ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Yingchen Li,Chao Liu,Hongkun Cai,Xiaoguang Luo,Qinwen Guo,Baoyu Han,Zhihao Hu,Juan Li,Jian Ni,Jianjun Zhang
The successful commercialization of flexible perovskite solar cells (FPSCs) hinges on their long-term stability and scalability. Surface defects and residual stress stand out as the main factors impeding their performance. These elements play a substantial role in causing perovskite instability, which not only undermines the efficiency of FPSCs but also expedites device degradation. In this research, for the first time, aminopropyl double-ended polydimethylsiloxane (AP-PDMS) is employed to passivate the surface of perovskite films. The AP-PDMS spatial symmetric part like “pincers” captures two Pb2+ and forms a hydrogen bond with FA+, thereby effectively relieving the residual stress. Moreover, the hydrophobic siloxane within AP-PDMS acts as a protective barrier, preventing water from penetrating the perovskite. This approach yields high-quality perovskite films characterized by large grain sizes, low defect densities, and excellent crystallinity. Consequently, the enhanced device exhibits excellent moisture resistance stability. The FPSCs obtained a champion power conversion efficiency of 23.32%. More importantly, these FPSCs show the mechanical robustness with T90 > 10,000 bending cycles (bending radius of 5 mm) and operational stability with T80 > 1000 h.
研究领域:
材料科学
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聚合物化学
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光伏技术
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纳米技术
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固体物理
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产品关联
DOI
PubMed
高影响因子
Biomaterials Science
·
2017
·Vol. 5
·期 11
·2268-2275
·
IF 4.21
Haobo Han,Jiebing Yang,Yudi Wang,Wenqi Chen,Jiawen Chen,Yan Yang,Quanshun Li
The nucleobase analogue 2-amino-6-chloropurine was modified on the surface of polyamidoamine (PAMAM) to construct a derivative AP-PAMAM, and then it was used as a gene carrier for miR-23b delivery to achieve the anti-tumor effects. The carrier AP-PAMAM could condense miR-23b into stable nanoparticles with a particle size of 97.3 nm (N/P ratio of 50), which was favorable for the cellular uptake of nanoparticles. Compared with PAMAM, AP-PAMAM exhibited an obviously enhanced transfection efficiency through the transfection assay of plasmids pEGFP-N3 and pGL-3. Using the human lung adenocarcinoma cell line A549 as a model, AP-PAMAM-mediated miR-23b delivery could achieve a stronger anti-proliferative effect than PAMAM/miR-23b. The inhibition of cell proliferation was elucidated to be associated with the apoptotic induction (apoptotic ratio of 23.2%) and S phase arrest owing to the decreased expression level of cyclin D1. Meanwhile, the AP-PAMAM-mediated miR-23b delivery could suppress the cell migration and invasion of cancer cells through wound healing and Transwell migration assays. In summary, the PAMAM derivative-mediated miR-23b delivery could be a promising strategy for achieving tumor gene therapy.
研究领域:
药学
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分子生物学
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癌症研究
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基因治疗
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产品关联
DOI
PubMed
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2019
·
IF 4.527
Yang Wu,Yan Li,Liangqing Zheng,Pengcheng Wang,Yan liu,Yongning Wu,ZhiYong Gong
Nε-(carboxymethyl)lysine (CML) is a potentially noxious compound that is causing widespread concern due to its use in various food products. In this study, we investigated CML neurotoxicity via an in vivo experiment with mice, and an in vitro experiment using a 3D microvascular network model (with human brain vascular endothelial cell and human astrocyte) that simulated the blood-brain barrier. We found that CML could induce cell survival status variations, and histopathological changes to the brain. In addition, CML increased levels of oxidative stress , prompted the protein expression of the receptor for advanced glycation end-products (RAGE). CML up-regulated both the gene expression of RAGE, the activating protein-1 (AP-1), the inflammatory cytokines Interleukin-6 (IL-6), vascular cell adhesion molecule1 (VCAM-1), monocyte chemotactic protein1 (MCP-1). We, therefore, postulated that CML has the potential to deleteriously affect the nervous system through oxidative stress and that activation of the p38 MAPK-AP-1 signaling pathway might be implicated in this pathological process.
