Sensors and Actuators Reports
·
2023
·
IF 5.9
Keren Shi,Xiangming Liang,Mingming Li,Zhenhua Zhai,Ying Liu,Xiaoyan Shan,Yang Ma,Qianqian Gan,Huiqin Yao
In this work, poly( N,N -diethylacrylamide) (PDEA) hydrogel films were polymerized on glassy carbon (GC) electrode surface, and isoniazid (INH) was chosen as an electroactive pharmaceutical molecule probe, aiming to investigate the switchable electrochemical behaviors of INH. Determining the contents of INH tablets under different external stimuli conditions and constructing its logic gate computing systems. The triple-sensitive electrochemical CV behaviors of INH on this film system toward pH, temperature and salt concentration were observed and explored. Thus, a 3-input/8-output combinational pharmaceutical logic gate network and a 3-to-8 decoder were designed and constructed based on the stimulus-responsive characteristics of the electrochemical response of INH on PDEA hydrogel-modified electrodes. Besides, the relationship between the oxidation peak current ( I pa ) and concentration of INH ( C INH ) was studied by the differential pulse voltammetry (DPV) method. Apply this film system, and the INH tablets could be switchable detected. The construction of the logic-gate computing system based on isoniazid drug molecule may provide a novel approach and model to design new style drug sensors, which might be applied to intelligent medical diagnostics and drug release.
研究领域:
药学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2023
·
IF 8.4
Ning Sui,Yifeng Xu,Peng Zhang,Shuang Cao,Tingting Zhou,Tong Zhang
The crucial challenge to exploit effective ozone (O 3 ) gas sensors lies in developing novel functional sensing materials to meet the requirement of trace-level detection threshold (50 ppb). Metal oxide semiconductors (MOSs) with controllable heterogenous composites as high-performance sensing layers are expected to break through this bottleneck. This work proposes the hybridization of MIL-68 (In) and ZIF-8, which are employed as dual metal organic frameworks (MOFs) sacrificial templates to design n-n heterostructures . The derived In 2 O 3 backbone showed a hexagonal prismatic structure with a large aspect ratio. The robust architecture enabled the uniform decoration of mass of ZnO nanoparticles (NPs) on the surfaces without the damage of high porosity for the gas diffusion. Consequently, the optimal sensor with appropriate ZnO NPs loading amount exhibited trace O 3 detection ability as low as 15 ppb, which was attributed to the smart design of n-n heterostructure, rich active sites and improved oxygen-adsorbing capacity. Thus, this work inspires a new way to utilize the versatile dual MOFs template for constructing heterogenous composites as O 3 sensing materials.
研究领域:
材料科学
·
传感器技术
·
环境监测
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2018
·
IF 6.434
Genming Li,Wenbo Zhao,Muyuan Chai,Yanhong Li,Qingming Jia,Yuan Chen
In the present work, liquid-liquid phase-change absorption of SO 2 was investigated using N , N -dimethylcyclohexylamine (DMCHA) as an absorbent, and high boiling liquid paraffin (LP) as a solvent to reduce volatilization of the absorbent. The homogenous solution was split into two immiscible phases upon SO 2 loading. The phase-change mechanism was attributed to the polarity variation of DMCHA before and after absorption by forming the charge-transfer complex DMCHA·SO 2 . The viscosity of the lower phase reached a maximum value of 24.5 mPa s at the absorption capacity of 1 mol SO 2 /mol DMCHA, and the viscosity of the corresponding upper phase was 46.4 mPa s. Both are lower than the reported viscosity of most ionic liquids. This solution exhibited extremely high mass selectivity of SO 2 /CO 2 with a value of 626. The mass absorption capacity was founded to be 1.19 g SO 2 /g DMCHA at 1 atm, which is comparable with the highest reported mass absorption capacity. At low partial pressure, the absorption capacity still reached 0.78 g/g at 0.1 atm, 0.43 g/g at 0.02 atm and 0.27 g/g at 0.001 atm. Furthermore, DMCHA could be completely regenerated in 10 min via microwave heating. All the results indicated this phase-change solution is a promising candidate for SO 2 capture.
