JOURNAL OF HAZARDOUS MATERIALS
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2023
·
IF 13.6
Jingxuan Zhao,Hongxu Liu,Peng Xue,Yuchao Qi,Ziwei Lv,Ruijia Wang,Yucheng Wang,Shulin Sun
In the process of removing dye wastewater, the membrane surface is susceptible to contamination, resulting in reduced performance and limited dye separation efficiency. A single hydrophilic modification layer is not enough to achieve effective separation of different types of dyes. The present research designed a "double layer protection" method in order to overcome the above deficiencies. A solution of dopamine (DA) coated carbon nanotubes (CNTs-COOH) was covered on the surface of the polyvinylidene fluoride (PVDF) membrane by deposition, followed by grafting a layer of chitosan (CS) polymer brushes on its surface. The spatial double layer structure provides an excellent barrier effect and effectively reduces the contamination of dyes. When filtering different types of dyes, effective filtration of anionic and cationic dyes through the electrostatic effect of the first layer, the adsorption of CNTs in the second layer and the hydration layer of both layers. All membranes have excellent rejection properties. More importantly, the membranes also had good chemical and mechanical stability and their serviceability was not degraded. Therefore, the prepared PVDF-based multi-layer composite membranes behave a potential application prospect in the wastewater purification field.
研究领域:
材料科学
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环境工程
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化学工程
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DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
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2020
·
IF 3.594
Candi Liu,Nan Zhang,Xin Huang,Qiwen Wang,Xiaohong Wang,Shengtian Wang
A novel two-dimensional ZnO-MoO 3 -C nanocomposite was synthesized by the green thermal calcination method with the biochar of mushroom derived carbon nanosheets and Zn 1.5 PMo 12 O 40 polyoxometallate. The nanocomposite was used to modify a glassy carbon electrode (GCE) for the first time to construct an acetaminophen (AP) electrochemical biosensor. Scanning electron microscopy (SEM), X-ray diffraction (XRD) and nitrogen adsorption/desorption isotherm (BET) results showed that the synthesized ZnO-MoO 3 -C nanocomposite has many layered nanostructure and a large surface area. Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) indicated that ZnO-MoO 3 -C/GCE presented highly effective and accurate toward the oxidation of AP due to the stable molecular structure of the electrode surface. The DPV response of the proposed sensor exhibited selectively and sensitively determination for AP with a wider linear dependence on the concentration of AP from 2.5 to 2000 μM, and lower limits of detection (LOD) 1.14 μM, compared with other carbon-base material modified GCE and GCE electrodes. In addition, the proposed sensor was applied to detection of AP in real samples, and the recovery was the range from 94.7 to 101.0%, and RSD was less than 5%. It indicates that the proposed sensor has a hopeful capacity of extensive applications in bioanalysis and tablets.
研究领域:
材料科学
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分析化学
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生物医学工程
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DOI
高影响因子
Small
·
2018
·Vol. 14
·期 20
·1704433
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IF 9.598
Yizhi Zhang,Zhuyuan Wang,Lei Wu,Shenfei Zong,Binfeng Yun,Yiping Cui
Isolating and in situ profiling the heterogeneous molecular phenotype of circulating tumor cells are of great significance for clinical cancer diagnosis and personalized therapy. Herein, an on-chip strategy is proposed that combines size-based microfluidic cell isolation with multiple spectrally orthogonal surface-enhanced Raman spectroscopy (SERS) analysis for in situ profiling of cell membrane proteins and identification of cancer subpopulations. With the developed microfluidic chip, tumor cells are sieved from blood on the basis of size discrepancy. To enable multiplex phenotypic analysis, three kinds of spectrally orthogonal SERS aptamer nanovectors are designed, providing individual cells with composite spectral signatures in accordance with surface protein expression. Next, to statistically demultiplex the complex SERS signature and profile the cellular proteomic phenotype, a revised classic least square algorithm is employed to obtain the 3D phenotypic information at single-cell resolution. Combined with categorization algorithm partial least square discriminate analysis, cells from different human breast cancer subtypes can be reliably classified with high sensitivity and selectivity. The results demonstrate that this platform can identify cancer subtypes with the spectral information correlated to the clinically relevant surface receptors, which holds great potential for clinical cancer diagnosis and precision medicine.
