FOOD AND CHEMICAL TOXICOLOGY
·
2023
·
IF 4.3
Xin Xie,Yan Zhu,Huimin Cheng,Haili Li,Yadi Zhang,Rong Wang,Wenyong Li,Fengrui Wu
Long-term exposure to bisphenol A (BPA) in humans may promote ovarian cancer development. In present study, the mechanisms by which BPA mediates the aggression metastatic behavior of ovarian cancer were investigated in vitro/in vivo . The results showed that BPA (10 μM) significantly promoted the proliferation, migration and invasion of human ovarian cancer cells (ES-2 and OVCAR-3 cells); moreover, it promoted ES-2 and OVCAR-3 cell glucose uptake, lactic acid release and intracellular ATP synthesis. After administration of 5 μg/kg/day BPA, tumor volume was increased compared with that in control group. KEGG and GO enrichment analyses showed that the genes from ES-2 cell in 10 μM BPA-treated group were enriched mainly in central carbon metabolism and PI3K-AKT signaling pathway. Then, qRT‒PCR and western blotting results showed that BPA (10 μM) increased the mRNA and protein expression levels of glycolysis-related genes and mTOR, p-AKT HIF-1α and ERα in vitro/vivo ; whereas this effect was reduced after treatment with the ERα inhibitor methyl-piperidino-pyrazole. Furthermore, coimmunoprecipitation and mass spectrometry showed that BPA promoted the direct interaction of ERα with lactate dehydrogenase A. These results show that BPA directly promoted the proliferation, migration and invasion of ovarian cancer cells through the ERα/AKT/mTOR/HIF-1α signaling axis to enhance glycolysis.
研究领域:
肿瘤学
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分子生物学
·
细胞生物学
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产品关联
DOI
PubMed
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2018
·
IF 11.698
Penghui Ding,Jun Di,Xiaoliu Chen,Junze Zhao,Kaizhi Gu,Yi Zhang,Sheng Yin,Gaopeng Liu,Jiexiang Xia,Huaming Li
Light-mediated reactive oxygen species generation with water and oxygen is generally regarded as a mild and efficient way for organic pollutants removal. However, it is highly difficult but desirable to construct a photochemical system with increased reactive oxygen species production. Herein, by using Bi 2 O 2 CO 3 as a prototype, we devise a simple metal chloride-involved etching method to achieve better light absorption and charge carriers separation in a wide-band-gap semiconductor, thus giving rise to improved molecular oxygen activation. The improved photoinduced reactive oxygen species production is further verified by excellent photocatalytic degradation ability of RhB, TC and BPA under visible and ultraviolet light illumination. In addition, the metal chloride-induced strategies—heterojunction formation and cation doping—significantly affect the dynamics and transfer of carriers, which are advantageous to manipulate one-/two-electron pathway for producing reactive oxygen species.
研究领域:
环境科学
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材料科学
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光化学
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催化
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DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2024
·
IF 5.7
Mengqiong Zhang,Guowen Wang,Jiping Chen,Xianbo Lu
Bisphenol compounds (BPA, BPS, BPAF, etc.) are one class of the most important and widespread pollutants that poses severe threat to human health and the ecological environment. Because of the presence of multiple bisphenols in environmental and food samples, it is urgent and challenging to develop a rapid and cheap technique for simultaneously detecting BPA and its analogues. In this study, a series of M - N -C (M = Cu, Mg, Ni, Co, Fe, K) single-atom nanozymes (SAzymes) were created by simulating the structure of natural enzyme molecules, which were used as novel sensing platform for the fabrication of electrochemical sensors. Through systematic screening and characterization, it was interestingly discovered that the electrochemical sensor based on Cu- N -C SAzymes exhibited the best sensing performance for bisphenols among all SAzymes, which catalyzed not only BPA like tyrosinase, but also showed excellent catalytic capacity beyond tyrosinase (tyrosinase has no catalytic activity for BPS, BPAF, etc.), and achieved potential-resolved simultaneous rapid detection of BPA, BPS and BPAF. Further structure-activity relationship and catalytic mechanism characterizations of Cu- N -C SAzymes revealed that the presence of single atom Cu was predominantly in the form of Cu + and Cu 2+ , which were anchored onto graphene nanosheet support through four coordination bonds with pyridinic N and pyrrolic N and acted as highly efficient active centers for electrocatalytic oxidation of bisphenols. The developed electrochemical sensing method exhibited excellent selectivity, sensitivity, and reliability for the rapid detection of multiple bisphenols in actual samples.
