Science Advances
·
2020
·Vol. 6
·期 32
·
IF 13.117
Lingling Ma,Yanling Zhou,Zhaowenbin Zhang,Yaqin Liu,Dong Zhai,Hui Zhuang,Qin Li,Jianding Yuye,Chengtie Wu,Jiang Chang
Photothermal therapy (PTT), an emerging tumor treatment technology, has attracted tremendous interest, but excessive heat will cause damage to surrounding healthy tissues. Therefore, in situ temperature monitoring during PTT is of great importance to determine optimal treatment temperature and repair heat-damaged normal tissues. Here, we report the preparation of multifunctional Nd-Ca-Si silicate glasses and glass/alginate composite hydrogels that not only have photothermal property but also emit fluorescence under 808-nm laser irradiation, and its fluorescence intensity is linearly correlated with in situ temperature. With this feature, optimal PTT temperature for effective tumor treatment with minimal normal tissue damage can be obtained. In addition, because of the bioactive silicate components, the composite hydrogel has bioactivity to repair heat damage caused by PTT. This implantable multifunctional material with unique temperature monitoring, photothermal function, and wound healing bioactivity can be used for localized thermal therapy.
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DOI
PubMed
高影响因子
Regenerative Biomaterials
·
2020
·Vol. 7
·期 3
·303-311
·
IF 4.882
Huang Deqiu,Zhao Fujian,Gao Wendong,Chen Xiaofeng,Guo Zhouyi,Zhang Wen
Strontium-substituted bioactive glass (Sr-BG) has shown superior performance in bone regeneration. Sr-BG-induced osteogenesis has been extensively studied; however, Sr-BG-mediated osteoclastogenesis and the underlying molecular mechanism remain unclear. It is recognized that the balance of osteogenesis and osteoclastogenesis is closely related to bone repair, and the receptor activators of nuclear factor kappaB ligand (RANKL) signaling pathway plays a key role of in the regulation of osteoclastogenesis. Herein, we studied the potential impact and underling mechanism of strontium-substituted sub-micron bioactive glass (Sr-SBG) on RANKL-induced osteoclast activation and differentiation in vitro. As expected, Sr-SBG inhibited RANKL-mediated osteoclastogenesis significantly with the experimental performance of decreased mature osteoclasts formation and downregulation of osteoclastogenesis-related gene expression. Furthermore, it was found that Sr-SBG might suppress osteoclastogenesis by the combined effect of strontium and silicon released through inhibition of RANKL-induced activation of p38 and NF-κB pathway. These results elaborated the effect of Sr-SBG-based materials on osteoclastogenesis through RANKL-induced downstream pathway and might represent a significant guidance for designing better bone repair materials.
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PubMed
高影响因子
JOURNAL OF NON-CRYSTALLINE SOLIDS
·
2014
·
IF 1.716
Xijia He,Xuhui Xu,Youming Shi,Jianbei Qiu
The Ag ions were introduced into the Bi doped silicogermanate glasses by Ag + for Na + ion exchange method. After ion exchange, the X-ray photoelectron spectroscopy (XPS) spectrum implied the Ag ions were mainly in ionic form (Ag + ) within the glasses. With the increase of the Ag + concentration, more relaxation of local structure would be induced at the non-bridging oxygen (NBO), meaning that the network gave more negative sites. Bi 3+ ions could be reduced to lower valence states of Bi containing Bi near infrared (NIR) active centers with the depolymerization of glass network, resulting in the enhancement of the Bi NIR luminescence. After heat treatment, the XPS, absorption spectra and transmission electron microscope (TEM) images revealed Ag nanoparticles (Ag NPs) formed in glasses. With the increase of the Ag NPs concentration, more NBOs released from Ag + , which led to reduce more Bi 3+ ions to lower valence states of Bi containing Bi NIR active centers, resulting in further enhancement of the NIR luminescence. Our research may extend the understanding of structural modulation in Bi valence states and offer a valuable way to enhance the NIR luminescence of Bi in glasses.