研究领域:
生物医学工程
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癌症研究
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分析化学
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微流控技术
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DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2018
·Vol. 185
·期 10
·1-9
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IF 5.705
Wang Yanying,Yang Li,Liu Yaqin,Zhao Qingbiao,Ding Fang,Zou Ping,Rao Hanbing,Wang Xianxiang
A composite consisting of NiCo 2 S 4 and reduced graphene oxide (rGO) was prepared via a hydrothermal process. Compared to individual NiCo 2 S 4 nanomaterials or reduced graphene oxide, the composite exhibits enhanced oxidase-like activity. It is found that dopamine (DA) inhibits the ability of NiCo 2 S 4 -rGO to oxidize the substrate 3,3′,5′,5′-tetramethylbenzidine (TMB) to form blue colored ox-TMB. Based on these findings, a colorimetric method for determination of DA was worked out. The absorption, best measured at 652 nm, increases linearly in the 0.5–100 μM DA concentration range, and the limit of detection is 0.42 μM. This method was successfully applied to the detection of DA in spiked human serum samples.
A hierarchical NiCo 2 S 4 -rGO composite was prepared through two-step hydrothermal process. It exhibits enhanced oxidase-like activity which, however, is inhibited by dopamine (DA). Hence, less blue colored ox-TMB is formed by oxidation of 3,3′,5,5′-tetramethylbenzidine in the presence of dopamine.
研究领域:
材料科学
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分析化学
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生物传感器
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PubMed
高影响因子
LUMINESCENCE
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2022
·Vol. 37
·期 9
·1414-1426
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IF 2.613
Xiaoyu Yang,Lulu Lei,Donghui Song,Yue Sun,Meng Yang,Zhen Sang,Jianan Zhou,Hui Huang,Yongxin Li
To realize the efficient differential sensing of phenolic pollutants in sewage, a novel sensing strategy was successfully developed based on a nanozyme (GMP-Cu) with polyphenol oxidase activity. Phenolic pollutants can be oxidized using GMP-Cu, and the oxidation products reacts subsequently with 4-aminoantipyrine to produce a quinone-imine compound. The absorption spectra of final quinone-imine products that resulted from different phenolic pollutants showed obvious differences, which were due to the interaction difference between GMP-Cu and phenolic pollutants, as well as the different molecular structures of the quinone-imine products from different phenolic pollutants. Based on the difference in the absorption spectra, a novel differential sensing strategy was developed. A genetic algorithm was used to select the characteristic wavelengths at different enzymatic reaction times. Hierarchical cluster analysis and PLS-DA algorithms were utilized for the discriminant sensing of seven representative phenolic pollutants, including hydroquinone, resorcinol, catechol, resorcinol, phenol, p -chlorophenol, and 2,4-dichlorophenol. A scientific wavelength selection algorithm and a recognition algorithm resulted in the successful identification of phenolic pollutants in sewage with a discriminant accuracy of 100%, and differentiation of the phenolic pollutants regardless of their concentration. These results indicated that a sensing strategy can be used as an effective tool for the efficient identification and differentiation of phenolic pollutants in sewage.