研究领域:
分析化学
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环境科学
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材料科学
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纳米技术
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产品关联
DOI
PubMed
高影响因子
ACS Catalysis
·
2021
·
IF 13.084
Lipeng Wu,Bin Li,Yang Li,Xiaobin Fan,Fengbao Zhang,Guoliang Zhang,Qing Xia,Wenchao Peng
Herein, a series of Co@N–C materials are synthesized using nitrates (LiNO3, NaNO3, and KNO3) as templates to control the preferential growth of the cobalt (200) facet. Co@N–C–X (X = LiNO3, NaNO3, and KNO3) exhibit excellent activities and long-term stabilities for Fenton-like degradation of bisphenol A (BPA) with peroxymonosulfate (PMS) as an oxidant. The texture coefficient (TC) is used to investigate the relationship between the Co facets and their catalytic activities, and a linear relation is built between the TC of Co(200) and the reaction rate constant (k). Co(200) is therefore the most active facet for PMS activation, while nitrates can promote the preferential growth of the Co(200) facet. Moreover, the Co(200) facet is more stable against leaching and can achieve more quick transformation between Co2+/Co3+. Quenching tests, electron paramagnetic resonance spectra, and electrochemical tests show that singlet oxygen (1O2) plays the dominant role for BPA degradation. Density functional theory verifies that Co nanoparticles coated with a graphitic nitrogen-doped carbon layer have the best activity for PMS activation. This work first proposes the strategy of using nitrates to control the preferential growth of Co facets and reveals the relationship between the TC value and k, thus attracting great interest in the environmental field.
研究领域:
环境科学
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催化
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材料科学
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产品关联
DOI
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
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2021
·
IF 7.963
Muhammad Usman,Adeel Ahmed,Zhijian Ji,Bing Yu,Youqing Shen,Hailin Cong
Heavy metals and endocrine disrupters often co-exist in wastewater, while their possible competition behaviours make uptake removal more challenging. Therefore, β-Cyclodextrin based nanocomposite adsorbent was successfully fabricated (β-Cyclodextrin/ZrO 2 ) for the simultaneous uptake of Pb(II) and Bisphenol A from wastewater. FTIR, XRD , and XPS confirmed the successful fabrication of the β-Cyclodextrin/ZrO 2 nanocomposite. In this setting, oxygen-containing groups are primarily responsible for the Pb(II) binding, while the β-Cyclodextrin cavities adsorb Bisphenol A through host-guest interaction, enabling the simultaneous removal of Pb(II) and Bisphenol A. In the mono contaminant system, the nanocomposite displayed prominent removal ability toward Pb(II) and Bisphenol A with adsorption characteristics of pseudo-second-order, Langmuir, and Freundlich isotherm model. The maximum adsorption capacities were identified for Pb(II) and Bisphenol A to be 274.4 mg/g and 174.9 mg/g at 298 K, respectively. Most importantly, the β-Cyclodextrin/ZrO 2 could efficiently attain simultaneous removal of Pb(II) and Bisphenol A by avoiding their competitive behaviours was due to the different adsorption mechanisms (electrostatic interaction and host-guest interaction). Moreover, the adsorbed Pb(II) and Bisphenol A could be successfully recovered with a slight decline in nanocomposite removal performance even after 4 cycles in the binary-component system. All these findings provide insights into the fabrication of highly effective adsorbent with separated adsorption sites to treat wastewater bearing heavy metal and endocrine disrupters.
研究领域:
环境科学
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纳米技术
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水处理
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材料科学
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吸附技术
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2011
·
IF 3.074
Wenlu Guo,Wei Hu,Jianming Pan,Hongchun Zhou,Wei Guan,Xue Wang,Jiangdong Dai,Longcheng Xu
Magnetic molecularly polymers (MMIPs) based on kaolinite/Fe 3 O 4 composites were successfully synthesized for the selective adsorption and separation of bisphenol A (BPA) from aqueous solutions. During polymerization, the modified kaolinite/Fe 3 O 4 (KLT/Fe 3 O 4 ) not only was used as supporter but also functional monomer. The properties of MMIPs were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) analysis, and thermogravimetric analysis (TGA) and so on. The SEM graphs showed that much of KLT/Fe 3 O 4 was successfully coated by the imprinted layer, TGA analysis suggested the grafting yield of imprinted layer to KLT/Fe 3 O 4 was 72.51 wt%. The effects of pH, initial BPA concentration, contact time and temperature of the medium on the adsorption were studied by the batch mode experiment. The equilibrium data was well described by the Langmuir isotherm model. The kinetics of adsorption followed the pseudo-second-order model and the rate constant decreased with the increase of temperature, indicating exothermal nature of adsorption process. For desorption studies, the highest desorption efficiency (95.75%) was obtained using methanol and acetic acid as eluting solution (v:v = 8:2). Moreover, the selectivity of MMIPs was further demonstrated through HPLC analysis of the stimulant water samples, the result showed that MMIPs could effectively recognize BPA in mixed solution.
