BIOSENSORS & BIOELECTRONICS
·
2017
·
IF 7.78
Wenjing Jiang,Linni Wu,Junling Duan,Huanshun Yin,Shiyun Ai
An ultrasensitive sandwiched electrochemiluminescence (ECL) immunosensor was developed for 5-hydroxymethylcytosine (5hmC) detection in genomic DNA by using Fe 3 O 4 @SiO 2 core–shell magnetic nanomaterial as a immobilization matrix for anti-5hmC antibody, PAMAM conjugated avidin and Ru(bpy) 2 (phen-5-NH 2 )(PF 6 ) 2 as signal amplification unit. Importantly, Fe 3 O 4 @SiO 2 nanoparticles were verified to not only possess enormous surface for loading antibody by amido link, but also exhibit excellent bioactivity . With the dual signal amplification strategy, the ECL immunosensor showed wide detection range from 0.1 to 30 nM with low detection limit of 0.047 nM (S/N = 3). Based on the specific immunoreaction, the developed method also illustrated excellent detection selectivity . The fabricated immunosensor was also applied to detect the 5hmC in genomic DNA of cancer tissue, which indicated that the immunosensor possess potential applications in clinical detection.
研究领域:
分析化学
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生物化学
·
分子生物学
·
癌症研究
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产品关联
DOI
PubMed
高影响因子
ChemMedChem
·
2017
·Vol. 12
·期 19
·1600-1609
·
IF 3.225
Xinyu Hu,Yongmei Wang,Liangliang Zhang,Man Xu,Jianfa Zhang,Wei Dong
Graphical The power of attraction : Salecan-based composite hydrogels have magnetic-field-responsive properties due to the introduction of Fe 3 O 4 @SiO 2 nanoparticles into the hydrogel system. As a model anticancer drug, doxorubicin (DOX) was loaded into the composite hydrogels with high efficiency via strong electrostatic interactions between the amine group in DOX and carboxyl groups present in the hydrogels. These DOX-loaded salecan-g-PPH/Fe 3 O 4 @SiO 2 composite hydrogels show pH-responsive controlled drug release, and the liberated DOX can be effectively taken up by A549 cells. Salecan is a water-soluble extracellular β-glucan and has excellent physicochemical and biological properties for hydrogel preparation. In this study, a new pH/magnetic field dual-responsive hydrogel was prepared by the graft copolymerization of salecan with 4-pentenoic acid (PA) and N -hydroxyethylacrylamide (HEAA) in the presence of Fe 3 O 4 @SiO 2 nanoparticles for doxorubicin hydrochloride (DOX) release. Integration of Fe 3 O 4 @SiO 2 nanoparticles in salecan-g-poly(PA-co-HEAA) copolymers afforded magnetic sensitivity to the original material. DOX-loaded hydrogels exhibited a clear capacity for pH/magnetic field dual-responsive controlled drug release. Lowering the pH to acidic conditions or introducing an external magnetic field caused an enhancement in DOX release. This salecan-g-poly(PA-co-HEAA)/Fe 3 O 4 @SiO 2 composite hydrogel is a promising drug carrier for magnetically targeted drug delivery with enhanced DOX cytotoxicity against A549 cells.
研究领域:
材料科学
·
药学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2019
·
IF 2.298
Rong Wo,Qiu-Lin Li,Chao Zhu,Yan Zhang,Ge-fei Qiao,Kai-yu Lei,Ping Du,Wei Jiang
In this work, a novel core@double-shell three-layer structure adsorbent (Fe3O4@SiO2@Zn–TDPAT) [TDPAT = 2,4,6-tris(3,5-dicarboxyl phenylamino)-1,3,5-triazine] was prepared to remove congo red (CR) and methylene blue (MB). The as-obtained magnetic adsorbent Fe3O4@SiO2@Zn–TDPAT was characterized by X-ray diffraction, Fourier transform infrared spectra, vibrating sample magnetometry, transmission electron microscopy, and scanning electron microscopy. The influencing adsorption parameters including adsorbent amounts, extraction time, pH, and ionic strength were investigated. Under the optimized conditions, the removal efficiencies of CR and MB reached 100 and 99%, respectively. The pseudo-second-order kinetic model and Langmuir model were suitable to illustrate the adsorption processes of CR and MB. The thermodynamic values, including Gibbs free energy (ΔG°), enthalpy (ΔH°), and entropy (ΔS°), showed that the adsorption processes were spontaneous and endothermic in nature. Moreover, the obtained nanocomposite remained stable in different acid–alkaline solutions and exhibited good reusability after multiple cycles. All of the experimental results indicated that Fe3O4@SiO2@Zn–TDPAT could be a potential adsorbent to purify dye wastewater.