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Optical Materials Express
·
2025
·Vol. 15
·期 4
·737-751
·
IF 3.1
Chenbo Yu,Xi Zhang,Li Huang,Xueqing Xiao,Shuguang Cai,Xingfang Huang,Chan Zheng,Chan Zheng
The ever-increasing demands of high-performance nonlinear optical (NLO) electronic and optoelectronic devices promote the investigation of the compatibility of the NLO characteristics of solid-state matrix hosts and doped functional components. In this work, we developed a facile and efficient sol-gel wet chemical method for preparing stable and transparent monolithic oxide glasses exhibiting controllable NLO responses by collaboratively designing the glassy composition, which can be readily applied to solid-state matrices to encapsulate NLO components. We systematically characterized the structures and compositions of the glasses. The linear optical (LO) and NLO properties of the glasses highly depended on the introduction of heavy-metal ions. For gel glasses, the optical bandgap narrows with increasing radius of the heavy-metal ions and is associated with the heavy-metal ion-induced structural transformation of the glass. The NLO properties of both the binary and ternary glasses were extensively investigated using a well-developed Z-scan technology, and the possible NLO mechanisms were discussed. The results revealed that the NLO parameters, including the nonlinear absorption coefficient (β), nonlinear refraction index (n2), and third-order nonlinear susceptibility (χ(3)), all continuously increased with the increasing radius of the metal cation in the glasses, strongly suggesting that the optical nonlinearities can be easily controlled by adjusting the glasses’ compositions. The orders of magnitude of β, n2, and χ(3) were calculated at 10−12 m/W, 10−14cm2/W, and 10−13 electrostatic units (esu), respectively, which are comparable to those of recently reported glasses. Depending on the energy gap (Eg) value, the nonlinear absorption (NLA) can be attributed to two- or three-photon absorption. Furthermore, for the investigated glasses, the figure of merit (FOM) > 1. Our work provides an effective composition-tuning strategy for drastically improving third-order NLO properties, and these sol-gel-derived transparent glasses are suitable for use in ultrafast NLO-limiting applications.
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高影响因子
EUROPEAN POLYMER JOURNAL
·
2025
·
IF 6.3
Hao Deng,Xiaolu Chen,Wei Zhang,Hulin Yang,Xinyue Yang,Qiyi Zhang,Yonggang Yan
Reactive oxygen species (ROS) plays a crucial role in normal physiological activities. But hypoxia-induced oxidative stress leads to excessive accumulation of ROS in the microenvironment of bone defects, which could hinder tissue repair. Therefore, the regulation of ROS is essential for promoting bone repair. Herein, a mesoporous bioactive glass-based nanoenzyme (MBGNs@PDA@MnO 2 ) with the property to manage ROS was designed and prepared. The MBGNs@PDA@MnO 2 powders displayed excellent mineralization properties and antioxidation activity. The hydrogel with double-network structure were constructed and synthesized using oxidized chitosan (OCS) and dopamine-grafted gelatin (Gel-DA) by Schiff-base and oxidative coupling reaction, and then MBGNs@PDA@MnO 2 was incorporated into the hydrogel. Cell experiments demonstrated that the composite hydrogels could effectively reduce intracellular ROS level, and had good cytocompatibility and osteogenesis promotion capability. Hence, the composite hydrogels with ROS regulation had the potential to be a new strategy for the treatment of bone defects.
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OPTICAL MATERIALS
·
2025
·
IF 4.2
Chenxiang Ma,Minghui Zhang,Haichuan Zeng,Jingjing Hua,Hexing Yuan,Shibo Zhao
Fluorescent glass shows promising applications in solar cell covers with high mechanical properties and effective wavelength conversion. By high-temperature feeding melting-pouring-annealing integration synthetic technique, (58-x)B 2 O 3 -25La 2 O 3 -8.5CaO-3.5ZnO-3SiO 2 -xTb 4 O 7 (x = 2–9 mol%) glass was fabricated to examine the impact of Tb 4 O 7 concentration. These glasses exhibited high thermal stability (T g > 670 °C), along with excellent optical properties, including a refractive index >1.7 and transmittance reaching 85%. The fluorescent properties optimized through excitation spectroscopy, emission spectroscopy, fluorescence lifetime measurement and auxiliary XPS testing, which demonstrated that 3 mol % Tb concentration of sample yielded the most favorable results. Micro-area fluorescence testing revealed that the coefficient of variation of the fluorescence intensity integral was 1.65%, indicating the sample had decent fluorescence uniformity. These results provided important guidance for the design of fluorescent glasses with superior service performance and luminescent properties.
