SENSORS AND ACTUATORS B-CHEMICAL
·
2021
·
IF 7.46
Jie Zhou,Xueliang Wang,Jiajie Chen,Youjun Zeng,Dayong Gu,Bruce Zhi Gao,Yonghong Shao
Occult blood testing is a routine screening method for evaluating the function of the urinary system and digestive tract. The hemoglobin (Hb) content in human excreta is an important indicator of the presence of occult blood. In this study, a surface plasmon resonance imaging (SPRi)-based immunosensor with high sensitivity was developed for the detection of Hb. The immunosensor was constructed by physically immobilizing anti-Hb antibodies on the detection channels. Samples for evaluation were pre-incubated with the polymeric microsphere-antibody conjugate. The shift in resonance wavelength induced by the specific binding of microsphere-antibody-antigen and immobilized antibodies was monitored in real time. Owing to the amplification effect of microspheres, the detection limit of the immunosensor was reduced 42-fold to 4.8 ng/mL under the optimized concentration of immobilized antibody (10 μg/mL) with microsphere-antibody conjugate dilution ratio of 1:200 and incubation time of the microsphere-antibody conjugate and samples (10 min). The immunosensor displayed a good linear response to Hb ranging from 10 ng/mL to 500 ng/mL in both test solutions and in 1:30 urine sample, as well as a good specificity toward Hb and an acceptable recovery rate for spiked Hb solution in urine sample. The immunosensor was also exploited to detect the Hb concentration in 50 clinical urine samples. Therefore, the proposed SPRi immunosensor developed in this study provides a simple, rapid, high-throughput, and sensitive immunology strategy for the detection of occult blood.
研究领域:
生物传感器
·
分析化学
·
医学诊断
·
生物医学工程
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产品关联
DOI
高影响因子
CHEMICAL PHYSICS LETTERS
·
2019
·
IF 1.901
Jie Hu,Yi Lu,Xiao-Fang Zhao,Yu-Qian Tang,Yuan-Zhou Li,Yu-Xuan Xiao,Zhi-Yi Hu,Bao-Lian Su,Xiao-Yu Yang
TiO 2 hierarchical microsphere assembled from anatase TiO 2 nanosheets has been successfully prepared and exhibited excellent catalytic activities of H 2 production and benzyl alcohol selective oxidized to benzaldehyde. These enhanced photoactivity can be mainly ascribed to the charge separation promoted by the surface F and nanosheet units, enhancement of substrate molecular transport profited from the hierarchical structure.
研究领域:
材料科学
·
光催化领域
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产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2022
·
IF 6.371
Min Zhao,Yajun Yang,Zhenxing Zha,Shihai Cui,Yafei Li,Jing Yang
In this work, carbon microsphere/BiOCl heterojunction with oxygen vacancy was synthesized by the hydrothermal method . The structure, morphology and physicochemical properties have been investigated and discussed through a series of characterizations. The photocatalytic performance of the carbon microsphere/BiOCl composite for tetracycline degradation was twice as high as that of pristine BiOCl. The increased photocatalytic activity was attributed to oxygen vacancies and suitable charge transfer pathways. In addition, three-dimension excitation emission matrix fluorescence spectroscopy and Fukui indices were used to speculate the degradation products and pathways of tetracycline. The organic norfloxacin was found to have an antagonistic effect and the inorganic Cr (VI) had a synergistic effect on tetracycline degradation. Furthermore, the possible photocatalytic mechanism was explored through density functional theory and energy band structure . Therefore, this composite has great potential for the photocatalytic removal of tetracycline from water.
