JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2022
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IF 3.119
Shaohua Lv,Yun Hao,Bohao Yang,Linghong Tang
In this article, a calorimeter was established on the basis of steady-flow calorimetry. The present calorimeter was utilized to measure the isobaric heat capacity (cp) of target fluids. First, water was measured to verify the reliability of the experimental system. Then the measurements of cp for methyl hexanoate and ethyl hexanoate were carried out at temperatures from 313 K to 433 K and pressures of up to 10 MPa. To implement easier industrial application, a correlation was proposed on the basis of the experimental data to calculate the cp values of methyl hexanoate and ethyl hexanoate, with maximum absolute relative deviations of 0.77% and 0.65%, respectively. The newly reported data will be helpful for use with methyl hexanoate and ethyl hexanoate.
研究领域:
化学工程
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热力学
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL LETTERS
·
2021
·
IF 2.329
Penghui Jin,Daoqing Ma,Yabiao Gao,Libin Wang,Zhihong Gao,Yating Zhang,Mingxin Liu,Jingying Xu,Jidong Wang
A highly sensitive and dual-directional fluorescent sensing system was developed to detect both cisplatin prodrug cross-linked hyaluronic acid (CPHA) hydrogel (quencher) and DNA (receptor) based on mercaptopropionic acid (MPA) capped CdTe quantum dots (QDs). Different from the previous work for this platinum compound, a multifunctional delivery system, CPHA hydrogel, which was used to address the challenges in drug resistance and severe side effects, was prepared and accurately detected based on the synthesis of the cisplatin prodrug and fluorescence quenching of CdTe QDs resulting from photo-induced electron transfer. When DNA was conjugated with Pt ions in a system composed of CdTe QDs and CPHA hydrogel, the fluorescence of the system was recovered for the determination of DNA. This reversible “turn off–on” strategy presented a high sensitivity and low detection for CPHA hydrogel from 10 to 50 nM with a detection limit of 1.50 nM and DNA from 0 to 75 nM with a detection limit of 0.60 nM. This approach provides a novel direction for further study of the Pt based drug-load with reduced side effects and improved therapy efficacy, effective screening of anticancer drugs, and accurate determination of DNA at low concentrations.
研究领域:
生物医学工程
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药物化学
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分析化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2017
·
IF 2.323
Ying Zhang,Xiong Zheng,Yutian Chen,Maogang He
The thermal diffusivities of 2-ethoxy-2-methylpropane (ETBE) and 2-methoxy-2-methylbutane (TAME) (mass purity > 0.990, GC) were measured by the dynamic light scattering method. The investigated p–T regions are T = (293 to 523) K and p = (4 to 10) MPa, including saturated liquid, saturated vapor, and liquid. The expanded relative uncertainty in thermal diffusivity was estimated to be less than 2.4% over the whole investigated range. The influences of temperature and pressure on thermal diffusivity were presented. The empirical correlation of thermal diffusivities for both saturated liquid/vapor and liquid were also proposed with absolute average relative deviations (AARDs) of 0.22 and 0.26% for saturated-liquid ETBE and TAME, 0.13 and 0.20% for saturated-vapor ETBE and TAME, and 0.23 and 0.69% for liquid ETBE and TAME, respectively.
研究领域:
热物理
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化学工程
·
物理化学
✓ 已验证
DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2018
·
IF 2.196
Ying Zhang,Yutian Chen,Taotao Zhan,Maogang He
The speed of sound in n-heptane was measured by the Brillouin light scattering (BLS) method. The examined region is T = (513.40 to 650.90) K along seven isobaric lines at p = (2.5, 3.0, 4.0, 5.0, 6.0, 8.0, and 10.0) MPa, which was near the critical point of n-heptane. The relative expanded uncertainty (k = 2) of BLS experimental system is estimated to be <0.013 for the speed of sound measurement. The variation tendencies of the speed of sound with increasing temperature and pressure were illustrated. Moreover, the calculated results from the multiparameter equation of state (EOS) proposed by Span and Wagner were employed to assess the experimental data in this paper. The absolute average of the deviations (AAD) between the experimental data and the calculated results is 1.22% in the whole investigated p–T region.