研究领域:
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
·
2015
·Vol. 54
·期 8
·1036-1043
·
IF 3.113
Xueteng Cao,Daniel Horák,Zesheng An,Zdeněk Plichta
Nonspecific interaction is a key parameter affecting the efficiency of proteins, nucleic acids or cell separation. Currently, many approaches to introduce antifouling properties to materials have been developed. Among these, surface modification with polymer brushes plays a prominent role. The aim of this study was to synthesize new magnetic microspheres grafted with poly( N,N -dimethylacrylamide) (PDMA) that resist nonspecific protein adsorption. Monodisperse macroporous poly(2-hydroxyethyl methacrylate) (PHEMA) microspheres, 4 μm in size, were synthesized by a multiple swelling polymerization method. To render the microspheres magnetic, iron oxide was precipitated inside the microsphere pores. Functional carboxyl groups, introduced by the hydrolysis of the 2-(methacryloyl)oxyethyl acetate (HEMA-Ac) comonomer, were used to react with propargylamine, followed by coupling of a chain transfer agent via an azide-alkyne click reaction. PDMA was grafted from the PHEMA microspheres using reversible addition-fragmentation chain transfer polymerization (RAFT), resulting in surfaces with more than 81 wt % PDMA attached. The successful modification of the microspheres was confirmed by XPS. The magnetic microspheres grafted with PDMA showed excellent antifouling properties as tested in bovine serum protein solutions. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016 , 54 , 1036–1043
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2019
·Vol. 136
·期 20
·47473
·
IF 2.188
Xiaoning Wang,Yacheng Xing,Xihui Zhao,Quan Ji,Yanzhi Xia,Xiaomei Ma
To seek adsorptive hydrogels with high stability, poly(N,N-dimethylacrylamide) (PDMAM)-based hydrogels were fabricated employing vinylated chitosan as a macro-crosslinker. The prepared hydrogels achieves a maximum compressive stress above 11 MPa (98% strain), a maximum tensile strength, and fracture elongation of 0.037 MPa and 929%. The recovery ratios after three consecutive compressions (90% strain) and 1 h's resting (600% stretch) exceed 94% and 85%, respectively. The optimal adsorption effect (>90% removal efficiency) is achieved at pH 3 and 318 K in 2.5 h using hydrogels crosslinked by 9.77 wt % chitosan. The kinetic study indicates that the experimental data fit to the pseudo-second-order kinetic model better. The adsorption isotherm fits to the Freundlich model, indicating nonhomogeneous adsorption of the dyes on the hydrogels. Most adsorbed dyes are desorbed in 2 h at pH 10 and 318 K, both adsorption/desorption efficiencies exceed 90% after five adsorption–desorption cycles, confirming reusability of the hydrogels. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136 , 47473.
研究领域:
材料科学
·
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2023
·
IF 2.6
Xin Huang,Qiufen Wang,Shouxiang Jiang,Bin Wang,Wenjun Xie,Chengfei Wang,Haoran Li,Guan Wang,Gengxiu Zheng
The solubility of N,N’-oxalyldiglycine (OG) in 11 pure solvents, including methanol, ethanol, n-propanol, isopropyl alcohol, n-butanol, acetonitrile, ethyl acetate, tetrahydrofuran (THF), water, N,N’-dimethylformamide (DMF), and dimethyl sulfoxide (DMSO), and a binary solvent system composed of DMSO and water was measured by a dynamic laser monitoring method with the temperature ranging from 293.15 to 333.15 K. Results of these experiments demonstrated that the solubility of OG in all pure solvents increases with rising temperature. The highest solubility appeared in DMSO while the lowest solubility appeared in ethyl acetate. Besides, the mole fraction solubility of OG in binary solvents increases with increasing content of DMSO. Furthermore, the experimental solubility of OG in pure solvents was correlated with the modified Apelblat, Van’t Hoff, λh, and Wilson models. Four models (Van’t Hoff, CNIBS/R–K, modified Jouyban–Acree, and Wilson) were used for the binary solvents. The Van’t Hoff model best correlates with the experimental values in pure and binary solvents, and the calculated values by the Wilson model have a large deviation from the experimental values.
