ANALYTICAL CHEMISTRY
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2019
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IF 6.35
Huan Gao,Junfang Zhang,Ying Liu,Wenwen Tu,Tianxiang Wei,Zhihui Dai
Development of sensitive detection methods for microRNAs has realistic application value for early clinical analysis and accurate diagnosis. In this study, a triple-helix molecular switch electrochemiluminescence resonance energy transfer (ECL-RET) nanoamplifier was designed to construct an electrochemiluminescence (ECL) biosensor for microRNA determination. The newly synthesized S-doped Lu2O3, which shows a 3 times better ECL performance than Lu2O3, was chosen as the donor in this ECL-RET system. Accordingly, Ag2S quantum dots (QDs) were used as the matched acceptor. They exhibited overlapping spectra and efficient energy transfer between each other. Furthermore, using a triple-helix switch structure with an improved quenching effect for signal amplification and a nano-DNA walker transformational system as a powerful method for target amplification, a supernanoamplifier was achieved. As a consequence, the proposed ECL biosensor for microRNA-141 detection exhibited good analytical performance with a low detection limit (16 aM). The sensor not only led to the development of a novel ECL-RET pair but also provided a strong nanoamplifier for biosensing platform construction, which may offer some new considerations regarding material design, signal amplification, and show promising application value in biomedical and clinical diagnosis.
研究领域:
生物传感技术
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纳米材料科学
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临床诊断
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
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2016
·Vol. 6
·期 81
·77701-77708
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IF 3.289
Yaxiong Guo,Hongwei Lei,Borui Li,Zhao Chen,Jian Wen,Guang Yang,Guojia Fang
We successfully constructed a heterojunction structure composed of Ag2S nanocrystals/P3HT conjugated polymer with a relatively high absorption coefficient and broader absorption from the ultraviolet to near-infrared region. The assembled P3HT:Ag2S devices exhibited outstanding short-circuit current density around 19 mA cm−2. Meanwhile, we demonstrated that a low-temperature solution-processed nanocrystalline SnO2 thin film prepared by a facile synthesis method can be an excellent electron transport layer (ETL) material for hybrid solar cells. The SnO2 based hybrid solar cells exhibit an open circuit voltage of 280 mV, which was 100 mV higher than those for devices without SnO2. Based on the above work, we hypothesized that the higher power conversion efficiency is due to the excellent properties of nanocrystalline SnO2 films, such as high electron mobility and excellent transparency at visible wavelength and enhanced exciton dissociation efficiency, and better energy level alignment between FTO and Ag2S for greater photovoltage retention. The simple low temperature low energy consumption, and low-cost soft-chemical process is compatible with the roll-to-roll manufacturing of low-cost hybrid solar cells on flexible substrates.
研究领域:
材料科学
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太阳能
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纳米技术
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有机电子学
✓ 已验证
产品关联
DOI
高影响因子
CHEMISTRY OF MATERIALS
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2023
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IF 8.6
Pengyu Zang,Yaqian Du,Chenghao Yu,Dan Yang,Shili Gai,Lili Feng,Shikai Liu,Piaoping Yang,Jun Lin
The newly developed thermoelectric dynamic therapy (TEDT) may not only solve the problem that photothermal therapy (PTT) is limited by the overexpression of heat shock proteins (HSPs) in tumor cells but also improve the killing effect through a dynamic process. Here, we propose photothermal-driven TEDT based on Ag–Ag2S nanoparticles that integrate Ag2S with Ag+ vacancies (VAg) and Ag in a Janus structure. VAg and Ag optimize the band structure and thermoelectric properties of Ag2S, and additional electrons from the introduction of Ag enhance the PTT effect and facilitates the construction of a significant thermoelectric field for electron–hole migration in the reverse direction, thereby markedly enhancing the TEDT effect. Furthermore, the generated VAg can also serve as a hole trap to suppress electron–hole recombination to promote 1O2 production, which inactivates HSPs to produce positive feedback on PTT, leading to better antitumor efficacy. The combined photothermal–thermoelectric therapeutic properties of Ag–Ag2S were verified from both in vivo and in vitro perspectives using ESR, UV–visible spectroscopy, cellular experiments, simulated tumor models, and other experiments.