研究领域:
环境科学
·
材料科学
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Huanyu Zhuang,Xiaoyu Li,Xin Du
Bacterial infections represent one of the foremost threats to global human health. Furthermore, the misuse of antibiotics has exacerbated the public health crisis. Therefore, the development of high-performance novel antibacterial materials is of utmost importance. However, there are still several issues regarding the antibacterial performance and recyclability of existing antibacterial materials. To address these issues, this study synthesized a core@shell@shell@satellite structured Fe 3 O 4 @SiO 2 @polydopamine (PDA)@tannic acid (TA)@Ag nanocomposite, aiming to achieve excellent photothermal effect and synergistic antibacterial activity with silver. The composite particles exhibited improved dispersibility due to the SiO 2 coating. The modification of TA on the Fe 3 O 4 @SiO 2 @PDA achieved the uniform loading of silver nanoparticles (NPs), which significantly enhanced the photothermal conversion efficiency (η) of up to 74.9 %. Additionally, the superparamagnetic property facilitated magnetic separation, ensuring the efficient recovery and reutilization of the nanocomposites. Under low concentration and low-power near-infrared (NIR) light irradiation (808 nm, 1.0 W cm −2 ), the nanocomposite demonstrated excellent synergistic antibacterial activity, achieving efficient eradication of Escherichia coli (100 %) and Staphylococcus aureus (98 %). Furthermore, the material could be recycled up to five times without significant loss of antibacterial activity. Overall, our approach demonstrates the potential of novel multifunctional composite NPs in the treatment of bacterial infections and the sustainable application of antibacterial agents.
研究领域:
材料科学
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微生物学
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生物医学工程
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产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2023
·Vol. 34
·期 24
·1-18
·
IF 2.8
Li Qunbo,Yu Gaoqiang,Ye Mingquan,Han Aijun,Liu Qingzhong,Su Yaojing,Chen Cheng
Transition metal dichalcogenides (TMDCs) are considered to have remarkable electromagnetic (EM) wave attenuation due to their perfect dielectric property and graphene-like structure, but they still often fail to function due to impedance mismatch problems. Here, using a multilayer coating strategy, we prepared flower-like Fe 3 O 4 @SiO 2 @MoSe 2 absorbers with core–shell structure. SiO 2 can form the Fe 3 O 4 -SiO 2 and SiO 2 -MoSe 2 heterogeneous interfaces when it is applied to the Fe 3 O 4 surface as an impedance matching layer in the Fe 3 O 4 @SiO 2 @MoSe 2 composite, increasing the interfacial polarization loss to the absorber. In addition, Fe 3 O 4 @SiO 2 as a magnetic core also reduces the relative density of the substance compared to Fe 3 O 4 . Products with the absorption performance of various electromagnetic waves were produced by varying the amount of magnetic components (Fe 3 O 4 @SiO 2 ) in the absorber. With a minimal reflect loss (RL) of − 51.86 dB and an effective absorption bandwidth (EAB, RL < -10 dB) of 4.96 GHz at a matching thickness of 1.8 mm, the Fe 3 O 4 @SiO 2 @MoSe 2 (sample S3) demonstrated exceptional properties in EM wave absorption. In addition, we synthesized Fe 3 O 4 @MoSe 2 and determined its RL value and maximum EAB (EAB max ) in order to highlight the significance of the impedance matching layer SiO 2 . Fe 3 O 4 @MoSe 2 appears to perform less well than Fe 3 O4@SiO 2 @MoSe 2 in terms of EM wave absorption, with a minimal RL value of -50.20 dB and an EAB max of only 2.00 GHz at the matching thickness of 4.8 mm. The remarkable properties in EM wave absorption of Fe 3 O 4 @SiO 2 @MoSe 2 is the result of the combined effect from impedance match and loss mechanisms of various compositions, so the component SiO 2 has a non-negligible function as an impedance matching layer. This study has blazed the trail for developing the lightweight and excellent performance of absorbers.
