MOLECULES
·
2023
·Vol. 28
·期 8
·3307
·
IF 4.6
Jiaxuan Yang,Ning Chu,Xuwei Chen
A novel porous polyoxometalate (POM)-based composite (Co4PW–PDDVAC) was prepared via the solidification of water-soluble polytungstate (Co4PW) on the polymeric ionic liquid dimethyldodecyl-4-polyethylene benzyl ammonium chloride (PDDVAC) via a cation-exchange reaction. The solidification was confirmed by EDS, SEM, FT-IR, TGA, and so on. The strong covalent coordination and hydrogen-bonding interaction between the highly active Co2+of the Co4PW and the aspartic acid residues of proteinase K endowed the obtained Co4PW–PDDVAC composite with excellent proteinase K adsorption properties. Thermodynamic investigations indicate that the adsorption behavior of proteinase K was consistent with the linear Langmuir isothermal model, giving an adsorption capacity as high as 1428 mg g−1. The Co4PW–PDDVAC composite was applied in the selective isolation of highly active proteinase K fromTritirachium albumLimber crude enzyme fluid.Keywords:polyoxometalate;water-soluble polytungstate;polymeric ionic liquid;proteinase K (PrK);isolation
研究领域:
材料科学
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生物化学
·
生物技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Xiang Li,Xueqian Wang,Li Yuan,Langlang Wang,Yixing Ma,You Wu,Yibing Xie,Rui Cao,Yiran Xiong,Ping Ning
The lengthy processes and cumbersome operations for the separate removal of COS and H 2 S have severely limited the development of blast furnace gas recycling process. CuO exhibits excellent H 2 S oxidation performance, but weak COS hydrolysis performance; in contrast, ZrO 2 shows the opposite trend. However, the functional combination of CuO and ZrO 2 has never been used for simultaneous removal of COS and H 2 S. In this study, a Cu/Zr co-doped K@TiO 2 bifunctional catalyst was tailored to simultaneously remove COS and H 2 S. The combined COS and H 2 S capacity of this catalyst reaches 340.5 mg/g at a low temperature of 60 °C, which is much higher than those of other reported bifunctional catalysts. The microcrystal structure formed by Cu/Zr co-doping increases the specific surface area of the catalyst and promotes the adsorption of COS/H 2 S. Specifically, Zr doping increases the content of moderate basic sites and significantly improves the hydrolysis efficiency of COS. Moreover, Cu doping induces lattice distortion of TiO 2 , while CuO captures 4 s valence electrons of K to form Cu 2 O. These two processes lead to the release of lattice oxygen from TiO 2 and CuO, generating oxygen vacancies and ·O 2 − , which promotes H 2 S oxidation. By proposing a simple route for the bifunctionalization of a desulfurization catalyst, this study drives innovation in both the theory and application of simultaneous removal of COS and H 2 S.
研究领域:
环境科学
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催化化学
✓ 已验证
产品关联
DOI
高影响因子
MACROMOLECULAR BIOSCIENCE
·
2017
·Vol. 17
·期 9
·1700143
·
IF 3.238
Shan Yan,Lin-Yan Wan,Xiao-Jie Ju,Jiang-Feng Wu,Lei Zhang,Ming Li,Zhuang Liu,Wei Wang,Rui Xie,Liang-Yin Chu
In this work, a novel type of block copolymer micelles with K + -responsive characteristics for targeted intracellular drug delivery is developed. The proposed smart micelles are prepared by self-assembly of poly(ethylene glycol)- b -poly( N -isopropylacry-lamide- co -benzo-18-crown-6-acrylamide) (PEG- b -P(NIPAM- co -B18C6Am)) block copolymers. Prednisolone acetate (PA) is successfully loaded into the micelles as the model drug, with loading content of 4.7 wt%. The PA-loaded micelles display a significantly boosted drug release in simulated intracellular fluid with a high K + concentration of 150 × 10 −3 m , as compared with that in simulated extracellular fluid. Moreover, the in vitro cell experiments indicate that the fluorescent molecules encapsulated in the micelles can be delivered and specifically released inside the HSC-T6 and HepG2 cells responding to the increase of K + concentration in intracellular compartments, which confirms the successful endocytosis and efficient K + -induced intracellular release. Such K + -responsive block copolymer micelles are highly potential as new-generation of smart nanocarriers for targeted intracellular delivery of drugs.
