COMPOSITES SCIENCE AND TECHNOLOGY
·
2020
·
IF 7.094
Hongji Chen,Jianxiao Yang,Qin Shuai,Jun Li,Qin Ouyang,Shu Zhang
The high modulus PAN-based carbon fibers (CFs) were prepared using the B 4 C-doped PAN as a precursor which was synthesized by in-situ polymerization of acrylonitrile monomer with B 4 C nanoparticles , and were characterized to investigate the effects of B 4 C nanoparticles on stabilization and carbonization behaviors of the as-spun fibers and to compare the structural properties of the B 4 C-doped CFs (B-CF) with the pristine CFs (P-CF). The results showed that the B-CF-1000 prepared at carbonization temperature of 1000 °C had lower tensile strength than P–CF–1000 due to the defects and disordered structures in the B-CF-1000 caused by the doped B 4 C, while the B-CF-3000 prepared at graphitization temperature of 3000 °C had much higher tensile modulus of 399 GPa than P–CF–3000 of 251 GPa under the effect of boron catalytic graphitization. Moreover, the skin-core structure of B-CF had significantly improved compared to P-CF, which was caused by the fact that B 4 C inhibited the oxidation reaction and limited the shrinkage of the fibers during stabilization so as to benefit the entry of oxygen into the fiber core. The above results indicated that the in-situ doped B 4 C does play a significant role in catalytic graphitization and improving microstructure of PAN-based CFs.
研究领域:
材料科学
·
化学工程
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yan-Mei Zhang,Li-Hao Xu,Xiao-Xue Hu,Bing-Hong Chen,Xin-Ru Chen,Qian-Qian Li,Heng Mao,Zhi-Ping Zhao
Metal-organic framework (MOF) membranes, by virtue of their high selectivity and low diffusion resistance, make a significant contribution to energy conservation and CO 2 emission reduction via separation technology. Despite possessing substantial potential for propelling the production of high-performance membranes, hurdles persist in the process of constructing MOF membranes that are both highly integrated and structurally sound on flexible polymer substrates. We propose a strategy for constructing highly stable cobalt zeolitic imidazolate framework (ZIF-67) composite membranes on seeded polyacrylonitrile (PAN) substrate. Through a timed-interrupted in-situ growth process, the amino-modified polycrystalline ZIF-67 as a CO 2 affinity layer is precisely and completely confined within the “top sites” and partial “face sites” of the vertical layered double hydroxide (LDH) precursor layer, creating a barrier-low passage for CO 2 as a fast diffusion layer. The substrate and the hybrid ZIF-67@LDH layer were robustly anchored together by the pre-embedded LDH seeds, thereby producing an appealing membrane-multilayer interlocked-support (MMIS) composite architecture. This fast diffusion-CO 2 affinity Pebax/ZIF-67@LDH/PAN membranes with MMIS architecture show average CO 2 permeability of 1487 Barrer and CO 2 /N 2 selectivity of above 55.1 after the surface repair coating of polyether-block-amide (Pebax), maintaining stable performance over 150 h, surpassing the Robeson upper bound. The Pebax/ZIF-67@LDH/PAN membranes also exhibit the durability and mechanical robustness, because of the highly inducible activity of LDH precursor layer serving as a linker between the membrane and substrate. These results promote the development of MOF-based membranes in practical separation applications.
研究领域:
材料科学
·
环境工程
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Zongzhe Liu,Shaobo Ma,Xue Mu,Renlong Li,Geping Yin,Pengjian Zuo
A silicon anode with ultra-high specific capacity has motivated tremendous exploration for high-energy-density lithium ion batteries while it still faces serious issues of irreversible lithium loss, unstable electrode electrolyte interface (SEI), and huge volume expansion. Prelithiation is a crucial technology to alleviate the harm of active lithium loss of silicon-based full-cell systems. Herein, we reported a cathode prelithiation method using Li2S-PAN as a lithium “donor”, which was synthesized via chemical reaction between sulfurized polyacrylonitrile and Li-biphenyl complex. The Li2S-PAN with an initial charging capacity of 668 mAh g–1 (2.5–4.0 V) is loaded on the LiFePO4 electrode, and the LiFePO4/Li2S-PAN composite electrode displays a high initial charge capacity of 206 mAh g–1, which is 22.3% higher than the pristine LiFePO4. With a silicon/graphite/carbon (Si/G/C) composite anode, the Si/G/C||LiFePO4/Li2S-PAN full cell exhibits a reversible capacity of 123 and 107 mAh g–1 in the 1st and 10th cycle, which is 15.5 and 24.5% higher than the Si/G/C||LiFePO4 battery, respectively. The SEI layer of the silicon anode in the Si/G/C||LiFePO4/Li2S-PAN cell contains abundant conductive LiF species, which can enhance the interfacial stability and reaction kinetics of the cells. The proposed cathode prelithiation process is compatible with the industrial roll-to-roll electrode preparation process, exhibiting a promising application prospect.
