查找使用阿拉丁产品的科研文献

Speed and precision: unveiling an ICP-MS method for ultra-trace 239Pu quantification in food

Yinjie Zou,Hong Ren,Lei Zhou,Peng Wang,Yiyao Cao

A rapid, accurate, and sensitive inductively coupled plasma mass spectrometry (ICP-MS) method has been developed and validated for the determination of ultra-trace levels of Plutonium-239 ( 239 Pu) in food. After ashing, samples were digested with lefort aqua regia and treated with FeCl 3 to mask phosphorus (P) interference, thereby preventing it from inhibiting the adsorption of Pu by the resin column. Subsequently, a two-stage TK200 resin column was employed for separation and purification, followed by ICP-MS analysis using kinetic energy discrimination (KED) mode. By combining a chromatographic column with ICP-MS, this method achieved an overall decontamination factor (DF) of 3.53×10 12 for uranium hydride ions ( 238 UH + ) and demonstrated excellent linearity within the given concentration range, with a correlation coefficient ( r ) exceeding 0.999. The limit of detection (LOD) was 3.6 fg/g (ash), with an average recovery of over 74% and a relative standard deviation below 6.6%. Furthermore, the proposed method's applicability was evaluated by quantifying 239 Pu in food. The results indicate that this method is rapid, accurate, and sensitive, making it ideal for 239 Pu detection.

The compound-independent calibration of alkyl organophosphorus flame retardants in rice using GC-ICP-MS

Chen Hongze,Wan Yuebing,Li Kangcong,Li Xiuqin,Li Xiaomin,Chu Hongtao,Zhang Qinghe

Organophosphorus flame retardants (OPFRs) are widespread environmental contaminants with bioaccumulative potential and associated human health risks. The lack of commercial reference standards for many OPFRs limits the accuracy of their quantification. In this study, a compound-independent calibration (CIC) method using gas chromatography-inductively coupled plasma mass spectrometry (GC-ICP-MS) was developed for the simultaneous quantification of seven alkyl OPFRs, with tripropyl phosphate (TnPP) as a single universal calibrant. Key parameters were optimized: a DB-5MS column (15 m × 0.25 mm × 0.10 μm) with pulsed splitless injection (70 psi, 280 °C), and ICP-MS settings including an RF power of 1600 W, sampling depth of 7.5 mm, dilution gas flow rate of 0.5 mL/min, and octopole voltage of − 5 V. The method exhibited excellent linearity ( R 2  = 0.9994 to 0.9999) over the range of 0.01–1.0 μg/mL. Limits of detection and quantification were 0.22 to 0.91 ng/mL and 0.75 to 3.02 ng/mL, respectively. For six of the seven OPFRs (excluding TEHP), the relative P response ratios compared to TnPP ranged from 0.91 to 1.01, confirming effective structure-independent calibration. The matrix effect in rice was moderate (enhancement factors 1.13–1.35). Quantitative results obtained by the CIC method agreed well with those from an external standard approach, with relative deviations within −8.54% to +7.78%. This work demonstrates that CIC-GC-ICP-MS using a single, readily available calibrant provides a reliable, practical solution for quantifying alkyl OPFRs in complex food matrices, effectively overcoming the challenge posed by the scarcity of compound-specific reference standards. Graphical The alternative text for this image may have been generated using AI.

High-precision molybdenum isotope analysis of low-Mo igneous rock samples by MC–ICP–MS

Jing-Jing Fan,Jie Li,Qiang Wang,Le Zhang,Jing Zhang,Xiang-Lan Zeng,Lin Ma,Zi-Long Wang

Recent advances in analytical techniques have achieved high-precision (2σ ≤ 0.06‰) determinations of Mo isotopic ratios in silicate rocks but few such data are as yet available, especially for low-Mo (<50 ppb) rocks such as leucogranites . Here we present two low-blank, double-spike, high-yield, ion-exchange chromatographic methods (single- and two-column) for precise determination of Mo isotopic ratios in low-Mo rock samples (10–500 ppb) using multicollector–inductively coupled plasma–mass spectrometry (MC–ICP–MS). The two-column technique involved AG 1-X8 anion-exchange (100–200 mesh) and BPHA chelatin resins, with the latter also used in the single-column procedure. Two USGS reference materials (basalt BIR-1a and diabase W-2a) were analyzed for quality-control purposes. Their δ 98/95 Mo values determined using the two methods are consistent within uncertainties, and with those determined by previously published methods. We provide the first Mo isotopic data for the reference materials of dunite DTS-2b (USGS), GPt-3 (NRCG) and peridotite WPR-1 (CCRMP). δ 98/95 Mo values for DTS-2b and WPR-1 by using two-column procedure are in good agreement with those obtained by single-column separation. Repeated analyses of these standards indicate a long-term external reproducibility of better than ±0.05‰. However, the δ 98/95 Mo values of GPt-3 show poor reproducibility due to either the sample heterogeneity or existing undigested minerals (e.g., spinel). The methods were applied to leucogranites with low Mo contents of 10–74 ppb from the Himalaya orogen and southern Lhasa terrane of Tibet . The isotopic analyses yielded δ 98/95 Mo values of −0.2‰ to 0.34‰ and −0.41‰ to −0.68‰ (against NIST SRM 3134), respectively, within the range of values for igneous crust. Their contrasting Mo isotopic compositions may indicate compositional diversity in their sources or differences in magma evolution .