研究领域:
材料科学
·
电磁学
·
纳米技术
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产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2020
·Vol. 44
·期 14
·5324-5332
·
IF 3.288
Jinfei Liu,Huijiao Qiu,Fei Zhang,Yan Li
In this study, a new magnetic composite material zeolitic imidazolate framework-8 coated Fe3O4@SiO2 (Fe3O4@SiO2/ZIF-8) was prepared by in situ growth of ZIF-8 on the surface of Fe3O4@SiO2 microspheres at room temperature. In addition, it had a large surface area, high superparamagnetism and great adsorption capacity. As is well known, MOFs have extraordinary adsorption capacity. As one of the classic MOFs, ZIF-8 has open metal sites, hydrophobic properties, and especially excellent water stability. Fe3O4 is generally used for the synthesis of different magnetic materials, which can make the preconcentrated material easy to separate from the extraction medium. All these features make the composite material Fe3O4@SiO2/ZIF-8 suitable to be developed as an adsorbent for preconcentration of bisphenols (BPs) including bisphenol F, bisphenol A, bisphenol B and bisphenol AP. Most of all, applying Fe3O4@SiO2/ZIF-8 to magnetic solid-phase extraction (MSPE) coupled with high performance liquid chromatography (HPLC) for detection of BPs can greatly improve the sensitivity of the method, and the process is simple and convenient. Under the optimal conditions, four BPs were detected with large linear ranges (0.05–200 μg L−1), low limits of detection (LODs) (10–15 ng L−1), relative standard deviations (RSDs) ranging from 2.0 to 4.5% and enrichment factors (EFs) ranging from 110 to 186. Additionally, the proposed method was applied to detect BPs in water and plastic packagings of food and drinks generally used in daily life.
研究领域:
材料科学
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环境化学
·
分析化学
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产品关联
DOI
高影响因子
Biochar
·
2023
·Vol. 5
·期 1
·1-20
·
IF 12.7
Yang Bowen,Dai Jiawei,Zhao Yuan,Wang Zhanchao,Wu Jingwei,Ji Caiya,Zhang Yuhu,Pu Xiao
Biochar-coupled Fe 3 O 4 @SiO 2 /TiO 2 /g-C 3 N 4 composites were successfully constructed through simple sol–gel and calcination methods. The composites efficiently removed high-concentration toxic tetracycline (TC) by means of ·OH and · \({\rm O}_2^{-}\) , whose removal rate exhibited 91.88% during 3 h, and the degradation rate constant reached up to 0.0068 min −1 . The excellent performance can be attributed to the high specific surface area, enhanced visible light response, the introduction of magnetic nanoparticles and biochars expediting charge transfer, Z-scheme heterojunction enhancing the spatial separation of photo-generate carriers and, importantly extraordinary adsorption capacity of 147.96 mg g −1 . Moreover, the composites showed the most excellent efficiency under the calcination temperature of 450 ℃, and exhibited good stability with tolerance to a wide range of pH and anions. Interestingly, a synergistic photocatalytic effect was discovered in the TC/Cr(VI) combined pollution systems, resulting in significantly improved removal of Cr(VI). Besides, the photocatalytic mechanism and degradation path of tetracycline were also elucidated. All these findings suggested the as-synthesized catalyst was an excellent photocatalyst for removal of TC/Cr(VI)-contaminated water. Graphical Abstract
研究领域:
环境科学
·
材料科学
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产品关联
DOI
高影响因子
Environmental Technology & Innovation
·
2021
·
IF 5.263
Lihua Liu,Gang Su,Xing Liu,Wenhao Dong,Mengyuan Niu,Qiujuan Kuang,Anping Tang,Jianrong Xue