研究领域:
环境科学
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材料科学
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分析化学
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产品关联
DOI
高影响因子
CHROMATOGRAPHIA
·
2018
·Vol. 81
·期 5
·749-758
·
IF 1.401
Yin Dan,Chen Yanlong,Zhang Yanhao,Yang Zhicong,Mao Hongyan,Xia Shaige,Zhang Wenfen,Zhao Wuduo,Zhang Shusheng
Abstract A rapid and effective solid-phase extraction high-performance liquid chromatography fluorescence detection (SPE-HPLC–FLD) method, using a novel porous aromatic framework (PAF-6) as solid-phase extraction sorbent, was established to enrich and determine bisphenol (BPA) in milk and its packing samples. Parameters influencing the extraction efficiency, such as volume of the sample solutions, pH of the sample, and the eluent volume, were examined. The limits of detection and quantitation were 0.1 and 0.33 ng mL −1 , respectively. The recovery of the method was desirable at 81–91% and the relative standard deviation was less than 2.35%. Besides, the PAF-6-based cartridges exhibited superior reusability for milk sample analysis. In addition, theoretical computations were performed to further understand the molecular interaction mechanism between the PAF-6 and the BPA. The results showed that PAF-6 had an excellent adsorption capability for BPA based on hydrogen bonding and the inclusion interactions of host–guest. The proposed method is sensitive, simple, and cost-saving, and provides a detection platform for the monitoring of BPA residues in real milk samples. Graphical Abstract
研究领域:
分析化学
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环境科学
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食品安全
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产品关联
DOI
高影响因子
JOURNAL OF APPLIED ELECTROCHEMISTRY
·
2022
·Vol. 52
·期 11
·1617-1628
·
IF 2.925
Chen Jinyang,Huang Xiaozhou,Ye Ruihong,Huang Dihui,Wang Yanjun,Chen Sheng
A series of conductive metal–organic frameworks (M-CATs) were synthesized using 2,3,6,7,10,11-hexahydroxytriphenylas a ligand following a solvothermal method, and the Cu-CAT system exhibiting the best performance was identified. Conductive Cu-CAT-anchored reduction graphene oxide composites (Cu-CAT@rGO) were prepared following a hydrothermal method. The microstructures of the systems were further characterized using X-ray diffraction, scanning electron microscopy, energy dispersion spectroscopy, and transmission electron microscopy techniques. The drip-casting membrane method was used for the fabrication of a novel electrochemical sensor based on the conductive Cu-CAT-anchored rGO (Cu-CAT@rGO/GCE). The electrochemical performance of Cu-CAT@rGO/GCE was studied using electrochemical impedance spectroscopy and cyclic voltammetry techniques. The differential pulse voltamme try technique was used for electrochemical sensing to detect the content of bisphenol A (BPA) in beverage bottles. An excellent linear detection range (0.05–100 µmol L −1 ) and a low detection limit (4.9 nmol L − 1 ; based on S/N = 3) were recorded. Therefore, this method can potentially be used to develop a new route for the detection of BPA. Graphical abstract
研究领域:
材料科学
·
分析化学
·
环境科学
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产品关联
DOI
高影响因子
Journal of Environmental Chemical Engineering
·
2023
·
IF 7.7
Enliang Zhang,Peng Zhao,Guogang Xu,Fanpeng Meng,Xinzhen Wang,Yuanhui Gao,Lulu Liu,Shaowei Jin
In recent years, micropollutants contamination in aquatic environments has received increasing attention. Bisphenol A (BPA), an endocrine-disrupting compound, has emerged as a substantial threat to water safety owing to its widespread presence in various aquatic environments. To address this issue, this study focused on the development of ceramic membranes incorporating manganese-cobalt oxides (MCOs) to catalyze the ozone-based degradation of BPA. The catalytic layer was prepared by hydrothermal in-situ growth method, which enhanced BPA degradation during water treatment and improved the ceramic membrane’s resistance to contamination. Moreover this study investigated the synergistic effect of catalytic ozone oxidation in mitigating ceramic membrane pollution and degrading micropollutants. The catalytic mechanism and the contamination modeling were examined systematically to determine the mechanism of micropollutant contamination on ceramic membranes. The experimental results showed that the modified ceramic membrane exhibited a higher BPA removal efficiency (90.6%) and flux recovery (99.5%) than the unmodified membrane (64.2% and 79%, respectively). Furthermore, the MCOs-modified ceramic membrane (CCM) effectively enhanced the generation of hydroxyl radicals during ozonolysis. This enhancement resulted in better degradation of organic pollutants in water, thus improving the quality of the treated water. The combination of ceramic membrane catalytic separation with ozone oxidation technology offers a potential solution for the degradation of emerging pollutants and the mitigation of ceramic membrane pollution.
