cycles, so the hydrogel might have the wide application prospect in adsorption science and technology area.
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
ACS Biomaterials Science & Engineering
·
2019
·
IF 4.511
Lingna Deng,Fang Zhang,Yanlin Wu,Jiahao Luo,Xuhong Mao,Lingli Long,Maling Gou,Liqun Yang,David Y. B. Deng
Studies have shown that the use of proangiogenic genes can improve the prognosis of ischemic stroke by promoting angiogenesis at the injury site. For example, within this study, hypoxia-inducible factor 1-α (HIF-1α) has exhibited an angiogenic effect. Our previous study reported a more stable HIF-1α mutant form (HIF-1α-AA), which was transfected into mesenchymal stem cells to provide neuroprotective effects against ischemic stroke. The safety of nonviral gene vectors has attracted researchers’ attention. This study encapsulated the HIF-1α-AA plasmid DNA into a newly synthesized effective nonviral gene vector, a hyperbranched cationic amylopectin derivative (DMAPA-Amyp) nanocarrier. In addition, a targeting strategy was applied to select the RGD peptides and bind to the designed nanocarrier as a molecule targeting endothelial cells. The targeting strategy is used to directly deliver the nanocarriers to the vascular endothelial cells of the brain peri-infarct site. This study emphasizes the targeting ability of nanocarrier and its therapeutic effect on cerebral ischemia. The results showed that RGD-DMAPA-Amyp had good biocompatibility and a high cell uptake rate, indicating that it is a safe nonviral gene vector that can be endocytosed by human cells. In rat models of ischemic stroke, compared with the nontargeted nanocarrier group, more RGD-DMAPA-Amyp nanoparticles aggregated in vascular endothelial cells of the peri-infarct region and significantly improved the recovery of neurological function. It is indicated that the RGD-modified nanomedicine promotes the recovery of nerve function more efficiently. Further study on the mechanism of RGD-DMAPA-Amyp/HIF-1α-AA in the treatment of cerebral ischemia displayed potential to significantly promote the formation of new blood vessels in vivo. Our findings suggest that the RGD-modified nonviral gene vector containing HIF-1α-AA appears to be a safe and promising therapeutic strategy for ischemic stroke gene therapy.
研究领域:
神经科学
·
分子生物学
·
基因治疗
·
药学
✓ 已验证
DOI
PubMed
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2024
·
IF 10.7
Chen Ye,Diwei Shi,Yangguang Zhu,Peizheng Shi,Ningbin Zhao,Zhuang Sun,Zhe Zhang,Diming Zhang,Yaokang Lv,Wenqi Wu,Jiancheng Yu,Hassan Karimi-Maleh,He Li,Li Fu,Nan Jiang,Juewen Liu,Cheng-Te Lin
Simultaneous monitoring of key metabolites like dopamine, ascorbic acid, and uric acid is essential for early disease diagnosis and evaluating treatment. Electrochemical techniques are increasingly used for precise, point-of-care testing (POCT) of these metabolites. Herein, a sample pretreatment method called effervescent solid-phase extraction (ESPE) was proposed for efficient enrichment of trace analytes for electrochemical detection. In an ESPE process, effervescent tablets made of gold nanoparticle-decorated graphene oxide (Au/GO) were first self-dispersed in a test solution to promote the enrichment of analytes on the Au/GO adsorbents, followed by the addition of flocculant effervescent tablets to cause Au/GO sheets to form self-assembled aggregates, which then can be efficiently collected by the foam electrodes. The entire sample pretreatment process operates without external power and takes only 5 min. With the assistance of the ESPE method, our electrochemical sensors achieve an ultralow detection limit for dopamine, ascorbic acid, and uric acid of 80 pM, 1.8 nM, and 460 pM, respectively, which are two to three orders of magnitude lower than the results obtained by the drop casting technique. The enhancement mechanism of our approach is based on increasing the contact probability with analytes through dynamic dispersion of the Au/GO adsorbents, in contrast to the static diffusion mechanism relied on Brownian motion. We also show that combining the ESPE solution kit with a portable micro-electrochemical workstation can attain the same detection level as HPLC in real urine samples. The proposed ESPE approach holds great promise for POCT applications in 2D material-based biosensors.
