JOURNAL OF CONTROLLED RELEASE
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2025
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IF 11.5
Jianfeng Yang,Hongyi Jiang,Congcong Wu,Yuzhe Lin,Guancan Tan,Juannan Zhan,Lijiang Han,Yiting Zhu,Ping Shang,Liangle Liu,Haixiao Liu
With the increasing global aging population, osteoarthritis (OA) has emerged as a major public health concern. OA pathogenesis is characterized by a complex interplay among inflammatory cytokines, reactive oxygen species, and extracellular matrix components, leading to cartilage degradation. Astragaloside-IV (AS-IV), a natural antioxidant, has shown promise in alleviating OA symptoms but is limited by poor bioavailability and ineffective cartilage drug delivery. To address these challenges, we aimed to develop a drug delivery system using copper silicate nanoparticles modified with polyethylene glycol and loaded with AS-IV (referred to as CSP@AS-IV). This system uses mesoporous silica nanoparticles with a hybrid metal framework to enhance drug release and efficacy. CSP@AS-IV degrades in the acidic OA microenvironment, releasing copper ions (Cu 2+ ) and AS-IV, which synergistically exert antioxidant, antibacterial, anti-inflammatory, and chondroprotective effects. Both in vitro and in vivo rat model experiments demonstrated that CSP@AS-IV significantly alleviated joint inflammation, downregulated inflammatory marker expression, and promoted cartilage repair. These findings underscore that CSP@AS-IV offers considerable clinical potential for enhancing OA treatment outcomes.
研究领域:
药理学
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纳米技术
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骨科
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炎症研究
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
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2024
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IF 8.3
Xue-Bo Liu,Rui Zhao,Min-Min Xu,Shang-Xiong Wei,Xue-Feng Cheng,Jing-Hui He
The electrochemical reduction of nitrate to ammonia (NO3RR) provides a desired alternative of the traditional Haber–Bosch route for ammonia production, igniting a research boom in the development of electrocatalysts with high activity. Among them, molecular electrocatalysts hold considerable promise for the NO3RR, suppressing the competing hydrogen evolution reaction. However, the complicated synthesis procedure, usage of environmentally unfriendly organic solvents, and poor stability of Cu-based molecular electrocatalysts greatly limit their employment in NO3RR, and the development of desired Cu-based molecular catalysts remains challenging. Herein, a simple nonorganic solvent involving a one-step strategy was proposed to synthesize d−π-conjugated molecular electrocatalysts metal–amidinothiourea (M-ATU). Cu-ATU is composed of Cu coordinated with two S and two N atoms, whereas Ni-ATU is formed by Ni with four N atoms from two ATU ligands. Remarkably, Cu-ATU with a Cu–N2S2 coordination configuration exhibits superior NO3RR activity with a NH3 yield rate of 159.8 mg h–1 mgcat–1 (−1.54 V) and Faradaic efficiency of 91.7% (−1.34 V), outperforming previously reported molecular catalysts. Compared to Ni-ATU, Cu-ATU transfers more electrons to the *NO intermediate, effectively breaking the strong sp2 hybridization system and weakening the energy of N═O bonds. The increase in free energy of *NO reduced the energy barriers of the rate-determining step, facilitating the further hydrogenation process over Cu-ATU. Our work opened up a new horizon for exploring molecular electrocatalysts for nitrate activation and paved a way for the in-depth understanding of catalytic behaviors, aligning more closely with industrial demands.
研究领域:
化学
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环境科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL TECHNOLOGY
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2024
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IF 2.2
Yueming Zhu,Yuexiang Gao,Fei Yang
It is critical to effectively eliminate recalcitrant organic pollutants from wastewater. In this paper, the MoSe2/SrTiO3 (MST) catalysts were synthesized through simply controlling the amount of MoSe2 in the hydrothermal method to activate peroxymonosulfate (PMS) for the degradation of pollutants. The results demonstrated that sulfamethoxazole and tetracycline were almost eliminated by PMS/MST-3 (MoSe2/SrTiO3 mass ratio 0.3: 1) activation system. The effect of inorganic anions (Cl –, H2PO4 –, HCO3 –) and metal ions (Cu2+, Ni2+, Zn2+) commonly found in actual water bodies on catalytic reaction was explored. Moreover, SO4• –, •OH and 1O2 were identified by EPR tests and scavenger experiments, where the SO4• – and •OH were the dominant reactive species. The XPS analysis indicated that the oxygen vacancies and charge transfer on the catalyst surface were the keys of PMS activation. The effect of active sites in SMX and TC on the catalytic degradation activity was explored by density functional theory, and it was obtained that the central nitrogen site of SMX was more vulnerable in the catalytic system, while the edge oxygen site of TC was more susceptible to attack.