研究领域:
化学工程
·
物理化学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2017
·
IF 3.671
Ting Liu,Enyong Ding,Feng Xue
Natural polymer flocculants for wastewater treatment have received close attention in recent years. Here we used two flocculants, polyacrylamide and poly( N , N -dimethylacrylamide) grafted cellulose nanocrystals synthesized by a “macro-RAFT assisted” strategy, for the flocculation of kaolin suspension. The flocculation performance of these two flocculants, including flocculants dosage, settling time and floc size, was carefully studied and compared. Results suggested that poly( N , N -dimethylacrylamide) grafted cellulose nanocrstyals showed better flocculation performance than polyacrylamide grafted ones. Meanwhile, their flocculation behavior was also compared with other cellulose-based flocculants in literature and we suggested polymer modified cellulose nanocrstals as flocculants might have higher flocculation performance, but this needs further verification.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Sustainable Chemistry and Pharmacy
·
2024
·
IF 5.5
Gang Zhou,Liyong Hu,Zeyu Wang,Changjie Shi,Jiachao Yao,María C. Veiga,Christian Kennes,Jun Chen
This study investigated the interaction during biodegradation between hydrophilic N, N-dimethylacetamide (DMAC) and hydrophobic n -hexane, both of which are common volatile organic compounds (VOCs) in the pharmaceutical industry. A rotating drum biofilter (RDB) was utilized to remove DMAC and n -hexane simultaneously. The results indicated that the addition of 800 mg/L DMAC shorten the start-up time from 23 days to 18 days of RDB, and increased the n -hexane removal efficiency from 42% to 60%, compared with the biodegradation of n -hexane alone. Further, the protein (PN)/polysaccharide (PS) ratio in the extracellular polymer substance (EPS) was increased from 1:5.62 to 2.25:1. Interestingly, microbial community analysis revealed that the addition of DMAC led to an increase in the proportion of Proteobacteria , which tended to secrete EPS with a high proportion of PN. This PN-rich EPS enhanced the adhesive force of the biofilm and lowered the surface tension of the liquid, which led to the improvement of biofilm trapping of n -hexane. Meanwhile, the excitation-emission-matrix results suggested that the tryptophan-like and tyrosine-like substances provided protection during acid stress and acted as a carbon source for cellular life activities during starvation. Finally, as a further validation, the molecular ecological network also showed that Proteobacteria had the most positive connections (65.47%). Overall, this study found that the removal of hydrophobic compounds could be facilitated by the addition of hydrophilic compounds in the bioreactor, which contributes to the biological treatment of mixed VOCs in practical exhaust gases.
研究领域:
环境工程
·
生物技术
·
微生物学
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2016
·
IF 3.299
Shiyu Zhang,Yun Zou,Tengyou Wei,Chunxia Mu,Xiangjun Liu,Zhangfa Tong
The blended membranes of polyvinyl alcohol (PVA) and chitosan (CS) (PVA-CS) were prepared for pervaporation dehydration of a binary system of n -butyl acetate/water and a ternary mixture of n -butyl acetate/ n -butanol/water. Membranes were characterized by FTIR, DSC and XRD to investigate the intermolecular interactions, the blending compatibility and the effects of blending on crystallinity. Tensile strengths were measured to determine the influence of blending ratios on the membrane’s mechanical properties. The membrane’s degree of swelling in water dropped significantly with increasing CS fraction. The results agreed well with the calculation of the solubility parameter. Separation factor and permeation flux increased when the temperature was raised for both the binary and ternary pervaporation systems. An optimal separation factor of 27,000 with a total flux of 402 g·m −2 ·h −1 was obtained using the blend membrane containing 25 wt% CS at 40 °C for the binary system. For the ternary system, the maximum separation factor and total flux were obtained for blend membranes at 75 wt% and 50 wt% CS content, respectively.