研究领域:
环境科学
·
材料科学
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产品关联
DOI
高影响因子
Frontiers in Bioengineering and Biotechnology
·
2023
·
IF 5.7
Ruan Yejiao,He Lingyun,Chen Jiamin,Wang Jinfeng,Zhao Shujing,Guo Xiaoling,Xie Yao,Cai Zhenzhai,Shen Xian,Li Chao
Hypoxia is one of the major causes of cancer resistance and metastasis. Currently, it is still lack of convenient ways to simulate the in vivo hypoxic tumor microenvironment (TME) under normoxia in vitro. In this study, based on multi-polymerized alginate, we established a three-dimensional culture system with a core-shell structure (3d-ACS), which prevents oxygen diffusion to a certain extent, thereby simulating the hypoxic TME in vivo. The cell activity, hypoxia inducible factor (HIF) expression, drug resistance, and the related gene and protein changes of the gastric cancer (GC) cells were investigated in vitro and in vivo. The results demonstrated that the GC cells formed organoid-like structures in the 3d-ACS and manifested more aggressive growth and decreased drug responses. Our study provides an accessible hypoxia platform in the laboratory with moderate configuration and it may be applied in studies of the hypoxia-induced drug resistances and other preclinical fields.
研究领域:
癌症研究
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生物医学工程
·
药学
·
细胞生物学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2023
·
IF 9.9
Chengwei Wang,Liu Han,Shuo Yang,Zhaolin Liu,Ming Liu,Bing Li
We report zinc cobalt-layered double hydroxides (ZnCo-LDH) as the active cathode materials for the development of high-performance Zn-ZnCo batteries . Electrochemical investigations show the battery’s capacity increases linearly with increasing the ZnCo-LDH loading (up to 60 mg cm −2 ). The resulting Zn-ZnCo battery exhibits excellent rate performance and cycle stability, retaining 86% of its capacity even after 5000 cycles of testing. By incorporating ZnCo-LDH with a Pt/C-coated gas diffusion layer to form an integrated multifunctional air-cathode, we demonstrate a hybrid Zn battery, which combines the merits of Zn-ZnCo and Zn-air batteries to show a characteristic two-stage charge-discharge voltage profile. The current work demonstrates the linear relationship between the battery capacity and the active material loading. The results also highlight that a greater battery capacity requires further increasing of loading though very challenging.
研究领域:
材料科学
·
电化学
·
能源存储
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产品关联
DOI
PubMed
高影响因子
DYES AND PIGMENTS
·
2019
·
IF 4.018
Jing Ma,Li-Min Zhao,Chuan-Yu Jin,Bing Yan
In this context, novel luminescence responsive composites are assembled with both rare earth metal-organic framework of 2-aminoterephthalic acid (2 amino-1,4-benzendicarboxylic acid, NH 2 -BDC) and two microsphere-like polymer resins (Wang resin (WR) and Merrifield resin (MR)) through the covalently post-synthetic modification. The final composites MR/WR-MOF-RE (RE = Eu, Tb, Sm) are prepared by the nucleophilic substitution reaction between amino groups of RE-MOF and methyl chloride groups of WR/MR to achieve the chemical linking from each other, whose physical characterization and luminescence responsive property are studied in detail. The composites present the regular microsphere morphology and characteristic photoluminescence of RE 3+ under specific excitation wavelength and the close white color emission can be tuned through adjusting the excitation wavelength for europium hybrid system. Furthermore, MR-MOF-Eu composite is chosen to check the luminescence sensing on volatile solvents, revealing that ammonia vapors and THF can cause apparent luminescence quenching for the different quenching performance.