研究领域:
材料科学
·
电化学
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产品关联
DOI
PubMed
高影响因子
COMPOSITES SCIENCE AND TECHNOLOGY
·
2023
·
IF 9.1
Xiangjie Gong,Tao Yang,Yan Song,Xiaodong Tian,Zihui Ma,Zhanjun Liu
MOFs-reinforced electrospun carbon nanofibers offer a wide range of applications in the field of energy storage. In this study, ZIF-67 nanoparticles were produced and combined with polyacrylonitrile for electrospinning before being stabilized and carbonized to form a carbon nanofiber. BET, FT-IR, EA, DSC , and other techniques were used to investigate the stabilizing behaviors of PAN electrospun fiber with varying ZIF-67 concentrations at different temperatures. Under the same stabilizing settings, it was discovered that PAN electrospun fiber containing ZIF-67 nanoparticles could absorb more oxygen, promoting a higher degree of cyclization and crosslinking. Therefore, it was preferred to prepare carbon nanofibers at a lower stabilization temperature. Importantly, the degree of stability and disorder of the PAN/ZIF-67 stabilized fiber has been described by the FT-IR and the Raman spectra . This research deepens understanding about the formation of MOF-reinforced carbon nanofibers and expands our knowledge of the stability of PAN/MOF hybrid fibers.
研究领域:
材料科学
·
能源存储
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产品关联
DOI
高影响因子
Journal of Pharmaceutical Analysis
·
2025
·
IF 8.9
Yuexiang CHANG,Hao TIAN,Jia-Huan QU,Jiaming YUAN,Rongkai GU,TingTing ZHANG,Jincai WANG,Zhengjin JIANG
The N -terminal domain of influenza viral polymerase (PA N ), a highly conserved region with critical catalytic function related to viral RNA replication and transcription, is considered as a very promising anti-influenza drug target. There is an urgent need for highly efficient and rapid screening methods to identify potential PA N inhibitors (PA N Is) from complex matrices. In this work, a novel high-throughput screening (HTS) platform was established by coupling high performance liquid chromatography and high-resolution mass spectrometry (HPLC-HRMS) with a fluorescence resonance energy transfer (FRET)-based endonuclease activity assay through an at-line nanofractionation system (ANF). The proposed screening platform could rapidly identify potential PA N Is from plant extracts with good sensitivity (baloxavir at the half maximal inhibitory concentration (IC 50 ) could be detected) and reliability ( Z ’ factor of 0.77). This platform was then successfully applied to the screening of potential inhibitors against PA N /PA N I38T from an aqueous extract of Artemisiae Argyi and 17 potential PA N Is were identified. Among them, three compounds (cynarine, isochlorogenic acid B and isochlorogenic acid C) showed comparable inhibitory activity against PA N and even better activity against PA N I38T compared to baloxavir. This study not only established a novel high-throughput ANF-based PA N Is screening platform, but also proved the feasibility to discover PA N Is from complex TCMs, which has a great potential in future anti-influenza drug discovery.
研究领域:
病毒学
·
药物筛选
·
植物药理学
·
生物分析技术
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产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2025
·
IF 3.9
Jun Zhang,Chao Hou,He Yu,Md All Amin Newton,Binjie Xin,Tingxiao Li
To address persistent challenges in wound care, including exudate management, infection prevention, and healing monitoring, this study developed a multifunctional fiber dressing using electrospinning technology. The system integrates a patterned hydrophobic polylactic acid/zinc oxide (PLA/ZnO) inner layer providing antimicrobial protection and exudate drainage; a polyacrylonitrile/polydopamine (PAN/PDA) intermediate water transport layer enabling unidirectional exudate transfer; and an outer PAN-based functional membrane incorporating sodium polyacrylate (SPA), phenol red (PSP), and tetracycline hydrochloride (TCH) for controlled drug release and visual wound status monitoring. The comprehensive evaluation revealed exceptional performance: rapid exudate removal within 3.35 s, 96 h sustained antibacterial drug release (68.6% cumulative release), pH-responsive chromatic transition (yellow-to-red at pH 5–9), and significant antimicrobial efficacy against Escherichia coli and Staphylococcus aureus (inhibition zone diameters of 10 and 18 mm, respectively). The dressing exhibited a balance of mechanical strength (6.1 MPa tensile strength) and breathability (13.4 mm/s air permeability rate). By integrating three core functions─efficient exudate management, antimicrobial regulation, and intelligent healing monitoring─this multifunctional architecture demonstrates clinical applicability in postoperative care and chronic wound therapy.