研究领域:
环境科学
·
材料科学
·
化学工程
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产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2023
·
IF 5.2
Xiaoyi Dong,Zhaoyi Yin,Liang Xu,Junhao Ma,Haomiao Cao,Yongjin Li,Qi Wang,Jin Han,Jianbei Qiu,Zhengwen Yang,Zhiguo Song
To achieve efficient degradation of organic pollutants, two critical objectives are enhancing photogenerated carrier separation and expanding the spectral response range. In this study, we synthesized atom-sharing Bi/Bi 4 O 5 Br 2 :Yb 3+ ,Tm 3+ (Bi/BYT) heterojunctions with surface plasmon resonance (SPR) effects and upconversion (UC) by employing self-sacrificial Bi 4 O 5 Br 2 :Yb 3+ ,Tm 3+ (BYT) fractions as a source of metallic Bi. Results revealed that the optimal Bi/BYT-2 catalyst exhibited the highest BPA degradation efficiency within 120 min, representing a significant 1.3-fold improvement over BYT alone. This outstanding catalytic performance can be attributed to the synergistic interplay between UC fluorescence, the unique SPR effect of Bi metal, and the atom-sharing heterojunction. These factors effectively broaden the spectral absorption range and significantly enhance the separation and utilization efficiency of photoinduced carriers. This study lays the groundwork for the development and design of novel atomic-level contact heterojunctions, offering insights into enhancing photocatalytic efficiency through plasmon resonance and UC fluorescence on non-precious metal surfaces.
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产品关联
DOI
高影响因子
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2023
·Vol. 25
·期 19
·13716-13727
·
IF 3.3
Caihong Wang,Yong Liu,Fengshen Han,Yongzhe Han,Tianyu Liu,Haitao Ren,Xu Han
Using metal-free catalysts is widely recognized as a promising approach toward wastewater remediation because of the absence of metal leaching. However, the oxidation products involved in the oxidation process and the corresponding mechanisms are still not clear. In this work, N-doped carbocatalysts (CN) were fabricated using as-prepared g-C3N4 and glucose solution, and the reactivity of the as-prepared catalysts was optimized by controlling calcination temperature. Correspondingly, increasing the calcination temperature promotes the catalytic oxidation of BPA. The positive correlations between the contents of pyridinic-N and graphitic-N and the kobs values of BPA oxidation, as well as XPS analysis indicate the important roles of pyridinic-N and graphitic-N in BPA oxidation. According to the series of characterizations of the oxidation products and Raman analysis of the reaction process, the moderately activated persulfate (PS) on the CN catalyst is the predominant species in BPA oxidation and BPA can be oxidized to BPA polymers with high selectivity by H-abstraction under alkaline conditions. This work highlights the important role of the moderate activation of PS in the polymerization of phenolic contaminants under alkaline conditions, which enriches our understanding of the oxidation of aromatic contaminants by PS under alkaline conditions.
研究领域:
环境科学
·
催化化学
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产品关联
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Ning Chen,Jun Han,Xingchen He,Junhui Shao,Najun Li,Dongyun Chen,Jianmei Lu
Efficient and recyclable piezocatalysts are expected to use natural mechanical energy to degrade organic pollutants in water during piezoelectric degradation. Herein, flexible piezocatalytic membrane (HPVDF/Ti 3 C 2 ) was obtained by introducing Ti 3 C 2 nanosheets into PVDF with further hydrophilic modification. Polar functional groups on the Ti 3 C 2 surface interact with PVDF chains to form the high piezoelectric β-phase. The good conductivity of Ti 3 C 2 contributes to enhanced electron transport in PVDF/Ti 3 C 2 . The hydrophilic and porous HPVDF/Ti 3 C 2 composite membranes facilitate the abundant adsorption and catalytic sites. Thus, HPVDF/Ti 3 C 2 degraded BPA in water under ultrasonic vibration at a rate constant 29.5 times higher than that of the pure PVDF. Furthermore, HPVDF/Ti 3 C 2 membranes coated on stainless steel packing in filled column were found to be effective in the removal of bisphenol A (BPA) under conditions of peristaltic pump-driven water flow, thus providing a promising piezoelectric membrane for water purification using low-frequency mechanical energy from nature.
研究领域:
环境科学
·
材料科学
·
纳米技术
·
水净化技术
·
电化学
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高分子科学
·
催化作用
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）