A novel magnetic core–shell architecture Fe 3 O 4 @Sio 2 @Bi 2 O 2 CO 3 –sepiolite composite was successfully fabricated by coating a layer of Bi 2 O 2 CO 3 –sepiolite mixture onto Fe 3 O 4 @Sio 2 cores through a facile hydrothermal method. The photodegradation rates of ciprofloxacin (CIP) and tetracycline hydrochloride (TC-H) were 92.1% and 100%, respectively. A suitable amount of sepiolite in Fe 3 O 4 @Sio 2 @Bi 2 O 2 CO 3 –sepiolite can enlarge the specific surface area, promote the formation of an excellent photocatalyst structure, and generate a strong interfaces effect between the sepiolite and Fe 3 O 4 @Sio 2 @Bi 2 O 2 CO 3 . This condition endowed the as-prepared photocatalyst with high light harvesting capability and abundant active reaction sites. It also boosted the separation of photogenic e − /h + pairs. Moreover, this condition inhibited the recombination of e − /h + pairs and decreased the energy band gap, thereby enhancing the visible light catalytic degradation of antibiotics. The active species produced during photocatalysis included h + and •O 2 − , with h + as the dominant active species. The as-prepared photocatalyst exhibited excellent photocatalytic degradation activity, magnetic separation performance, recyclability , and stability.
研究领域:
环境科学
·
材料科学
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Juanjuan Wan,Lijuan Zhang,Bo Yang,Boyu Jia,Jiakuan Yang,Xintai Su
Enzymes have important advantages in sludge dewatering , but their catalytic performance is limited by their poor activity and stability. To address this issue, we develop a series of immobilized enzymes (immobilized acid protease, IE 1; immobilized pectinase, IE 2; immobilized laccase, IE 3) prepared by the electrostatic interaction between the Fe 3 O 4 @SiO 2 -NH 2 as immobilized carrier and the free enzyme, and used for sludge dewatering. As-obtained immobilized enzymes endowed high efficiency and stable sludge dewatering performance in a wide pH range, and had the best dewatering performance when the pH was 5. Specifically, the specific resistance filtration (SRF) performance of the immobilized enzyme at pH 5 was better than that of the control group, and the order was FE 3, 3.84 × 10 13 m kg −1 > FE 1, 2.52 × 10 13 m kg −1 > CL 1, 2.16 × 10 13 m kg −1 > CL 2, 1.34 × 10 13 m kg −1 > FE 2, 2.06 × 10 13 m kg −1 > IE 2, 0.89 × 10 13 m kg −1 > IE 1, 0.82 × 10 13 m kg −1 > IE 3, 0.73 × 10 13 m kg −1 . Such improvement is attributed to two respects: Firstly, the immobilized enzyme has good activity, stability, and abundant functional groups on the surface, which is conducive to the attachment and continuous decomposition of organic matter. Secondly, the solid immobilized carrier can construct the skeleton structure in situ and effectively promote the release of water in sludge. This study provides a feasible way for the practical application of biological enzyme in sludge dewatering.
研究领域:
环境工程
·
生物技术
·
材料科学
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产品关联
DOI
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 107
·88492-88499
·
IF 3.84
Huimin Duan,Xiaojiao Wang,Yanhui Wang,Jianbo Li,Chuannan Luo
An ultrasensitive chemiluminescent biosensor with a high selectivity, based on a bioreceptor surface molecular imprinted polymer (SMIP) that used core–shell Fe3O4@SiO2–multi-walled carbon nanotube nanostructures (Fe3O4@SiO2/MWCNTs) as the backbone material, for bovine hemoglobin (BHb) determination was proposed. The Fe3O4@SiO2/MWCNTs were synthesized with a new method, and then were characterized using SEM, FTIR and XRD techniques. The adsorption ability of Fe3O4@SiO2/MWCNTs–SMIP was evaluated to be 91 mg g−1 following the Langmuir isotherm equation and it demonstrated an excellent recognition and adsorption ability for the imprinted sites located on the surface or near the surface of the Fe3O4@SiO2/MWCNTs. Under optimum conditions of CL, the detection range of BHb was from 5.0 × 10−10 to 7.0 × 10−7 mg mL−1 with a detection limit of 1.5 × 10−10 mg mL−1 (3δ). The proposed biosensor was successfully applied in the determination of BHb in real samples with high selectivity and sensitivity, and the recoveries were excellent and varied from 92% to 106%. Finally, the possible CL mechanism of the BHb in amplifying the CL signal of the luminol–NaOH–H2O2 system was discussed.