Cadmium and cobalt ions enhanced-photochemical vapor generation for determination of trace rhenium by ICP-MS

Yafei Zhen,Hanjiao Chen,Meng Zhang,Jing Hu,Xiandeng Hou

Quantitative Detection of Zinc Oxide Nanoparticle in Environmental Water by Cloud Point Extraction Combined ICP-MS

Yuan Yang,Xin Liu,Lin Luo,Wenjing Wei,Qiang Wang,Jiachao Zhang

The increasing usage of zinc oxide nanoparticles (ZnONPs) inevitably leads to their release into the environment. To understand their fate and toxicity in water systems, a reliable method for the quantitative analysis of ZnONPs in environmental waters is urgently needed to be established. In this study, a quantitative analytical method of ZnONPs in environmental waters was developed by cloud point extraction (CPE) combined inductively coupled plasma mass spectrometry (ICP-MS). To obtain high recoveries of ZnONPs, the CPE parameters including pH, surfactant concentration, salt concentration, bath temperature, and time were optimized. The results demonstrated that the addition of β-mercaptoethylamine could significantly reduce the interference of Zn2+ on the extraction of ZnONPs, while the CPE approach was not affected significantly by the typical environmental inorganic ion and ENMs (such as Au, TiO2, and Al2O3). The extraction method of ZnONPs with different diameters was also assessed, and satisfactory extraction efficiency was obtained. The results of ZnONP concentration in collected environmental water were in the range of - μg/L. And the recoveries of ZnONPs in different environmental waters were - at low concentration spiked levels (12.57-54.68 μg/L), demonstrating that it is efficient to extract trace ZnONPs from real environmental waters. This established method offered a reliable method for the quantitative determination of ZnONPs in environmental waters, which could further promote the study of the environmental behavior, fate, and toxicity of ZnONPs in an aqueous environment.

ICP-MS based detection method combined with Au NP and Ag NP labeling for bacteremia diagnosis

Xiaoting Li,Xin Li,Jiayi Chen,Zuomin Tan,Chuan Wang

Bacteremia , as a serious infectious disease, has an increasing incidence and a high mortality rate . Early diagnosis and early treatment are crucial for improving the cure rate. In this work, we proposed an inductively coupled plasma mass spectrometry (ICP-MS)-based detection method combined with gold nanoparticle (Au NP) and silver nanoparticle (Ag NP) labeling for the simultaneous detection of Salmonella and Escherichia coli ( E. coli O157:H7) in human blood samples. Salmonella and E. coli O157:H7 were captured by magnetic beads coupled with anti-8G3 and anti-7C2, and then specifically labeled by Au NP-anti-5H12 and Ag NP-anti-8B1 respectively, which were used as signal probes for ICP-MS detection. Under the optimal experimental conditions, the limits of detection of 164 CFU mL −1 for Salmonella , 220 CFU mL −1 for E. coli O157:H7 and the linear ranges of 400–80,000 CFU mL −1 Salmonella , 400–60,000 CFU mL −1 E . coli O157:H7 were obtained. The proposed method can realize the simultaneous detection of two types of pathogenic bacteria in human whole blood in 3.5 h, showing great potential for the rapid diagnosis of bacteremia in clinic.