研究领域:
神经科学
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毒理学
·
细胞生物学
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食品科学
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DOI
PubMed
高影响因子
POLYMER DEGRADATION AND STABILITY
·
2025
·
IF 7.4
Hui Ren,Shun-Zhi Zhou,Tian Yu,Meng Jin,Jia-Rong Chen,Bin Wu,Zhong-Xiang Tang,Ning Ma,Fang-Chang Tsai
Traditional flame-retardant methods for wood, which employ organic reagents and halogens, are detrimental to human health and the environment. Therefore, a PVA (Polyvinyl alcohol)-based coating (PX-AP) incorporating xanthan gum (XG), phytic acid (PA), and aluminum phosphate (AP) was developed to enhance flame retardancy, antibacterial performance, and thermal insulation of wood. XG improves viscosity, stabilizes AP suspension, facilitates carbon formation, and collaborates with AP to form a dense char layer. PX-AP achieves UL-94 V-0 rating with LOI > 60%; TGA results show residual carbon content increases by 102.8% compared to natural wood; cone calorimeter tests indicate Total heat release (THR) decreases by 36.9% and Peak heat release rate (pHRR) by 43.7%; and the maximum backside combustion temperature drops by 44.1% in thermal insulation tests. Bio-inorganic carbon armor enhances fire-resistance & structural integrity of wood for safer evacuation. It also exhibits strong adhesion, meeting diversified demands for wood applications.
研究领域:
材料科学
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高分子化学
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纳米复合材料
·
防火工程
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绿色化学
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木材科学
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热防护
·
生物基材料
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产品关联
DOI
高影响因子
Drug Metabolism and Pharmacokinetics
·
2013
·
IF 2.071
Qiuxia Chen,Yicong Bian,Su Zeng
Caco-2 is a widely used cell model in drug absorption and P-glycoprotein (P-gp,MDR1) substrate identification. Long term vinblastine treatment of Caco-2 cells could increase the expression of P-gp, thus, the vinblastine resistant Caco-2 (Caco-2 vbl) cells can be used as a rapid and sensitive alternative model in identifying P-gp substrates. The mechanism of P-gp induction in this model is not clear, this study was therefore intended to clarify the possible factors involved in P-gp up- regulation in Caco-2 vbl cells. Since vinblastine is the inducer of both activator protein-1 (AP-1) and nuclear factor kappa B(NF-κB), we investigated the role of AP-1 and NF-κB in regulation of MDR1 gene expression. Our results indicated that the AP-1 and NF-κB luciferase activity was higher in Caco-2 vbl cells than that in Caco-2 cells by reporter gene assay. The mRNA expression of AP-1 subunit c-Jun and NF-κB was increased in Caco-2 vbl cells. The c-Jun inhibitor SP600125 and NF-κB inhibitor pyrrolidine dithiocarbamate (PDTC) suppressed the expression of MDR1 mRNA in Caco-2 vbl cells. In conclusion, this study provides the evidence that AP-1 and NF-κB are involved in the P-gp induction in Caco-2 vbl cells.
研究领域:
药理学
·
细胞生物学
·
分子生物学
·
癌症研究
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DOI
PubMed
高影响因子
COMBUSTION AND FLAME
·
2024
·
IF 5.8
Wenke Zhang,Peihui Xu,Daolun Liang,Jianzhong Liu
Studying the ignition and combustion performances of modified aluminum-based metallic fuels in variable oxidizing atmospheres is highly important for large-scale space exploration. In this study, Al–B–Mg multi-metal composite powders (MMP) were prepared using the mechanical ball-milling method.It was coated respectively by ammonium perchlorate (AP), lithium perchlorate (LP), and potassium nitrate (KN) to obtain modified multi-metal composite powder fuels (AP@MMP, LP@MMP, and KN@MMP, respectively) by a recrystallization method. The samples were characterized and their thermal oxidation, ignition and combustion processes were investigated through a TG and laser-ignition experiment under Air/H 2 O environments. The results show that the MMP samples can potentially be called pure aluminum substitutes. All three samples exhibit fast ignition characteristics with ignition delay times of 2.95–6.75 ms in air. AP@MMP exhibits the highest ignition speed. The thermal oxidation, ignition, and combustion properties of all samples decayed with increasing water content in the atmosphere (Air→Air+H 2 O→H 2 O). AP@MMP exhibits a significantly more intense and stable combustion overall than LP@MMP and KN@MMP. This study expands the direction and application range of aluminum-based composite metal fuels, guiding their applications in Air/H 2 O environments.