研究领域:
生物医学工程
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Macromolecular Science Part A-Pure and Applied Chemistry
·
2020
·
IF 1.349
Guanjie Liu,Xin Qin,Xuehong Wei,Ziwei Wang,Jianguo Ren
EPEG (ethylene-glycol monovinyl polyethylene glycol)-AA (acrylic acid) copolymerization is a typical representative of free radical copolymerization for the preparation of PCs that has been discussed and used increasingly in recent years. The calculation of the reactivity ratio can be used for the analysis of the monomers reactivity, which is of great significance to the study of copolymerization process. In this paper, combined with GPC test results, the monomer reactivity ratios in EPEG-AA copolymerization were calculated with the linear (Fineman–Ross, YBR, Kelen–Tüdös) methods and the nonlinear least square method, and the uncertainty of the methods were calculated. In addition, it has been found that compared with the widely used IPEG (isobutylene polyethylene glycol)-AA copolymerization, the monomer activity of EPEG is higher and closer with AA, so the copolymerization efficiency should be higher. This problem has been verified by experimental results, and the unity of theory and experiment has been realized. At the same time, the experimental results show that the PCs prepared by EPEG macromonomers have better dispersion of cement paste. To sum up, EPEG macromonomer will be more widely used in the future.
研究领域:
高分子化学
·
材料科学
·
建筑材料
·
化学工程
✓ 已验证
DOI
高影响因子
POLYMER INTERNATIONAL
·
2023
·Vol. 72
·期 7
·664-670
·
IF 3.2
Bin Li,Mengjing Zhou,Xiaojia Xu,Jizhen Liu,Wenrui Hao,Aolin Wu
Choline chloride, acrylamide (AM) and acrylic acid (AA) were used as raw materials to prepare deep eutectic solvent, and β-cyclodextrin (β-CD) was used as filler to prepare β-CD/P(AM- co -AA) composite hydrogel by frontal polymerization. The composite hydrogel was characterized by Fourier transform infrared spectroscopy and scanning electron microscopy. The pH response, mechanical properties and self-healing of the hydrogel were studied. The results show that AA contains easily ionized –COOH, which makes the composite hydrogel have excellent pH response and super-high swelling ratio under alkaline conditions. With the addition of β-CD, due to the increase of hydrogen bonds and the combination of β-CD and polymer chains the mechanical properties of the hydrogel are obviously improved and the tensile strength and compressive strength are increased by 4.12 and 2.26 times respectively. The introduction of β-CD can improve the self-healing performance of the composite hydrogel. With the increase of β-CD content, the healing rate and healing speed of the composite hydrogel show an upward trend. In this study, a simpler and faster method is proposed to prepare self-healing composite hydrogel with excellent mechanical properties and pH responsiveness. The self-healing property and the existence of a hydrophobic cavity of β-CD make β-CD/P(AM- co -AA) composite hydrogel have potential application in wound healing. © 2023 Society of Industrial Chemistry.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
POLYMER
·
2025
·
IF 4.5
Zhanjian Liu,Ping Wang,Jing Jing,Meiling Li,Yuxin Fu,Xiguang Zhang,Huaiyuan Wang
Superwetting oil-water separation membranes are effective materials for treatment of wastewater containing emulsified oil, but the problem of membrane pollution remains a huge challenge during its long-term operation. In this study, we successfully developed a superhydrophilic/underwater superoleophobic membrane using a simple phase separation method. The fabrication process involved three key steps: (1) surface hydroxylation of pristine PVDF using NaOH etching to generate active hydrogen bonds and hydroxyl groups, (2) acrylic acid (AA) grafting onto the hydroxylated PVDF surface to introduce carboxyl functionalities, and (3) in-situ chelation of needle-like ZnO onto the AA-grafted matrix. The synergistic effect of the surface needle-like ZnO and the hydration layer endowed the PVDF-OH/AA@ZnO membrane with an outstanding oil-water separation efficiency of n-hexane up to 99.68 %, and higher than 98 % for various emulsions (e.g. kerosene, petroleum ether, chloroform, and dichloromethane) under gravity. Moreover, compared with the basement membrane, the tensile strength of the modified membrane increased from 106.21 kPa to 153.84 kPa, indicating its excellent mechanical properties under strong external forces. The PVDF-OH/AA@ZnO membrane demonstrated exceptional recycling performance, with a separation efficiency above 97.25 % after five cycles, and exhibited anti-fouling capability with simple water rinsing used to remove surface oil residues. Overall, this study provides a scalable strategy for the design of superhydrophilic/underwater superoleophobic separation membranes for the practical treatment of oily wastewater.