研究领域:
环境科学
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分析化学
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纳米技术
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PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2026
·
IF 12.5
Yue Li,Peihua Li,Rufeng Tian,Xingzi Bian,Jian Wang,Rui Li,Wanggang Zhang,Jiancheng Wang,Yiming Liu
Photoelectrochemical (PEC) seawater splitting offers a sustainable route for hydrogen production; however, it is challenged by the corrosion and sluggish kinetics of photoanodes in chloride-rich electrolytes. To overcome this, we developed a bimetallic metal-organic framework (MOFs) structure with oxygen vacancies (O V ) on TiO 2 nanorods, denoted as (DA)Ni/Mo–MOFs@TiO 2 . This photoanode achieved a high photocurrent density of 2.21 mA·cm −2 and H 2 production rate of 36.07 μmol·cm −2 ·h −1 in real seawater. Notably, it undergoes in situ reconstruction during the oxygen evolution reaction (OER), forming catalytically active Ov–NiOOH accompanied by a protective MoO 4 2− layer. In situ Raman and X-ray photoelectron spectroscopy (XPS) directly revealed the reconstruction process and interfacial adsorption. Density functional theory (DFT) calculations further demonstrated that the reconstructed surface selectively stabilized *OH intermediates (E ad = −4.26 eV), thereby enhancing the OER selectivity and corrosion resistance. This system demonstrated exceptional stability, exhibiting minimal faradaic efficiency loss (1.2–2.3%) in high chloride ion environments (0.7–1 mol/L NaCl). This study provides a novel strategy for designing durable photoelectrodes via pre-catalyst reconstruction.
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DOI
高影响因子
Foods
·
2025
·Vol. 14
·期 14
·2441
·
IF 5.1
Erlin Zhai,Jing Zhang,Jiancai Zhu,Rujuan Zhou,Yunwei Niu,Zuobing Xiao
Lard imparts unique organoleptic properties that underpin its essential role in Chinese gastronomy; however, the specific lipid precursors contributing to its aroma remain unclear. This study explores the flavor formation mechanism of lard by comparing its texture and aroma at two preparation temperatures, 130 °C and 100 °C. We identified a total of 256 and 253 lipids at these temperatures, respectively, with triacylglycerols (TGs) and diacylglycerols (DGs) being the predominant lipid species. An HS-GC-IMS analysis detected 67 volatile compounds, predominantly aldehydes, acids, and alcohols. A subsequent Orthogonal Partial Least Squares-Discriminant Analysis (OPLS-DA) identified 49 discriminatory lipids and 20 differential volatiles. A correlation analysis showed a positive relationship between aldehydes and unsaturated triglycerides in lard, with TG (16:1-16:1-18:0), TG (17:2-18:1-18:1), TG (16:1-17:1-18:1), and TG (18:1-18:1-20:1) identified as characteristic markers at both temperatures. Furthermore, there was a positive correlation between ketones and alcohols and phospholipids and sphingolipids containing unsaturated fatty acid chains. TGs and glycerophospholipids (GPs), rich in polyunsaturated fatty acids, are likely key precursors driving the formation of distinct flavors during lard processing. This study elucidates the mechanistic interactions between lipids and volatile organic compounds, providing a framework for optimizing lard processing protocols and flavor modulation.