研究领域:
材料科学
·
化学
✓ 已验证
DOI
高影响因子
JOURNAL OF POLYMER ENGINEERING
·
2020
·Vol. 40
·期 4
·321-332
·
IF 1.126
Yuan Lin,Yangchuan Ke,Chengcheng Yu,Xu Hu,Shichao Lu,Cancan Bai,Xi Zhao,Yi Zhao
Exfoliated organo-montmorillonite (O-Mt) layers were successfully encapsulated in a terpolymer microsphere (PAAA) of acrylamide (AM)/acrylic acid (AA)/2-acrylamido-2-methylpropanesulfonic acid (AMPS) via in situ inverse suspension polymerization, with the aid of the organic modification by cetyltrimethylammonium bromide (CTAB) and sodium lauryl sulfonate (SLS). The chemical structure and properties of the Mt were characterized by Fourier transform infrared (FTIR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA), which showed that SLS molecules successfully intercalated Mt interlayers and enhanced the thermostability of Mt. The microsphere morphologies of the polymer and its nanocomposites were detected by scanning electron microscopy (SEM). The results of X-ray diffraction (XRD) and transmission electron microscopy (TEM) confirmed that the exfoliated O-Mt dispersed in the polymer matrix. The introduction of well-dispersed O-Mt layers significantly enhanced the comprehensive performance of these microspheres, including thermostability and plugging properties. The T max of PAAA/1.5 wt.% O-Mt nanocomposite is increased by 46°C compared to the pure terpolymer. The plugging rate of PAAA/2.0 wt.% O-Mt reached up to 85.8%. Therefore, these selected nanocomposite microspheres can provide an effective plugging in the high-permeability layers.
研究领域:
材料科学
·
高分子化学
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DOI
高影响因子
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2016
·Vol. 16
·期 4
·4115-4119
·
IF 1.338
Qiao Xiuqing,Hu Fuchao,Hou Dongfang,Li Dongsheng
SnO2/Ag hollow microsphere, assembled form SnO2 and Ag nanoparticles, was synthesized via a facile one-step hydrothermal synthesis method using Na2SnO3.3H2O, CO(NH2)2 and AgNO3 as raw materials.
XRD, SEM, and TEM results revealed that the obtained SnO2/Ag hollow microsphere with diameters of ca.3∼5 μm was built from uniformly distributed rutile SnO2 and cubic Ag nanoparticles. Moreover, XPS results indicate the existence of strong interaction between
Ag and SnO2 nanoparticles, rather than simply physical contact, endowing the SnO2/Ag hollow microspheres with excellent photocatalytic performance in the degradation of RhB solution under visible light irradiation.
研究领域:
材料科学
·
纳米技术
·
环境科学
✓ 已验证
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2016
·
IF 3.902
Hua Wu,Jiaoyan Liu,Jingjing Wu,Ying Wan,Yun Chen
Platelet-derived growth factor-BB (PGDF-BB) loaded gelatin microspheres with an average size of about 2 μm was incorporated into chitosan/silk fibroin/glycerophosphate (GP) solutions to prepare composites. The formulated composite solutions were able to form into hydrogels in a temperature range between 32 and 37 °C at a pH of ca.7. They had good fluidity at 25 °C and showed shear-thinning features at both 25 and 37 °C, revealing that they are injectable at room temperature. Elastic modulus of some composites at 37 °C was about 10-fold higher than that of chitosan/GP gel, confirming that these composites behave like mechanically strong gels. Optimal composites showed abilities to administrate PDGF-BB release in an approximately linear manner up to 5 weeks. The PDGF-BB release could be regulated by the PDGF-BB load and the silk fibroin content in the composites in an individual or cooperative way. In vivo degradation of composites demonstrated that some of them had markedly enhanced degradation endurance as compared to the chitosan/GP gel. PDGF-BB-stimulated DNA synthesis in Balb/c 3T3 fibroblasts and PDGF-BB-induced cell migration suggested that the bioactivity of released PDGF-BB was well retained.