A new two-stage purification method for high-precision indium isotope measurement by MC-ICP-MS

Bingyu Peng,Qiaohui Zhong,Gaobin Chu,Jie Li

Conventional indium (In) separation methods based on anion-exchange resins typically involve multiple evaporation and medium-transfer steps or require large volumes of concentrated acids, leading to prolonged processing times and potential contamination risks. Herein, we present an efficient two-stage column separation method for the separation and purification of In from complex geological matrices using two self-made trioctylamine (N235) and tri-n-octylphosphine oxide (TOPO) resins, enabling high-precision In isotopic analysis by multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS). In the first column, most matrix elements were efficiently removed in HBr medium, and the In fraction together with trace amounts of Mo and Sn were eluted using 0.2 M HCl, and were ready for a second column purification without any evaporation. Subsequently, the residual interference of Mo and Sn was quantitatively removed from the In fraction using the TOPO resin column. This method not only eliminates hazardous reagents such as hydrofluoric acid (HF) but also significantly reduces resin and acid consumption compared to previous methods, achieving high In recoveries (>95%) and low procedural blanks (<0.2 ng). For In isotopic analysis, a combination of standard-sample bracketing with an Sb external method was employed for instrumental mass bias correction. NIST SRM 3124a In standard solution, for the first time, was adopted as a reference with an external reproducibility of 0.07‰ (2SD, n = 233) over a year. The method was validated using nine diverse geological reference materials (RMs). The In isotopic compositions obtained for three internationally recognized RMs were in good agreement with previously reported literature values. For the six other RMs, In isotope data are reported here for the first time, and they exhibit excellent external reproducibility. Moreover, all purified samples showed negligible isobaric interferences and matrix effects during MC-ICP-MS analysis, confirming the method's suitability for challenging geological samples.

Structure-switching locked hairpin triggered rolling circle amplification for ochratoxin A (OTA) detection by ICP-MS

Jie Zhang,Yuheng Lu,Wei Gao,Peng Yang,Nansheng Cheng,Yanwen Jin,Junbo Chen

Ochratoxin A (OTA) is usually found in the contaminated cereal food that its trace concentration would cause severe carcinogenicity and neurotoxicity. Herein, a recognition-triggered structure switching-based element spectrometric assay was proposed for ultrasensitive and highly specific detection of OTA. OTA aptamer was first adapted into a primer for the formation of a locked hairpin (LHP), and followed by attachment on the surface of magnetic beads (MBs). In the presence of OTA, the binding event between OTA molecule and its aptamer induced the liberation of the primer for that is otherwise unable to spontaneously structure-switching. For the rolling circle amplification (RCA), thereby a dumbbell structure was designed as the template (DT). The hybridization of the dumbbell template with free primer initiates the rolling circle amplification along with the production of repeated sequences. To obtain the signal output, the DNA-AuNP tag was prepared which contained the complementary sequences with RCA products. Thus, each tag can hybridize with the repeated sequences derived from the RCA, enabling the formation of detectable signal by the following ICP-MS measurement. Such design can translate a single recognition event into numerous AuNPs, enabling amplified detection of OTA. Taking advantage of this principle, the OTA in real sample (AFP, PSA) can be quantified at femtomolar concentration and it can be expanded into application in food safety inspection.

Analytical methods for plutonium speciation using CE-ICP-MS: Migration behavior, method validation, and uranium matrix effects

Shuang Qin,Di Wu,Chu-Ting Yang,Feng-Cheng Wu,Ning Wang

Accurately identifying plutonium (Pu) valence states is critical to the safety and efficiency of nuclear fuel reprocessing. In this study, an analytical method for Pu valence state speciation was developed based on capillary electrophoresis hyphenated to inductively coupled plasma mass spectrometry (CE-ICP-MS), enabling effective separation and quantification of Pu(III), Pu(IV), and Pu(VI). Optimal separation conditions were established using surrogate elements with stable oxidation states and 2-hydroxyisobutyric acid (α-HIBA) as the background electrolyte (BGE). Under optimized conditions, the migration order of Pu valence states was determined as Pu(III) > Pu(VI) > Pu(IV), with a relative standard deviation (RSD) of migration time < 1.5%, indicating excellent analytical repeatability. The method was successfully applied to monitor the reduction of Pu(VI) by zero-valent iron (Fe 0 ), elucidating the valence state transformation kinetics (Pu(VI) → unstable Pu(IV) intermediate → Pu(III)). Notably, the method exhibited robust anti-interference capability in high uranium (U) matrices, maintaining baseline separation of Pu valence states even at a U/Pu ratio of 100. This study provides a novel, reliable approach for Pu speciation analysis in complex nuclear matrices, with significant implications for process control and Pu recovery in nuclear fuel reprocessing.