研究领域:
热力学
·
物理化学
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL LETTERS
·
2020
·
IF 1.467
Jiajia Hong,Xiaotang Hao,Tiantian Liu,Weiting Liu,Meiyi Xie,Mei Wang,Qian Xu,Bingyi Yang
A sensitive method termed rapid synergistic cloud point extraction (RS-CPE) combined with partial least squares (PLS) was developed for the extraction and simultaneous determination of trace amounts of phenol and three detrimental chlorophenols (CPs) via a microplate assay (MPA). In this study, n-pentanol was used as a novel synergistic inducer and the linear nonionic surfactant Tergitol 15-S-7 was used as an extractant. The whole process of RS-CPE was accomplished in a few minutes without the need for the time-consuming water- or ice-bath steps used in traditional cloud point extraction. An automated and high-throughput assay using a 96-well plate allowed for the simultaneous processing of multiple samples with low sample volume requirements (approximately 200 µL). However, synchronized determination of several CPs using MPA method was problematic because of spectral interferences. Fortunately, a multivariate calibration method using PLS was applied to circumvent these limitations. Under the optimum conditions, the linear dynamic concentration ranges were from 0.5 to 15 µg/mL for 2-chlorophenol and 0.5 to 20 µg/mL for the other analytes. The detection limit range was from 0.275 to 0.419 µg/mL. The enrichment factor was up to 15.4 fold. The developed methodology was successfully applied to quantitative analysis of phenol and three CPs in water samples with recoveries from 90.0% to 109%.
研究领域:
分析化学
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环境科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2009
·
IF 2.063
Li Hongling,Zhu Rongjiao,Xu Wei,Xu Hongfei,Dong Zeliang,Tian Yiling
High-pressure vapor−liquid equilibrium data for (methyl propionate + carbon dioxide) and (propyl propionate (PP) + carbon dioxide) were measured at pressures from (1.00 to 12.00) MPa and temperatures in the range from (313.0 to 373.0) K. Experimental results were correlated with the Peng−Robinson equation of state with the two-parameter van der Waals mixing rule. At the same time, the Henry’s coefficient and partial molar enthalpy change and partial molar entropy change of CO2 during dissolution at different temperature were also calculated.
研究领域:
化学工程
·
热力学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2022
·
IF 3.119
Yun-Jia Liu,Liu-Ying Yu,Ke-Jun Wu,Chao-Hong He
In this work, the thermal conductivities of 1,3-dichloro-2-propanol + N,N-dimethylformamide (DMF) were measured from 303 to 368 K at pressures up to 15.10 MPa by using a transient hot-wire method. Measurements were made for six compositions over the entire concentration range from 0 to 1 mass fractions of DMF, namely, 0.000, 0.200, 0.400, 0.600, 0.800, and 1.000 mass fractions of DMF. The experimental data were correlated as a function of temperature, pressure, and mass fraction of DMF. The expanded uncertainty of the obtained data was estimated to be 2% with a confidence level of 0.95 (k = 2).
研究领域:
热力学
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化学工程
·
物理化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
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2023
·
IF 2.6
Juan Wang,Zenghui Li,Xianyang Meng,Jiangtao Wu
In this work, liquid densities of n -octane, ethylcyclohexane and their binary mixtures {( x ) n -octane) + (1 − x ) ethylcyclohexane} with mole fraction x = (0.200, 0.400, 0.600, 0.800) are reported. The density measurements were performed with a high-pressure vibrating-tube densimeter at temperatures from (283 to 363) K and pressures up to 60 MPa. The combined expanded uncertainties (0.95 level of confidence, k = 2) are estimated to be 16 mK for temperature, 0.062 MPa for pressure, and up to 0.6 kg/m 3 for density. The experimental densities were correlated using the modified Tait equation. The average absolute percentage deviations of measurement results from the modified Tait equation correlations of n -octane, ethylcyclohexane and their binary mixtures {( x ) n -octane) + (1 − x ) ethylcyclohexane} are all lower than 0.1%. The isothermal compressibility and isobaric expansivity have also been derived from the experimental densities.
研究领域:
化学工程
·
物理化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2011
·
IF 2.089
Li Hongling,Zhu Rongjiao,Xu Wei,Li Yanfen,Su Yongju,Tian Yiling
High-pressure vapor−liquid equilibrium data for the binary systems of ethyl butyrate (EB) + carbon dioxide and propylene carbonate (PC) + carbon dioxide were measured. The experimental pressure range was from (1.00 to 13.00) MPa and the temperature range from (313.0 to 373.0) K. Experimental results were correlated with the Peng−Robinson equation of state with the two-parameter van der Waals mixing rule. At the same time, the Henry’s coefficient and solution enthalpy and solution entropy of CO2 during dissolution at different temperature were also calculated.