✓ 已验证
DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2015
·Vol. 3
·期 41
·10907-10915
·
IF 4.696
Haie Zhu,Bing Yan,Shuxue Zhou,Zengbo Wang,Limin Wu
Microspheres can function as optical superlenses for nanoscale super-resolution imaging. The imaging performance is mainly affected by the size and refractive index of the microsphere. Precise control of these parameters is a challenging task but of fundamental importance to the further development of the technique. In this study, we demonstrate for the first time a nanoparticle-hybrid suspension polymerization approach to chemically synthesize high-quality microspheres (ZrO2/polystyrene) with optical properties that are highly controllable. Microspheres of different sizes (d: 2–20 μm) and refractive indexes (np: 1.590–1.685) were synthesized and their super-resolution imaging performances were evaluated and compared. Our results show that continuously increasing the refractive index of microspheres can enhance the imaging resolution and quality. A 60 nm resolution has been obtained in the wide-field imaging mode and a 50 nm resolution has been obtained in the confocal mode imaging of semiconductor chip samples. The obtained 50–60 nm resolutions have significantly gone beyond the conventional 200 nm resolution limit for visible light optical microscopes; the super-resolution mechanism has been discussed. The synthesized microsphere superlenses may find applications in many other areas as well, including nanolithography, nano-sensing, nano-diagnosis, nano-spectroscopy and ultra-high density optical data storage.
研究领域:
光学
·
材料科学
·
纳米技术
✓ 已验证
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2020
·
IF 3.573
Zhiyou Tan,Shan Wang,Zhuorong Hu,Weilong Chen,Zhencai Qu,Changan Xu,Qian Zhang,Kun Wu,Jun Shi,Mangeng Lu
In this work, we offered a facile strategy to produce lignin microspheres (LMS) with loading of benzotriazole (BTA) inhibitors, which were released as the pH changed. The morphological and compositional characterizations demonstrated that the BTA inhibitors were efficiently encapsulated in the LMS whose load was up to 15.5 wt %. Tests of crossed scratches of coatings indicated that the LMS@BTA/pure waterborne epoxy resin (WEP) had a good self-healing property. By the electrochemical impedance spectroscopy test, the long-term anticorrosion property of LMS@BTA/WEP composites was 1 order of magnitude higher than that of WEP, which indicated that LMS@BTA greatly improved the corrosion resistance. The highly effective anticorrosion should be attributed to the pH-responsive release behavior of BTA from LMS, which actively protected the steel substrate. The enhanced anticorrosion and the controlled release of BTA enlarged the high value-added applications of lignin.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
ACS Sustainable Chemistry & Engineering
·
2021
·
IF 8.198
Xianghai Kong,Srinivasan Vinju Vasudevan,Mengjie Cao,Jin Cai,Hanping Mao,Quan Bu
A simple hydrothermal carbonization method was used to synthesize sulfonated carbon catalysts from glucose in reflux conditions. The concentration of sulfuric acid played a specific role in preparing sulfonated hydrothermal carbon microsphere (SHCS) and sulfonated hydrothermal carbon (SHC) catalysts. All of the samples were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and Brunauer–Emmett–Teller (BET) analyses, and the influence of different reaction conditions on 5-hydroxymethylfurfural (HMF) production from fructose was investigated in microwave conditions. The effect of microwave input power and energy efficiency on HMF formation was determined to understand the role of sulfonated carbon catalysts in a water medium. Results showed that the catalyst with a moderate sulfur content and spherical stacking was beneficial to enhance the heat-transfer efficiency on the catalyst surface during microwave-assisted heating, thus effectively enhancing the energy efficiency of the fructose dehydration reaction. The optimum reaction condition for HMF production was obtained at microwave input power 60 W, reaction temperature 186 °C, and reaction time 10 min. At this condition, the HMF yield and the energy efficiency were 88.3 mol % and 0.147 mmol kJ–1, respectively. Furthermore, the prepared catalyst showed good recyclability, wherein a simple reactivation process could rapidly recover the catalyst activity with 1 M sulfuric acid solution. This work provides a way to design a potential microwave-responsive catalyst that improves the energy efficiency and HMF yield for the fructose–HMF conversion process.
研究领域:
化学工程
·
催化科学
·
可再生资源利用
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DOI
高影响因子
危险品化学品经营许可证（带存储）