研究领域:
生物材料学
·
伤口护理
·
药剂学
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产品关联
DOI
PubMed
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2026
·Vol. 227
·期 2
·e00468
·
IF 2.7
Songsong Li,Yuliang Liu,Chunqi Wang,Yunjiao Deng,Shiling Jia,Zhongyu Fu,Huixuan Zhang
This study investigates the microscale dual-diffusion process of polyacrylonitrile (PAN) solutions in the coagulation bath and the process of PAN fiber formation. The interaction peaks assignment between solvent and water were identified by analyzing the Fourier transform infrared spectroscopy (FTIR) characteristic peaks of red or blue shift. The time-resolved attenuated total reflection FTIR technique was employed to analyze the dual-diffusion process. Enabling quantitative determination of diffusion coefficients based on Fick's second law. A correlation was established between diffusion coefficients, the microstructural characteristics of PAN membranes and the cross-sectional morphology of PAN nascent fibers. Additionally, examination of the microstructure of triple times stretched PAN nascent fibers revealed the formation mechanism of fibers with “Fibrils Within a Filament”.
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DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2022
·
IF 7.392
Yuenan Pan,Qi Chu,Shuang Guo,Sila Jin,Eungyeong Park,Yeonju Park,Yantao Sun,Lei Chen,Young Mee Jung
The purpose of this paper is to study the charge transfer (CT) process of a Ag/MBA/PAN system with different thicknesses of PAN and explore its SERS enhancement mechanism. It is found that as the PAN thickness is increased, the frequency and intensity of the characteristic MBA band gradually increases. The intensity of the b 2 mode increases significantly, which is attributed to the CT mechanism. As the PAN thickness is increased, the degree of CT (ρ CT ) gradually increases, which is due to the excited SPR from Ag. The electromagnetic enhancement mechanism, which occurs at the interface between PAN and Ag, generates hot electrons and rearranges the interface between PAN and Ag, thereby promoting electron transfer for the whole CT in Ag/MBA/PAN. These results show that CT occurs from the Fermi level of Ag to the LUMO level of MBA and then to the LUMO level of PAN. Additionally, the direction of CT is verified by 2D-COS. Therefore, this study not only reveals the ultrahigh SERS activity of the substrate but also explains the detailed process of regulating the substrate through the PAN thickness, which affects the SERS mechanism. This conductive polymer will open up a new horizon of SERS research and applications.
研究领域:
材料科学
·
光谱学
·
纳米技术
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产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2012
·Vol. 177
·期 1
·195-200
·
IF 3.033
Iqbal Jibran,Yin Changhai,Geng Jinpei,Li Xiaoyu,Li Xiuyong,Du Yiping,Liu Bing Xiang
We report on a simple, sensitive and selective method for the spectrophotometric determination of Ni 2+ in water samples. The analyte ions were collected on a membrane filter in the form of their red complex with 1-(2-pyridylazo)-2-naphthol (PAN), and the absorption spectra of the colored membrane filters were acquired. Effects of pH value, sample volume, and amount of PAN were examined in order to optimize sensitivity. The interference by common other ions was eliminated using appropriate masking agents. The absorbance is linearly related to the concentration of Ni 2+ in the ranges from 0.3 to 1.5 μg L −1 , and from 2 to 10 μg L −1 , respectively, the correlation coefficients (R 2 ) being 0.9871 and 0.9954. Under the optimal conditions, the detection limit is 0.1 μg L −1 . The recoveries in case of spiked samples are between 95.0% and 101.5%, and the relative standard deviations range from 2.8% to 4.1%.