研究领域:
材料科学
·
燃烧学
·
航天工程
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产品关联
DOI
高影响因子
Frontiers in Immunology
·
2026
·
IF 7
Tianyi Xu,Qilei Yang,Yue Peng,Congcong Xie,Huimin Yu
Rheumatoid arthritis (RA) therapy demands agents that are both effective and safe, yet many natural products with promising bioactivity, such as curcumin, face major translational challenges due to poor solubility and bioavailability. To overcome these limitations, we designed and synthesized a series of dual-functional curcumin-borneol prodrugs via a succinate ester linkage, including the parent ester (CBS), its water-soluble sodium salt (CBS-Na), and a disubstituted analog (DCBS), to enhance delivery and synergize therapeutic action. These derivatives markedly improved cellular uptake and nuclear localization, potently scavenged reactive oxygen species, and effectively suppressed the MAPK/AP-1 signaling axis by inhibiting ERK and p38 phosphorylation and c-Fos expression, leading to downregulation of matrix metalloproteinase MMP9 and pro-inflammatory cytokines (TNF-α, IL-6, IL-1β). In a collagen-induced arthritis rat model, the derivatives demonstrated superior efficacy over native curcumin in alleviating joint inflammation and destruction, while exhibiting an excellent safety profile, thus representing a novel and promising therapeutic strategy for RA.
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DOI
PubMed
高影响因子
JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
·
2025
·
IF 6.2
Xin Li,Ruixuan Xu,Hao Zhang,Heng Deng,Qi-Long Yan,Hongqi Nie
Aluminum (Al) can significantly improve the energy density and specific impulse (I sp ) of solid rocket propellants as the primary metal fuel, but its incomplete combustion results in an undesirable energy release performance. The strategy of fuel/oxidizer interfacial control has been proved to effectively enhance the reaction efficiency of Al-based composites and thus improving the combustion properties of solid propellants. Ammonium perchlorate (AP) is commonly used as a high-energy oxidizer in solid propellant, and its thermal decomposition behavior directly affects the combustion characteristics of propellants. The addition of combustion catalysts can decrease thermal decomposition temperature and increase thermal reactivity of AP. As an emerging catalytic material, MoO 3-x quantum dots (QDs) with oxygen vacancies possess a high specific surface and strong charge adsorption capacity, which renders it a great potential for catalyzing AP. In this study, MoO 3-x QDs were introduced as catalyst and compared with traditional nano-metal oxides (M x O y ), the spherical Al@AP/M x O y composites with polydopamine as interfacial layer were prepared by spray drying method. The particle morphology, thermal decomposition kinetics and ignition properties of Al@AP/M x O y were investigated. The phase composition, morphology and particle size distribution for the condensed combustion products of composites were further analyzed. The decreased particle size and less unreacted Al content in CCPs indicated the increase of combustion efficiency between Al and AP. In particular, Al@AP/MoO 3-x has the higher heat of reaction, lower thermal decomposition temperature and small CCPs particle size distribution, which collectively suggested that the MoO 3-x is capable to improve the thermal reactivity of Al@AP composites with a higher combustion efficiency.
研究领域:
材料科学
·
燃烧与推进
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产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2022
·
IF 5.532
Baoyun Ye,Hongyi Chen,Binhao Shen,Chang Liu,Chongwei An,Jingyu Wang,Yong Zhang
In this work, a novel CuO-based nanocomposite was successfully prepared by hydrothermal method . The results of FT-IR, XRD , XPS and SEM indicated that the nano CuO was successfully loaded on GO/MoS 2 sheets. The catalytic ability of the CuO-based composite was researched by the AP thermal decomposition behavior and the combustion behavior of AP/HTPB. The CuO-based composite could significantly enhance the AP thermal decomposition performance through decreasing the activation energy of AP during the thermal decomposition process. Especially for CuO(90)@MG(10), the AP thermal decomposition temperature was reduced from 437.5 to 334.9 °C and the heat release increased from 396.7 to 1576.8 J/g by adding 4% of the CuO-based nanocomposite. After adding the CuO-based nanocomposite, the ignition delay time of AP/HTPB solid propellant decreased obviously from 0.346 s to 0.109 s with a higher flame height and a stronger flame brightness during the combustion process, indicating that the CuO-based nanocomposite could effectively promote the combustion behavior of AP/HTPB composite solid propellant. In summary, the CuO-based nanocomposite could be applied as an excellent catalyst for improving AP thermal decomposition and a combustion catalyst for AP-based composite solid propellants.