研究领域:
化学工程
·
热力学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2021
·
IF 9.776
Yudi Deng,Zhijie Jiang,Yincheng Jin,Jianan Qiao,Shan Yang,Hui Xiong,Jing Yao
Detrimental tumor microenvironment (TME) relies on distorted tumor vasculature for further tumor expansion. Vascular normalization therapy partly improves TME through vessel repairing, while these therapies enter an unbreakable Möbius ring due to each attempt hindered by pro-angiogenic factors from TME, leading to limited duration and extent of vascular normalization. Here, we developed a nanosystem including FLG and MAR/MPA nanodrugs to regulate both tumor vasculature and TME. FLG nanodrugs were constructed by connecting VEGF/VEGFR2 inhibitory low molecular weight heparin and gambogic acid with F3 peptide decoration for directly regulating on vascular endothelial cells and inducing vascular normalization. Meanwhile, MAR/MPA nanodrugs encapsulating CCL5/CCR5 blocker maraviroc were designed to restrict cytokine functions of angiogenesis and TME deterioration, contributing to vasculature repairing and TME reconstruction. Our results demonstrated this combined nanosystem synergistically induced vascular normalization window lasting 9 days and restored vascular permeability and oxygen supply in Panc-1 tumor. Furthermore, in melanoma, our nanosystem achieved immune improvements with increased infiltration of CD4 + and CD8 + T cells in a remodeled TME. The two nanodrugs assisting each other in terms of both vascular repairing and TME improvements successfully reversed the vicious crosstalk to a positive one, achieving overall TME remodeling and promoting therapeutic efficiency.
研究领域:
肿瘤学
·
纳米技术
·
药理学
·
免疫学
·
癌症生物学
✓ 已验证
DOI
PubMed
高影响因子
ANALYTICAL BIOCHEMISTRY
·
2023
·
IF 2.9
Yan Xiong,Shu Zhu,Hua Zhao,Jin Li,Yanting Li,Tao Gong,Yanru Tao,Jiangling Hu,Hongmei Wang,Xinhui Jiang
For patients receiving organ transplants, monitoring the blood concentration of MPA can provide timely information on whether MPA has reached the effective therapeutic window to better function while reducing the incidence of rejection or adverse reactions. In this study, an electrochemical sensor for the detection of MPA was built using a nanocomposite made of CS-MWCNT and AuNPs. At the same time, the high performance liquid phase (HPLC) method for MPA was established and compared with this sensor. The surface morphology, structure, and roughness of the material on the electrode were characterized by scanning electron microscopy (SEM), Fourier transforms infrared spectroscopy (FTIR), and atomic force microscopy (AFM). In addition, the electrochemical behavior of the modified electrode was characterized by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The standard curve was obtained in blank plasma, not pure buffer solution. The peak current was linearly related to the MPA concentration in the linear range of 0.001–0.1 mM with a detection limit of 0.05 μM and good anti-interference ability. Moreover, the sensor was employed with success for the determination of MPA in rat plasma with good recovery. The electrochemical sensor presented here is eco-friendly, and sensitive, and offers a great possibility for practical applicability.
研究领域:
电化学
·
纳米技术
·
分析化学
·
生物医学工程
·
药物分析
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2023
·
IF 5.9
Meili Guo,Gang Zhang,Ruoli Zhao,Huizhen Ma,Yuxing Yan,Shuyu Yang,Jian Meng,You Huang,Xiao-Dong Zhang,Hao Wang,Ruiping Zhang
Near-infrared-II (NIR-II) imaging has shown great potential in medical diagnosis and surgical navigation, but developing safe, photostable, high-brightness molecular probes remains a great challenge. Due to their ultrasmall size resulting in highly efficient renal clearance, gold nanoclusters have shown great clinical potential. In this work, we systematically explored the effect of different ligands on the luminescence and bioactivity of gold nanoclusters. Our results show that gold nanoclusters protected by thioglycolic acid (TGA) and 6-mercaptohexanoic acid (MHA) exhibit the strongest fluorescence, while 3-mercaptopropionic acid (MPA)- and sodium sulfide (Na2S)-protected gold nanoclusters show the weakest NIR-II signal. Further doping showed that the Cd-doped MPA and MHA-protected gold nanoclusters exhibited enhanced fluorescence, but the cysteine (Cys)-, glutathione (GSH)-, and Na2S-protected gold nanoclusters showed fluorescence quenching after doping, indicating significant ligand selectivity. Because of the unique multi-energy structure and the large number of electronic states at the highest occupied molecular orbital energy level, MPA- and MHA-protected gold nanoclusters exhibit high stability and photostability. In addition, gold nanoclusters with different ligands exhibited different selective enzyme-mimicking activities of peroxidase (POD), superoxide dismutase (SOD), and catalase (CAT). Imaging in vivo showed that gold nanoclusters could accomplish reliable imaging of cerebral vasculature, hindlimb vessels, and spine as well as monitor renal clearance. The stable nanoclusters allow the time window of imaging to reach 125 min for hindlimb imaging and 270 min for spinal imaging. The gold nanoclusters exhibit a high signal-to-noise ratio of up to 11 for whole-body imaging and show efficient renal clearance and low toxicity at an injected dose of 50 mg/kg.
研究领域:
生物医学工程
·
纳米技术
·
医学成像
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）