研究领域:
材料科学
·
化学工程
·
膜技术
✓ 已验证
产品关联
DOI
高影响因子
GREEN CHEMISTRY
·
2018
·Vol. 21
·期 3
·567-577
·
IF 8.586
Wenfeng Zhao,Xiaoping Chi,Hu Li,Jian He,Jingxuan Long,Yufei Xu,Song Yang
Catalytic fixation of CO2 to produce valuable fine chemicals is of great significance to develop a green and sustainable circulation of excessive carbon in the environment. Herein, a series of non-toxic, biodegradable and recyclable acetylcholine-carboxylate bio-ionic liquids with different cations and anions were simply synthesized for producing formamides and methylamines using atmospheric CO2 as a carbon source, and phenylsilane as a hydrogen donor. The selectivity toward products was tuned by altering the reaction temperature under solvent or solvent-free conditions. N-Methylamines (ca. 96% yield) were obtained in acetonitrile at 50 °C, while N-formamides (ca. 99% yield) were attained without a solvent at 30 °C. The established bio-ionic liquid catalytic system found a wide range of applicability in substrates and possessed a high potentiality in scale-up to gram-grade production. The developed catalytic system was fairly stable, which could be easily reused without an apparent loss of reactivity, possibly due to the strong electrostatic interactions between the cation and anion. The combination of experimental and computational results explicitly elucidated the reaction mechanism: PhSiH3 activated by a bio-IL was favorable for the formation of silyl formate from hydrosilylation of CO2, followed by a reaction with an amine to give an N-formamide, while an N-methylamine was formed by further hydrosilylation of the N-formamide.
研究领域:
绿色化学
·
环境科学
·
有机化学
✓ 已验证
产品关联
DOI
高影响因子
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
·
2020
·
IF 2.506
Xingchen Liu,Yihan Liu,Qi Cao,Ying Wu,Xueyun Huo,Xiaoyan Du,Zhenwen Chen
Age is an important factor in the evaluation of chemical toxicology. Chemical carcinogenic compounds can induce genomic mutations. However, few studies have been conducted on the association between genomic mutation frequency, such as microsatellite instability (MSI), and the age of mice treated with a nitrosourea mutagen. In the current work, we treated young (6 weeks) and old (10 months) mice with N -methyl- N -nitrosourea (MNU) for 4 months; the MSI frequency was then measured using polymerase chain reaction (PCR) and short tandem repeat (STR) scanning. The percentage of animals with MSI in the old group was significantly higher than that in the young group (100% and 75%). The frequency of MSI events was significantly different between the two groups as well (15.8% for old and 9.4% for young). The ratio of MSI loci displayed no obvious difference between the two groups. In addition, a few loci, including D15Mit5 and D8Mit14 exhibited the highest frequency of MSI events. Since specific loci showed increased MSI in the present study and a higher frequency in previous studies, these loci could be regarded as “hot spot”. These results suggested that old mice would be more susceptible to this mutagen, and prone to accrue MSI. The hot spot microsatellite loci are potentially useful markers for genomic instability analysis.
研究领域:
毒理学
·
遗传学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2020
·Vol. 55
·期 18
·7652-7664
·
IF 3.553
Gao Ailin,Chen Shuju,Zhao Shuai,Zhang Guangfa,Cui Jian,Yan Yehai
In this work, mechanically strong and electrically conductive poly( N , N -dimethylacrylamide) (PDMAA)/pristine graphene (GR) nanocomposite hydrogel was synthesized by directly dispersing pristine GR into N , N -dimethylacrylamide (DMAA) monomers, which have been commonly used to prepare polymeric hydrogel as reactive monomers. Results showed that the introduction of GR nanosheets as physical cross-linking and its cooperation with organic cross-linker N , N -methylene bisacrylamide (BIS) were found to efficiently improve the mechanical strength, dimensional homogeneity of pore structure, thermal and electrical conductivity of resultant PDMAA hydrogels. More importantly, the intrinsic interaction between DMAA monomer and GR was systematically analyzed by ultraviolet–visible (UV–Vis) spectrophotometer, nuclear magnetic resonance ( 1 H NMR) and rheological test for the first time. These studies help us understand the formation mechanism of PDMAA hydrogel when graphene was added, as well as the fundamental parameters that govern the properties of hydrogels.
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）