研究领域:
纳米技术
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癌症治疗
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材料科学
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生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
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2015
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IF 2.711
X.P. Qiu,J.S. Yu,H.M. Xu,W.X. Chen,W. Hu,H.Y. Bai,G.L. Chen
In this study, the synthesis of a highly hybrid, heterogeneously structured nanocomposite catalyst consisting of Ag 2 S nanoparticles dotted on a Co 3 O 4 microrod array is reported. The average diameter and length of the Co 3 O 4 microrods was optimized to be approximately 300 nm and 20 μm, respectively, and the average size of the Ag 2 S nanoparticles was approximately 10 nm. When the Ag 2 S nanoparticles were deposited on the Co 3 O 4 microrods, the characteristic optical band gap energy of Co 3 O 4 decreased from 1.26 eV to 1.23 eV, and the intensity of the absorbance peak at 650 nm increased significantly. The catalytic activity of nanosized Ag 2 S/Co 3 O 4 for the photodegradation of organic contaminants with potassium hydrogen persulfate (PMS) or ozone (O 3 ) was evaluated using basic green 1 dye (BG1) as a model pollutant. In the presence of the hybrid Ag 2 S/Co 3 O 4 catalyst developed in this study, the complete photodegradation of the BG1 solution was achieved in 20 min and 6 min when PMS and O 3 were used, respectively. In addition, the experimental results suggest that the catalytic photodegradation of BG1 using the Ag 2 S/Co 3 O 4 /PMS and Ag 2 S/Co 3 O 4 /O 3 processes was dominated by the OH and O 2 − radicals, respectively.
研究领域:
环境科学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
BIOMATERIALS
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2013
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IF 7.604
Yan Zhang,Yejun Zhang,Guosong Hong,Wei He,Kun Zhou,Kai Yang,Feng Li,Guangcun Chen,Zhuang Liu,Hongjie Dai,Qiangbin Wang
Ag 2 S quantum dots (QDs) have been demonstrated as a promising near-infrared II (NIR-II, 1.0–1.4 μm) emitting nanoprobe for in vivo imaging and detection. In this work, we carefully study the long-term in vivo biodistribution of Ag 2 S QDs functionalized with polyethylene glycol (PEG) and systematically examine the potential toxicity of Ag 2 S QDs over time. Our results show that PEGylated-Ag 2 S QDs are mainly accumulated in the reticuloendothelial system (RES) including liver and spleen after intravenous administration and can be gradually cleared, mostly by fecal excretion. PEGylated-Ag 2 S QDs do not cause appreciable toxicity at our tested doses (15 and 30 mg/kg) to the treated mice over a period of 2 months as evidenced by blood biochemistry , hematological analysis and histological examinations. Our work lays a solid foundation for further biomedical applications of Ag 2 S QDs as an important in vivo imaging agent in the NIR-II region.
研究领域:
生物医学工程
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药理学
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毒理学
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纳米技术
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成像科学
✓ 已验证
DOI
PubMed
高影响因子
MATERIALS RESEARCH BULLETIN
·
2024
·
IF 5.3
Chuanyun Yang,Xingjian Zhang,Zhengdao Li,Zhishuai Wang,Jiping Shi,Haiquan Xie,Ting Li,Yong Zhou
A series of hybrid films were designed and fabricated by in situ growth of Ag 2 S nanoparticles with varying content on BiVO 4 nanosheets deposited on stainless steel mesh. The formation of a p-n heterojunction between Ag 2 S and BiVO 4 enabled an extended spectral response range and facilitated the separation of charge carriers through a single directional pathway for electron transport. Exploiting these advantages, Ag 2 S/BiVO 4 composites were employed in various photocatalytic applications under simulated solar irradiation. The results demonstrated, in terms of water purification, that the composite not only possessed photocatalytic ability to degrade RhB or Cr(VI) individually but also exhibited significantly enhanced photocatalytic efficiency in simultaneously removing mixed pollutants containing RhB and Cr(VI). In terms of CO 2 conversion, Ag 2 S/BiVO 4 also displayed a stronger photocatalysis capability compared to pure BiVO 4 film. Furthermore, the immobilized Ag 2 S/BiVO 4 film exhibited improved mechanical strength and long-term stability, making it highly suitable for practical applications.