Direct ultra-sensitive spectrophotometric determination of Ni 2+ as Ni-PAN complex on membrane filters
研究领域:
分析化学
·
环境科学
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产品关联
DOI
高影响因子
Advanced Science
·
2025
·
IF 14.1
Cai Zhang,Wen-Hui Zhao,Duo Zuo,Tianxing Zhou,Wenjing Hou,Lingwei Wang,Shangheng Shi,Yang Yang,Yuanyuan Liu,Shao-Kai Sun,Li Ren,Zhaoxiang Ye,Dingbin Liu,Dong Li,Xiaoyuan Chen,Jihui Hao
Early and accurate detection of multiple cancers through a single test remains an unmet clinical need, hindered by current limitations in accuracy, throughput, automation, and multiplexing. Here, we present an AI-powered SERS chip that combines automated exosome capture with AI-enabled molecular fingerprinting to accurately distinguish ten common cancer types from a single serum test. The system employs a peptide-functionalized SERS chip enabling the selective enrichment of exosomes directly from patient serum, enhancing label-free Raman fingerprint signals. AI-driven spectral analysis achieved 97.4% accuracy in distinguishing cancer from healthy samples, 97.08% accuracy for early-stage cancer detection, and 93.89% accuracy in classifying ten common cancer types, including breast, thyroid, esophageal, kidney, pancreatic, duodenal, lung, colorectal, ovarian, and gastric cancers. Crucially, based on molecular profiling, we identified exosomal deoxyadenosine triphosphate as a promising pan-cancer biomarker consistently upregulated across diverse tumor types. This discovery establishes a potential pan-cancer diagnostic marker, while the fully automated, scalable platform offers significant promise for clinical translation in early and differential cancer diagnosis.
研究领域:
肿瘤学
·
生物医学工程
·
纳米技术
·
医疗人工智能
·
分子诊断
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Science
·
2026
·
IF 14.1
Bin Ma,Huimin Gong,Ran Zhuo,Zaixiao Rao,Yanxi Wan,Mingyang Wang,Zahra Zeinalzadeh,Yuan Gao,Aohan Guan,Xinrun Li,Wanting Chen,Xiliang Wang,Yun Wan,Sihua Zhang,Yuncai Xiao,Qi Huang,Paul R. Langford,Xiangru Wang,Rui Zhou,Rui Luo,Hongbo Zhou,Chengliang Zhu,Hui Jin
Epigenetic modifications furnish a hidden regulatory layer that shapes cellular fate and evolutionary potential without rewriting the genetic code. In eukaryotes, methylome maps have profoundly transformed our understanding of development, disease, and lineage diversification. In bacteria, which represent the most abundant and ecologically versatile forms of life, the epigenome remains a largely uncharted dimension. To enable population-scale comparison of bacterial methylomes, we develop a principled strategy to prioritize methylation systems that are enzymatically encoded, broadly conserved and phylogenetically informative, thereby defining a stable substrate for quantitative comparative analysis. We reconstruct the first population-scale bacterial methylation-informed phylogenies that broadly recapitulate sequence-based relationships while resolving epi-phylogroups associated with GC content and environmental stress resilience. We introduce a three-metric quantitative framework (MPK, MR, and MFR) that converts site-level methylation calls into standardized, cross-sample comparable quantitative traits, enabling robust identification of highly methylated core genes from as few as 30 Escherichia coli strains. Finally, co-methylation network analysis identifies virulence-enriched modules and coordinated methylation of horizontally acquired virulence loci, providing the first evidence that horizontally acquired virulence loci are epigenetically assimilated into host regulatory circuitry. Together, this framework enables locus-resolved, population-scale integration of bacterial methylation data to interrogate epigenetic contributions to evolution, fitness and pathogenicity.
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产品关联
DOI
PubMed
高影响因子
Interdisciplinary Materials
·
2026
·
IF 22.5
Jia Qi,Hairu Lin,Caiyun Fang,Jia Li,Fangying Shi,Chunhui Deng
Cancer remains a major global health challenge, underscoring the urgent need for early diagnostic strategies. Altered cancer metabolism can be captured through serum analysis by laser desorption/ionization mass spectrometry (LDI-MS). Here, we report the design of gold nanoparticle-modified manganese–cobalt oxide heterojunctions (Au/MCOHs) as a high-performance LDI-MS nano-matrix. The Au/MCOHs combine strong ultraviolet absorption, enhanced charge separation, and favorable surface potential to achieve efficient laser energy conversion and ionization. Leveraging this platform, we performed serum metabolomic analysis on 698 participants, comprising healthy controls and patients with six different cancer types. Machine learning models distinguished cancer patients from healthy controls with area under the curve (AUC) values up to 0.955. Critically, early-stage cancers were also detected, with AUCs ranging from 0.776 to 0.938. Thirteen cancer-associated metabolites were identified, and a combined diagnostic panel achieved an AUC of 0.865. This study demonstrates how rationally engineered plasmonic heterojunction nanomatrices can bridge materials innovation and clinical translation, offering a robust, non-invasive route for pan-cancer metabolomic screening.
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DOI
高影响因子
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