研究领域:
环境科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
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2024
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IF 5.8
Jie Zhao,Dequan Zhou,Qiang He,Jian Zhang,Binghua Yao
Piezoelectric catalysis is a recently developed eco-friendly approach for the treatment of pollutant. In this study, a piezoelectric catalytic system of manganese indium sulphide (MnIn 2 S 4 ) was constructed for eliminating oxytetracycline (OTC) residues. X-ray diffraction and Scanning electron microscopy showed that MnIn 2 S 4 microspheres with a grain size of 3–5 μm could be hydrothermally produced. Brunauer–Emmett–Teller analysis showed that the specific surface area of the MnIn 2 S 4 sample was 26.6 m 2 ·g −1 , and the average pore size was 20.2 nm. The electrochemical performance test showed that the piezoelectric response current of the MnIn 2 S 4 sample was 0.35 × 10 −6 A. Using OTC as a degradation model, the piezoelectric catalytic performance of MnIn 2 S 4 was explored. The results showed that the maximum degradation efficiency of the OTC could reach 82.2 % after 60 min while the piezoelectric power was 455 W, the pH of the reaction system was 4, the OTC concentration was 0.02 mM, and the MnIn 2 S 4 dosage was 1.4 g·L −1 . During the piezoelectric catalytic process, the main active species were identified as h + , 1 O 2 , and •OH. Meanwhile, eight intermediate products of OTC and three possible degradation pathways were found. This study is important for exploring the application of sulfide-based piezoelectric catalytic materials in wastewater treatment.
研究领域:
环境科学
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材料科学
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Da-Qi Cao,Rong-Kun Fang,Yi-Xuan Song,Ming-Guo Ma,Haiyan Li,Xiao-Di Hao,Rongling Wu,Xiangyu Chen
Antibiotic contamination of water bodies is a major concern in environmental management. Despite their superior efficacy in antibiotic removal, advanced oxidation processes (AOPs) have yet to be widely adopted owing to their substantial cost associated with the large amounts of chemicals required. In this study, a novel contact-electro-catalysis (CEC) process with reusable polytetrafluoroethylene (PTFE) particles as a trigger catalyst was applied to replace traditional AOPs, and it was able to degrade three typical antibiotics (sulfamethoxazole [SMX], ciprofloxacin [CIP], and tetracycline [TET]) in the secondary effluent of a wastewater treatment plant for the first time. The PTFE particles at a concentration of 0.8 g/L were introduced into antibiotic solutions with an antibiotic concentration of 1 mg/L, and the removal rates of SMX, CIP, and TET after a 90-min operation time reached 50 %, 80 %, and 90 %, respectively. Our findings revealed that the CEC reaction generated ● OH and 1 O 2 , contributing substantially to antibiotic degradation. Thus, new reactive oxygen species generation mechanisms during the CEC process were proposed. Furthermore, we fabricated polyvinylidene fluoride nanofiber membranes using electrospinning to recycle PTFE particles, where a nearly 100 % recovery rate through dead-end filtration was realized with a high water flux of 7.5 m 3 /(m 2 ∙h). The results of this study provide a promising approach for antibiotic removal from wastewater.
研究领域:
环境工程
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水处理
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催化
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纳米技术
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产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
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2024
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IF 6.3
Zhihao Zhang,Jing Wang,Huidi Zhang,Yao Deng,Binbin Tan,Jiang Wang,Ting Yang,Wenlei Wang
The strategy of constructing edge sulfur vacancies at cellulose surface interfaces has attracted widespread interest in fields such as electronics, photonics, optoelectronics, electrocatalysis, environmental remediation, and biosensing. In this study, NiCo 2 S 4 (NCS) was modified onto cellulose sulfide nanocrystals (SCNC) with chiral helical structures. Utilizing high energy β Particle bombardment on the surface of photocatalysts induces the generation of edge S vacancies in SCNC, while promoting the formation of heterometallic single-atom clusters (Co n , Ni n ) in NCS. The edge sulfur vacancies on the surface of SCNC exhibit high reactivity and adsorption capacity. The aggregation of Co and Ni at this position can transfer photo generated electrons to the edge sulfur vacancies, thereby protecting the edge sulfur vacancies and prolonging the carrier lifetime. Electrons enriched in edge S vacancies can activate the O–O bond of PMS, thereby achieving efficient degradation of ciprofloxacin (CIP). The degradation kinetics constant of Co n -Ni n /NCS/SCNC-S v /PMS is 1.69 times higher than that of NCS/SCNC/PMS. In addition, electron paramagnetic resonance (EPR) shows that the sample produces a large amount of 1 O 2 during photocatalysis This article constructs a new approach for protecting edge S vacancies with heterogeneous single atom clusters, providing a new perspective for achieving efficient photocatalytic degradation of CIP.