研究领域:
材料科学
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环境科学
✓ 已验证
DOI
高影响因子
MICROCHEMICAL JOURNAL
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2024
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IF 4.9
Pengfei Yu,Yuyin Wu,Anqi Liu,Mati Ullah Khan,Jun Yang,Jiaqi Cui,Shun Wang,Jiawen Liu,Anqi Chu,Ling Kong,Zhiwei Chen
Ochratoxin A (OTA) is a kind of mycotoxin. It widely exists in all kinds of mammals and has teratogenicity and cytotoxicity. In this paper, a label-free photoelectrochemical (PEC) aptamer sensor based on bismuth oxyiodide/cadmium tungstate (BiOI/CdWO 4 ) was designed to detect OTA. The BiOI/CdWO 4 heterojunction is an excellent optoelectronic active material with remarkable chemical stability. AgNO 3 and Na 2 S were selected to grow in situ to form Ag 2 S quantum dots, which were sensitized to enhance the absorption of visible light and promote the generation of photocurrent. In this system, with the increasing of OTA concentration, the photoelectric signal intensity reduces as the specific binding with aptamer. When the concentration of OTA is between 0.01 ng/mL and 50.00 ng/mL, the linear equation is I (μA) = 48.95 – 10.276 lg c ( c OTA , ng/mL), R 2 = 99.281, and the detection limit is 0.823 pg/mL. The newly designed PEC aptamer sensor has exceptional stability, sensitivity, and reproducibility, making it capable of detecting OTA effectively and sensitively.
研究领域:
食品安全检测
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分析化学
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生物传感技术
✓ 已验证
产品关联
DOI
高影响因子
Energy Storage Materials
·
2022
·
IF 20.831
Chang Liu,Cheng Yang,Yu Liu
Sulfur with high specific capacity is a promising candidate for electrode material of aqueous/nonaqueous metal-sulfide batteries , however, it suffers from poor cycle stability due to its poor conductivity, large volume change and shuttle effect of polysulfide . For the first time, this work employs a semiconductor Ag 2 S with good electronic conductivity as cathode of aqueous metal-sulfide batteries, which gives a four-electron electrode reaction through a three-step all-solid-state conversion reaction of Ag 2 S→Ag 3 CuS 2 →AgCuS→Cu 2 S with a specific capacity of 432 mAh g −1 . Besides, low volume expansion and the elimination of shuttle effect due to the small K sp of Ag 2 S contribute to satisfactory cycle performance. The as-proposed Cu-Ag 2 S battery shows an extremely low overpotential of 50 mV and excellent cycle performance of 9000 cycles, which are the lowest and highest values respectively among all the reported metal-sulfide batteries. By pairing with Zn of lower potential, a cascade Zn-Ag 2 S battery is designed and achieves high working voltage up to1.22 V successfully. After Ag 2 S fully reducing into Cu 2 S in discharge process, Cu 2+ in the electrolyte can provide additional capacity for the battery, thus, the cascade battery design can achieve a higher energy density , representing a promising route to energy-dense aqueous batteries.
研究领域:
电池技术
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电化学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Nano Materials
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2024
·
IF 5.3
Lili Zhao,Haoyu Chen,Jiawei Zhou,Peipei Li,Wenying Zhao,Xiaohua Zhu,Youyu Zhang,Meiling Liu
A photoelectrochemical (PEC) sensing platform for the detection of alkaline phosphatase (ALP) and its inhibitor F– ions was developed based on the Ag2S/Bi2S3 composite. The signal variation strategy was triggered by the in situ formation and consumption of the electron donor. Ag2S quantum dots (QDs) on the Bi2S3 surface effectively suppress the recombination of photogenerated carriers, leading to an enhanced photocurrent response. After ALP is immobilized on the Ag2S/Bi2S3 surface, the in situ catalyzed hydrolysis of l-ascorbic acid 2-phosphate trisodium salt (AAP) appeared, resulting in the production of ascorbic acid (AA). AA acts as an electron donor, enhancing the photocurrent and offering a strategy for quantifying ALP activity. Sodium fluoride (NaF) induces a reduction in ALP activity, and by exposing the sensing platform to various concentrations of NaF, the inhibition of ALP can be identified. The developed PEC sensor demonstrates outstanding detection performance for NaF, featuring a linear concentration range from 100 pM to 20 μM and a low detection limit of 1.28 pM. The integration of Ag2S/Bi2S3 to the in situ formation of electron donors in PEC technology presents an innovative approach for detecting ALP activity and its inhibitors. This platform delivers enhanced sensitivity and selectivity, making it valuable for diverse applications in detecting enzyme activity and screening their inhibitors in biofluid and food samples.