研究领域:
药学
·
纳米技术
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药物递送系统
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细胞生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Zhihao Dong,Peiyao Zhao,Xiao Ma,Limin Guo,Longtu Li,Xiaohui Wang
To reconcile the contradiction between piezoelectric property and its temperature stability, the preparation of composite piezoceramics using multiple components has become an emerging direction. Herein, (K,Na)NbO 3 -based piezoceramics are adopted to prepare high-performance laminated composite ceramics inspired by the lamination composite strategy, and sintered in the reducing atmosphere to meet the development of multilayer piezoelectric actuators with base metal internal electrodes. By adjusting the composition ratio, a high inverse piezoelectric coefficient d 33 * of 1065 pm/V (@ 2 kV/mm) is obtained in the two-component composite ceramics, which fluctuated less than ± 6% in the range of 25–160 °C. In the three-component composite ceramics, a higher d 33 * value of 1326 pm/V (@ 2 kV/mm) is achieved and maintained > 90% until 150 °C. The electric-field-induced strain performances of laminated composite ceramics significantly exceed those of their basic components, which is related to the piezoresponse gain provided by the internal interfaces. The excellent temperature stabilities come from the more diffused phase transition temperature range formed by the complementation of multiple components. The combination of ultrahigh strain performance, high temperature stability, and good fatigue resistance, together with sintering in the reducing atmosphere, constitutes an important step to promote the application of (K,Na)NbO 3 -based multilayer piezoelectric actuators.
研究领域:
材料科学
·
陶瓷工程
·
电陶瓷
✓ 已验证
DOI
高影响因子
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2024
·
IF 3.3
Wenxian Liu,Liting Xu,Haina Cheng,Zhu Chen,Hongbo Zhou,Yuguang Wang
BACKGROUND The potential for the efficient conversion of lignocellulosic biomass has been extensively explored to produce a wide range of bioproducts. Many approaches have been sought for the deep conversion of lignin to generate products that are toxin-free and beneficial for processing into high-value-added components. RESULTS This study reported a fungus isolated from the deep sea with strong synthesis of multiple lignocellulases, conversion of lignin and guaiacol (0.1%) by 71.6% and 86.1% within 9 days at 30 °C respectively, and outstanding environmental adaptability (20–50 °C and pH 3–8). Metabolic pathway profiling showed that this fungus utilized lignin to rapidly activate multiple ring-opening reactions including the 2,3- and 3,4-cleavage pathways, with the 2,3-cleavage pathway predominating after 5 days. Conversion of metabolic intermediates confirmed the superb potential of this strain for lignin treatment. Meanwhile, its shikimic acid pathway was metabolically active under lignin. CONCLUSION This further expands the potential to produce valuable bioproducts during lignin treatment, especially under ambient conditions, which can significantly enhance high-value precursor compound production. © 2024 Society of Chemical Industry.
研究领域:
生物技术
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环境科学
·
微生物学
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生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2023
·
IF 6.7
Xiaokun Zhu,Shuaizhao Jin,Xiaohan Yu,Zhiyuan Yu,Xin Gu,Xiaoli Guan,Kaikai Wu,Yixin Yan,Liming Zhao,Jiamei Han,Jiabin Jiang,Xiang Liu,Xiangming Li
In this study, La 0.7 Ag 0.3- x K x MnO 3 (LAKMO, x = 0.15, 0.16, 0.17, 0.18, and 0.19) films with excellent electrical properties and low surface roughness were prepared on SrTiO 3 ( 0 0 1 ) substrates using the spin-coating method. The crystal structures and ion valence states of the LAKMO films were modified by adjusting the doping amounts of Ag and K. The Jahn–Teller effect and electron–lattice coupling were enhanced with the MnO 6 octahedron undergoes distortion. Moreover, the double-exchange interaction was improved with an increase in the number of Mn 4+ /Mn 3+ ion pairs. Under the influence of these factors, the electrical transport properties especially the temperature coefficient of resistivity ( TCR ) of the LAKMO films can be refined modulated or optimized via A-site Ag and K co-doping. When x = 0.17, the maximum TCR of LAKMO reached 11.23 % K −1 at 293.23 K. Thus, La 0.7 Ag 0.13 K 0.17 MnO 3 film with a large TCR exhibited excellent thermal properties at room temperature and was considered material for application to uncooled infrared bolometers.