研究领域:
分析化学
·
生物医学工程
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DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2019
·
IF 4.561
Yang Wang,Si Sun,Lin Shi,Pengcheng Gao,Yingying Wei,Chuan Zhang,Yong Jiang
A facile and energy-efficient synthesis of Fe 3 O 4 @SiO 2 -PHEMA complex and its application as adsorbent for removal of Cu 2+ from aqueous solution were investigated. Fe 3 O 4 @SiO 2 -PHEMA was synthesized by mixing Fe 3 O 4 @SiO 2 and HEMA monomer and then initiating the polymerization of HEMA monomer by H 2 O 2 under Fe 2+ catalyzing at room temperature . As adsorbent, the maximum sorption capacity of Fe 3 O 4 @SiO 2 -PHEMA for Cu 2+ was calculated to be 20.7 mg/g at pH 6.0. And the efficient enrichment of Cu 2+ on Fe 3 O 4 @SiO 2 -PHEMA depended on its multiple carbonyl groups and the electrostatic interaction between carboxyl groups and Cu 2+ . The carboxyl groups were from slow hydrolysis of partial ester bonds of PHEMA under acidic conditions. The possible hydrolysis process of ester bonds was facilitated to avoid sorption capacity of Cu 2+ decreasing caused by other ions sorption (like Fe 2+ ) during the synthesis of the adsorbent. The adsorption of Cu 2+ on Fe 3 O 4 @SiO 2 -PHEMA coincided with Langmuir model. The Fe 3 O 4 @SiO 2 -PHEMA had good dispersity in water and it could be easily collected from wastewaters by a magnet. The results showed that Fe 3 O 4 @SiO 2 -PHEMA was a promising adsorbent in wastewater treatment.
研究领域:
环境科学
·
材料科学
·
化学工程
·
水处理
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产品关联
DOI
高影响因子
Chemosensors
·
2023
·Vol. 11
·期 6
·347
·
IF 4.2
Chao Liu,Hui Wang,Shengmin Xu,Hongbao Li,Yilin Lu,Chuhong Zhu
Mercury ions can be enriched along the food chain and even low concentrations of mercury ions can seriously affect human health and the environment. Therefore, rapid, sensitive, and highly selective detection of mercury ions is of great significance. In this work, we synthesized Fe3O4@SiO2@Au three-layer core/shell nanoparticles, and then modified 4-MPy (4-mercaptopyridine) to form a SERS sensor. Mercury ions in water can be easily captured by 4-MPy which were used as the reporter molecules, and the concentration of mercury ions can be evaluated based on the spectral changes (intensification and reduction of peaks) from 4-MPy. After the mercury ion was combined with the pyridine ring, the peak intensity at 1093 cm−1increased with the concentration of mercury ion in the range of 10 ppm–1 ppb, while the Raman intensity ratio I (416 cm−1)/I (436 cm−1) decreased with the increase of mercury ion concentration. This magnetically separatable and recyclable SERS sensor demonstrates good stability, accuracy, and anti-interference ability and shows the potential to detect actual samples. Furthermore, we demonstrate that the probe is applicable for Hg2+imaging in macrophage cells.Keywords:core/shell nanoparticles;4-pyridinethiol;surface-enhanced Raman spectroscopy (SERS);Mercury (II) ion;Raman cell imaging
研究领域:
纳米技术
·
分析化学
·
环境科学
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）