研究领域:
材料科学
·
环境工程
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2022
·Vol. 12
·期 30
·19022-19028
·
IF 4.036
Bin Li,Xiaojia Xu,Zhigang Hu,Yongjing Li,Mengjing Zhou,Jizhen Liu,Yajun Jiang,Peng Wang
Deep eutectic solvent (DES) was prepared by using acrylic acid (AA) and acrylamide (AM) as hydrogen bonding donors (HBD) and choline chloride (ChCl) as hydrogen bonding receptors (HBA). Nitrogen-doped carbon nanotubes (N-CNTs) were dispersed in DES as fillers, and N-CNTs/P(AA-co-AM) composite hydrogels were prepared by FP. The interaction mode between the hydrogel and N-CNTs was characterized by Fourier infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The mechanical properties, pH response and electrical conductivity of the composite hydrogels were studied. The results showed that the mechanical properties of the hydrogel were significantly enhanced with the increase of N-CNT content. The tensile strength and compressive strength of the FP4 composite hydrogel reached 5.42 MPa and 4.29 MPa, respectively. Due to the dissociation of carboxyl groups in AA in an alkaline environment the composite hydrogel showed excellent pH response performance. The conductivity of the hydrogel was also found to be improved with the content of N-CNTs. When the content of N-CNTs is 1.0 wt%, the conductivity of the hydrogel was 4.2 times higher than that of the hydrogel without N-CNTs, and connecting it to a circuit can make an LED lamp emit bright light. In this study, a simple and green method was proposed to prepare composite hydrogels with excellent mechanical properties and electrical conductivity by FP of DES in less than 5 min.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2022
·
IF 9.231
Ying Li,Rida Javed,Rui Li,Yuyang Zhang,Ziyue Lang,Hongbin Zhao,Xing Liu,Hongmei Cao,Daixin Ye
Ascorbic acid is one of the important vitamins to maintain human life activities and plays an irreplaceable role in regulating human redox metabolism. Fresh fruit can provide plenty of AA to maintain human metabolic balance. Thus, it is great significant to develop a rapid and convenient method for detection of AA to evaluate the freshness and nutritional quality of fruits. In this work, Fe single-atom nanoenzyme (Fe-SAN) based colorimetric sensor assisted with smartphone was designed for rapid and on-site AA detection in tropical fruits. Firstly, Fe-SAN with high oxidase-mimicking activity was synthesized by using green tea leaves as sources of carbon and nitrogen and NaH 2 PO 2 as P source to obtain Fe-P/N C SAN, in which P was used to reconstruct the distribution of electronic to enhance the oxidase-mimicking activity of Fe-SAN. Besides, the as-synthesized Fe-P/N C SAN with remarkable oxidase-like activities could oxidize 3,3́,5,5́-tetramethylbenzidine (TMB) to blue colored oxidized TMB. AA could inhibit the oxidation of TMB, leading to blue fading. Based on the above principle, colorimetric sensor integrated with smartphone RGB mode was fabricated and exhibited a good linear detection range (0.5–100 μM) and low detection limit of 0.315 μM for AA detection under optimal conditions. More importantly, the developed sensor could rapidly and accurately detect AA in real sample, such as pineapple, wax apple and mango. Therefore, this research provides a new cost-effective method for the efficient and exact detection of AA in tropical fruit, which has a broad application prospect.
研究领域:
生物化学
·
食品科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）