研究领域:
材料科学
·
电子工程
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Limei Yang,Ye Liu,Rongxue Wang,Linqian Hou,Yaling Yang
A K-doped carboxylated polydopamine (PDA) modification of the g-C3N4 (K-g-C3N4@PDA) nanozyme was effectively performed by one-step potassium salt-assisted thermal copolymerization and hydrothermal strategies. K-g-C3N4@PDA showed excellent peroxidase (POD)-like activity, and ferric ammonium citrate (FAC) efficiently promoted the generation of hydroxyl radicals (˙OH). Furthermore, K-g-C3N4@PDA oxidized 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) in the presence of H2O2 to produce a blue-green product, and FAC boosted the POD-like activity with an exceptional linear relationship and low detection limit (0.018 μg mL−1). Importantly, a recovery rate of 94.09–105.17% was attained when the developed method was effectively used to assess FAC in culinary salt samples using a spiking procedure.
研究领域:
纳米技术
·
分析化学
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酶模拟物
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食品安全
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
Optoelectronics Letters
·
2017
·Vol. 13
·期 4
·291-294
·
IF 0
Wang Shuo,Ma Rui-xin,Wang Cheng-yan,Li Shi-na,Wang Hua
Quaternary chalcogenide Cu 2 FeSnS 4 (CFTS) nanoparticles, as a kind of potential absorber layer material in thin film solar cells (TFSCs), were successfully synthesized by using a convenient solvothermal method. Alkali element K is incorporated into CFTS thin films in order to further improve the surface morphology and the optical properties of related films. X-ray diffraction (XRD), Raman spectroscopy and field emission scanning electron microscopy (FESEM) were used to characterize the phase purity, morphology and composition of CFTS particles and thin films. The results show that the particle elemental ratios of Cu/(Fe+Sn) and Fe/Sn are 1.2 and 0.9, respectively, which are close to the characteristics of stoichiometric CFTS. The band gaps of CFTS films before and after doping K ions are estimated to be 1.44 eV and 1.4 eV with an error of ±0.02 eV.
研究领域:
材料科学
·
半导体物理
·
薄膜太阳能电池
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无机功能材料
·
光电材料
✓ 已验证
DOI
JOURNAL OF LUMINESCENCE
·
2020
·
IF 3.28
Rui Zhang,Yaoxin Yuan,Jinhong Li,Zhenxing Qin,Qingmei Zhang,Bangyun Xiong,Zesong Wang,Fenghua Chen,Xiujuan Du,Wen Yang
All-inorganic lead halide perovskite nanocrystals (NCs) as new emerging semiconducting luminescent materials have attracted tremendous attention for designing optoelectronic devices . We have synthesized high quality of the CsPbX 3 NCs with tunable entire visible spectral region by a modified lower temperature method, featured with facile, low-cost and easily operating in an open environment without vacuumization or glovebox system. Besides, we have investigated the incorporation of Ni and K ions into CsPbX 3 NCs by adjusting all kinds of composition concentration from halogen salts, based on above mentioned preparation method. The absolute photoluminescence quantum yields (PLQYs) of doped CsPbX 3 NCs with different dopant (Ni or K ions) concentration were discussed. It is found that a certain amount of doping is beneficial for suppressing the defects and improving the lattice structure of nanocrystals, whereas an excessive dopant may induce quenching centers of the emission. In addition, a glorious absolute PLQYs of doped CsPbX 3 NCs can be obtained by our method, especially for CsPbBr 3 and CsPbI 3 NCs, and nearly reach 80%.