研究领域:
生物化学
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分析化学
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医学检测
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2019
·
IF 7.65
Lixiang Zhang,Pan Li,Luping Feng,Xi Chen,Jiatian Jiang,Sheng Zhang,Chunxian Zhang,Anchao Zhang,Guofu Chen,Hua Wang
A visible-light-driven photoelectrochemical (PEC) sensor has been developed for the “signal-on” analysis of Hg 2+ by the synergetic combination of low-bandgap Ag 2 S and wide-bandgap ZnS quantum dots (QDs). Ag 2 S QDs were synthesized with bead-chain-like structure by the self-assembly route and further covalently bound with ZnS QDs to be coated onto the indium tin oxide (ITO) electrodes. It was discovered that the ZnS@Ag 2 S-modified electrodes could display the visible-light-driven PEC behavior, of which Ag 2 S and ZnS QDs could act as the PEC sensitizer and Hg 2+ -recognition probe, respectively. More importantly, the photocurrent responses of the developed electrodes could be specifically turned on in the presence of Hg 2+ under the visible-light irradiation, presumably due to that Hg 2+ might conduct a Zn-to-Hg exchange on ZnS QDs to trigger the formation of HgS/ZnS@Ag 2 S heterojunction towards the enhanced electron-hole separation. The as-prepared PEC sensor could facilitate the detection of Hg 2+ with concentrations ranging from 0.010–1000 nM, with a detection limit of about 1.0 pM. Besides, the feasibility of practical applications of the developed PEC analysis strategy was verified by probing Hg 2+ in environmental water samples. Such a visible-light-driven PEC detection platform with the unique “turn-on” signal output may promise for the extensive applications for Hg 2+ evaluation.
研究领域:
分析化学
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环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2016
·
IF 7.145
Jing Zhang,Guangyu Hao,Chenfei Yao,Jiani Yu,Jun Wang,Weitao Yang,Chunhong Hu,Bingbo Zhang
Bimodal imaging has captured increasing interests due to its complementary characteristics of two kinds of imaging modalities. Among the various dual-modal imaging techniques, MR/fluorescence imaging has been widely studied owing to its high 3D resolution and sensitivity. There is, however, still a strong demand to construct biocompatible MR/fluorescence contrast agents with near-infrared (NIR) fluorescent emissions and high relaxivities. In this study, BSA-DTPAGd derived from bovine serum albumin (BSA) as a novel kind of biotemplate is employed for biomineralization of paramagnetic NIR Ag2S quantum dots (denoted as Ag2S@BSA-DTPAGd pQDs). This synthetic strategy is found to be bioinspired, environmentally benign, and straightforward. The obtained Ag2S@BSA-DTPAGd pQDs have fine sizes (ca. 6 nm) and good colloidal stability. They exhibit unabated NIR fluorescent emission (ca. 790 nm) as well as high longitudinal relaxivity (r1 = 12.6 mM–1 s–1) compared to that of commercial Magnevist (r1 = 3.13 mM–1 s–1). In vivo tumor-bearing MR and fluorescence imaging both demonstrate that Ag2S@BSA-DTPAGd pQDs have pronounced tiny tumor targeting capability. In vitro and in vivo toxicity study show Ag2S@BSA-DTPAGd pQDs are biocompatible. Also, biodistribution analysis indicates they can be cleared from body mainly via liver metabolism. This protein-mediated biomineralized Ag2S@BSA-DTPAGd pQDs presents great potential as a novel bimodal imaging contrast agent for tiny tumor diagnosis.
研究领域:
生物医学工程
·
材料科学
·
纳米技术
·
医学成像
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2018
·Vol. 53
·期 16
·11355-11366
·
IF 2.993
Tang Shilin,He Chuansheng,Li Dong,Cai Wenhao,Fan Louzhen,Li Yunchao
To obtain dual active near-infrared (NIR) nanomaterial with strong absorption and emission properties, we report herein a novel precursor reactivity differentiation strategy, i.e., utilizing 1-octadecene (ODE)–Se having the ability to react with Ag salts much stronger and faster than ODE–thiourea, for single-step preparation of Ag 2 Se@Ag 2 S nanocrystals (NCs). With this strategy, we were able to synthesize high-quality Ag 2 Se@Ag 2 S NCs with both excellent NIR absorption and emission properties. Particularly, these nanocrystals possess a rather strong and sharp excitonic absorption peak with a full width at half maximum less than 70 nm and a maximum fluorescence quantum yield as high as 24.3%. Their appealing optical properties and structural features were founded to be highly dependent on the Se to S precursor ratio in the reaction solutions, owing to such a ratio exerting a direct influence on the core sizes and shell thicknesses of the as-formed NCs. Taking advantage of their remarkable NIR absorption properties, self-powered photoelectrochemical-type photodetectors based on the as-prepared Ag 2 Se@Ag 2 S NCs were successfully fabricated, which demonstrate a much better response performance and photostability in comparison with those based on Ag 2 Se NCs.
研究领域:
材料科学
·
光学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）