研究领域:
食品化学
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脂质科学
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风味化学
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分析化学
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食品加工
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DOI
PubMed
高影响因子
ANNALS OF MEDICINE
·
2025
·
IF 4.3
Yun Yang,Lengqiu Guo,Jinghua Yu,Wei Peng,Qi Wang,Lan Wei,Xihua Chen,Chunyan Min,Xiaogang Jiang,Song Zhu,Haixin Zhao,Zhenyu Xuan,Jianzhong Yu,Jian Zhang
Background Da-Yuan-Yin Decoction (DYY), used since the early Qing Dynasty in China for damp-heat syndrome, was evaluated for its comprehensive protective effects.Materials and methods Rats received a high-fat/high-sugar diet for 14 days, then daily exposure to high temperature/humidity (31.0 ± 0.5°C, 85%-95%) for 10 hours over 14 days. Damp-heat syndrome was induced on day 29 via intraperitoneal lipopolysaccharide (LPS) injections (1 mg/kg and 0.5 mg/kg after 4 hours). Two hours post-modeling, rats received DYY (400 or 800 mg/kg/day) orally for 5 days. Symptoms were scored. On day 33, kidney, spleen, tongue, lung, liver, stomach, and colon tissues underwent histopathological and immunochemical/immunofluorescence analysis. Serum levels of inflammation factors, C-reactive protein (CRP), cell-free DNA (cfDNA), myeloperoxidase (MPO), and superoxide dismutase (SOD) were quantified. Complete blood count (CBC), blood biochemistry, short-chain fatty acids (SCFAs), gut microbiota composition in the colon, and metabolites in the cecum were analyzed.Results DYY significantly reduced symptom scores and decreased CRP level, while also regulating parameters in CBC and biochemical profiles. The treatment ameliorated tissue damage in the kidney, spleen, tongue, lung, liver, stomach, and colon. DYY downregulated citrullinated histone H3 (Cit H3), polyclonal peptidylarginine deiminase 4 (PADI4), and MPO expressions in the lung, stomach, and colon. Furthermore, it modulated inflammatory responses, suppressed the interleukin-23 (IL-23)/janus kinase-2 (JAK2)/signal transduction and transcription activator-3 (STAT3) signaling pathway and enhanced antioxidant activity. DYY administration significantly increased total SCFA content. The intervention restored gut microbiota diversity and abundance, while ameliorating metabolic dysregulation.Conclusion Systemic pathophysiological alterations were observed in rats with damp-heat syndrome. The comprehensive protective effects of DYY involved suppression of neutrophil extracellular traps (NETs) formation through downregulation of PADI4 expression, modulation of inflammatory responses, inhibition of the IL-23/JAK2/STAT3 signaling pathway, restoration of intestinal microecological balance and metabolic homeostasis, and enhancement of antioxidant.
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PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2024
·
IF 5.4
Xiaoduo Zhao,Lumin Yang,Licheng Zhang,Le Ji,Shuanhong Ma,Feng Zhou
The early stages of osteoarthritis (OA) in the joints are typically characterized by two key factors: the dysfunction of articular cartilage lubrication and inflammation resulting from the excessive production of reactive oxygen species (ROS). Synthetic injectable macromolecular materials present great potential for preventing the progression of early OA. In this study, to mimic the excellent lubricity of brush-like aggregates found in natural synovial fluid, we develop a novel macromolecular biolubricant (CS-PS-DA) by integrating adhesion and hydration groups onto backbone of natural biomacromolecules. CS-PS-DA exhibits a strong affinity for cartilage surfaces, enabling the formation of a stable lubrication layer at the sliding interface of degraded cartilages to restore joint lubrication performance. In vitro results from ROS scavenging and anti-inflammatory experiments indicate the great advantage of CS-PS-DA to decrease the levels of proinflammatory cytokines by inhibiting ROS overproduction. Finally, in vivo rats OA model demonstrates that intra-cavitary injection of CS-PS-DA could effectively resist cartilage wear and mitigated inflammation in the joints. This novel biolubricant provides a new and timely strategy for the treatment of OA.
研究领域:
生物材料
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骨科
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生物医学工程
·
药理学
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产品关联
DOI
PubMed
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2022
·
IF 6.056
Bingsong Ma,Jiacai Wang,Binxing Zhou,Zihao Wang,Youyi Huang,Cunqiang Ma,Xinghui Li
To explore the impact of harvest season in white tea, high-performance liquid chromatography (HPLC) and amino acid analyzer were developed for the determinations of 17 phenolic compounds, 3 purine alkaloids, 19 amino acids, γ-aminobutyric acid (GABA) and 4 main quality components in 18 Bai mudan sub-type of Xinyang white teas harvested in spring, summer and autumn seasons, respectively. Additionally, the in vitro antioxidant capacity was evaluated by 5 various assays. Principal component analysis (PCA), hierarchical cluster analysis (HCA) and partial least squares-discriminant analysis (PLS-DA) could completely classify these white teas by the harvest season, and indicated its profound impact on chemical composition in white tea. 14 Characteristic compounds (VIP ≥1.0), such as (−)-epigallocatechin (EGC), gallic acid, caffeine, l -theanine, conduced to identify the harvest season of white tea. Through comparison, the spring tea was observed to possess the highest amino acids, catechins contents and in vitro antioxidant capacity. (−)-Epicatechin (EC), EGC, (−)-epicatechin gallate (ECG) and (−)-epigallocatechin gallate (EGCG) were considered as the major antioxidants in white tea due to their highly significantly ( p < 0.01) positive correlations. Overall, the research results provided support for the identification of harvest season in white tea.