研究领域:
材料科学
·
光学工程
✓ 已验证
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2022
·
IF 6.633
Hui Lu,Xiaoran Li,Feng Li,Xiuquan Xu,Rong Zhao,Chenyi Xiong,Qing Hu,Zhuoqing Miao,Miao Tian
Photocatalytic technique has been widely accepted as a promising and effective candidate for eliminating antibiotic and pathogen pollutants in aquatic environment. Herein, a novel O, K co-doped g-C 3 N 4 photocatalyst embedded with single-atom Ag (denoted as Ag/OKCN) was successfully constructed to achieve the enhanced photocatalytic degradation and disinfection efficiency under visible light irradiation. The optimal Ag/OKCN-6 could eliminate 80.4 % of tetracycline (TC) within 60 min with a rate constant of 0.0259 min −1 , which was 4.98 times of pristine g-C 3 N 4 . Meanwhile, Ag/OKCN-6 could also completely inactivate>7-log CFU·mL −1 of Escherichia coli ( E. coli ) by efficient disruption of cell membranes. The synergistic effect of O, K co-doping and single-atom Ag embedding contributed to an extended light response, preeminent separation and transfer of photoexcited charges, prolonged carrier lifetime as well as ameliorative hydrophilicity, which was conducive to the excellent photocatalytic performance. Radical trapping and electron spin resonance (ESR) experiments validated that superoxide radicals ( • O 2 − ) were crucially responsible for the superior photocatalytic activity. This work provides a facile route to construct multi-strategy modified g-C 3 N 4 -related photocatalysts for efficiently eliminating aquatic environmental pollutants.
研究领域:
环境科学
·
材料科学
·
生物学
✓ 已验证
产品关联
DOI
高影响因子
ACS Chemical Neuroscience
·
2023
·
IF 5
Xiaoyi Shi,Meng Li,Qiming Huang,Liuming Xie,Zhibing Huang
Monacolin K (MK), a polyketo secondary metabolic compound of the mold genus Monascus, can promote the apoptosis of malignant cancer cells, possessing potential antitumor properties. However, its mechanism of action on gliomas remains unclear. Here, we explored and investigated the potential of the monacolin K’s antitumor effect on human glioma U251 cells and its possible molecular mechanism. Results showed that the application of 10 μM monacolin K inhibited the proliferation of U251 cells, with an inhibitory rate of up to 53.4%. Additionally, monacolin K induced the generation of reactive oxygen species and activated mitochondria-mediated pathways, including decreased MMP, activation of caspase3/caspase9, decreased Na+/K+-ATPase and Ca2+-ATPase activities, and disruption of the antioxidant system, resulting in the disruption of intracellular reduction–oxidation homeostasis. Monacolin K also activated MAPK and NF-κB pathways, upregulating P38 activity and downregulating JNK/ERK/P65/IκBα expression, ultimately leading to apoptosis of U251 cells. Importantly, monacolin K was not cytotoxic to normal human cells, hUC-MSCs. We concluded that monacolin K can induce apoptosis in U251 cells by triggering ROS-mediated oxidative damage and regulating MAPKs and NF-κB pathways.
研究领域:
肿瘤学
·
细胞生物学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL BIOCHEMISTRY
·
2014
·
IF 2.305
Xian Fang,Lijuan Bai,Xiaowei Han,Jiao Wang,Anqi Shi,Yuzhong Zhang
In this study, an ultra-sensitive hairpin DNA-based electrochemical DNA biosensor for K-ras gene detection is described. Gold nanoparticles (Au-NPs) and horseradish peroxidase (HRP)–streptavidin capped Au-NPs (HAS) conjugates are used for signal amplification. Initially, hairpin DNA dually labeled with thiol at its 5′ end and with biotin at its 3′ end is immobilized on the surface of Au-NPs modified electrode , and the hairpin DNA is in a “closed” state; hence, the HAS conjugates are shielded from being approached by the biotin due to steric hindrance . However, in the presence of target DNA, the target DNA hybridizes with the loop structure of hairpin DNA and causes conformational change, resulting in biotin forced away from the electrode surface, thereby becoming accessible for the HAS conjugates. Thus, the HAS conjugates are linked to the electrode surface via the specific interaction between biotin and streptavidin . Electrochemical detection was performed in phosphate-buffered saline (PBS) containing tetramethylbenzidine (TMB) and H 2 O 2 . Under optimal conditions, the peak current differences (Δ I ) are linear with the target DNA in the range from 0.1 fM to 1 nM with a detection limit of 0.035 fM. Furthermore, this biosensor also demonstrates its excellent specificity for single-base mismatched DNA.
研究领域:
生物化学
·
分子生物学
·
纳米技术
·
基因工程
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）