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高影响因子
ACS Applied Nano Materials
·
2025
·
IF 5.5
Yujie Chen,Fanlei Qin,Jiawen Wang,Kai Yang,Yinyan Li,Gongxun Bai
Perovskite quantum dots with halogen elements (Cl, Br, I) have been extensively studied due to their unique optoelectronic properties. However, the spectral properties of luminescent materials continue to present challenges in perovskite quantum dot glasses. Here, Eu3+-doped CsPbBr3 quantum dot glasses were successfully prepared. Meanwhile, optimizing the doping concentration of Eu3+ significantly improved the formation of quantum dots and enhanced their fluorescence intensity. After a heating–cooling cycle, the CsPbBr3:0.5% Eu3+ glass still retained 95% of its initial value. By coating CsPbBr3:0.5% Eu3+ glass powder with red phosphor on a blue chip, a white LED with a CCT of 5417 K can be prepared. Therefore, Eu3+-doped CsPbBr3 quantum dot glasses demonstrate significant potential as an efficient material for optical lighting applications.
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高影响因子
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2024
·Vol. 108
·期 4
·e20312
·
IF 3.5
Shuangli Dong,Weichao Wang,Qinyuan Zhang
Theoretical prediction of glass compositions with certain performance requirements is a long-standing challenge in glass research. The difficulty lies in revealing the relationship of glass's composition–structure–property (C–S–P), and establishing a predictive calculation method for glass properties with high accuracy. Here we determine quantitatively the C–S–P relationships of four silicate laser glasses using nearest-neighboring congruently melting compounds (CMCs) as “component and structural motifs”. For all studied silicate systems, physical properties such as density and refractive index are predicted with an error of less than 5%. Spectroscopic properties, including Judd–Ofelt parameters, fluorescence branching ratio ( β ), effective bandwidth (Δ λ eff ), emission cross-section ( σ e ), gain bandwidth, and lifetime, are predicted with an error of less than 10%, with some properties such as β , Δλ eff , and σ e showing an error of less than 5% in specific systems. Four C–S–P databases have also been constructed, containing detailed physical and spectroscopic properties of over 1200 compositions, facilitating the optimization of glass composition. These findings highlight the significance of nearest-neighboring CMCs in understanding and developing high-performance laser glasses.
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高影响因子
JOURNAL OF NON-CRYSTALLINE SOLIDS
·
2020
·
IF 2.929
Tongyao Zhao,Xuyang Zhang,Jinjun Ren
A series of glasses with the compositions of 10NaF-(90-x) NaPO 3 -xYF 3 ( x = 5, 10, 15 and 20 mol%) were prepared via the conventional melt-quenching method. The structures of these glasses were characterized by multiple advanced solid-state nuclear magnetic resonance (SSNMR) techniques. Multiple phosphorus species Q m nY were resolved at atomic level. Here, the value m and n denote the number of P–O–P bonds and the number of Y 3+ ion bounding to phosphorus oxygen tetrahedron, respectively, which were identified by two dimensional (2D) J -resolved spectroscopy. 19 F MAS spectra, 19 F↔ 23 Na and 19 F↔ 31 P rotational echo double resonance (REDOR) prove that F − ions are involved into the glass networks through Y-F•••Na and P-F•••Na linkages. The 31 P { 19 F} J -coupling based heteronuclear multiple quantum coherence ( J -HMQC) spectrum proves that F − ions selectively connect with Q 1 species. F − ions show significant preference to connecting with Y 3+ over P 5+ .