Rapid Determination of Trace Element Compositions in Peridotites by LA-ICP-MS Using an Albite Fusion Method

Shenyang Y. Zhang,Hongluo L. Zhang,Zhenhui Hou,Dmitri A. Ionov,Fang Huang

A rapid sample preparation procedure is described to determine trace element compositions of peridotites using LA-ICP-MS. Peridotite powders were fused with albite in a molybdenum–graphite assembly to obtain homogeneous glasses. Best conditions for the fusion procedure (heating at 1500–1550 °C for 10–15 min with a sample-to-flux ratio of 1:2) were constrained with melting experiments on two USGS reference materials, PCC-1 and DTS-2B. Mass fractions of first series transition elements, Ba and Pb, in quenched glasses of PCC-1 and DTS-2B are consistent with published data within 10% RSD. Three spinel peridotite xenoliths from eastern China were analysed following both our method and conventional solution ICP-MS. Compared with solution ICP-MS, the relative deviations of our method for most elements were within 10%, while for the REE, Ta, Pb, Th and U, the relative deviations were within 20%. In particular, volatile elements (e.g., Pb and Zn) are retained in the glass. Compared with conventional wet chemistry digestion, our method is faster. Additional advantages are complete sample fusion, especially useful for samples with acid-resistant minerals (spinel and rutile), and long-term conservation of glasses allowing unlimited repeated measurements with microbeam techniques. The same approach can be used for analyses of other mantle rocks, such as eclogites and pyroxenites.

Monolithic capillary microextraction combined with ICP-MS for the determination of TiO2 NPs in environmental water samples

Xiaolan Liu,Man He,Beibei Chen,Bin Hu

Increasing use of TiO 2 nanoparticles (NPs) leads to an accumulation in environment and a risk to human. In this work, an on-line monolithic capillary microextraction (CME)-inductively coupled plasma mass spectrometry (ICP-MS) method was developed for sensitive determination of TiO 2 NPs in environmental water samples. With the presence of citric acid , TiO 2 NPs can be selectively adsorbed on the poly(acrylamide)-vinylpyridine-methylene bis-(acrylamide) (poly(AA-VP-Bis)) monolithic column at pH 1, whereas Ti ions cannot be adsorbed. Factors affecting the extraction efficiency such as sample pH, concentration of citric acid and elution conditions were carefully investigated. Under the optimum conditions, a detection limit of 0.63 μg L −1 for TiO 2 NPs and a sample throughput of 6 h −1 were achieved. The method can be applied to the determination of TiO 2 NPs in the size range of 5–100 nm. The developed method was then applied to the analysis of TiO 2 NPs in the East Lake water and Yangtze River water, and recoveries of 84–109% were obtained for spiked samples. Compared with other reported methods for the determination of metal oxide NPs, the developed on-line monolithic CME-ICP-MS has the merits of simple operation, high throughput and no need for digestion before ICP-MS detection.

In-situ elemental quantitative imaging in plant leaves by LA-ICP-MS with matrix-matching external calibration

Zewei Cui,Man He,Beibei Chen,Bin Hu

Due to the enormous interest in plants related to bioscience, environmental and toxicological research, analytical methods are expected with the ability of getting information on elemental transfer, distribution and contents in plants. In this work, a mixture of gelatin (GA) and hydroxypropyl methyl cellulose (HPMC) was prepared to simulate plant matrix, a method based on laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) with matrix-matching external calibration was proposed for direct quantification of multiple elements in plants. The composition of GA&HPMC substrate was optimized, such as the concentration of spiked nitric acid , the mass fraction of both GA and HPMC in the substrate and the mass ratio of GA: HPMC. After spiking elemental solution, coating the mixture onto a glass slide and drying overnight at room temperature , GA&HPMC substrate was obtained. The substrate obtained with GA: HPMC of 8: 2 was used to fabricate the standard series, which exhibited good elemental homogeneity and similar elemental signal intensities in LA-ICP-MS detection to that obtained for plant Certified Reference Material (CRM). CRMs of different plants including Citrus leaf (GBW10019), Tea (GBW07605), Beans (GBW10021) and Scallions (GBW10049) were further pressed into pellets and subjected to the proposed method, and the quantification accuracy was demonstrated. The limits of detections of this method were found to be 0.003 (Ce)-104 (Ca) μg g −1 , with a wide linear range (0.01–10000 μg g −1 ) for 17 target elements. The application potential of the method was further demonstrated by performing elemental imaging in Trigonotis peduncularis leaves. Rapid in-situ quantitative imaging of Zn, Cu, Sr and Mn was achieved, and the elemental quantitative distributions were discussed. The constructed substrate helped direct elemental quantification in plants. It provided a powerful and efficient tool for the investigation of the distribution and transfer of elements in plants, favoring further exploration of elemental bioavailability , transport and toxicity mechanisms.