研究领域:
材料科学
·
推进剂研究
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Xin Li,Yunlong Zhang,Ruixuan Xu,Qi-Long Yan,Hongqi Nie
The synergistic regulation of high energy output and low sensitivity has been a persistent research focus in solid propellant development. In this study, oxygen-deficient MoO3–x quantum dots (QDs)-modified Al@AP core–shell composites were fabricated via spray-drying, with a reference system containing fine AP (s-AP) serving as a control group. Systematic investigations were conducted on the interfacial modification effects and the incorporation of MoO3–x QDs on the energy release characteristics, ignition-combustion performance, and safety properties of HTPB-based composite propellants. The results indicate that SP4 with Al@AP/MoO3–x has significantly enhanced energy outputs compared with SP1 containing Al/AP, and the heat of reaction increased from 6270 to 6615 J·g–1 under identical loading densities. Meanwhile, the ignition delay time of SP4 was shortened from 25.76 to 16.38 ms, and the flame radiation intensity was increased from 1640.8 to 1944.2, indicating a significantly improved ignition property. Furthermore, the higher burning rate at low pressure and suppressed rate surges at high pressure of SP4 result in a reduced burning rate pressure exponent (from 0.57 to 0.39). Safety tests revealed lower impact sensitivity for Al@AP/MoO3–x versus Al/AP/s-AP systems based on the increased burning rate. Condensed combustion product (CCP) analyses demonstrated that the core–shell structure effectively mitigated Al agglomeration, evidenced by increased fine particles and decreased Al residues, indicating an enhanced combustion efficiency. MoO3–x QDs further optimized the CCP size distribution, reducing the dominant particle size from 44.7 to 22.3 μm.
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2021
·
IF 4.311
Shao-Bo Cao,Lin-Yu Zhou,Guolei Xiang,Guang-Wen Chu,Liang-Liang Zhang,Jian-Feng Chen
Sub-10 nm Co 3 O 4 nanoparticles with a narrow size distribution are prepared by a surfactant-free liquid precipitation method in a rotating packed bed (RPB) reactor. The mean size of the material is about 8.5 nm, and is the smallest among previous reports via surfactant-free liquid precipitation. The growth mechanisms show that the sizes of Co 3 O 4 nanoparticles inherit from the precursory Co(OH) 2 . Compared to the traditional stirred tank reactor, RPB can enhance the nucleation of Co(OH) 2 through enhanced micro-mixing, which leads to thinner and more uniform products. As-prepared Co 3 O 4 can show enhanced catalytic performance for ammonium perchlorate (AP) decomposition. The peak temperatures of AP decomposition reduce to 296.8 °C, 291.8 °C, 290.0 °C, and 286.6 °C by adding 2 wt% 22.6 nm, 15.0 nm, 10.9 nm, and 8.5 nm of Co 3 O 4 nanoparticles, respectively. Density functional theory (DFT) calculations and thermogravimetry coupled with mass spectrometry (TG-MS) analysis reveal that the size-dependent catalytic activity of Co 3 O 4 for AP decomposition origin from varied O 2 activation ability and NH 3 adsorption capacity at the edge and corner sites.
研究领域:
材料科学
·
化学工程
·
催化反应
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产品关联
DOI
高影响因子
FUEL
·
2022
·
IF 8.035
Shuai-Zhong Wang,Binbin Huang,Shuwen Chen,Pei-Jin Liu,Wei Li,Qi-Long Yan
In this paper, energetic combustion catalysts doped core–shell Al@PVDF/AP composites have been fabricated via a spray-drying method, where three kinds of graphene-based energetic coordination polymers (GECPs, GO-CHZ-Co, GO-CHZ-Ni and GO-CHZ-Cu) are employed. These composites have been characterized comprehensively in terms of morphologies, thermal decomposition behaviors, energy density, combustion performances and condensed combustion products (CCPs). The results show that the GO-CHZ-Co and GO-CHZ-Cu could increases the heat of explosion for Al@PVDF/AP composites from 6885.2 J·g −1 to 7491.0 J·g −1 and 7390.1 J·g −1 , respectively, which are 8.8 % and 7.3 % higher than the blank reference samples. Moreover, the burn rates for these composites decrease when GO-CHZ-Co or GO-CHZ-Ni is included, indicating that these composites are promising candidates with improved energy density even unusually with decreased burn rates.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）