研究领域:
环境科学
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材料科学
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光催化
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产品关联
DOI
高影响因子
Journal of Water Process Engineering
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2025
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IF 6.7
Yu Yao,Chengqi Lu,Qianhong Shen,Yijin Yang,Kaiyue Huang,Libei Jiang,Jie Liu,Yue Li,Xudan Cao,Hui Yang
A novel ternary composite photocatalyst of nitrogen-doped carbon quantum dots (NCQDs)/tetrapods silver phosphate (Ag 3 PO 4 )/silver (Ag) nanoparticles was designed and fabricated. Kelvin probe force microscopy and in-situ irradiated X-ray photoelectron spectrum demonstrated the cooperative action between the S-scheme heterojunction and Schottky junction within this ternary composite system, which facilitate efficient dual-channel charge transfer and achieve high oxidation potential. Moreover, the incorporating of persulfate into the photocatalytic reaction system enhanced the capture of photogenerated electrons, while the generated SO 4 -· radicals further improved photocatalytic reaction efficiency. Consequently, the NCQDs/Ag 3 PO 4 /Ag photocatalyst exhibited remarkable photocatalytic performance for the removal of ciprofloxacin (CIP). The mineralization rate of CIP over NCQDs/Ag 3 PO 4 /Ag photocatalyst activated by persulfate was about 6.7 times greater compared to the bare Ag 3 PO 4 photocatalyst. Additionally, four potential pathways for the photocatalytic degradation of CIP were proposed utilizing the LC-MS analysis. Furthermore, this ternary composite photocatalyst not only demonstrated high cyclic stability but also exhibited robust photocatalytic activity in systems containing coexisting anions, cations or various natural water sources, thereby exhibiting its application potential for antibiotic degradation in real environmental settings.
研究领域:
环境科学
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材料科学
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产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
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2025
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IF 10.5
Suimin Deng,Yun Hao,Lina Yang,Tongtong Yu,Xiangfeng Wang,Hailing Liu,Yuan Liu,Mengxia Xie
Nanozymes possess the advantages of high stability, adjustable catalytic activity and simple preparation processes, which position them as a promising alternative to natural enzymes. In this work, an oxidase-like nanozyme has been prepared by loading mixed valence manganese oxides (Mn x O y ) on defective PCN-224 MOFs (dPCN). Dodecanoic acid was utilized to introduce abundant mesoporous defects into the dPCN, allowing manganese oxide to grow in situ on the surface and within the pores. The mixed valence state of manganese oxides endowed the Mn x O y @dPCN nanozyme (MdP) with redox and catalytic properties, and the high oxidase-like catalytic performance of MdP for TMB substrate also originated from its favorable electrical conductivity and affinity to the substrate. The reactive oxygen species of the catalytic reaction were mainly singlet oxygen ( 1 O 2 ) and peroxyl radicals (·O 2 − ). Without the existence of hydrogen peroxide (H 2 O 2 ), the nanozyme can rapidly and efficiently oxidize TMB substrate into blue oxidation state, which has strong absorbance at 650 nm. An immunosensor for detecting biomarker procalcitonin (PCT) in human serum samples has been established based on the high catalytic property of MdP nanozyme. The immunoassay for PCT has satisfactory accuracy and repeatability, and its linear detection range can reach to be 0.05–100 ng mL −1 with a limit of detection (LOD) of 0.011 ng mL −1 . The result affords a promising idea to construct oxidase-like nanozyme, and provides a method for sensitive determination of PCT in complex matrices.
研究领域:
生物化学
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医学检测
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材料科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2025
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IF 9.7
Yao Gong,Wenxin Qi,Wenyi Lu,Qing Chang,Yijun Xie,Jiao Wang,Xiaoyong Deng
Diabetic wounds are highly prone to persistent pathogenic infections due to the complex nature of their microenvironment, which significantly hinders the healing process under hyperglycemic conditions. In this study, we developed a bio-heterojunction enzyme system consisting of hollow CeO 2 /Ti 3 C 2 T x MXene quantum dots (CeO 2 @MQD) integrated with glucose oxidase (GOx-CeO 2 @MQD). The GOx-CeO 2 @MQD system exhibits multifunctional enzymatic activities, including peroxidase (POD) and catalase (CAT)-like activity, resulting in the production of •OH and O 2 , alongside the consumption of glucose and glutathione (GSH). The incorporation of GOx effectively mitigates the hyperglycemic microenvironment by catalyzing glucose, leading to a significant increase in H 2 O 2 production, which is subsequently converted into bactericidal •OH through POD activity. Furthermore, H 2 O 2 can be catalyzed into H 2 O and O 2 via the CAT pathway, thereby alleviating inflammation caused by the excessive accumulation of reactive oxygen species. In vitro antibacterial assays demonstrated that the GOx-CeO 2 @MQD system achieved remarkable bactericidal efficiencies of 99.99% against E. coli and S. aureus at concentrations of 12.5 ppm and 2.0 ppm, respectively. In vivo experiments further revealed that GOx-CeO 2 @MQD significantly promoted angiogenesis, accelerated wound epithelialization, and induced a strong anti-inflammatory response, thus facilitating the regeneration of infected diabetic skin. This study proposes a novel approach for diabetic wound treatment by harnessing the synergistic effects of multiple enzyme-like activities.