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高影响因子
CERAMICS INTERNATIONAL
·
2022
·
IF 5.532
Xufeng Zhang,Huidan Zeng,Xin Wang,Weichang Li,Lili Hu,Shubin Chen
MgO–Al 2 O 3 –SiO 2 glass-ceramics have been widely used in military, industrial, and construction applications. The nucleating agent is one of the most important factors in the production of glass-ceramics as it can control the crystallization temperature or the grain size. In this study, we investigated the effect of replacing P 2 O 5 with different amounts of TiO 2 on the crystallization, structure, and mechanical properties of an MgO–Al 2 O 3 –SiO 2 system. The crystallization and microstructure were investigated by differential scanning calorimetry , Raman spectroscopy , X-ray diffraction, scanning electron microscopy, and transmission electron microscopy . The mechanical properties were investigated by measuring the Vickers hardness , Young's modulus , and fracture toughness. The results showed that adding TiO 2 favored the precipitation of fine grains and significantly increased the Vickers hardness, Young's modulus, and fracture toughness of the glasses. Introducing an appropriate amount of TiO 2 can make a glass structure more compact, promote crystallization, and improve the mechanical properties of MgO–Al 2 O 3 –SiO 2 glass-ceramics.
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高影响因子
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2022
·Vol. 105
·期 5
·3291-3302
·
IF 4.186
Yan Sun,Juping Ma,Chongyun Shao,Xin Wang,Fei Yu,Meisong Liao,Lili Hu,Jonathan Knight
In this work, we revealed the possible mechanisms of the photodarkening in Pr 3+ ions singly doped and Pr 3+ /Ce 3+ co-doped silicate glasses and fibers induced by X-ray and 488-nm laser radiations and studied the role of Ce 3+ in increasing radiation resistance in Pr 3+ -doped silicate glasses and fibers. The absorption, emission, electron paramagnetic resonance (EPR), radiation induced attenuation spectra, and X-ray photoelectron spectroscopy (XPS) of Pr 3+ singly doped and Pr 3+ /Ce 3+ co-doped silicate glasses before and after X-ray radiation were measured and analyzed. The fluorescence intensity and photoinduced attenuation of Pr 3+ singly doped and Pr 3+ /Ce 3+ co-doped silicate fibers at visible wavelengths pumped by 488-nm laser were measured and analyzed. The influence of Ce 3+ ions co-doping on the spectroscopic properties of Pr 3+ ions as well as the radiation-induced defects in silicate glasses was studied. Results demonstrate that both X-ray and 488-nm laser radiations will induce photodamage in Pr 3+ ions-doped silicate glasses and fibers. Co-doping Ce 3+ (by up to 1 mol%) is efficient to suppress the darkening induced by both X-ray and 488-nm laser radiations without influence on the luminescence behavior of Pr 3+ ions in silicate glasses and fibers. Our studies demonstrate the promising potential of Pr 3+ /Ce 3+ co-doped silicate glasses for visible lasing applications.
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高影响因子
Inorganics
·
2025
·Vol. 13
·期 5
·153
·
IF 3
Qianhong Zheng,Genying Zeng,Chenxing Liao,Huoming Huang,Weixiong You,Xinyu Ye,Liaolin Zhang
Bi-doped glasses and fibers have been widely applied in solid-state and fiber lasers. However, the mechanism underlying near-infrared (NIR) luminescence remains unclear, and Bi-related luminescence centers (BLCs) are prone to alteration during fiber fabrication, making it challenging to achieve high-performance Bi-doped glass fibers. In this work, Bi-, Bi-Al-, and Bi-Ge-doped silica glasses were investigated to elucidate the origin of NIR luminescence. Two broad NIR fluorescence bands were observed in silica glasses, originating from distinct BLCs. The longer-wavelength fluorescence band at 1423 nm, demonstrating sensitivity to Bi doping concentration and homogeneity, is attributed to Bi clusters (aggregates of Bi+ions), whereas the shorter-wavelength emission, independent of Bi concentration, originates from isolated Bi+ions. A vacuum-assisted melting-in-tube method with a single-step heating process was employed to fabricate Bi-doped silica-based glasses and fibers. The fluorescence bands of the fibers remained consistent with those of the precursor glasses, indicating no new BLCs were formed during fiber fabrication. The modulation of fluorescence bands was primarily governed by Bi cluster formation. Suppressing Bi clustering through co-doping with Al/Ge or optimizing fabrication conditions offers an effective route to tailor the fluorescence properties of Bi-doped glasses and fibers.
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