研究领域:
食品科学
·
化学
·
农业科学
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DOI
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2023
·
IF 8.1
Xiao-Li Yin,Zhi-Xin Peng,Yuan Pan,Yi Lv,Wanjun Long,Hui-Wen Gu,Haiyan Fu,Yuanbin She
Wine is a very popular alcoholic drink owing to its health benefits of antioxidant effects. However, profits-driven frauds of wine especially false declarations of variety frequently occurred in markets. In this work, an UHPLC-QTOF-MS-based untargeted metabolomics method was developed for metabolite profiling of 119 bottles of Chinese red wines from four varieties (Cabernet Sauvignon, Merlot, Cabernet Gernischt, and Pinot Noir). The metabolites of red wines from different varieties were assessed using orthogonal partial least-squares discriminant analysis (OPLS-DA) and analyzed using KEGG metabolic pathway analysis. Results showed that the differential compounds among different varieties of red wines are mainly flavonoids, phenols, indoles and amino acids. The KEGG metabolic pathway analysis showed that indoles metabolism and flavonoids metabolism are closely related to wine varieties. Based on the differential compounds, OPLS-DA models could identify external validation wine samples with a total correct rate of 90.9% in positive ionization mode and 100% in negative ionization mode. This study indicated that the developed untargeted metabolomics method based on UHPLC-QTOF-MS is a potential tool to identify the varieties of Chinese red wines.
研究领域:
食品科学
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分析化学
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代谢组学
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产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Yuanyuan Tang,Lili Zhang,Xinxin Ge,Yingying Zhang,Yan Liu,Juncheng Wang
Heavy metal ion contamination poses a significant threat to both our environment and human health. Consequently, there is a need for proficient and environmentally friendly remediation techniques to tackle this issue. Among various strategies, membrane-based separation using graphene oxide (GO) laminate membranes has emerged as a promising solution. However, traditional GO membranes have low water permeance, poor selectivity, structural instability, and inconsistent layer spacing. In this study, we cross-linked GO with polydopamine/polyethyleneimine (DA/PEI) using a mild one-step strategy to prepare a GO@DA/PEI membrane for heavy metal ion removal and evaluated the effect of cross-linking duration on the interlayer structure, membrane properties, and heavy metal ion removal performance. The successful formation of a cross-linked network between DA/PEI and GO was proven by various characterization methods. Compared with previously reported GO-based membranes, the prepared GO@DA/PEI 40 membrane exhibited excellent performance, including a peak pure water flux of 326.7 L/m 2 h and ion rejection of 99.6 % for Cu 2+ , 93.5 % for Pb 2+ , and 96.6 % for Zn 2+ , thereby overcoming the conventional trade-off” effect. The mechanism for the high flux was discussed. The cross-linking reaction between the oxygen-containing functional groups at the edges and basal planes of the GO flakes and DA/PEI were crucial to the high flux. In addition, the GO@DA/PEI 40 membrane had excellent anti-fouling performance in the presence of humic acid and long-term stability under different conditions. Overall, the GO@DA/PEI membrane has good potential for heavy metal ion removal.
研究领域:
环境科学
·
材料科学
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DOI
高影响因子
危险品化学品经营许可证（带存储）