研究领域:
生物材料学
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医学
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纳米生物学
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产品关联
DOI
PubMed
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
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2024
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IF 20.2
Hongwei Zhu,Xu Yin,Yi Wang,Kajia Wei,Liankai Gu,Yonghao Zhang,Zhenshan Duan,Zhen Huang,Haoming Chen,Weiqing Han
This study developed a self-supported MOF/FeOOH heterojunction cathode without binders for boosted Fe(Ⅲ) reduction in heterogeneous electro-Fenton (EF) processes. The electron transport channels from FeOOH to in-situ grown NH 2 -MIL-88B(Fe) were established through the spontaneous formation of an internal electric field (IEF), which enhanced the electrical conductivity and disrupted the chemical inertness of the Fe(Ⅲ) reduction. The MOF/FeOOH cathode increased sulfamethazine (SMT) removal up to 95.76 %, 2.5 times better than using PTFE as binders. After ten-consecutive degradation experiments, the Fe(Ⅱ) content at cathode surface increased from 39.23 % to 56.73 %. Density functional theory (DFT) calculations and advanced characterization techniques demonstrated the efficient Fe(Ⅲ) reduction and H 2 O 2 activation during the reaction. These results elucidate the promoting effect of modulating the “contact” between the catalyst and current collectors, as to provide a feasible and promising strategy for the development of efficient heterogeneous EF cathodes.
研究领域:
环境科学
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材料科学
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电化学
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催化
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Fangxian Wang,Junwei Yang,Shihao Li,Junwen Liang,Yuwei Wang,Rong Du,Bo Zhou,Qiong Liu,Changping Li
Bromate is a commonly identified carcinogenic and genotoxic disinfection byproduct in water. Electrochemical debromination is an environmentally friendly and effective approach but it often suffers the limited reducing atomic H (H*) ability and high metal catalyst dosage. In this study, a unique composite catalyst comprised of ultra-low loading Cu single atoms (0.016 wt%) and Fe 2 O 3 nanoparticles supported on a Nb 2 C MXene (denoted as Cu 0.2 /Fe 0.1 /Nb 2 C) was synthesized by one-step high-temperature molten salt method. The Cu 0.2 /Fe 0.1 /Nb 2 C significantly outperformed the Nb 2 C, Cu 0.2 /Nb 2 C and Fe 0.1 /Nb 2 C counterparts in the electrochemical debromination with a 94.2 % removal efficiency of bromate. It is revealed that the introducing of Cu single atoms, efficiently promotes the adsorption of H* and inhibition of competitive H 2 evolution. The incorporation of Fe 2 O 3 nanoparticles significantly increased the electronic metal-support interaction effect between the metal components and Nb 2 C, thereby forming a noticeable electronic cloud bridge to facilitate efficient charge transfer. Ultimately, the synergistic interplay between Cu single atoms and Fe 2 O 3 nanoparticles plays a crucial role in achieving the remarkable removal performance of bromate. This work not only presents a significant instance of a synergistic catalyst involving metal single atoms and metal nanoparticles for effective electrochemical debromination but also advances the understanding of the electronic metal-support interaction.
研究领域:
环境科学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
Arabian Journal of Chemistry
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2024
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IF 5.3
Jin Liu,Qian Zhong,Yanjin Wang,Zezhi Zhang,Huiqin Zheng,Bin Yan,Yurong Shi
Designing photocatalysts with p-n heterojunction structures is an effective way to boost the separation of photogenerated carriers and stimulate the photocatalytic degradation activity. Herein, an efficient visible-light responsive AgI/BiSI p-n heterojunction photocatalyst was successfully constructed. X-ray photoelectron spectroscopy (XPS), photoluminescence (PL) spectroscopy, and electrochemical measurements confirmed that the AgI/BiSI p-n heterojunction structure was beneficial to the separation and transfer of photogenerated carriers, promoting the generation of main active species (•O 2 − and h + ). Furthermore, the photocatalytic degradation rate constants of Acid Red 1 (0.4699 min −1 ) and metronidazole (0.0730 min −1 ) over the optimal AgI/BiSI were about 8.4 and 3.0 times higher than those over pure AgI, respectively. This work provides a heterojunction engineering strategy to design high-efficient photocatalysts for the degradation of refractory organic pollutants.
研究领域:
材料科学
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环境科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）